The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.
Regulation of immune responses by L-arginine metabolism
Abstract
L-Arginine is an essential amino acid for birds and young mammals, and it is a conditionally essential amino acid for adult mammals, as it is important in situations in which requirements exceed production, such as pregnancy. Recent findings indicate that increased metabolism of L-arginine by myeloid cells can result in the impairment of lymphocyte responses to antigen during immune responses and tumour growth. Two enzymes that compete for L-arginine as a substrate - arginase and nitric-oxide synthase - are crucial components of this lymphocyte-suppression pathway, and the metabolic products of these enzymes are important moderators of T-cell function. This Review article focuses on the relevance of L-arginine metabolism by myeloid cells for immunity under physiological and pathological conditions.
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“Along with activation of innate or adaptive immune cells, neutrophils, by releasing arginase or ROS, can inhibit NK-cell or T-cell activation by depriving extracellular levels of L-arginine, necessary for T-cell activation [225].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [225]
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Panagiotakopoulou, V., Botsakis, K., Delis, F., Mourtzi, T., Tzatzarakis, M. N., Dimopoulou, A., Poulia, N., Antoniou, K., Stathopoulos, G. T., Matsokis, N., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107919 · Cited by 15
Faustmann, G., Meinitzer, A., Magnes, C., Tiran, B., Obermayer-Pietsch, B., Gruber, H.-J., Ribalta, J., Rock, E., Roob, J. M., & Winklhofer-Roob, B. M. (2018) · PLOS ONE · doi:10.1371/journal.pone.0200489 · Cited by 16
Metadata
- Authors
- Bronte, V., & Zanovello, P.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Bronte, Vincenzo
- Venue
- Nature Reviews Immunology
- Published
- 2005-08
- Volume
- 5
- Issue
- 8
- Pages
- 641-654
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W1977179270
- Cited by
- 1,775
- References
- 146
- Citations by year
- 2026: 69 · 2025: 78 · 2024: 75 · 2023: 96 · 2022: 81 · 2021: 114 · 2020: 100 · 2019: 92 · 2018: 97 · 2017: 89 · 2016: 119 · 2015: 92 · 2014: 95 · 2013: 96 · 2012: 97
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Bacterial Cancer Therapy
- Keywords
- arginine metabolism, immune regulation, arginase, nitric oxide synthase, myeloid cells, T cell function, lymphocyte suppression, tumor growth, immunosuppression, essential amino acids
- MeSH terms
- Animals, Arginase, Arginine, Humans, Immunity, Cellular, Suppressor Factors, Immunologic, T-Lymphocytes, Reactive Oxygen Species, Nitric Oxide Synthase, Myeloid Cells, Reactive Nitrogen Species
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