The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Neutrophils and immunity: challenges and opportunities
Abstract
Scientists who study neutrophils often have backgrounds in cell biology, biochemistry, haematology, rheumatology or infectious disease. Paradoxically, immunologists seem to have a harder time incorporating these host-defence cells into the framework of their discipline. The recent literature discussed here indicates that it is appropriate for immunologists to take as much interest in neutrophils as in their lymphohaematopoietic cousins with smooth nuclei. Neutrophils inform and shape immune responses, contribute to the repair of tissue as well as its breakdown, use killing mechanisms that enrich our concepts of specificity, and offer exciting opportunities for the treatment of neoplastic, autoinflammatory and autoimmune disorders.
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“Neutrophils are critical for starting and regulating the innate immune defense through phagocytosis, apoptotic action, chemotactic role, oxidative stress, and secretion of inflammatory mediators (Nathan, 2006).”
From Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: effect of inflammatory biomarkers at three-month follow-up (2021) · cites this paper as Nathan, 2006
Citations
Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Singer, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
Nitric oxide as a secretory product of mammalian cells
Nathan, C. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.12.1381691 · Cited by 4,350
The Danger Model: A Renewed Sense of Self
Matzinger, P. (2002) · Science · doi:10.1126/science.1071059 · Cited by 4,205
Tissue Destruction by Neutrophils
Epstein, F. H., & Weiss, S. J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902093200606 · Cited by 3,950
Tissue Destruction by Neutrophils
(1989) · New England Journal of Medicine · doi:10.1056/nejm198908033210513 · Cited by 3,634
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125
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Wen, X., Xu, X., Sun, W., Chen, K., Pan, M., Wang, J. M., Bolland, S. M., & Jin, T. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-06-0358 · Cited by 30
Hamilton, T., Li, X., Novotny, M., Pavicic, P. G., Datta, S., Zhao, C., Hartupee, J., & Sun, D. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0811404 · Cited by 32
Hart, S. P., Rossi, A. G., Haslett, C., & Dransfield, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033142 · Cited by 24
Yu, M., Li, X., Xu, L., Zheng, C., Pan, W., Chen, H., Liu, X., Zhang, X., & Zhang, J. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000513 · Cited by 19
Photoprotection conferred by low level summer sunlight exposures against pro-inflammatory UVR insult
Felton, S. J., Shin, B. B., Watson, R. E. B., Kift, R., Webb, A. R., & Rhodes, L. E. (2020) · Photochemical & Photobiological Sciences · doi:10.1039/c9pp00452a · Cited by 11
Metadata
- Authors
- Nathan, C.
- Affiliations
- Cornell University (US)
- Corresponding author
- Nathan, Carl
- ORCID
- Nathan, Carl
- Venue
- Nature reviews. Immunology
- Published
- 2006-02-17
- Volume
- 6
- Issue
- 3
- Pages
- 173-182
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2069375519
- Cited by
- 2,971
- References
- 99
- Citations by year
- 2026: 73 · 2025: 112 · 2024: 128 · 2023: 131 · 2022: 166 · 2021: 145 · 2020: 157 · 2019: 171 · 2018: 148 · 2017: 161 · 2016: 142 · 2015: 173 · 2014: 168 · 2013: 200 · 2012: 197
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- neutrophils, innate immunity, immune response initiation, inflammation, tissue repair, autoinflammatory disease, autoimmune disease, cancer immunotherapy, host defense
- MeSH terms
- Animals, Calcium, Humans, Immunity, Peroxidase, Neutrophils, Wound Healing, Signal Transduction, Leukosialin
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