Cited by 2,971Neutrophil, Myeloperoxidase and Oxidative MechanismsInflammation biomarkers and pathwaysImmune cells in cancer

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Neutrophils and immunity: challenges and opportunities

Nathan, Carl·2006·Nature reviews. Immunology

DOI 10.1038/nri1785

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Abstract

Scientists who study neutrophils often have backgrounds in cell biology, biochemistry, haematology, rheumatology or infectious disease. Paradoxically, immunologists seem to have a harder time incorporating these host-defence cells into the framework of their discipline. The recent literature discussed here indicates that it is appropriate for immunologists to take as much interest in neutrophils as in their lymphohaematopoietic cousins with smooth nuclei. Neutrophils inform and shape immune responses, contribute to the repair of tissue as well as its breakdown, use killing mechanisms that enrich our concepts of specificity, and offer exciting opportunities for the treatment of neoplastic, autoinflammatory and autoimmune disorders.

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Authors: Nathan, C.
Affiliations: Cornell University (US)
Corresponding author: Nathan, Carl
ORCID: Nathan, Carl
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2006-02-17
Volume: 6
Issue: 3
Pages: 173-182
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1785
OpenAlex: W2069375519
Cited by: 2,971
References: 99
Citations by year: 2026: 73 · 2025: 112 · 2024: 128 · 2023: 131 · 2022: 166 · 2021: 145 · 2020: 157 · 2019: 171 · 2018: 148 · 2017: 161 · 2016: 142 · 2015: 173 · 2014: 168 · 2013: 200 · 2012: 197
FWCI: 8.88
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: neutrophils, innate immunity, immune response initiation, inflammation, tissue repair, autoinflammatory disease, autoimmune disease, cancer immunotherapy, host defense
MeSH terms: Animals, Calcium, Humans, Immunity, Peroxidase, Neutrophils, Wound Healing, Signal Transduction, Leukosialin

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