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Neutrophils and immunity: challenges and opportunities
Abstract
Scientists who study neutrophils often have backgrounds in cell biology, biochemistry, haematology, rheumatology or infectious disease. Paradoxically, immunologists seem to have a harder time incorporating these host-defence cells into the framework of their discipline. The recent literature discussed here indicates that it is appropriate for immunologists to take as much interest in neutrophils as in their lymphohaematopoietic cousins with smooth nuclei. Neutrophils inform and shape immune responses, contribute to the repair of tissue as well as its breakdown, use killing mechanisms that enrich our concepts of specificity, and offer exciting opportunities for the treatment of neoplastic, autoinflammatory and autoimmune disorders.
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“Neutrophils are critical for starting and regulating the innate immune defense through phagocytosis, apoptotic action, chemotactic role, oxidative stress, and secretion of inflammatory mediators (Nathan, 2006).”
From Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: effect of inflammatory biomarkers at three-month follow-up (2021) · cites this paper as Nathan, 2006
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Metadata
- Authors
- Nathan, C.
- Affiliations
- Cornell University (US)
- Corresponding author
- Nathan, Carl
- ORCID
- Nathan, Carl
- Venue
- Nature reviews. Immunology
- Published
- 2006-02-17
- Volume
- 6
- Issue
- 3
- Pages
- 173-182
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2069375519
- Cited by
- 2,971
- References
- 99
- Citations by year
- 2026: 73 · 2025: 112 · 2024: 128 · 2023: 131 · 2022: 166 · 2021: 145 · 2020: 157 · 2019: 171 · 2018: 148 · 2017: 161 · 2016: 142 · 2015: 173 · 2014: 168 · 2013: 200 · 2012: 197
- FWCI
- 8.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- neutrophils, innate immunity, immune response initiation, inflammation, tissue repair, autoinflammatory disease, autoimmune disease, cancer immunotherapy, host defense
- MeSH terms
- Animals, Calcium, Humans, Immunity, Peroxidase, Neutrophils, Wound Healing, Signal Transduction, Leukosialin
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