The complex STATes of astrocyte reactivity: How are they controlled by the JAK-STAT3 pathway?

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Regulation of Mn-Superoxide Dismutase Activity and Neuroprotection by STAT3 in Mice after Cerebral Ischemia

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High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes

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Disruption of Astrocyte STAT3 Signaling Decreases Mitochondrial Function and Increases Oxidative Stress In Vitro

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Early Activation of STAT3 Regulates Reactive Astrogliosis Induced by Diverse Forms of Neurotoxicity

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The Dark Side of Cell Signaling: Positive Roles for Negative Regulators

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Astrocytic GAP43 Induced by the TLR4/NF-κB/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity

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Multi-Tasking: Nuclear Transcription Factors with Novel Roles in the Mitochondria

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Translational potential of astrocytes in brain disorders

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A star is born: new insights into the mechanism of astrogenesis

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Dynamics and non-canonical aspects of JAK/STAT signalling

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Notch1–STAT3–ETB R signaling axis controls reactive astrocyte proliferation after brain injury

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STAT3‐Mediated astrogliosis protects myelin development in neonatal brain injury

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The Sin3a repressor complex is a master regulator of STAT transcriptional activity

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Ciliary Neurotrophic Factor Activates Astrocytes, Redistributes Their Glutamate Transporters GLAST and GLT-1 to Raft Microdomains, and Improves Glutamate HandlingIn Vivo

Escartin, C., Brouillet, E., Gubellini, P., Trioulier, Y., Jacquard, C., Smadja, C., Knott, G. W., Goff, L. K., Déglon, N., Hantraye, P., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0302-06.2006 · Cited by 95 · see citing works

Touched and Moved by STAT3

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A new minimally-invasive method for microinjection into the mouse spinal dorsal horn

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Upregulation of gp130 and STAT3 activation in the rat hippocampus following transient forebrain ischemia

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Endogenous IL-6 of mesenchymal stem cell improves behavioral outcome of hypoxic-ischemic brain damage neonatal rats by supressing apoptosis in astrocyte

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Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling ( SOCS ) proteins

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Distinct transcriptional regulatory modules underlie STAT3’s cell type-independent and cell type-specific functions

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Role of Signal Transducer and Activator of Transcription-3 in Up-Regulation of GFAP After Epilepsy

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Spatiotemporal analysis of signal transducer and activator of transcription 3 activation in rat brain astrocytes and pituitary following peripheral immune challenge

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PI3K Signaling and Stat92E Converge to Modulate Glial Responsiveness to Axonal Injury

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Traumatically injured astrocytes release a proteomic signature modulated by <scp>STAT</scp>3‐dependent cell survival

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Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease

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Inhibition of Signal Transducer and Activator of Transcription 3 ( STAT 3) reduces neonatal hypoxic‐ischaemic brain damage

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STAT3 and NFκB Activation Precedes Glial Reactivity in the Excitotoxically Injured Young Cortex but not in the Corresponding Distal Thalamic Nuclei

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Glial Fibrillary Tangles and JAK/STAT-Mediated Glial and Neuronal Cell Death in a Drosophila Model of Glial Tauopathy

Colodner, K. J., & Feany, M. Β. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2491-10.2010 · Cited by 67 · see citing works

P2 purinergic receptors signal to STAT3 in astrocytes: Difference in STAT3 responses to P2Y and P2X receptor activation

Washburn, K. B., & Neary, J. T. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.034 · Cited by 66 · see citing works

Differential Regulation of Proliferation and Differentiation in Neural Precursor Cells by the Jak Pathway

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Stat3 Inhibition Attenuates Mechanical Allodynia through Transcriptional Regulation of Chemokine Expression in Spinal Astrocytes

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Chronic Perinatal Hypoxia Reduces Glutamate–Aspartate Transporter Function in Astrocytes through the Janus Kinase/Signal Transducer and Activator of Transcription Pathway

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Upregulation of gp130 and differential activation of STAT and p42/44 MAPK in the rat hippocampus following kainic acid-induced seizures

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The Complex of Ciliary Neurotrophic Factor-Ciliary Neurotrophic Factor Receptor α Up-Regulates Connexin43 and Intercellular Coupling in Astrocytes via the Janus Tyrosine Kinase/Signal Transducer and Activator of Transcription Pathway

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Induction of STAT3 Signaling in Activated Astrocytes and Sprouting Septal Neurons Following Entorhinal Cortex Lesion in Adult Rats

Xia, X. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1180 · Cited by 55 · see citing works

Astrocyte Activation via Stat3 Signaling Determines the Balance of Oligodendrocyte versus Schwann Cell Remyelination

de Castro, G. M., Deja, N. A., Ma, D., Zhao, C., & Franklin, R. J. M. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.05.011 · Cited by 54 · see citing works

Enhancement of Hypothalamic STAT3 Acetylation by Nuclear Receptor Nur77 Dictates Leptin Sensitivity

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JAK‐STAT signaling pathway mediates astrogliosis in brains of scrapie‐infected mice

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Activation of STAT3 and inhibitory effects of pioglitazone on STAT3 activity in a mouse model of SOD1-mutated amyotrophic lateral sclerosis

Shibata, N., Yamamoto, T., Hiroi, A., Omi, Y., Kato, Y., & Kobayashi, M. (2009) · Neuropathology · doi:10.1111/j.1440-1789.2009.01078.x · Cited by 46 · see citing works

Genetic approaches to study glial cells in the rodent brain

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Transgenic analysis of GFAP promoter elements

Yeo, S., Bandyopadhyay, S., Messing, A., & Brenner, M. (2013) · Glia · doi:10.1002/glia.22536 · Cited by 43 · see citing works

Activation of Signal Transducer and Activator of Transcription-3 in the Spinal Cord of Sporadic Amyotrophic Lateral Sclerosis Patients

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Acetylation and phosphorylation of STAT3 are involved in the responsiveness of microglia to beta amyloid

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Elevated Activity of STAT3C due to Higher DNA Binding Affinity of Phosphotyrosine Dimer Rather than Covalent Dimer Formation

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Stat3 mediates LIF‐induced protection of astrocytes against toxic ROS by upregulating the UPC2 mRNA pool

Lapp, D. W., Zhang, S. S.-M., & Barnstable, C. J. (2013) · Glia · doi:10.1002/glia.22594 · Cited by 38 · see citing works

JAK2 inhibition is neuroprotective and reduces astrogliosis after quinolinic acid striatal lesion in adult mice.

Ignarro, R. S., Vieira, A. S., Sartori, C., Langone, F., Rogerio, F., & Parada, C. (2013) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2013.02.005 · Cited by 29 · see citing works

Expression and Activation of STAT3 in the Astrocytes of Optic Nerve in a Rat Model of Transient Intraocular Hypertension

Zhang, S., Li, W., Wang, W., Zhang, S. S.-M., Huang, P. C., & Zhang, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055683 · Cited by 28 · see citing works

Redox regulation of Janus kinase

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Signal transducer and activator of transcription 3 regulation by novel binding partners

Matsuda, T. (2015) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v6.i4.324 · Cited by 19 · see citing works

The Regulation of Reactive Changes Around Multiple Sclerosis Lesions by Phosphorylated Signal Transducer and Activator of Transcription

Lu, J., Power, C., Blevins, G., Giuliani, F., & Yong, V. W. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000011 · Cited by 18 · see citing works

Disrupted nuclear import-export in neurodegeneration

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Identification of STAT3 and STAT5 proteins in the rat suprachiasmatic nucleus and the Day/Night difference in astrocytic STAT3 phosphorylation in response to lipopolysaccharide

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Activation of STAT3 signaling in axotomized neurons and reactive astrocytes after fimbria–fornix transection

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Overexpression of SCLIP promotes growth and motility in glioblastoma cells

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Visualization of Stat3 and Stat5 transactivation activity with specific response element dependent reporter constructs integrated into lentiviral gene transfer vectors

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Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

Kwon, H. S., & Koh, S.-H. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00221-2 · Cited by 2,595 · see citing works

Reactive Astrocytes: Production, Function, and Therapeutic Potential

Liddelow, S. A., & Barres, B. A. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.006 · Cited by 2,336 · see citing works

Function and therapeutic value of astrocytes in neurological diseases

Lee, H.-G., Wheeler, M. A., & Quintana, F. J. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00390-x · Cited by 662 · see citing works

The Role of Astrocytes in CNS Inflammation

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Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration

Patani, R., Hardingham, G. E., & Liddelow, S. A. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00822-1 · Cited by 531 · see citing works

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

Litvinchuk, A., Wan, Y.-W., Swartzlander, D. B., Chen, F., Cole, A., Propson, N. E., Wang, Q., Zhang, B., Liu, Z., & Zheng, H. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.031 · Cited by 523 · see citing works

High complement levels in astrocyte‐derived exosomes of Alzheimer disease

Goetzl, E. J., Schwartz, J. B., Abner, E. L., Jicha, G. A., & Kapogiannis, D. (2018) · Annals of Neurology · doi:10.1002/ana.25172 · Cited by 369 · see citing works

Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration

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A1/A2 astrocytes in central nervous system injuries and diseases: Angels or devils?

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Questions and (some) answers on reactive astrocytes

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Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

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Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury

Yang, T., Dai, Y., Chen, G., & Cui, S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00078 · Cited by 257 · see citing works

Activation and Role of Astrocytes in Ischemic Stroke

Shen, X.-Y., Gao, Z.-K., Han, Y., Yuan, M., Guo, Y., & Bi, X. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.755955 · Cited by 189 · see citing works

Brain-derived estrogen and neural function

Brann, D., Lu, Y.-J., Wang, J., Zhang, Q.-G., Thakkar, R., Sareddy, G., Pratap, U. P., Tekmal, R., & Vadlamudi, R. (2021) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.11.014 · Cited by 140 · see citing works

Emerging Roles of Astrocytes in Neuro-Vascular Unit and the Tripartite Synapse With Emphasis on Reactive Gliosis in the Context of Alzheimer’s Disease

Liu, C.-Y., Yang, Y., Ju, W.-N., Wang, X., & Zhang, H.-L. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00193 · Cited by 131 · see citing works

Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective following Ischemic Brain Injury

Wang, J., Sareddy, G. R., Lu, Y., Pratap, U. P., Tang, F., Greene, K. M., Meyre, P. L., TEKMAL, R. R., Vadlamudi, R. K., & Brann, D. W. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0888-20.2020 · Cited by 125 · see citing works

Quinones as Neuroprotective Agents

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Friend, Foe or Both? Immune Activity in Alzheimer’s Disease

Frost, G. R., Jonas, L. A., & Li, Y. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00337 · Cited by 86 · see citing works

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

Soucy, J. R., Aguzzi, E. A., Cho, J. Y., Gilhooley, M. J., Keuthan, C. J., Luo, Z., Monavarfeshani, A., Saleem, M. A., Wang, X., Wohlschlegel, J., et al. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00655-y · Cited by 82 · see citing works

Regulation of RhoA by STAT3 coordinates glial scar formation

Renault-Mihara, F., Mukaino, M., Shinozaki, M., Kumamaru, H., Kawase, S., Baudoux, M., Ishibashi, T., Kawabata, S., Nishiyama, Y., Sugai, K., et al. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201610102 · Cited by 82 · see citing works

Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity

Cunningham, C. M., Dunne, A., & López-Rodríguez, A. B. (2018) · The Neuroscientist · doi:10.1177/1073858418809941 · Cited by 78 · see citing works

Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice

Guo, Q., Gobbo, D., Zhao, N., Zhang, H., Awuku, N.-O., Liu, Q., Fang, L., Gampfer, T. M., Meyer, M. R., Zhao, R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50466-y · Cited by 81 · see citing works

microRNA‐132 is overexpressed in glia in temporal lobe epilepsy and reduces the expression of pro‐epileptogenic factors in human cultured astrocytes

Korotkov, A., Broekaart, D. W. M., Banchaewa, L., Pustjens, B., van Scheppingen, J., Anink, J. J., Baayen, J. C., Idema, S., Gorter, J. A., van Vliet, E. A., et al. (2019) · Glia · doi:10.1002/glia.23700 · Cited by 77 · see citing works

Traumatic brain injury increases plasma astrocyte‐derived exosome levels of neurotoxic complement proteins

Goetzl, E. J., Yaffe, K. S., Peltz, C. B., Ledreux, A., Gorgens, K. A., Davidson, B. S., Granholm, A., Mustapić, M., Kapogiannis, D., Tweedie, D., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201902842r · Cited by 74 · see citing works

Astrocyte-Derived Exosomal microRNA miR-200a-3p Prevents MPP+-Induced Apoptotic Cell Death Through Down-Regulation of MKK4

Shakespear, N., Ogura, M., Yamaki, J., & Homma, Y. (2020) · Neurochemical Research · doi:10.1007/s11064-020-02977-5 · Cited by 72 · see citing works

Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathway

Abjean, L., Haim, L. B., Riquelme‐Perez, M., Gipchtein, P., Derbois, C., Palomares, M.-A., Petit, F., Hérard, A., Gaillard, M., Guillermier, M., et al. (2022) · Brain · doi:10.1093/brain/awac068 · Cited by 72 · see citing works

Astrocytes in functional recovery following central nervous system injuries

Alhadidi, Q., Bahader, G. A., Arvola, O., Kitchen, P., Shah, Z. A., & Salman, M. M. (2023) · The Journal of Physiology · doi:10.1113/jp284197 · Cited by 64 · see citing works

Astrocytic STAT3 activation and chronic itch require IP3R1/TRPC-dependent Ca2+ signals in mice

Shiratori‐Hayashi, M., Chiharu, Y., Eguchi, K., Shiraishi, Y., Kohno, K., Mikoshiba, K., Inoue, K., Nishida, M., & Tsuda, M. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.06.039 · Cited by 62 · see citing works

The Amyloid-Beta Clearance: From Molecular Targets to Glial and Neural Cells

Cai, W., Wu, T., & Chen, N. (2023) · Biomolecules · doi:10.3390/biom13020313 · Cited by 65 · see citing works

Zika Virus Infection Disrupts Astrocytic Proteins Involved in Synapse Control and Axon Guidance

Sher, A. A., Glover, K. K. M., & Coombs, K. M. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00596 · Cited by 60 · see citing works

Hyper-inflammation of astrocytes in patients of major depressive disorder: Evidence from serum astrocyte-derived extracellular vesicles

Xie, X., Lai, W., Xu, S., Forti, M. D., Zhang, J., Chen, M., Yao, L., Wang, P., Hao, K., & Rong, H. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.12.014 · Cited by 60 · see citing works

Targeting signal transducers and activators of transcription (STAT) in human cancer by dietary polyphenolic antioxidants

Amani, H., Ajami, M., Maleki, S. N., Pazoki–Toroudi, H., Daglia, M., Sokeng, A. J. T., Lorenzo, A. D., Nabavi, S. F., Devi, K. P., & Nabavi, S. M. (2017) · Biochimie · doi:10.1016/j.biochi.2017.08.007 · Cited by 56 · see citing works

Role of glia in optic nerve

Yazdankhah, M., Shang, P., Ghosh, S., Hose, S., Liu, H., Weiss, J., Fitting, C. S., Bhutto, I. A., Zigler, J. S., Qian, J. X., et al. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100886 · Cited by 58 · see citing works

Early Optic Nerve Head Glial Proliferation and Jak-Stat Pathway Activation in Chronic Experimental Glaucoma

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MicroRNA-125a-5p plays a role as a tumor suppressor in lung carcinoma cells by directly targeting STAT3

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Glucose Transport and Utilization in the Hippocampus: From Neurophysiology to Diabetes-Related Development of Dementia

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Neuroprotective Effects of Celastrol in Neurodegenerative Diseases-Unscramble Its Major Mechanisms of Action and Targets

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Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke

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HSF1 is involved in suppressing A1 phenotype conversion of astrocytes following spinal cord injury in rats

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Glial Cells as Key Regulators in Neuroinflammatory Mechanisms Associated with Multiple Sclerosis

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Janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis

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Immunometabolic Changes in Glia – A Potential Role in the Pathophysiology of Obesity and Diabetes

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Innate Immune Signaling and Role of Glial Cells in Herpes Simplex Virus- and Rabies Virus-Induced Encephalitis

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Mechanical pain of the lower extremity after compression of the upper spinal cord involves signal transducer and activator of transcription 3-dependent reactive astrocytes and interleukin-6

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Dopaminergic Signaling as a Plausible Modulator of Astrocytic Toll-Like Receptor 4: A Crosstalk between Neuroinflammation and Cognition

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Intracellular DAMPs in Neurodegeneration and Their Role in Clinical Therapeutics

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Targeting of cell cycle and let-7a/STAT3 pathway by niclosamide inhibits proliferation, migration and invasion in oral squamous cell carcinoma cells

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Limb remote ischemic post-conditioning mitigates brain recovery in a mouse model of ischemic stroke by regulating reactive astrocytic plasticity

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The long non-coding RNA LINC00473 contributes to cell proliferation via JAK-STAT3 signaling pathway by regulating miR-195-5p/SEPT2 axis in prostate cancer

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Neuroinflammation in Autoimmune Disease and Primary Brain Tumors: The Quest for Striking the Right Balance

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Azithromycin Affords Neuroprotection in Rat Undergone Transient Focal Cerebral Ischemia

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Astrocytic Yes-associated protein attenuates cerebral ischemia-induced brain injury by regulating signal transducer and activator of transcription 3 signaling

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Lactate Promotes Reactive Astrogliosis and Confers Axon Guidance Potential to Astrocytes under Oxygen-Glucose Deprivation

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Resveratrol Downregulates STAT3 Expression and Astrocyte Activation in Primary Astrocyte Cultures of Rat

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Endothelin-1 stimulates expression of cyclin D1 and S-phase kinase–associated protein 2 by activating the transcription factor STAT3 in cultured rat astrocytes

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Spinal Microglia and Astrocytes: Two Key Players in Chronic Visceral Pain Pathogenesis

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Low-dose brain irradiation normalizes TSPO and CLUSTERIN levels and promotes the non-amyloidogenic pathway in pre-symptomatic TgF344-AD rats

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The Role of Astrocytes in the Molecular Pathophysiology of Schizophrenia: Between Neurodevelopment and Neurodegeneration

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Adiponectin Promotes Neurogenesis After Transient Cerebral Ischemia Through STAT3 Mediated BDNF Upregulation in Astrocytes

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Calpain-Mediated Alterations in Astrocytes Before and During Amyloid Chaos in Alzheimer’s Disease

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Neuronutraceuticals Combating Neuroinflammaging: Molecular Insights and Translational Challenges—A Systematic Review

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H2A.Z.1 crosstalk with H3K56-acetylation controls gliogenesis through the transcription of folate receptor

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The day/night difference in the circadian clock's response to acute lipopolysaccharide and the rhythmic Stat3 expression in the rat suprachiasmatic nucleus

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In vitro modelling of the neurovascular unit for ischemic stroke research: Emphasis on human cell applications and 3D model design

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Macrophages play a leading role in determining the direction of astrocytic migration in spinal cord injury via ADP-P2Y1R axis

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Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure

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Osteopontin is indispensable for activation of astrocytes in injured mouse brain and primary culture

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Astrocytic EphA4 signaling is important for the elimination of excitatory synapses in Alzheimer’s disease

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Maternal DBP exposure promotes synaptic formation in offspring by activating astrocytes via the AKT/NF-κB/IL-6/JAK2/STAT3 signaling pathway

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Binge‐like ethanol drinking activates anaplastic lymphoma kinase signaling and increases the expression of STAT3 target genes in the mouse hippocampus and prefrontal cortex

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Bidirectional Responses of Eight Neuroinflammation-Related Transcriptional Factors to 64 Flavonoids in Astrocytes with Transposable Insulated Signaling Pathway Reporters

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Tumor‐associated astrocytes promote tumor progression of Sonic Hedgehog medulloblastoma by secreting lipocalin‐2

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