ChemR23 Dampens Lung Inflammation and Enhances Anti-viral Immunity in a Mouse Model of Acute Viral Pneumonia
Open accessAbstract
Viral diseases of the respiratory tract, which include influenza pandemic, children acute bronchiolitis, and viral pneumonia of the elderly, represent major health problems. Plasmacytoid dendritic cells play an important role in anti-viral immunity, and these cells were recently shown to express ChemR23, the receptor for the chemoattractant protein chemerin, which is expressed by epithelial cells in the lung. Our aim was to determine the role played by the chemerin/ChemR23 system in the physiopathology of viral pneumonia, using the pneumonia virus of mice (PVM) as a model. Wild-type and ChemR23 knock-out mice were infected by PVM and followed for functional and inflammatory parameters. ChemR23(-/-) mice displayed higher mortality/morbidity, alteration of lung function, delayed viral clearance and increased neutrophilic infiltration. We demonstrated in these mice a lower recruitment of plasmacytoid dendritic cells and a reduction in type I interferon production. The role of plasmacytoid dendritic cells was further addressed by performing depletion and adoptive transfer experiments as well as by the generation of chimeric mice, demonstrating two opposite effects of the chemerin/ChemR23 system. First, the ChemR23-dependent recruitment of plasmacytoid dendritic cells contributes to adaptive immune responses and viral clearance, but also enhances the inflammatory response. Second, increased morbidity/mortality in ChemR23(-/-) mice is not due to defective plasmacytoid dendritic cells recruitment, but rather to the loss of an anti-inflammatory pathway involving ChemR23 expressed by non-leukocytic cells. The chemerin/ChemR23 system plays important roles in the physiopathology of viral pneumonia, and might therefore be considered as a therapeutic target for anti-viral and anti-inflammatory therapies.
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Chemerin and CMKLR1 recruit immune cells to injury sites and might affect the occurrence and development of inflammation.
“Chemerin and CMKLR1 (which is expressed on immature dendritic cells, myeloid dendritic cells, macrophages, and natural killer cells) were later shown to recruit immune cells to injury sites and might affect the occurrence and development of inflammation (37, 38).”
From Circulating Adipokine Levels in Nonobese Women with Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis (2021) · cites this paper as [37]
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Cites
Respiratory Syncytial Virus Infection in Elderly and High-Risk Adults
Falsey, A. R., Hennessey, P., Formica, M. A., Cox, C., & Walsh, E. E. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043951 · Cited by 2,239 · see citing works
Plasmacytoid dendritic cells in immunity
Colonna, M., Trinchieri, G., & Liu, Y. (2004) · Nature Immunology · doi:10.1038/ni1141 · Cited by 1,659 · see citing works
Wittamer, V., Franssen, J.-D., Vulcano, M., Mirjolet, J.-F., Le Poul, E., Migeotte, I., Brézillon, S., Tyldesley, R., Blanpain, C., Detheux, M., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030382 · Cited by 888 · see citing works
Self-citationde Heer, H. J., Hammad, H., Soullié, T., Hijdra, D., Vos, N., Willart, M. A. M., Hoogsteden, H. C., & Lambrecht, B. N. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040035 · Cited by 784 · see citing works
Moseman, E. A., Liang, X., Dawson, A. J., Panoskaltsis‐Mortari, A., Krieg, A. Μ., Liu, Y., Blazar, B. R., & Chen, W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.7.4433 · Cited by 636 · see citing works
Respiratory syncytial virus infection
Simões, E. A. F. (1999) · The Lancet · doi:10.1016/s0140-6736(99)80040-3 · Cited by 603 · see citing works
Antigen-presentation properties of plasmacytoid dendritic cells.
Villadangos, J., & Young, L. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.002 · Cited by 577 · see citing works
Geurtsvankessel, C., Willart, M., van Rijt, L. V., Muskens, F., Kool, M., Baas, C., Thielemans, K., Bennett, C. L., Clausen, B., Hoogsteden, H., et al. (2008) · Journal of Experimental Medicine · doi:10.1084/jem.20071365 · Cited by 541 · see citing works
Graham, B. S., Bunton, L. A., Wright, P. F., & Karzon, D. T. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115362 · Cited by 501 · see citing works
Tuning inflammation and immunity by chemokine sequestration: decoys and more
Mantovani, A., Bonecchi, R., & Locati, M. (2006) · Nature Reviews Immunology · doi:10.1038/nri1964 · Cited by 481 · see citing works
The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues
Parolini, S., Santoro, A., Marcenaro, E., Luini, W., Massardi, L., Facchetti, F., Communi, D., Parmentier, M., Majorana, A., Sironi, M., et al. (2007) · Blood · doi:10.1182/blood-2006-08-038844 · Cited by 372 · see citing works
Self-citationChemerin Activation by Serine Proteases of the Coagulation, Fibrinolytic, and Inflammatory Cascades
Zabel, B. A., Allen, S. J., Kulig, P., Allen, J. A., Cichy, J., Handel, T. M., & Butcher, E. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504868200 · Cited by 369 · see citing works
Asselin‐Paturel, C., Brizard, G., Pin, J., Brière, F., & Trinchieri, G. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6466 · Cited by 360 · see citing works
Kaur, J., Adya, R., Tan, B. K., Chen, J., & Randeva, H. S. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.150 · Cited by 349 · see citing works
Biron, C. A. (1998) · Seminars in Immunology · doi:10.1006/smim.1998.0138 · Cited by 341 · see citing works
Albanesi, C., Scarponi, C., Pallotta, S., Daniele, R., Bosisio, D., Madonna, S., Fortugno, P., Gonzalvo-Feo, S., Franssen, J., Parmentier, M., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080129 · Cited by 328 · see citing works
Self-citationVermi, W., Riboldi, E., Wittamer, V., Gentili, F., Luini, W., Marrelli, S., Vecchi, A., Franssen, J., Communi, D., Massardi, L., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041310 · Cited by 289 · see citing works
Self-citationVermaelen, K. Y., & PAUWELS, R. A. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200410-1384so · Cited by 278 · see citing works
Luangsay, S., Wittamer, V., Bondue, B., Henau, O. D., Rouger, L., Brait, M., Franssen, J.-D., de Nadaı̈, P., Huaux, F., & Parmentier, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901037 · Cited by 256 · see citing works
Self-citationNeutrophil-Mediated Maturation of Chemerin: A Link between Innate and Adaptive Immunity
Wittamer, V., Bondue, B., Guillabert, A., Vassart, G., Parmentier, M., & Communi, D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.487 · Cited by 247 · see citing works
Self-citationSmit, J. J., Rudd, B. D., & Lukacs, N. W. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052359 · Cited by 244 · see citing works
Chemerin, a Novel Adipokine in the Regulation of Angiogenesis
Bozaoglu, K., Curran, J. E., Stocker, C. J., Zaibi, M. S., Segal, D., Konstantopoulos, N., Morrison, S., Carless, M. A., Dyer, T. D., Cole, S. A., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0042 · Cited by 226 · see citing works
Wittamer, V., Grégoire, F., Robberecht, P., Vassart, G., Communi, D., & Parmentier, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313016200 · Cited by 206 · see citing works
Self-citationJewell, N. A., Vaghefi, N., Mertz, S. E., Akter, P., Peebles, R. S., Bakaletz, L. O., Durbin, R. K., Flaño, E., & Durbin, J. E. (2007) · Journal of Virology · doi:10.1128/jvi.00530-07 · Cited by 172 · see citing works
Trafficking properties of plasmacytoid dendritic cells in health and disease
Sozzani, S., Vermi, W., Prete, A. D., & Facchetti, F. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.05.004 · Cited by 171 · see citing works
An Anti-Inflammatory Role for Plasmacytoid Dendritic Cells in Allergic Airway Inflammation
Kool, M., van Nimwegen, M., Willart, M. A. M., Muskens, F., Boon, L., Smit, J. J., Coyle, A. J., Clausen, B. E., Hoogsteden, H. C., Lambrecht, B. N., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900471 · Cited by 169 · see citing works
Wang, H., Peters, N., & Schwarze, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.6263 · Cited by 149 · see citing works
Activation of the IFN-Inducible Enzyme RNase L Causes Apoptosis of Animal Cells
Díaz‐Guerra, M., Rivas, C., & Estéban, M. (1997) · Virology · doi:10.1006/viro.1997.8719 · Cited by 139 · see citing works
Hammad, H., & Lambrecht, B. N. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.03.041 · Cited by 133 · see citing works
Respiratory Syncytial Virus Stimulates Neutrophil Degranulation and Chemokine Release
Jaovisidha, P., Peeples, M. E., Brees, A. A., Carpenter, L. R., & Moy, J. N. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.5.2816 · Cited by 126 · see citing works
Sikora, A. G., Jaffarzad, N., Hailemichael, Y., Gelbard, A. H., Stonier, S. W., Schluns, K. S., Frasca, L., Lou, Y., Liu, C., Andersson, H. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802982 · Cited by 117 · see citing works
Schwarze, J., Cieslewicz, G., Joetham, A., Ikemura, T., Hamelmann, E. H., & Gelfand, E. W. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.4207 · Cited by 116 · see citing works
Howard, T. S., Hoffman, L. H., Stang, P., et al. (2000) · The Journal of Pediatrics · doi:10.1067/mpd.2000.107525 · Cited by 111 · see citing works
Respiratory syncytial virus infection
Simões, E. A. F. (1999) · The Lancet · doi:10.1016/s0140-6736(98)10263-5 · Cited by 110 · see citing works
Plasmacytoid Dendritic Cells Are Dispensable during Primary Influenza Virus Infection
Wolf, A. I., Buehler, D. G., Hensley, S. E., Cavanagh, L. L., Wherry, E. J., Kastner, P., Chan, S. H., & Weninger, W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.871 · Cited by 101 · see citing works
A community-based, time-matched, case-control study of respiratory viruses and exacerbations of COPD
Hutchinson, A. F., Ghimire, A., Thompson, M. A., Black, J., Brand, C. A., Lowe, A. J., Smallwood, D. M., Vlahos, R., Bozinovski, S., Brown, G. V., et al. (2007) · Respiratory Medicine · doi:10.1016/j.rmed.2007.07.015 · Cited by 101 · see citing works
Dyer, K. D., Percopo, C. M., Fischer, E. R., et al. (2009) · Blood · doi:10.1182/blood-2009-01-199497 · Cited by 97 · see citing works
Davidson, S., Kaiko, G. E., Loh, Z., Lalwani, A., Zhang, V., Spann, K. M., Foo, S. Y., Hansbro, N. G., Uematsu, S., Akira, S., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002635 · Cited by 93 · see citing works
CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels
Maus, U. A., Wellmann, S., Hampl, C., Kuziel, W. A., Srivastava, M., Mack, M., Everhart, M. B., Blackwell, T. S., Christman, J. W., Schlöndorff, D., et al. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00061.2004 · Cited by 91 · see citing works
Flandre, T. D., Leroy, P. L., & Desmecht, D. J.-M. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00561.2002 · Cited by 87 · see citing works
Self-citationPotential role of chemerin in recruitment of plasmacytoid dendritic cells to diseased skin
Skrzeczyńska-Moncznik, J., Wawro, K., Stefańska, A., Oleszycka, E., Kulig, P., Zabel, B. A., Sułkowski, M., Kapińska-Mrowiecka, M., Czubak-Macugowska, M., Butcher, E. C., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.071 · Cited by 72 · see citing works
Pneumonia virus of mice: severe respiratory infection in a natural host
Rosenberg, H. F., & Domachowske, J. B. (2008) · Immunology Letters · doi:10.1016/j.imlet.2008.03.013 · Cited by 70 · see citing works
Bonville, C. A., Bennett, N. J., Koehnlein, M., Haines, D. M., Ellis, J. A., DelVecchio, A., Rosenberg, H. F., & Domachowske, J. B. (2006) · Virology · doi:10.1016/j.virol.2006.02.017 · Cited by 69 · see citing works
Cook, P., Easton, A. J., & Eglin, R. (1998) · Journal of General Virology · doi:10.1099/0022-1317-79-10-2411 · Cited by 65 · see citing works
Differential resistance/susceptibility patterns to pneumovirus infection among inbred mouse strains
Anh, D. B. T., Faísca, P., & Desmecht, D. J.-M. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00483.2005 · Cited by 59 · see citing works
Self-citationInflammatory Responses to Pneumovirus Infection in IFN-αβR Gene-Deleted Mice
Garvey, T. L., Dyer, K. D., Ellis, J. A., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4735 · Cited by 58 · see citing works
Emerging role of dendritic cells in respiratory viral infection
Grayson, M. H., & Holtzman, M. J. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0212-3 · Cited by 55 · see citing works
Role of T Cells in Virus Control and Disease after Infection with Pneumonia Virus of Mice
Frey, S., Krempl, C. D., Schmitt-Graeff, A. H., et al. (2008) · Journal of Virology · doi:10.1128/jvi.00375-08 · Cited by 40 · see citing works
The Phenotype and Function of Lung Dendritic Cells
Webb, T. J., Sumpter, T. L., Thiele, A. T., et al. (2005) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v25.i6.20 · Cited by 26 · see citing works
Decreased Asbestos-Induced Lung Inflammation and Fibrosis after Radiation and Bone Marrow Transplant
Levis, J. E., Loi, R., Butnor, K. J., Vacek, P. M., Steele, C. H., Mossman, B. T., & Weiss, D. J. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0249oc · Cited by 21 · see citing works
Meyer, K. B., & Ireland, J. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199805)28:05 · Cited by 17 · see citing works
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Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism
Bondue, B., Wittamer, V., & Parmentier, M. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.11.004 · Cited by 294 · see citing works
Self-citationUpdate on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7
Bäck, M., Powell, W. S., Dahlén, S., Drazen, J. M., Evans, J. F., Serhan, C. N., Shimizu, T., Yokomizo, T., & Rovati, G. E. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12665 · Cited by 217 · see citing works
Lin, K., Sun, X., Wang, X., Wang, H., & Chen, X. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.537809 · Cited by 81 · see citing works
Rice, T. A., Brenner, T. A., Percopo, C. M., Ma, M., Keicher, J. D., Domachowske, J. B., & Rosenberg, H. F. (2016) · Antiviral Research · doi:10.1016/j.antiviral.2016.06.002 · Cited by 30 · see citing works
“We and others have explored inflammatory responses to and immunomodulatory control of respiratory virus infection using the pneumonia virus of mice (PVM) model of acute pneumovirus infection (Dyer et al., 2012; Bondue et al., 2011; Walsh et al., 2014; Scheer et al., 2014; Siegle et al., 2011).”
Background
- Authors
- Bondue, B., Vosters, O., de Nadai, P., Glineur, S., De Henau, O., Luangsay, S., Van Gool, F., Communi, D., De Vuyst, P., Desmecht, D., & Parmentier, M.
- Affiliations
- Université Libre de Bruxelles (BE)
- University of Liège (BE)
- Corresponding author
- Parmentier, Marc
- ORCID
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-11-03
- Volume
- 7
- Issue
- 11
- Pages
- e1002358
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- PMC
- PMC3207933
- OpenAlex
- W1998934232
- Cited by
- 92
- References
- 51
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 2 · 2021: 11 · 2020: 3 · 2019: 5 · 2018: 10 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 7 · 2013: 5 · 2012: 8
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Pathogens (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- ORBi (University of Liège) (submittedVersion, other-oa)
- Funders
- Waalse Gewest
- European Commission (LSHB-CT-2005-518167)
- Fonds De La Recherche Scientifique - FNRS
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- ChemR23, chemerin, viral pneumonia, plasmacytoid dendritic cells, type I interferon, lung inflammation, viral clearance, neutrophil infiltration, antiviral immunity, Pneumocystis murina, chemokine receptors
- MeSH terms
- Animals, Chemotactic Factors, Dendritic Cells, Interferon Type I, Lung, Mice, Inbred C57BL, Pneumonia, Viral, Pneumovirus Infections, Mice, Knockout, Inflammation Mediators, Chemokines, Viral Load, Receptors, Chemokine, Murine pneumonia virus, Intercellular Signaling Peptides and Proteins, Receptors, G-Protein-Coupled, Mice
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