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Immunological aspects of cancer chemotherapy
Abstract
Accumulating evidence indicates that the innate and adaptive immune systems make a crucial contribution to the antitumour effects of conventional chemotherapy-based and radiotherapy-based cancer treatments. Moreover, the molecular and cellular bases of the immunogenicity of cell death that is induced by cytotoxic agents are being progressively unravelled, challenging the guidelines that currently govern the development of anticancer drugs. Here, we review the immunological aspects of conventional cancer treatments and propose that future successes in the fight against cancer will rely on the development and clinical application of combined chemo- and immunotherapies.
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“Activated but not resting γ-irradiated peripheral blood mononuclear cells can induce the expression of maturation markers (such as CD80, CD83 and CD86) and the secretion of pro-inflammatory cytokines by DCs in vitro29.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [29]
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“The immune modulatory effects of treatment with chemotherapy and radiotherapy in (reviewed in (Zitvogel et al., 2008)) have formed the basis for combination strategies to boost response to ICB”
From Hallmarks of response, resistance, and toxicity to immune checkpoint blockade (2021) · cites this paper as Zitvogel et al., 2008
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Metadata
- Authors
- Zitvogel, L., Apetoh, L., Ghiringhelli, F., & Kroemer, G.
- Affiliations
- Université Paris-Sud (FR)
- Corresponding author
- Zitvogel, Laurence
- Kroemer, Guido
- Venue
- Nature Reviews Immunology
- Published
- 2008-01
- Volume
- 8
- Issue
- 1
- Pages
- 59-73
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2047902191
- Cited by
- 1,712
- References
- 121
- Citations by year
- 2026: 78 · 2025: 93 · 2024: 99 · 2023: 131 · 2022: 162 · 2021: 118 · 2020: 89 · 2019: 70 · 2018: 79 · 2017: 105 · 2016: 79 · 2015: 81 · 2014: 75 · 2013: 94 · 2012: 95
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Institut National de la Santé et de la Recherche Médicale
- Conseil Régional, Île-de-France
- Ligue Contre le Cancer
- Institut National Du Cancer
- Cancéropôle Ile de France
- Institute of Cancer Research
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- cancer immunotherapy, chemotherapy, bystander effect, innate immunity, adaptive immunity, radiotherapy, cytotoxic drugs, anticancer drug development
- MeSH terms
- Animals, Antineoplastic Agents, Humans, Immune System, Immunologic Surveillance, Immunotherapy, Neoplasms, Cancer Vaccines
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