Dendritic cells as cancer therapeutics

Bryant, Christian E.; Sutherland, Sarah; Kong, Benjamin; Papadimitrious, Michael S.; Fromm, Phillip D.; Hart, Derek N.J.

doi:10.1016/j.semcdb.2018.02.015

Cited by 61Immunotherapy and Immune ResponsesCancer Research and TreatmentsCancer Immunotherapy and Biomarkers

Dendritic cells as cancer therapeutics

Bryant, Christian E., Sutherland, Sarah, Kong, Benjamin, Papadimitrious, Michael S., Fromm, Phillip D., Hart, Derek N.J.·2019·Seminars in Cell & Developmental Biology

DOI 10.1016/j.semcdb.2018.02.015

Open this paper in CoChat — free account

Abstract

The ability of immune therapies to control cancer has recently generated intense interest. This therapeutic outcome is reliant on T cell recognition of tumour cells. The natural function of dendritic cells (DC) is to generate adaptive responses, by presenting antigen to T cells, hence they are a logical target to generate specific anti-tumour immunity. Our understanding of the biology of DC is expanding, and they are now known to be a family of related subsets with variable features and function. Most clinical experience to date with DC vaccination has been using monocyte-derived DC vaccines. There is now growing experience with alternative blood-derived DC derived vaccines, as well as with multiple forms of tumour antigen and its loading, a wide range of adjuvants and different modes of vaccine delivery. Key insights from pre-clinical studies, and lessons learned from early clinical testing drive progress towards improved vaccines. The potential to fortify responses with other modalities of immunotherapy makes clinically effective "second generation" DC vaccination strategies a priority for cancer immune therapists.

Integrity signals

Registry

Crossref · 10.1016/j.semcdb.2018.02.015

Cites

212 of 212 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

RNA vaccines have exhibited encouraging results in both infection therapy and cancer immunotherapy.
“RNA vaccines, for example, have exhibited encouraging results in both infection therapy and cancer immunotherapy.[6, 7, 11–15]”
From RNA delivery biomaterials for the treatment of genetic and rare diseases (2019) · cites this paper as [13]

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673 · see citing works
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
Borghaei, H., Paz-Ares, L., Horn, L., Spigel, D. R., Steins, M., Ready, N. E., Chow, L. Q., Vokes, E. E., Felip, E., Holgado, E., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1507643 · Cited by 9,335 · see citing works
Pembrolizumab versus Ipilimumab in Advanced Melanoma
Robert, C., Schachter, J., Long, G. V., Arance, A., Grob, J. J., Mortier, L., Daud, A., Carlino, M. S., McNeil, C., Lotem, M., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1503093 · Cited by 5,887 · see citing works
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
Sharma, P., Hu-Lieskovan, S., Wargo, J. A., & Ribas, A. (2017) · Cell · doi:10.1016/j.cell.2017.01.017 · Cited by 5,588 · see citing works
Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer
Kantoff, P. W., Higano, C. S., Shore, N. D., Berger, E. R., Small, E. J., Penson, D. F., Redfern, C. H., Ferrari, A. C., Dreicer, R., Sims, R. B., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001294 · Cited by 5,572 · see citing works
Nivolumab in Previously Untreated Melanoma without <i>BRAF</i> Mutation
Robert, C., Long, G. V., Brady, B., Dutriaux, C., Maio, M., Mortier, L., Hassel, J. C., Rutkowski, P., McNeil, C., Kalinka-Warzocha, E., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1412082 · Cited by 5,519 · see citing works
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
Sallusto, F., & Lanzavecchia, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1109 · Cited by 5,129 · see citing works
Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma
Snyder, A., Makarov, V., Merghoub, T., Yuan, J., Zaretsky, J. M., Desrichard, A., Walsh, L. A., Postow, M. A., Wong, P., Ho, T. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1406498 · Cited by 4,286 · see citing works
Interleukin-12 and the regulation of innate resistance and adaptive immunity
Trinchieri, G. (2003) · Nature reviews. Immunology · doi:10.1038/nri1001 · Cited by 3,933 · see citing works
Liposome: classification, preparation, and applications
Akbarzadeh, A., Rezaei-Sadabady, R., Davaran, S., Joo, S. W., Zarghami, N., Hanifehpour, Y., Samiei, M., Kouhi, M., & Nejati‐Koshki, K. (2013) · Nanoscale Research Letters · doi:10.1186/1556-276x-8-102 · Cited by 3,648 · see citing works
A Third-Generation Lentivirus Vector with a Conditional Packaging System
Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D., & Naldini, L. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8463-8471.1998 · Cited by 3,341 · see citing works
Guidelines for the Evaluation of Immune Therapy Activity in Solid Tumors: Immune-Related Response Criteria
Wolchok, J. D., Hoos, A., O'Day, S. J., Weber, J. S., Hamid, O., Lebbé, C., Maio, M., Binder, M., Bohnsack, O., Nichol, G. M., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1624 · Cited by 3,214 · see citing works
Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., et al. (2007) · Nature Medicine · doi:10.1038/nm1622 · Cited by 3,056 · see citing works
Immune Checkpoint Blockade in Cancer Therapy
Postow, M. A., Callahan, M. K., & Wolchok, J. D. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.59.4358 · Cited by 2,736 · see citing works
Nomenclature of monocytes and dendritic cells in blood
Ziegler‐Heitbrock, L., Ancuța, P., Crowe, S. M., Dalod, M., Grau, V., Hart, D. N. J., Leenen, P. J. M., Liu, Y.-J., MacPherson, G. G., Randolph, G. J., et al. (2010) · Blood · doi:10.1182/blood-2010-02-258558 · Cited by 2,436 · see citing works
Dendritic Cells
Mellman, I., & Steinman, R. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00449-4 · Cited by 2,256 · see citing works
Taking dendritic cells into medicine
Steinman, R., & Banchereau, J. (2007) · Nature · doi:10.1038/nature06175 · Cited by 2,243 · see citing works
Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape
Taube, J. M., Anders, R. A., Young, G. D., Xu, H., Sharma, R., McMiller, T. L., Chen, S., Klein, A. P., Pardoll, D. M., Topalian, S. L., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003689 · Cited by 2,157 · see citing works
Pooled Analysis of Long-Term Survival Data From Phase II and Phase III Trials of Ipilimumab in Unresectable or Metastatic Melanoma
Schadendorf, D., Hodi, F. S., Robert, C., Weber, J. S., Margolin, K., Hamid, O., Patt, D., Chen, T.-T., Berman, D. M., & Wolchok, J. D. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.2736 · Cited by 2,141 · see citing works
Cancer immunotherapy via dendritic cells
Palucka, K., & Banchereau, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3258 · Cited by 2,060 · see citing works
Towards a systems understanding of MHC class I and MHC class II antigen presentation
Neefjes, J., Jongsma, M. L. M., Paul, P., & Bakke, O. (2011) · Nature Reviews Immunology · doi:10.1038/nri3084 · Cited by 2,044 · see citing works
Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo
Hawiger, D., Inaba, K., Dorsett, Y., Guo, M., Mahnke, K., Rivera, M. N., Ravetch, J. V., Steinman, R. M., & Nussenzweig, M. C. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.769 · Cited by 1,848 · see citing works
Classification, Functions, and Clinical Relevance of Extracellular Vesicles
van der Pol, E., Böing, A. N., Harrison, P., Sturk, A., & Nieuwland, R. (2012) · Pharmacological Reviews · doi:10.1124/pr.112.005983 · Cited by 1,756 · see citing works
Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon
Cella, M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A., & Colonna, M. (1999) · Nature Medicine · doi:10.1038/11360 · Cited by 1,734 · see citing works
Immunological aspects of cancer chemotherapy
Zitvogel, L., Apetoh, L., Ghiringhelli, F., & Kroemer, G. (2008) · Nature Reviews Immunology · doi:10.1038/nri2216 · Cited by 1,712 · see citing works
The roles of TLRs, RLRs and NLRs in pathogen recognition
Kawai, T., & Akira, S. (2009) · International Immunology · doi:10.1093/intimm/dxp017 · Cited by 1,666 · see citing works
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
Casares, N., Pequignot, M. O., Tesniere, A., Ghiringhelli, F., Roux, S., Chaput, N., Schmitt, E., Hamai, A., Hervas-Stubbs, S., Obeid, M., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050915 · Cited by 1,512 · see citing works
Dendritic-cell control of pathogen-driven T-cell polarization
Kapsenberg, M. L. (2003) · Nature reviews. Immunology · doi:10.1038/nri1246 · Cited by 1,440 · see citing works
Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance
Bonifaz, L. C., Bonnyay, D., Mahnke, K., Rivera, M. N., Nussenzweig, M. C., & Steinman, R. M. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021598 · Cited by 1,306 · see citing works
Nanoparticles target distinct dendritic cell populations according to their size
Manolova, V., Flace, A., Bauer, M., Schwarz, K., Saudan, P., & Bachmann, M. F. (2008) · European Journal of Immunology · doi:10.1002/eji.200737984 · Cited by 1,296 · see citing works
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
Gilliet, M., Cao, W., & Liu, Y.-J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2358 · Cited by 1,190 · see citing works
Immunogenic and tolerogenic cell death
Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176 · see citing works
Pro‐inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum‐free conditions
Jonuleit, H., Kühn, U., Müller, G., Steinbrink, K., Paragnik, L., Schmitt, E., Knop, J. X. F. R., & Enk, A. (1997) · European Journal of Immunology · doi:10.1002/eji.1830271209 · Cited by 1,163 · see citing works
Radiotherapy and immunotherapy: a beneficial liaison?
Weichselbaum, R. R., Liang, H. L., Deng, L., & Fu, Y. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.211 · Cited by 1,073 · see citing works
IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE
Steinman, R. M., Lustig, D. S., & Cohn, Z. A. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.139.6.1431 · Cited by 1,052 · see citing works
Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
Jongbloed, S. L., Kassianos, A. J., McDonald, K. J., Clark, G. J., Ju, X., Angel, C. E., Chen, C. J., Dunbar, P. R., Wadley, R. B., Jeet, V., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092140 · Cited by 1,019 · see citing works
The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893.
COLEY, W. B. (1991) · PubMed · Cited by 971 · see citing works
In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination
Bonifaz, L. C., Bonnyay, D., Charalambous, A., Darguste, D. I., Fujii, S., Soares, H., Brimnes, M. K., Moltedo, B., Moran, T. M., & Steinman, R. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20032220 · Cited by 921 · see citing works
CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative
Ghiringhelli, F., Larmonier, N., Schmitt, E., Parcellier, A., Cathelin, D., Garrido, C., Chauffert, B., Solary, É., Bonnotte, B., & Martin, F. (2004) · European Journal of Immunology · doi:10.1002/eji.200324181 · Cited by 878 · see citing works
Dendritic-Cell-Based Therapeutic Cancer Vaccines
Palucka, K., & Banchereau, J. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.004 · Cited by 869 · see citing works
Immunological surveillance against altered self components by sensitised T lymphocytes in lymphocytes choriomeningitis
Zinkernagel, R. M., & Doherty, P. C. (1974) · Nature · doi:10.1038/251547a0 · Cited by 854 · see citing works
Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity
Kadowaki, N., Antonenko, S. V., Lau, J. Y., & Liu, Y.-J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.219 · Cited by 847 · see citing works
Dendritic cell migration in health and disease
Worbs, T., Hammerschmidt, S. I., & Förster, R. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.116 · Cited by 826 · see citing works
IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE
Steinman, R. M., & Cohn, Z. A. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.139.2.380 · Cited by 817 · see citing works
Characterization of human blood dendritic cell subsets
MacDonald, K. P. A., Munster, D. J., Clark, G. J., Dzionek, A., Schmitz, J., & Hart, D. N. J. (2002) · Blood · doi:10.1182/blood-2001-11-0097 · Cited by 755 · see citing works
MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade.
Ebert, P. J. R., Cheung, J., Yang, Y., McNamara, E., Hong, R., Moskalenko, M., Gould, S. E., Maecker, H., Irving, B. A., Kim, J. M., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.024 · Cited by 713 · see citing works
Clinical use of dendritic cells for cancer therapy
Anguille, S., Smits, E., Lion, E., Tendeloo, V. F. V., & Berneman, Z. N. (2014) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70585-0 · Cited by 707 · see citing works
Immunotherapy of Hormone-Refractory Prostate Cancer With Antigen-Loaded Dendritic Cells
Small, E. J., Fratesi, P., Reese, D., Strang, G., Laus, R., Peshwa, M. V., & Valone, F. H. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.23.3894 · Cited by 625 · see citing works
Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells
Visintin, A., Mazzoni, A., Spitzer, J. H., Wyllie, D. H., Dower, S., & Segal, D. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.249 · Cited by 611 · see citing works
Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells
Gong, J., Chen, D., Kashiwaba, M., & Kufe, D. W. (1997) · Nature Medicine · doi:10.1038/nm0597-558 · Cited by 591 · see citing works
Interstitial dendritic cell guidance by haptotactic chemokine gradients
Weber, M., Hauschild, R., Schwarz, J., Moussion, C., de Vries, I., Legler, D. F., Luther, S. A., Bollenbach, T., & Sixt, M. (2013) · Science · doi:10.1126/science.1228456 · Cited by 555 · see citing works
Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling
Robbins, S. H., Walzer, T., Dembélé, D., Thibault-Carpentier, C., Defays, A., Bessou, G., Xu, H., Vivier, É., Sellars, M., Pierre, P., et al. (2008) · Genome biology · doi:10.1186/gb-2008-9-1-r17 · Cited by 534 · see citing works
Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin
Sancho, D., Mourão‐Sá, D., Joffre, O. P., Schulz, O., Rogers, N. C., Pennington, D. J., Carlyle, J. R., & Sousa, C. R. E. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34584 · Cited by 519 · see citing works
Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells
Scandella, E., Men, Y., Gillessen, S., Förster, R., & Groettrup, M. (2002) · Blood · doi:10.1182/blood-2001-11-0017 · Cited by 498 · see citing works
The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement
Caminschi, I., Proietto, A. I., Ahmet, F., Kitsoulis, S., Teh, J. S., Lo, J. C. Y., Rizzitelli, A., Wu, L., Vremec, D., van Dommelen, S. L. H., et al. (2008) · Blood · doi:10.1182/blood-2008-05-155176 · Cited by 481 · see citing works
Five-Year Survival Rates for Treatment-Naive Patients With Advanced Melanoma Who Received Ipilimumab Plus Dacarbazine in a Phase III Trial
Maio, M., Grob, J., Aamdal, S., Bondarenko, I., Robert, C., Thomas, L., Garbe, C., Chiarion‐Sileni, V., Testori, A., Chen, T., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.6018 · Cited by 480 · see citing works
Untitled work
(2003) · PubMed · Cited by 477 · see citing works
Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG
Schadendorf, D., Ugurel, S., Schuler‐Thurner, B., Nestle, F. O., Enk, A., Bröcker, E.-B., Grabbe, S., Rittgen, W., Edler, L., Sucker, A., et al. (2006) · Annals of Oncology · doi:10.1093/annonc/mdj138 · Cited by 467 · see citing works
CD4+ T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8+ T Lymphocytes
Bos, R., & Sherman, L. A. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1322 · Cited by 445 · see citing works
Dendritic cells are functionally defective in multiple myeloma: the role of interleukin-6
Ratta, M., Fagnoni, F. F., Curti, A., Vescovini, R., Sansoni, P., Oliviero, B., Fogli, M., Ferri, E., della Cuna, G. R., Tura, S., et al. (2002) · Blood · doi:10.1182/blood.v100.1.230 · Cited by 442 · see citing works
The molecular basis of electroporation
Tieleman, D. P. (2004) · BMC Biochemistry · doi:10.1186/1471-2091-5-10 · Cited by 440 · see citing works
The PI3 kinase, p38 SAP kinase, and NF-κB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte–derived dendritic cells
Ardeshna, K. M., Pizzey, A. R., Devereux, S., & Khwaja, A. (2000) · Blood · doi:10.1182/blood.v96.3.1039 · Cited by 430 · see citing works
Dendritic Cell Function in Vivo during the Steady State: A Role in Peripheral Tolerance
Steinman, R. M., Hawiger, D., Liu, K., Bonifaz, L. C., Bonnyay, D., Mahnke, K., Iyoda, T., Ravetch, J. V., Dhodapkar, M. V., Inaba, K., et al. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb06029.x · Cited by 427 · see citing works
A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation
Braun, D., Longman, R., & Albert, M. L. (2005) · Blood · doi:10.1182/blood-2005-03-0979 · Cited by 390 · see citing works
Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma
Phuphanich, S., Wheeler, C. J., Rudnick, J. D., Mazer, M., Wang, H., Nuño, M., Richardson, J., Fan, X., Ji, J., Chu, R. M., et al. (2012) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-012-1319-0 · Cited by 386 · see citing works
Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines
Sozzani, S., Luini, W., Borsatti, A., Polentarutti, N., Zhou, D., Piemonti, L., D’Amico, G., Power, C., Wells, T. N. C., Gobbi, M., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.4.1993 · Cited by 377 · see citing works
Induction of complete and molecular remissions in acute myeloid leukemia by Wilms’ tumor 1 antigen-targeted dendritic cell vaccination
Van Tendeloo, V. F., Van de Velde, A., Van Driessche, A., Cools, N., Anguille, S., Ladell, K., Gostick, E., Vermeulen, K., Pieters, K., Nijs, G., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008051107 · Cited by 377 · see citing works
IMMUNOLOGICAL ASPECTS OF MALIGNANT DISEASE
Burnet, F. M. (1967) · The Lancet · doi:10.1016/s0140-6736(67)92837-1 · Cited by 374 · see citing works
Induction of Antigen-Specific Immunity with a Vaccine Targeting NY-ESO-1 to the Dendritic Cell Receptor DEC-205
Dhodapkar, M. V., Sznol, M., Zhao, B., Wang, D., Carvajal, R. D., Keohan, M. L., Chuang, E., Sanborn, R. E., Lutzky, J., Powderly, J. D., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008068 · Cited by 367 · see citing works
Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells.
Su, Z. Z., Dannull, J., Heiser, A., Yancey, D. R., Pruitt, S. K., Madden, J., Coleman, D., Niedzwiecki, D., Gilboa, E., & Vieweg, J. (2003) · PubMed · Cited by 366 · see citing works
Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses
Liu, W. M., Fowler, D. W., Smith, P., & Dalgleish, A. G. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605465 · Cited by 356 · see citing works
Natural Human Plasmacytoid Dendritic Cells Induce Antigen-Specific T-Cell Responses in Melanoma Patients
Tel, J., Aarntzen, E. H. J. G., Baba, T., Schreibelt, G., Schulte, B. M., Benítez‐Ribas, D., Boerman, O. C., Croockewit, S., Oyen, W. J. G., van Rossum, M. M., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2583 · Cited by 351 · see citing works
Nod1-Mediated Innate Immune Recognition of Peptidoglycan Contributes to the Onset of Adaptive Immunity
Fritz, J. H., Bourhis, L. L., Sellge, G., Magalhaes, J. G., Fsihi, H., Kufer, T. A., Collins, C., Viala, J., Ferrero, R. L., Girardin, S. E., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.009 · Cited by 331 · see citing works
Dendritic cell dysfunction in cancer: A mechanism for immunosuppression
Pinzón‐Charry, A., Maxwell, T., & López, J. A. (2005) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2005.01371.x · Cited by 328 · see citing works
Cutting Edge: Selective Usage of Chemokine Receptors by Plasmacytoid Dendritic Cells
Penna, G., Sozzani, S., & Adorini, L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1862 · Cited by 323 · see citing works
Mature Dendritic Cells Derived from Human Monocytes Within 48 Hours: A Novel Strategy for Dendritic Cell Differentiation from Blood Precursors
Dauer, M., Obermaier, B., Herten, J., Haerle, C., Pohl, K., Rothenfußer, S., Schnurr, M. M., Endres, S., & Eigler, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.4069 · Cited by 318 · see citing works
CLEC9A Is a Novel Activation C-type Lectin-like Receptor Expressed on BDCA3+ Dendritic Cells and a Subset of Monocytes
Huysamen, C., Willment, J. A., Dennehy, K. M., & Brown, G. D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709923200 · Cited by 318 · see citing works
Induction of tumor immunity and cytotoxic T lymphocyte responses using dendritic cells transfected with messenger RNA amplified from tumor cells.
Boczkowski, D., Nair, S. K., Nam, J., Lyerly, H. K., & Gilboa, E. (2000) · PubMed · Cited by 313 · see citing works
Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A
Idoyaga, J., Lubkin, A., Fiorese, C. J., Lahoud, M. H., Caminschi, I., Huang, Y., Rodriguez, A. B., Clausen, B. E., Park, C. G., Trumpfheller, C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019547108 · Cited by 287 · see citing works
Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro
Cruz, L. J., Tacken, P. J., Fokkink, R., Joosten, B., Stuart, M. C., Albericio, F., Torensma, R., & Figdor, C. G. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.02.013 · Cited by 281 · see citing works
Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti–DC-SIGN antibody
Tacken, P. J., de Vries, I. J. M., Gijzen, K., Joosten, B., Wu, D., Rother, R. P., Faas, S. J., Punt, C. J. A., Torensma, R., Adema, G. J., et al. (2005) · Blood · doi:10.1182/blood-2005-01-0318 · Cited by 271 · see citing works
CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses
Rosalia, R. A., Cruz, L. J., van Duikeren, S., Tromp, A. T., Silva, A. L., Jiskoot, W., de Gruijl, T. D., Löwik, C. W. G. M., Oostendorp, J., van der Burg, S. H., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.053 · Cited by 269 · see citing works
Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules
Yoneyama, H., Matsuno, K., Zhang, Y., Nishiwaki, T., Kitabatake, M., Ueha, S., Narumi, S., Morikawa, S., Ezaki, T., Lu, B., et al. (2004) · International Immunology · doi:10.1093/intimm/dxh093 · Cited by 269 · see citing works
Priming tissue-specific cellular immunity in a phase I trial of autologous dendritic cells for prostate cancer.
Burch, P. A., Breen, J. K., Buckner, J. C., Gastineau, D. A., Kaur, J. A., Laus, R., Padley, D. J., Peshwa, M. V., Pitot, H. C., Richardson, R. L., et al. (2000) · PubMed · Cited by 263 · see citing works
Expression of CCR-7, MIP-3β, and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities
Parlato, S., Santini, S. M., Lapenta, C., Pucchio, T. D., Logozzi, M., Spada, M., Giammarioli, A. M., Malorni, W., Fais, S., & Belardelli, F. (2001) · Blood · doi:10.1182/blood.v98.10.3022 · Cited by 259 · see citing works
The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells
Schreibelt, G., Klinkenberg, L. J. J., Cruz, L. J., Tacken, P. J., Tel, J., Kreutz, M., Adema, G. J., Brown, G. D., Figdor, C. G., & de Vries, I. J. M. (2012) · Blood · doi:10.1182/blood-2011-08-373944 · Cited by 250 · see citing works
Differential migration behavior and chemokine production by myeloid and plasmacytoid dendritic cells
Penna, G., Vulcano, M., Sozzani, S., & Adorini, L. (2002) · Human Immunology · doi:10.1016/s0198-8859(02)00755-3 · Cited by 249 · see citing works
Fusion Cell Vaccination of Patients with Metastatic Breast and Renal Cancer Induces Immunological and Clinical Responses
Avigan, D., Vasir, B., Gong, J., Borges, V. F., Wu, Z., Uhl, L., Atkins, M. B., Mier, J. W., McDermott, D. F., Smith, T. M., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0347 · Cited by 245 · see citing works
Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic Cells
Schreibelt, G., Bol, K. F., Westdorp, H., Wimmers, F., Aarntzen, E. H. J. G., Boer, T. D., van de Rakt, M. W. M. M., Scharenborg, N. M., de Boer, A. J., Pots, J. M., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2205 · Cited by 243 · see citing works
Vaccination with dendritic cell/tumor fusion cells results in cellular and humoral antitumor immune responses in patients with multiple myeloma
Rosenblatt, J. M., Vasir, B., Uhl, L., Blotta, S., MacNamara, C., Somaiya, P., Wu, Z., Joyce, R., Levine, J. D., Dombagoda, D., et al. (2010) · Blood · doi:10.1182/blood-2010-04-277137 · Cited by 228 · see citing works
Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype
Lahoud, M. H., Ahmet, F., Kitsoulis, S., Wan, S. S., Vremec, D., Lee, C., Phipson, B., Shi, W., Smyth, G. K., Lew, A. M., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101176 · Cited by 227 · see citing works
Comparison of the ELISPOT and cytokine flow cytometry assays for the enumeration of antigen-specific T cells
Karlsson, A. C., Martin, J. N., Younger, S. R., Bredt, B. M., Epling, L., Ronquillo, R., Varma, A., Deeks, S. G., McCune, J. M., Nixon, D. F., et al. (2003) · Journal of Immunological Methods · doi:10.1016/j.jim.2003.09.001 · Cited by 224 · see citing works
Dendritic Cell Vaccination Combined with CTLA4 Blockade in Patients with Metastatic Melanoma
Ribas, A., Comı́n-Anduix, B., Chmielowski, B., Jalil, J., de la Rocha, P., McCannel, T. A., Ochoa, M. T., Seja, E., Villanueva, A., Oseguera, D. K., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1254 · Cited by 217 · see citing works
Dendritic Cell Based Tumor Vaccination in Prostate and Renal Cell Cancer: A Systematic Review and Meta-Analysis
Draube, A., Klein-González, N., Mattheus, S., Brillant, C., Hellmich, M., Engert, A., & von Bergwelt‐Baildon, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018801 · Cited by 213 · see citing works
Phase I/II trial of melanoma therapy with dendritic cells transfected with autologous tumor-mRNA
Kyte, J. A., Mu, L., Aamdal, S., Kvalheim, G., Dueland, S., Hauser, M., Gullestad, H. P., Ryder, T., Lislerud, K., Hammerstad, H., et al. (2006) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700961 · Cited by 212 · see citing works
Limited Amounts of Dendritic Cells Migrate into the T-Cell Area of Lymph Nodes but Have High Immune Activating Potential in Melanoma Patients
Verdijk, P., Aarntzen, E. H. J. G., Lesterhuis, W. J., Boullart, A. C. I., Kok, E., van Rossum, M. M., Strijk, S. P., Eijckeler, F., Bonenkamp, J. J., Jacobs, J. F. M., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2729 · Cited by 204 · see citing works
Prostaglandin E2 Is Generally Required for Human Dendritic Cell Migration and Exerts Its Effect via EP2 and EP4 Receptors
Legler, D. F., Krause, P., Scandella, E., Singer, E., & Groettrup, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.966 · Cited by 203 · see citing works
Tumor antigen processing and presentation depend critically on dendritic cell type and the mode of antigen delivery
Schnurr, M. M., Chen, Q., Shin, A., Chen, W., Toy, T., Jenderek, C., Green, S., Miloradovic, L., Drane, D. P., Davis, I. D., et al. (2004) · Blood · doi:10.1182/blood-2004-08-3105 · Cited by 203 · see citing works
Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells
Gong, J., Avigan, D., Chen, D., Wu, Z., Koido, S., Kashiwaba, M., & Kufe, D. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050587197 · Cited by 196 · see citing works
Route of Administration Modulates the Induction of Dendritic Cell Vaccine–Induced Antigen-Specific T Cells in Advanced Melanoma Patients
Lesterhuis, W. J., de Vries, I. J. M., Schreibelt, G., Lambeck, A. J. A., Aarntzen, E. H. J. G., Jacobs, J. F. M., Scharenborg, N. M., van de Rakt, M. W. M. M., de Boer, A. J., Croockewit, S., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1261 · Cited by 193 · see citing works
“MIATA”—Minimal Information about T Cell Assays
Janetzki, S., Britten, C. M., Kalos, M. D., Levitsky, H. I., Maecker, H. T., Melief, C. J. M., Old, L. J., Romero, P. J., Hoos, A., & Davis, M. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.007 · Cited by 192 · see citing works
Induction of CD4+ T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-beta.
Zeller, J. C., Panoskaltsis‐Mortari, A., Murphy, W. J., Ruscetti, F. W., Narula, S. K., Roncarolo, M., & Blazar, B. R. (1999) · PubMed · Cited by 189 · see citing works
Dendritic Cells Charged with Apoptotic Tumor Cells Induce Long-Lived Protective CD4+ and CD8+ T Cell Immunity against B16 Melanoma
Goldszmid, R. S., Idoyaga, J., Bravo, A., Steinman, R. M., Mordoh, J., & Wainstok, R. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.5940 · Cited by 188 · see citing works
Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells
Chatterjee, B., Smed‐Sörensen, A., Cohn, L. B., Chalouni, C. M., Vandlen, R. A., Lee, B.-C., Widger, J., Keler, T., Delamarre, L., & Mellman, I. (2012) · Blood · doi:10.1182/blood-2012-01-402370 · Cited by 187 · see citing works
Calcium ionophore-treated peripheral blood monocytes and dendritic cells rapidly display characteristics of activated dendritic cells
Czerniecki, B. J., Carter, C., Rivoltini, L., Koski, G. K., Kim, H. I., Weng, D. E., Roros, J. G., Hijazi, Y. M., Xu, S., Rosenberg, S. A., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.8.3823 · Cited by 185 · see citing works
Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines
Zhu, Q., Egelston, C. A., Aravindhan, V., Uematsu, S., Akira, S., Klinman, D. M., Belyakov, I. M., & Berzofsky, J. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805325105 · Cited by 183 · see citing works
High Efficiency Adenovirus-Mediated Gene Transfer to Human Dendritic Cells
Dietz, A. B., & Vuk‐Pavlović, S. (1998) · Blood · doi:10.1182/blood.v91.2.392.392_392_398 · Cited by 181 · see citing works
Human plasmacytoid dendritic cells efficiently cross-present exogenous Ags to CD8+ T cells despite lower Ag uptake than myeloid dendritic cell subsets
Tel, J., Schreibelt, G., Sittig, S. P., Mathan, T. S. M., Buschow, S. I., Cruz, L. J., Lambeck, A. J. A., Figdor, C. G., & de Vries, I. J. M. (2012) · Blood · doi:10.1182/blood-2012-06-435644 · Cited by 173 · see citing works
PD-1 blockade enhances the vaccination-induced immune response in glioma
Antonios, J. P., Soto, H., Everson, R. G., Orpilla, J. R., Moughon, D. L., Shin, N., Sedighim, S., Yong, W. H., Li, G., Cloughesy, T. F., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.87059 · Cited by 170 · see citing works
High Efficiency Adenovirus-Mediated Gene Transfer to Human Dendritic Cells
Dietz, A. B., & Vuk‐Pavlović, S. (1998) · Blood · doi:10.1182/blood.v91.2.392 · Cited by 169 · see citing works
Human blood mDC subsets exhibit distinct TLR repertoire and responsiveness
Hémont, C., Néel, A., Heslan, M., Braudeau, C., & Josien, R. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0912452 · Cited by 167 · see citing works
The cell biology of cross‐presentation and the role of dendritic cell subsets
Lin, M., Zhan, Y., Villadangos, J. A., & Lew, A. M. (2008) · Immunology and Cell Biology · doi:10.1038/icb.2008.3 · Cited by 165 · see citing works
PGE2-induced metalloproteinase-9 is essential for dendritic cell migration
Yen, J.-H. J., Khayrullina, T., & Ganea, D. (2007) · Blood · doi:10.1182/blood-2007-05-090613 · Cited by 163 · see citing works
Induction of CD4+ T Cell Alloantigen-Specific Hyporesponsiveness by IL-10 and TGF-β
Zeller, J. C., Panoskaltsis‐Mortari, A., Murphy, W. J., Ruscetti, F. W., Narula, S. K., Roncarolo, M. G., & Blazar, B. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3684 · Cited by 159 · see citing works
Abundant empty class II MHC molecules on the surface of immature dendritic cells
Santambrogio, L., Sato, A. K., Fischer, F. R., Dorf, M. E., & Stern, L. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15050 · Cited by 156 · see citing works
Tumor lysate–specific cytotoxic T lymphocytes in multiple myeloma: promising effector cells for immunotherapy
Wen, Y.-J., Min, R., Tricot, G. J. K., Barlogie, B., & Yi, Q. (2002) · Blood · doi:10.1182/blood.v99.9.3280 · Cited by 149 · see citing works
Paradigm Shift in Dendritic Cell-Based Immunotherapy: From in vitro Generated Monocyte-Derived DCs to Naturally Circulating DC Subsets
Wimmers, F., Schreibelt, G., Sköld, A. E., Figdor, C. G., & de Vries, I. J. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00165 · Cited by 145 · see citing works
Proliferative Assays for T Cell Function
Kruisbeek, A. M., Shevach, E. M., & Thornton, A. M. (2004) · Current Protocols in Immunology · doi:10.1002/0471142735.im0312s60 · Cited by 142 · see citing works
Antigen Presentation by MHC Class II Molecules: Invariant Chain Function, Protein Trafficking, and the Molecular Basis of Diverse Determinant Capture
Castellino, F., Zhong, G., & Germain, R. N. (1997) · Human Immunology · doi:10.1016/s0198-8859(97)00078-5 · Cited by 141 · see citing works
Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer
Mehrotra, S., Britten, C. D., Chin, S. H., Garrett-Mayer, E. S., Cloud, C. A., Li, M., Scurti, G. M., Salem, M. L., Nelson, M. H., Thomas, M. B., et al. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0459-2 · Cited by 137 · see citing works
A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-γ treatment
Mosca, P. J., Hobeika, A. C., Clay, T. M., Nair, S. K., Thomas, E. K., Morse, M. A., & Lyerly, H. K. (2000) · Blood · doi:10.1182/blood.v96.10.3499 · Cited by 136 · see citing works
Single administration of low dose cyclophosphamide augments the antitumor effect of dendritic cell vaccine
Liu, J.-Y., Wu, Y., Zhang, X.-S., Yang, J.-L., Li, H.-L., Mao, Y.-Q., Wang, Y., Cheng, X., Li, Y.-Q., Xia, J., et al. (2007) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-007-0305-4 · Cited by 134 · see citing works
Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs
Nakahara, T., Uchi, H., Lesokhin, A. M., Avogadri, F., Rizzuto, G. A., Hirschhorn-Cymerman, D., Panageas, K. S., Merghoub, T., Wolchok, J. D., & Houghton, A. N. (2010) · Blood · doi:10.1182/blood-2009-11-251231 · Cited by 134 · see citing works
Rapid Influx and Death of Plasmacytoid Dendritic Cells in Lymph Nodes Mediate Depletion in Acute Simian Immunodeficiency Virus Infection
Brown, K. N., Wijewardana, V., Liu, X., & Barratt‐Boyes, S. M. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000413 · Cited by 130 · see citing works
Vaccination of hormone‐refractory prostate cancer patients with peptide cocktail‐loaded dendritic cells: Results of a phase I clinical trial
Fuessel, S., Meye, A., Schmitz, M., Zastrow, S., Linné, C., Richter, K., Löbel, B., Hakenberg, O. W., Hoelig, K., Rieber, E. P., et al. (2006) · The Prostate · doi:10.1002/pros.20404 · Cited by 125 · see citing works
Phase I/II Study of Vaccination With Electrofused Allogeneic Dendritic Cells/Autologous Tumor-derived Cells in Patients With Stage IV Renal Cell Carcinoma
Avigan, D., Vasir, B., George, D. J., Oh, W. K., Atkins, M. B., McDermott, D. F., Kantoff, P. W., Figlin, R. A., Vasconcelles, M. J., Xu, Y., et al. (2007) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3180de4ce8 · Cited by 119 · see citing works
Tumor-Altered Dendritic Cell Function: Implications for Anti-Tumor Immunity
Hargadon, K. M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00192 · Cited by 118 · see citing works
Metastatic melanoma patients treated with dendritic cell vaccination, Interleukin-2 and metronomic cyclophosphamide: results from a phase II trial
Ellebæk, E., Engell-Noerregaard, L., Iversen, T. Z., Frøsig, T. M., Ahmad, S. M., Hadrup, S. R., Andersen, M. H., & Svane, I. M. (2012) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-012-1242-4 · Cited by 118 · see citing works
PGE2 transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells
Muthuswamy, R., Mueller-Berghaus, J., Haberkorn, U., Reinhart, T. A., Schadendorf, D., & Kaliński, P. (2010) · Blood · doi:10.1182/blood-2009-12-258038 · Cited by 117 · see citing works
Prophylactic Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor Decrease Febrile Neutropenia After Chemotherapy in Children With Cancer: A Meta-Analysis of Randomized Controlled Trials
Sung, L., Nathan, P. C., Lange, B. J., Beyene, J., & Buchanan, G. R. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.09.106 · Cited by 117 · see citing works
Clinical-grade manufacturing of autologous mature mRNA-electroporated dendritic cells and safety testing in acute myeloid leukemia patients in a phase I dose-escalation clinical trial
Driessche, A. V., de Velde, A. L. R. V., Nijs, G., Braeckman, T., Stein, B., de Vries, I. J. M., Berneman, Z. N., & Tendeloo, V. F. V. (2009) · Cytotherapy · doi:10.1080/14653240902960411 · Cited by 116 · see citing works
Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination
Radojčić, V., Bezak, K. B., Škarica, M., Pletneva, M., Yoshimura, K., Schulick, R. D., & Luznik, L. (2009) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-009-0734-3 · Cited by 107 · see citing works
Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma
Wang, S., Yang, J., Qian, J., Wezeman, M. J., Kwak, L. W., & Yi, Q. (2005) · Blood · doi:10.1182/blood-2005-06-2486 · Cited by 106 · see citing works
The C-Type Lectin Clec12A Present on Mouse and Human Dendritic Cells Can Serve as a Target for Antigen Delivery and Enhancement of Antibody Responses
Lahoud, M. H., Proietto, A. I., Ahmet, F., Kitsoulis, S., Eidsmo, L., Wu, L., Sathe, P., Pietersz, S., Chang, H.-W., Walker, I. D., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900464 · Cited by 106 · see citing works
A Phase I Clinical Trial of CD1c (BDCA-1)+ Dendritic Cells Pulsed With HLA-A*0201 Peptides for Immunotherapy of Metastatic Hormone Refractory Prostate Cancer
Prue, R. L., Vari, F., Radford, K. J., Tong, H., Hardy, M. Y., D’Rozario, R., Waterhouse, N. J., Rossetti, T. R., Coleman, R., Tracey, C., et al. (2015) · Journal of Immunotherapy · doi:10.1097/cji.0000000000000063 · Cited by 105 · see citing works
Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities
Tel, J., Smits, E., Anguille, S., Joshi, R. N., Figdor, C. G., & de Vries, I. J. M. (2012) · Blood · doi:10.1182/blood-2012-06-435941 · Cited by 103 · see citing works
Plasmacytoid Dendritic Cells Capture and Cross-Present Viral Antigens from Influenza-Virus Exposed Cells
Lui, G., Manches, O., Angel, J., Molens, J., Chaperot, L., & Plumas, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007111 · Cited by 98 · see citing works
Hybrids of Dendritic Cells and Tumor Cells Generated by Electrofusion Simultaneously Present Immunodominant Epitopes from Multiple Human Tumor-Associated Antigens in the Context of MHC Class I and Class II Molecules
Parkhurst, M. R., DePan, C., Riley, J. P., Rosenberg, S. A., & Shu, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.5317 · Cited by 98 · see citing works
Dendritic Cells Loaded With mRNA Encoding Full-length Tumor Antigens Prime CD4+ and CD8+ T Cells in Melanoma Patients
Nuffel, A. M. T. V., Benteyn, D., Wilgenhof, S., Pierret, L., Corthals, J., Heirman, C., van der Bruggen, P., Coulie, P. G., Neyns, B., Thielemans, K., et al. (2012) · Molecular Therapy · doi:10.1038/mt.2012.11 · Cited by 97 · see citing works
Vaccination of advanced prostate cancer patients with PSCA and PSA peptide‐loaded dendritic cells induces DTH responses that correlate with superior overall survival
Thomas-Kaskel, A. K., Zeiser, R., Jochim, R., Robbel, C., Schultze‐Seemann, W., Waller, C. F., & Veelken, H. (2006) · International Journal of Cancer · doi:10.1002/ijc.22097 · Cited by 97 · see citing works
The biology of GM-CSF: Regulation of production and interaction with its receptor
Griffin, J. D., Cannistra, S. A., Demetri, G. D., Ernst, T. J., Kanakura, Y., & Sullivan, R. (1990) · Stem Cells · doi:10.1002/stem.5530080705 · Cited by 97 · see citing works
Residual FDG ‐ PET metabolic activity in metastatic melanoma patients with prolonged response to anti‐ PD ‐1 therapy
Kong, B. Y., Menzies, A. M., Saunders, C. A. B., Liniker, E., Ramanujam, S., Guminski, A. D., Kefford, R. F., Long, G. V., & Carlino, M. S. (2016) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12503 · Cited by 97 · see citing works
Induction of leukemia-specific cytotoxic response by cross-presentation of late-apoptotic leukemic blasts by autologous dendritic cells of nonleukemic origin.
Spisek, R., Chevallier, P., Morineau, N., Milpied, N. J., Avet‐Loiseau, H., Harousseau, J., Méflah, K., & Grégoire, M. (2002) · PubMed · Cited by 94 · see citing works
Short-term cultured, interleukin-15 differentiated dendritic cells have potent immunostimulatory properties
Anguille, S., Smits, E., Cools, N., Goossens, H., Berneman, Z. N., & Tendeloo, V. F. V. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-109 · Cited by 94 · see citing works
Homing of intravenously and intralymphatically injected human dendritic cells generated in vitro from CD34 + hematopoietic progenitor cells
Mackensen, A., Krause, T., Blum, U., Uhrmeister, P., Mertelsmann, R. H., & Lindemann, A. (1999) · Cancer Immunology Immunotherapy · doi:10.1007/s002620050555 · Cited by 93 · see citing works
Exploiting the Immunogenic Potential of Cancer Cells for Improved Dendritic Cell Vaccines
Vandenberk, L., Belmans, J., Woensel, M. V., Riva, M., & Gool, S. V. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00663 · Cited by 90 · see citing works
Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non‐human primates
Li, J., Ahmet, F., Sullivan, L. C., Brööks, A. G., Kent, S. J., Rose, R. D., Salazar, A. Μ., Sousa, C. R. E., Shortman, K., Lahoud, M. H., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201445127 · Cited by 87 · see citing works
Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells
Schreibelt, G., Benítez‐Ribas, D., Schuurhuis, D. H., Lambeck, A. J. A., Hout-Kuijer, M. A. V., Schaft, N., Punt, C. J. A., Figdor, C. G., Adema, G. J., & de Vries, I. J. M. (2010) · Blood · doi:10.1182/blood-2009-11-251884 · Cited by 86 · see citing works
Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+T cell recognition
Tullett, K. M., Rojas, I. L., Minoda, Y., Tan, P. S., Zhang, J., Smith, C., Khanna, R., Shortman, K., Caminschi, I., Lahoud, M. H., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.87102 · Cited by 86 · see citing works
Multiparameter Intracellular Cytokine Staining
Lovelace, P., & Maecker, H. T. (2010) · Methods in molecular biology · doi:10.1007/978-1-61737-950-5_8 · Cited by 85 · see citing works
How many dendritic cells are required to initiate a T-cell response?
Celli, S., Day, M., Müller, A. J., Molina-Parı́s, C., Lythe, G., & Bousso, P. (2012) · Blood · doi:10.1182/blood-2012-01-408260 · Cited by 84 · see citing works
CD4+ T Cells Elicit Host Immune Responses to MHC Class II− Ovarian Cancer through CCL5 Secretion and CD40-Mediated Licensing of Dendritic Cells
Nesbeth, Y. C., Martinez, D. G., Toraya, S., Scarlett, U. K., Cubillos‐Ruiz, J. R., Rutkowski, M. R., & Conejo-Garcia, J. R. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903247 · Cited by 84 · see citing works
Peptide‐loaded dendritic‐cell vaccination followed by treatment interruption for chronic HIV‐1 infection: A phase 1 trial
Ide, F., Nakamura, T., Tomizawa, M., Kawana‐Tachikawa, A., Odawara, T., Hosoya, N., & Iwamoto, A. (2006) · Journal of Medical Virology · doi:10.1002/jmv.20612 · Cited by 81 · see citing works
Enumeration and Characterization of Human Memory T Cells by Enzyme-Linked Immunospot Assays
Calarota, S. A., & Baldanti, F. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/637649 · Cited by 80 · see citing works
Human CD 1c ( BDCA ‐1)+ myeloid dendritic cells secrete IL ‐10 and display an immuno‐regulatory phenotype and function in response to E scherichia coli
Kassianos, A. J., Hardy, M. Y., Ju, X., Vijayan, D., Ding, Y., Vulink, A. J. E., McDonald, K. J., Jongbloed, S. L., Wadley, R. B., Wells, C. A., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201142098 · Cited by 79 · see citing works
Antibody-Antigen-Adjuvant Conjugates Enable Co-Delivery of Antigen and Adjuvant to Dendritic Cells in Cis but Only Have Partial Targeting Specificity
Kreutz, M., Giquel, B., Hu, Q., Abuknesha, R., Uematsu, S., Akira, S., Nestle, F. O., & Diebold, S. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040208 · Cited by 78 · see citing works
A Comparative Study of the T Cell Stimulatory and Polarizing Capacity of Human Primary Blood Dendritic Cell Subsets
Sittig, S. P., Bakdash, G., Weiden, J., Sköld, A. E., Tel, J., Figdor, C. G., de Vries, I. J. M., & Schreibelt, G. (2016) · Mediators of Inflammation · doi:10.1155/2016/3605643 · Cited by 77 · see citing works
A phase I clinical trial combining dendritic cell vaccination with adoptive T cell transfer in patients with stage IV melanoma
Poschke, I. C., Lövgren, T., Adamson, L., Nystrom, M. L., Andersson, E. K., Hansson, J., Tell, R., Masucci, G. V., & Kiessling, R. W. (2014) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-014-1575-2 · Cited by 76 · see citing works
Concomitant Activation and Antigen Uptake via Human Dectin-1 Results in Potent Antigen-Specific CD8+ T Cell Responses
Ni, L., Gayet, I., Zurawski, S., Duluc, D., Flamar, A.-L., Li, X., O’Bar, A., Clayton, S., Palucka, A. K., Zurawski, G., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000999 · Cited by 76 · see citing works
Improved human T-cell responses against synthetic HLA-0201 analog peptides derived from the WT1 oncoprotein
Pinilla-Ibarz, J. A., May, R. J., Korontsvit, T., Gómez, M., Kappel, B. J., Zakhaleva, V., Zhang, R. H., & Scheinberg, D. A. (2006) · Leukemia · doi:10.1038/sj.leu.2404380 · Cited by 74 · see citing works
Blood Dendritic Cells Generated With Flt3 Ligand and CD40 Ligand Prime CD8+ T Cells Efficiently in Cancer Patients
Davis, I. D., Chen, Q., Morris, L., Quirk, J., Stanley, M. L., Tavarnesi, M. L., Parente, P., Cavicchiolo, T., Hopkins, W., Jackson, H. M., et al. (2006) · Journal of Immunotherapy · doi:10.1097/01.cji.0000211299.29632.8c · Cited by 71 · see citing works
Results of a phase I clinical study using autologous tumour lysate-pulsed monocyte-derived mature dendritic cell vaccinations for stage IV malignant melanoma patients combined with low dose interleukin-2
Nagayama, H., Sato, K., Morishita, M., Uchimaru, K., Oyaizu, N., Inazawa, T., Yamasaki, T., Enomoto, M., Nakaoka, T., Nakamura, T., et al. (2003) · Melanoma Research · doi:10.1097/00008390-200310000-00011 · Cited by 71 · see citing works
Functional Specialty of CD40 and Dendritic Cell Surface Lectins for Exogenous Antigen Presentation to CD8+ and CD4+ T Cells
Yin, W., Gorvel, L., Zurawski, S., Li, D., Ni, L., Duluc, D., Upchurch, K., Kim, J., Gu, C., Ouedraogo, R., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.01.029 · Cited by 68 · see citing works
Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor responses in melanoma patients at the cost of toxicity
Bol, K. F., Aarntzen, E. H. J. G., Pots, J. M., Nordkamp, M. A. M. O., van de Rakt, M. W. M. M., Scharenborg, N. M., de Boer, A. J., van Oorschot, T. G. M., Croockewit, S., Blokx, W. A. M., et al. (2016) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-016-1796-7 · Cited by 68 · see citing works
Fusion of dendritic cells with multiple myeloma cells results in maturation and enhanced antigen presentation
Vasir, B., Borges, V. F., Wu, Z., Grosman, D., Rosenblatt, J. M., Irie, M., Anderson, K. C., Kufe, D. W., & Avigan, D. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05507.x · Cited by 67 · see citing works
Repertoire of antiviral antibodies expressed by somatic cell hybrids.
Gerhard, W., Croce, C. M., Lopes, D., & Koprowski, H. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.3.1510 · Cited by 65 · see citing works
F lt3 ligand expands CD 4+ F ox P 3+ regulatory T cells in human subjects
Klein, O., Ebert, L. M., Zanker, D. J., Woods, K., Tan, B. S., Fucikova, J. P., Behren, A., Davis, I. D., Maraskovsky, E., Chen, W., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201242603 · Cited by 64 · see citing works
Novel cationic liposomes provide highly efficient delivery of DNA and RNA into dendritic cell progenitors and their immature offsets
Markov, O. V., Mironova, N. L., Maslov, M. A., Petukhov, I. A., Morozova, N. G., Vlassov, V. V., & Аркадьевна, З. М. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.11.034 · Cited by 61 · see citing works
Targeting of 111In-Labeled Dendritic Cell Human Vaccines Improved by Reducing Number of Cells
Aarntzen, E. H. J. G., Srinivas, M., Bonetto, F. J., Cruz, L. J., Verdijk, P., Schreibelt, G., van de Rakt, M. W. M. M., Lesterhuis, W. J., van Riel, M., Punt, C. J. A., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1879 · Cited by 60 · see citing works
Human blood dendritic cell subsets exhibit discriminative pattern recognition receptor profiles
Lundberg, K., Rydnert, F., Greiff, L., & Lindstedt, M. (2014) · Immunology · doi:10.1111/imm.12252 · Cited by 59 · see citing works
Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines
Banchereau, R., Baldwin, N. E., Cepika, A., Athale, S., Xue, Y., Yu, C. I., Metang, P., Cheruku, A., Berthier, I., Gayet, I., et al. (2014) · Nature Communications · doi:10.1038/ncomms6283 · Cited by 57 · see citing works
mRNA-electroporated mature dendritic cells retain transgene expression, phenotypical properties and stimulatory capacity after cryopreservation
Ponsaerts, P., Tendeloo, V. F. V., Cools, N., Driessche, A. V., Lardon, F., Nijs, G., Lenjou, M., Mertens, G., Broeckhoven, C. V., Bockstaele, D. V., et al. (2002) · Leukemia · doi:10.1038/sj.leu.2402511 · Cited by 56 · see citing works
Human dendritic cells express a 95 kDa activation/differentiation antigen defined by CMRF‐56
Hock, B. D., Fearnley, D. B., Boyce, A., McLellan, A. D., Sorg, R. V., Summers, K. L., & Hart, D. N. J. (1999) · Tissue Antigens · doi:10.1034/j.1399-0039.1999.530402.x · Cited by 52 · see citing works
Vaccination with filamentous bacteriophages targeting DEC‐205 induces DC maturation and potent anti‐tumor T‐cell responses in the absence of adjuvants
Sartorius, R., Bettua, C., D’Apice, L., Caivano, A., Trovato, M., Russo, D., Zanoni, I., Granucci, F., Mascolo, D., Barba, P., et al. (2011) · European Journal of Immunology · doi:10.1002/eji.201141526 · Cited by 51 · see citing works
Rationale for a Multimodality Strategy to Enhance the Efficacy of Dendritic Cell-Based Cancer Immunotherapy
Datta, J., Berk, E., Cintolo, J. A., Xu, S., Roses, R. E., & Czerniecki, B. J. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00271 · Cited by 46 · see citing works
Monocyte-Derived Dendritic Cells Exhibit Increased Levels of Lysosomal Proteolysis as Compared to Other Human Dendritic Cell Populations
McCurley, N., & Mellman, I. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011949 · Cited by 46 · see citing works
Antibody responses initiated by Clec9A-bearing dendritic cells in normal and Batf3−/− mice
Caminschi, I., Vremec, D., Ahmet, F., Lahoud, M. H., Villadangos, J. A., MURPHY, K. M. M., Heath, W. R., & Shortman, K. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.11.008 · Cited by 46 · see citing works
A CD2 high‐expressing stress‐resistant human plasmacytoid dendritic‐cell subset
Bryant, C. E., Fromm, P. D., Kupresanin, F., Clark, G. J., Lee, K. M. L., Clarke, C. J., Silveira, P. A., Suen, H., Brown, R. D., Newman, E., et al. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2015.116 · Cited by 45 · see citing works
Construction of a new anti-CD19 chimeric antigen receptor and the anti-leukemia function study of the transduced T cells
An, N., Tao, Z., Li, S., Xing, H., Tang, K., Tian, Z., Rao, Q., Wang, M., & Wang, J. (2016) · Oncotarget · doi:10.18632/oncotarget.7079 · Cited by 42 · see citing works
Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission
Beck, B., Dörfel, D., Lichtenegger, F. S., Geiger, C., Lindner, L., Merk, M., Schendel, D. J., & Subklewe, M. S. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-151 · Cited by 41 · see citing works
Dendritic/Tumor Fusion Cells as Cancer Vaccines
Avigan, D., Rosenblatt, J. M., & Kufe, D. W. (2012) · Seminars in Oncology · doi:10.1053/j.seminoncol.2012.02.003 · Cited by 41 · see citing works
Tumour‐mediated disruption of dendritic cell function: Inhibiting the MEK1/2‐p44/42 axis restores IL‐12 production and Th1‐generation
Jackson, A. M., Mulcahy, L. A., Zhu, X. W., O’Donnell, D., & Patel, P. M. (2008) · International Journal of Cancer · doi:10.1002/ijc.23530 · Cited by 38 · see citing works
Different maturation cocktails provide dendritic cells with different chemoattractive properties
Massa, C., Thomas, C., Wang, E., Marincola, F. M., & Seliger, B. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0528-7 · Cited by 37 · see citing works
Low-dose cyclophosphamide enhances antigen-specific CD4+ T cell responses to NY-ESO-1/ISCOMATRIX™ vaccine in patients with advanced melanoma
Klein, O., Davis, I. D., McArthur, G. A., Chen, L., Haydon, A. M., Parente, P., Dimopoulos, N., Jackson, H. M., Xiao, K., Maraskovsky, E., et al. (2015) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-015-1656-x · Cited by 36 · see citing works
An Optimized Method for Manufacturing a Clinical Scale Dendritic Cell-Based Vaccine for the Treatment of Glioblastoma
Nava, S., Dossena, M., Pogliani, S., Pellegatta, S., Antozzi, C. G., Baggi, F., Gellera, C., Pollo, B., Parati, E. A., Finocchiaro, G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052301 · Cited by 36 · see citing works
Immune Monitoring in Cancer Vaccine Clinical Trials: Critical Issues of Functional Flow Cytometry-Based Assays
Macchia, I., Urbani, F., & Proietti, E. (2013) · BioMed Research International · doi:10.1155/2013/726239 · Cited by 34 · see citing works
Evolution of B Cell Responses to Clec9A-Targeted Antigen
Park, H., Light, A., Lahoud, M. H., Caminschi, I., Tarlinton, D. M., & Shortman, K. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301947 · Cited by 32 · see citing works
Evaluation of dendritic cells loaded with apoptotic cancer cells or expressing tumour mRNA as potential cancer vaccines against leukemia
Jarnjak-Jankovic, S., Pettersen, R. D., Sæbøe‐Larssen, S., Wesenberg, F., & Gaudernack, G. (2005) · BMC Cancer · doi:10.1186/1471-2407-5-20 · Cited by 27 · see citing works
Designing the Optimal Vaccine: the Importance of Cytokines and Dendritic Cells ~!2009-07-02~!2009-12-31~!2010-02-12~!
Morel, P. A., & Turner, M. S. (2010) · The Open Vaccine Journal · doi:10.2174/1875035401003010007 · Cited by 25 · see citing works
Inhibiting effects on the induction of cytotoxic T lymphocytes by dendritic cells pulsed with lysates from acute myeloid leukemia blasts
Schui, D. K., Singh, L., Schneider, B., Knau, A., Hoelzer, D. F., & Weidmann, E. (2002) · Leukemia Research · doi:10.1016/s0145-2126(01)00141-2 · Cited by 24 · see citing works
Targeting the antigen encoded by adenoviral vectors to the DEC205 receptor modulates the cellular and humoral immune response
Tenbusch, M., Nchinda, G., Bonsmann, M. S. G., Temchura, V., & Überla, K. (2012) · International Immunology · doi:10.1093/intimm/dxs112 · Cited by 23 · see citing works
Primary Human Blood Dendritic Cells for Cancer Immunotherapy—Tailoring the Immune Response by Dendritic Cell Maturation
Sittig, S. P., de Vries, I. J. M., & Schreibelt, G. (2015) · Biomedicines · doi:10.3390/biomedicines3040282 · Cited by 23 · see citing works
Antigen loading of dendritic cells with apoptotic tumor cell-preparations is superior to that using necrotic cells or tumor lysates.
Inzkirweli, N., Gückel, B., Sohn, C., Wallwiener, D. R., Bastert, G., & Lindner, M. (2007) · PubMed · Cited by 22 · see citing works
Dendritic cells pulsed or fused with AML cellular antigen provide comparable in vivo antitumor protective responses
Weigel, B. J., Panoskaltsis‐Mortari, A., Diers, M. D., García, M. M., Lees, C. J., Krieg, A. Μ., Chen, W., & Blazar, B. R. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.05.011 · Cited by 21 · see citing works
A phase II study testing the safety and activity of AGS-003 as an immunotherapeutic in subjects with newly diagnosed advanced stage renal cell carcinoma (RCC) in combination with sunitinib.
Amin, A. M., Dudek, A., Logan, T. F., Lance, R. S., Holzbeierlein, J. M., Williams, W. L., Jain, R., Chew, T., Nicolette, C. A., Figlin, R. A., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.15_suppl.4588 · Cited by 21 · see citing works
Biosafety and product release testing issues relevant to replication-competent oncolytic viruses
Wisher, M. H. (2002) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700536 · Cited by 20 · see citing works
A multi‐laboratory comparison of blood dendritic cell populations
Fromm, P. D., Kupresanin, F., Brooks, A. E. S., Dunbar, P. R., Haniffa, M., Hart, D. N. J., & Clark, G. J. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.5 · Cited by 19 · see citing works
Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205
D’Apice, L., Costa, V., Sartorius, R., Trovato, M., Aprile, M., & Berardinis, P. D. (2015) · Journal of Immunology Research · doi:10.1155/2015/585078 · Cited by 18 · see citing works
CMRF-56+blood dendritic cells loaded with mRNA induce effective antigen-specific cytotoxic T-lymphocyte responses
Fromm, P. D., Papadimitrious, M. S., Hsu, J. L., Losio, N. V. K., Verma, N. D., Lo, K., Silveira, P. A., Bryant, C. E., Turtle, C. J., Prue, R. L., et al. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1168555 · Cited by 18 · see citing works
A Pilot Study of Peripheral Blood BDCA-1 (CD1c) Positive Dendritic Cells Pulsed with NY-ESO-1 ISCOMATRIX™ Adjuvant
Davis, I. D., Quirk, J., Morris, L., Seddon, L., Tai, T. Y., Whitty, G. A., Cavicchiolo, T., Ebert, L. M., Jackson, H. M., Browning, J., et al. (2017) · Immunotherapy · doi:10.2217/imt-2016-0132 · Cited by 17 · see citing works

Flagged first, then by citations

2 of the 214 references couldn’t be matched to a known paper.

Sorted by citations

The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma
Donné, R., & Lujambio, A. (2022) · Hepatology · doi:10.1002/hep.32740 · Cited by 651 · see citing works
Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice
Zuo, B., Han, Q., Lu, Z. F., Chen, L., Sun, B., Yang, R., Zhang, Y., Liu, Z., Gao, X., You, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15569-2 · Cited by 170 · see citing works
Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity
Saichi, M., Ladjemi, M. Z., Korniotis, S., Rousseau, C., Hamou, Z. A., Massenet-Regad, L., Amblard, E., Noël, F., Marie, Y., Bouteiller, D., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00681-2 · Cited by 151 · see citing works
Trial watch: dendritic cell vaccination for cancer immunotherapy
Sprooten, J., Ceusters, J., Coosemans, A., Agostinis, P., Vleeschouwer, S. D., Zitvogel, L., Kroemer, G., Galluzzi, L., & Garg, A. D. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1638212 · Cited by 148 · see citing works
Harnessing the innate immune system and local immunological microenvironment to treat colorectal cancer
Kather, J. N., & Halama, N. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0441-6 · Cited by 92 · see citing works
Photothermal-triggered immunogenic nanotherapeutics for optimizing osteosarcoma therapy by synergizing innate and adaptive immunity
Liu, K., Liao, Y., Zhou, Z., Zhang, L., Jiang, Y., Lu, H., Xu, T., Dong, Y., Gao, Q., Li, Z., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121383 · Cited by 90 · see citing works
Nanoparticles as Smart Carriers for Enhanced Cancer Immunotherapy
Thakur, N., Thakur, S., Chatterjee, S., Das, J., & Sil, P. C. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.597806 · Cited by 88 · see citing works
RNA delivery biomaterials for the treatment of genetic and rare diseases
Zhao, W., Hou, X., Vick, O. G., & Dong, Y. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119291 · Cited by 82 · see citing works
Application of dendritic cells in tumor immunotherapy and progress in the mechanism of anti-tumor effect of Astragalus polysaccharide (APS) modulating dendritic cells: a review
Wang, D., Cui, Q., Yang, Y. J., Liu, A. Q., Zhang, G., & Yu, J. C. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113541 · Cited by 81 · see citing works
Dysfunction of dendritic cells in tumor microenvironment and immunotherapy
Chen, J., Duan, Y.-H., Che, J., & Zhu, J. (2024) · 癌症：英文版 · doi:10.1002/cac2.12596 · Cited by 77 · see citing works
Zinc‐Organometallic Framework Vaccine Controlled‐Release Zn <sup>2+</sup> Regulates Tumor Extracellular Matrix Degradation Potentiate Efficacy of Immunotherapy
Ding, L., Liang, M., Li, Y., Zeng, M., Liu, M., Ma, W., Chen, F., Li, C., Reis, R. L., Li, F., et al. (2023) · Advanced Science · doi:10.1002/advs.202302967 · Cited by 68 · see citing works
PD-L1 methylation restricts PD-L1/PD-1 interactions to control cancer immune surveillance
Huang, C., Ren, S., Chen, Y., Liu, A., Wu, Q., Jiang, T., Lv, P., Song, D., Hu, F., Lan, J., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade4186 · Cited by 67 · see citing works
Promoting the activation of T cells with glycopolymer-modified dendritic cells by enhancing cell interactions
Yu, L., Feng, R., Zhu, L., Hao, Q., Chu, J., Gu, Y., Luo, Y., Zhang, Z., Chen, G., & Chen, H. (2020) · Science Advances · doi:10.1126/sciadv.abb6595 · Cited by 60 · see citing works
Combination therapy with dendritic cell vaccine and programmed death ligand 1 immune checkpoint inhibitor for hepatocellular carcinoma in an orthotopic mouse model
Teng, C., Wang, T., Wu, T., Lin, J., Shih, F., Shyu, W., & Jeng, L. (2020) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835920922034 · Cited by 57 · see citing works
Dendritic Cell-Based Vaccines Against Cancer: Challenges, Advances and Future Opportunities
Fu, C., Ma, T., Zhou, L., Mi, Q., & Jiang, A. (2022) · Immunological Investigations · doi:10.1080/08820139.2022.2109486 · Cited by 50 · see citing works
Exosome nanovesicles as potential biomarkers and immune checkpoint signaling modulators in lung cancer microenvironment: recent advances and emerging concepts
Khan, N. A., Asim, M., Biswas, K. H., Alansari, A. N., Saman, H. T., Sarwar, M. Z., Osmonaliev, K., & Shahab Uddin, M. S. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02753-7 · Cited by 47 · see citing works
Opportunities for Conventional and In Situ Cancer Vaccine Strategies and Combination with Immunotherapy for Gastrointestinal Cancers, A Review
Bouzid, R., Peppelenbosch, M. P., & Buschow, S. I. (2020) · Cancers · doi:10.3390/cancers12051121 · Cited by 46 · see citing works
Immune Curbing of Cancer Stem Cells by CTLs Directed to NANOG
Wefers, C., Schreibelt, G., Massuger, L. F. A. G., de Vries, I. J. M., & Torensma, R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01412 · Cited by 46 · see citing works
Preclinical models and technologies to advance nanovaccine development
Peres, C., Matos, A. I., Moura, L. I. F., Acúrcio, R. C., Carreira, B., Pozzi, S., Vaskovich‐Koubi, D., Kleiner, R., Satchi‐Fainaro, R., & Florindo, H. F. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.001 · Cited by 45 · see citing works
Selenium Regulation of the Immune Function of Dendritic Cells in Mice Through the ERK, Akt and RhoA/ROCK Pathways
Zhang, L., Xia, H., Xia, K., Liu, X., Zhang, X., Dai, J., Zeng, Z., & Jia, Y. (2020) · Biological Trace Element Research · doi:10.1007/s12011-020-02449-5 · Cited by 37 · see citing works
An immunological perspective for preventing cancer with berries
Pan, P., Huang, Y.-W., Oshima, K., Yearsley, M., Zhang, J., Yu, J., ARNOLD, M. W., & Wang, L.-S. (2018) · Journal of Berry Research · doi:10.3233/jbr-180305 · Cited by 34 · see citing works
Tumor-Derived Microvesicles Enhance Cross-Processing Ability of Clinical Grade Dendritic Cells
Dionisi, M., Archangelis, C. D., Battisti, F., Koshkaki, H. R., Belleudi, F., Zizzari, I. G., Ruscito, I., Albano, C., Filippo, A. D., Torrisi, M. R., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02481 · Cited by 33 · see citing works
Using Dendritic Cell-Based Immunotherapy to Treat HIV: How Can This Strategy be Improved?
da Silva, L. T., Santillo, B. T., de Almeida, A., Duarte, A. J. D. S., & Oshiro, T. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02993 · Cited by 30 · see citing works
Gut microbiota trigger host liver immune responses that affect drug-metabolising enzymes
Rao, J., Qiu, P., Zhang, Y., & Wang, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1511229 · Cited by 29 · see citing works
Preparation and evaluation of the adjuvant effect of curdlan sulfate in improving the efficacy of dendritic cell-based vaccine for antitumor immunotherapy
Jin, Y., Mu, Y., Zhang, S., Li, P., & Wang, F. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.12.256 · Cited by 28 · see citing works
Therapeutic efficacy of dendritic cell vaccine combined with programmed death 1 inhibitor for hepatocellular carcinoma
Teng, C., Wang, T., Shih, F., Shyu, W., & Jeng, L. (2021) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15398 · Cited by 27 · see citing works
Gold Compounds and the Anticancer Immune Response
Zhou, L., Liu, H., Liu, K., & Wei, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.739481 · Cited by 24 · see citing works
Ca2+-Mediated Surface Polydopamine Engineering to Program Dendritic Cell Maturation
Liu, Y., Han, Y., Dong, H., Wei, X., Shi, D., & Li, Y. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b20997 · Cited by 22 · see citing works
Harnessing the Immunogenic Potential of Gold Nanoparticle-Based Platforms as a Therapeutic Strategy in Breast Cancer Immunotherapy: A Mini Review
Chen, X., Yung, L. L., Tan, P. H., & Bay, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.865554 · Cited by 19 · see citing works
Tumor Immune Microenvironment in Intrahepatic Cholangiocarcinoma: Regulatory Mechanisms, Functions, and Therapeutic Implications
Ricci, A. D., Rizzo, A., Schirizzi, A., D’Alessandro, R., Frega, G., Brandi, G., Shahini, E., Cozzolongo, R., Lotesoriere, C., & Giannelli, G. (2024) · Cancers · doi:10.3390/cancers16203542 · Cited by 19 · see citing works
Exosomes from HPV-16 E7-pulsed dendritic cells prevent the migration, M1 polarization, and inflammation of macrophages in cervical cancer by regulating catalase 2 (CAT2)
Zhang, G., Liao, Y., Pan, X., & Zhang, X. (2022) · Annals of Translational Medicine · doi:10.21037/atm-21-6998 · Cited by 18 · see citing works
Mannose-Modified Chitosan Poly(lactic-co-glycolic acid) Microspheres Act as a Mannose Receptor-Mediated Delivery System Enhancing the Immune Response
Feng, H., Yang, X., Zhang, L., Liu, Q., Feng, Y., Wu, D., Liu, Y., & Yang, J. (2021) · Polymers · doi:10.3390/polym13132208 · Cited by 15 · see citing works
Cancer/testis antigens expression during cultivation of melanoma and soft tissue sarcoma cells
Danilova, A. B., Misyurin, V. A., Novik, A. V. N., Girdyuk, D. V., Avdonkina, N. A., Нехаева, Т. Л., Emelyanova, N. V., Pipia, N., Misyurin, A. V., & Балдуева, И. А. (2020) · Clinical Sarcoma Research · doi:10.1186/s13569-020-0125-2 · Cited by 15 · see citing works
The Expression of ILT4 in Myeloid Dendritic Cells in Patients with Hepatocellular Carcinoma
Wang, L., Fan, J., Ye, W., Han, J., Zhang, Y., Zhao, L., Duan, J., Yin, D., & Yi, Y. (2019) · Immunological Investigations · doi:10.1080/08820139.2019.1571507 · Cited by 14 · see citing works
Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment
Guisier, F., Barros‐Filho, M. C., Rock, L. D., Strachan-Whaley, M. R., Marshall, E. A., Dellaire, G., & Lam, W. L. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-35723-8_3 · Cited by 13 · see citing works
Effect of laminin environments and tumor factors on the biology of myeloid dendritic cells
Phillippi, B., Singh, M., Loftus, T., Smith, H. L., Muccioli, M., Wright, J., Pate, M., & Benencia, F. (2019) · Immunobiology · doi:10.1016/j.imbio.2019.10.003 · Cited by 12 · see citing works
Distinguishing human peripheral blood CD16+ myeloid cells based on phenotypic characteristics
Fromm, P. D., Silveira, P. A., Hsu, J. L., Papadimitrious, M. S., Lo, K., Ju, X., Kupresanin, F., Romano, A., Hsu, W., Bryant, C. E., et al. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.5a1119-362rrr · Cited by 11 · see citing works
Single-cell technology for drug discovery and development
Zhang, A., Zou, J., Xi, Y., Gao, L., Deng, F., Liu, Y., Gao, P., Tong, H. H. Y., Tan, L., Zou, X., et al. (2024) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2024.1459962 · Cited by 9 · see citing works
CAL-1 as Cellular Model System to Study CCR7-Guided Human Dendritic Cell Migration
Allmen, E. U.-V., Samson, G. P. B., Purvanov, V., Maeda, T., & Legler, D. F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.702453 · Cited by 9 · see citing works
Microenvironmental derived factors modulating dendritic cell function and vaccine efficacy: the effect of prostanoid receptor and nuclear receptor ligands
Raaijmakers, T. K., & Ansems, M. (2018) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-2205-1 · Cited by 9 · see citing works
The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology
Harding, S. D., Faccenda, E., Southan, C., Pawson, A. J., Maffia, P., Alexander, S. P. H., Davenport, A. P., Fabbro, D., Levi‐Schaffer, F., Spedding, M., et al. (2020) · Immunology · doi:10.1111/imm.13175 · Cited by 8 · see citing works
Laponite Lights Calcium Flickers by Reprogramming Lysosomes to Steer DC Migration for An Effective Antiviral CD8+ T‐Cell Response
Li, C., Hou, Y., He, M., Lv, L., Zhang, Y., Sun, S., Zhao, Y., Liu, X., Ma, P., Wang, X., et al. (2023) · Advanced Science · doi:10.1002/advs.202303006 · Cited by 8 · see citing works
Re-expression of CD14 in Response to a Combined IL-10/TLR Stimulus Defines Monocyte-Derived Cells With an Immunoregulatory Phenotype
Krakow, S., Crescimone, M. L., Bartels, C., Wiegering, V. A., Eyrich, M. K., Schlegel, P. G., & Wölfl, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01484 · Cited by 8 · see citing works
MMP9-Associated Tumor Stem Cells, CCL1-Silenced Dendritic Cells, and Cytokine-Induced Killer Cells Have a Remarkable Therapeutic Efficacy for Acute Myeloid Leukemia by Activating T Cells
Dong, M., Zhang, G., Meng, J., Liu, B., Jiang, D., & Liu, F. (2023) · Stem Cells International · doi:10.1155/2023/2490943 · Cited by 6 · see citing works
Clinical applications of monitoring immune status with 90 immune cell subsets in human whole blood by 10‐color flow cytometry
Wang, W., Li, H., Zhang, L., Jiang, W., Shen, L., & Fan, G. (2021) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.13541 · Cited by 6 · see citing works
Sendai virus acts as a nano-booster to excite dendritic cells for enhancing the efficacy of CD47-directed immune checkpoint inhibitors against breast carcinoma
Xu, Y., Zheng, B., Huang, M., Li, X., Wang, Z., Chang, J. K., & Wang, T. (2020) · Materials Chemistry Frontiers · doi:10.1039/d0qm00393j · Cited by 6 · see citing works
Cell Therapy for Liver Disease: From Promise to Reality
Khan, S., Khan, R. S., & Newsome, P. N. (2020) · Seminars in Liver Disease · doi:10.1055/s-0040-1717096 · Cited by 5 · see citing works
Biomimetic and Materials-Potentiated Cell Engineering for Cancer Immunotherapy
Zhang, T., Yang, Y., Huang, L. F., Liu, Y., Chong, G., Yin, W., Dong, H., Li, Y., & Li, Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040734 · Cited by 4 · see citing works
Anti-hepatoma Effect of DC2.4 Cells Transfected with Tumor-Associated Antigen Cdc25C In Vitro
Li, C., Li, Y., Lin, T., Zhang, Q., Zheng, F.-Y., & Mo, F. (2022) · Current Medical Science · doi:10.1007/s11596-022-2556-x · Cited by 4 · see citing works
Nanoparticles Targeting the Tumor Microenvironment for the Treatment of Osteosarcoma: Recent Progress and Perspectives
Liang, G., Wang, W., Li, C., Zhong, B., Zhao, L., Zhang, Z., & Liu, J. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s579152 · Cited by 3 · see citing works
In situ generation of dendritic cell vaccines in 3D printing scaffolds for cancer post-surgical therapy
Chen, L., Xu, Y., Hu, X., Pan, Y., She, P., Chen, X. S., Peng, Q., Li, Q., & Rao, L. (2026) · National Science Review · doi:10.1093/nsr/nwag037 · Cited by 2 · see citing works
Characterization of a Tumor-Microenvironment-Relevant Gene Set Based on Tumor Severity in Colon Cancer and Evaluation of Its Potential for Dihydroartemisinin Targeting
Liang, B., Zheng, B., Zhou, Y., Lai, Z., Zhang, C., Yan, Z., Li, Z., Li, X., Gong, P., Qu, J., et al. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/4812068 · Cited by 2 · see citing works
A Screening-Guided Biomimetic Exosome-Liposome Hybrid Nanoplatform Enables Pyroptosis-Enhanced Immune Reprogramming in Glioblastoma
Wang, Y., Zhao, R., Miao, L., Bian, J., Zhou, Y., Zhao, X., Song, W., Wang, Y., & Jiang, X. (2026) · ACS Nano · doi:10.1021/acsnano.6c08160 · Cited by 1 · see citing works
212 Co‐delivery of Vitamin D3 and Antigens by Nanoparticles Enhances Immune Tolerance through Induction of Tolerogenic Dendritic Cells in vivo
Gao, X. J., Cong, X., Li, H., Mao, K., Wang, H., Lin, G., Wang, J., Liu, F., Zhu, G., Tan, H., et al. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202200274 · Cited by 1 · see citing works
Melanoma Vaccines
Hersey, P., Gallagher, S. J., Kirkwood, J. M., & Cebon, J. S. (2020) · Springer eBooks · doi:10.1007/978-3-030-05070-2_37
Melanoma Vaccines
Hersey, P., Gallagher, S. J., Kirkwood, J. M., & Cebon, J. S. (2018) · Springer eBooks · doi:10.1007/978-3-319-46029-1_37-1
Perspektiven der medikamentösen Tumortherapie
Müller-Richter, U. D. A., Göbeler, M. E., Sayehli, C. M., & Einsele, H. (2022) · Springer eBooks · doi:10.1007/978-3-662-62808-9_13
Advances in the development of therapeutic mRNA vaccines for cancer therapy
Deng, K., Li, X., Liu, W., Liu, J., Wang, R., Yin, Y., & Zhang, C. Y. (2024) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2024-0878
Contribution à l'identification de marqueurs de la réponse des carcinomes bronchiques non à petites cellules aux immunothérapies
Guisier, F. (2019) · doi:10.70675/9de2ee5az6556z48b7z97b1zc402c970fc69
Harnessing dendritic cells (DCs) for melanoma immunotherapy: From basic biology to clinical strategies
Rodrigues, D. S., Saeed, B. I., Alkhathami, A. G., Kareem, A. K., Tillyashaykhov, M., Al-Khafaji, Z., Al‐Mashhadani, Z. I., Kadhum, W. R., Bokhoor, S. N., & Mustafa, Y. F. (2026) · Current Research in Translational Medicine · doi:10.1016/j.retram.2026.103604
Carfilzomib preserves dendritic cell phenotype and function compared with bortezomib
Wang, L., Dahlfrancis, M., Dörfel, D., Walz, J. S., Klatt, M. G., Grünebach, F., & Rittig, S. M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1936021

Dendritic cell vaccine for cancer therapy
Praveena, C. H., Pramod, K. S., & Ajithkumar, K. C. (2016) · Research Journal of Pharmacology and Pharmacodynamics · doi:10.5958/2321-5836.2016.00026.4 · Cited by 4 · see citing works
Dendritic cell-based vaccine research against cancer
Mody, N., Dubey, S., Sharma, R. K., Agrawal, U., & Vyas, S. P. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2015.987663 · Cited by 37 · see citing works
Dendritic Cell Vaccine and its Application in Cancer Therapy
Khansari, N. (2015) · International Journal of Vaccines & Vaccination · doi:10.15406/ijvv.2015.01.00002 · Cited by 6 · see citing works
[Dendritic cell-based therapeutic cancer vaccines].
Rizzo, M., Alaniz, L. D., & Mazzolini, G. D. (2016) · PubMed · Cited by 4 · see citing works
Cancer immunotherapy via dendritic cells
Palucka, K., & Banchereau, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3258 · Cited by 2,060 · see citing works

Authors: Bryant, C. E., Sutherland, S., Kong, B., Papadimitrious, M. S., Fromm, P. D., & Hart, D. N. J.
Affiliations: Royal Prince Alfred Hospital (AU)
The University of Sydney (AU)
Corresponding author: Bryant, Christian E.
ORCID: Bryant, Christian E.
Sutherland, Sarah
Kong, Benjamin
Fromm, Phillip D.
Hart, Derek N.J.
Venue: Seminars in Cell & Developmental Biology
Publisher: Elsevier BV
Published: 2019-02
Volume: 86
Pages: 77-88
ISSN: 1084-9521 (ISSN-L)
DOI: 10.1016/j.semcdb.2018.02.015
OpenAlex: W2793717314
Cited by: 61
References: 214
Citations by year: 2026: 5 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 13 · 2019: 9 · 2018: 6
FWCI: 0.92
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Seminars in Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Australian National Health and Medical Research Council, Australia (543727)
Cancer Institute New South Wales, Australia (11/TPG/3-012)
The Anthony Rothe Memorial Trust, Australia (RRE/700)
The Ainsworth Foundation, Australia. Cancer Australia, Australia (543713)
Enid Ng Fellowship
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: dendritic cells, cancer immunotherapy, dendritic cell vaccine, antigen presentation, T cell recognition, tumor antigens, adjuvants, vaccine delivery, monocyte-derived dendritic cells, combination immunotherapy, antitumor immunity
MeSH terms: Dendritic Cells, Humans, Immunotherapy, Neoplasms, T-Lymphocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dendritic cells as cancer therapeutics

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks