The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Deubiquitylation and regulation of the immune response
Open accessAbstract
Ubiquitylation is a fundamental mechanism of signal transduction that regulates immune responses and many other biological processes. Similar to phosphorylation, ubiquitylation is a reversible process that is counter-regulated by ubiquitylating enzymes and deubiquitylating enzymes (DUBs). Despite the identification of a large number of DUBs, our knowledge of the function and activities of this family of enzymes is just starting to accumulate. As described in this Review, recent studies of several DUBs, in particular CYLD and A20, show that deubiquitylation has an important role in the regulation of both innate and adaptive immune responses.
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Cites
Negative regulation of Toll-like receptor-mediated immune responses
Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509
Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice
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Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma
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Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family
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Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation
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Cited by
Breaking the chains: structure and function of the deubiquitinases
Komander, D., Clague, M. J., & Urbé, S. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2731 · Cited by 1,969
Detecting shared pathogenesis from the shared genetics of immune-related diseases
Zhernakova, A., van Diemen, C. C., & Wijmenga, C. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2489 · Cited by 551
Pulsatile Stimulation Determines Timing and Specificity of NF-κB-Dependent Transcription
Ashall, L., Horton, C. A., Nelson, D. E., Paszek, P., Harper, C. V., Sillitoe, K., Ryan, S., Spiller, D. G., Unitt, J. F., Broomhead, D. S., et al. (2009) · Science · doi:10.1126/science.1164860 · Cited by 543
NF-κB in inflammation and renal diseases
Zhang, H., & Sun, S.-C. (2015) · Cell & Bioscience · doi:10.1186/s13578-015-0056-4 · Cited by 383
Self-citationThe E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon
Wang, C., Chen, T., Zhang, J., Yang, M., Li, N., Xu, X., & Cao, X. (2009) · Nature Immunology · doi:10.1038/ni.1742 · Cited by 317
Metadata
- Authors
- Sun, S.-C.
- Venue
- Nature Reviews Immunology
- Published
- 2008-07
- Volume
- 8
- Issue
- 7
- Pages
- 501-511
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2005739512
- Cited by
- 355
- References
- 5
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- green
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