The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

Wang, Chen; Chen, Taoyong; Zhang, Jia; Yang, Mingjin; Li, Nan; Xu, Xiongfei; Cao, Xuetao

doi:10.1038/ni.1742

Cited by 318Immune Response and Inflammationinterferon and immune responsesNF-κB Signaling Pathways

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

Wang, Chen, Chen, Taoyong, Zhang, Jia, Yang, Mingjin, Li, Nan, Xu, Xiongfei, Cao, Xuetao·2009·Nature Immunology

DOI 10.1038/ni.1742

Open this paper in CoChat — free account

Abstract

E3 ubiquitin ligases are important in both innate and adaptive immunity. Here we report that Nrdp1, an E3 ubiquitin ligase, inhibited the production of proinflammatory cytokines but increased interferon-beta production in Toll-like receptor-triggered macrophages by suppressing adaptor MyD88-dependent activation of transcription factors NF-kappaB and AP-1 while promoting activation of the kinase TBK1 and transcription factor IRF3. Nrdp1 directly bound and polyubiquitinated MyD88 and TBK1, which led to degradation of MyD88 and activation of TBK1. Knockdown of Nrdp1 inhibited the degradation of MyD88 and the activation of TBK1 and IRF3. Nrdp1-transgenic mice showed resistance to lipopolysaccharide-induced endotoxin shock and to infection with vesicular stomatitis virus. Our data suggest that Nrdp1 functions as both an adaptor protein and an E3 unbiquitin ligase to regulate TLR responses in different ways.

Integrity signals

Registry

Crossref · 10.1038/ni.1742

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Parkin-deficient mice and mice expressing a dominant negative form of Nrdp1 are not reported to have significant neurodegenerative disease.
“Importantly, parkin-deficient mice and mice expressing a dominant negative form of Nrdp1 are not reported to have significant neurodegenerative disease171819.”
From Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival (2016) · cites this paper as [19]
Lack of reported neurodegeneration in parkin-deficient and Nrdp1 mutant mice makes it unlikely that the Nrdp1 interaction explains the finding of neurodegeneration in Clec16a mutant mice.
“The lack of reported neurodegeneration in parkin-deficient and Nrdp1 mutant mice171819 makes it unlikely that this interaction explains our finding of neurodegeneration in Clec16a mutant mice.”
From Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival (2016) · cites this paper as [19]

Toll-like receptor signalling
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312 · see citing works
Toll-like receptor control of the adaptive immune responses
Iwasaki, A., & Medzhitov, R. M. (2004) · Nature Immunology · doi:10.1038/ni1112 · Cited by 4,166 · see citing works
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., & Fujita, T. (2004) · Nature Immunology · doi:10.1038/ni1087 · Cited by 3,935 · see citing works
IKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680 · see citing works
Unresponsiveness of MyD88-deficient mice to endotoxin.
Kawai, T., Adachi, O., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80086-2 · Cited by 2,367 · see citing works
Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function.
Adachi, O., Kawai, T., Takeda, K., Matsumoto, M., Tsutsui, H., Sakagami, M., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80596-8 · Cited by 2,358 · see citing works
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
Wang, C., Deng, L., Hong, M., Akkaraju, G. R., Inoue, J.-I., & Chen, Z. J. (2001) · Nature · doi:10.1038/35085597 · Cited by 2,125 · see citing works
Self-citation
Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain
Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C., & Chen, Z. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00126-4 · Cited by 1,872 · see citing works
Self-citation
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
Wertz, I. E., O’Rourke, K. M., Zhou, H., Eby, M. T., Aravind, L., Seshagiri, S., Wu, P., Wiesmann, C., Baker, R. T., Boone, D. L., et al. (2004) · Nature · doi:10.1038/nature02794 · Cited by 1,852 · see citing works
VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
Xu, L., Wang, Y., Han, K.-J., Li, L., Zhai, Z., & Shu, H. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.08.014 · Cited by 1,849 · see citing works
Negative regulation of Toll-like receptor-mediated immune responses
Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509 · see citing works
Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction
Sato, M., Suemori, H., Hata, N., Asagiri, M., Ogasawara, K., Nakao, K., Nakaya, T., Katsuki, M., Noguchi, S., Tanaka, N., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)00053-4 · Cited by 1,342 · see citing works
Ubiquitin signalling in the NF-κB pathway
Chen, Z. J. (2005) · Nature Cell Biology · doi:10.1038/ncb0805-758 · Cited by 1,184 · see citing works
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
Boone, D. L., Turer, E. E., Lee, E. G., Ahmad, R., Wheeler, M. T., Tsui, C., Hurley, P. J., Chien, M., Chai, S., Hitotsumatsu, O., et al. (2004) · Nature Immunology · doi:10.1038/ni1110 · Cited by 1,091 · see citing works
The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination
Kovalenko, A., Chable-Bessia, C., Cantarella, G., Israël, A., Wallach, D., & Courtois, G. (2003) · Nature · doi:10.1038/nature01802 · Cited by 1,018 · see citing works
Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO
Ea, C.-K., Deng, L., Xia, Z.-P., Pineda, G., & Chen, Z. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.026 · Cited by 998 · see citing works
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
Häcker, H., Redecke, V., Blagoev, B., Kratchmarova, I., Hsu, L.-C., Wang, G. G., Kamps, M. P., Raz, E., Wagner, H., Häcker, G. A., et al. (2005) · Nature · doi:10.1038/nature04369 · Cited by 962 · see citing works
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
Oganesyan, G., Saha, S. K., Guo, B., He, J. Q., Shahangian, A., Zarnegar, B. J., Perry, A. K., & Cheng, G. (2005) · Nature · doi:10.1038/nature04374 · Cited by 881 · see citing works
TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway
Takaesu, G., Kishida, S., Hiyama, A., Yamaguchi, T., Shibuyà, H., Irie, K., Ninomiya‐Tsuji, J., & Matsumoto, K. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80244-0 · Cited by 606 · see citing works
NF‐κB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK‐related kinase
Pomerantz, J. L., & Baltimore, D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.23.6694 · Cited by 595 · see citing works
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1 -deficient mouse embryonic fibroblasts
McWhirter, S. M., Fitzgerald, K. A., Rosains, J., Rowe, D. C., Golenbock, D. T., & Maniatis, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2237236100 · Cited by 542 · see citing works
Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4
Burns, K., Janssens, S., Brissoni, B., Olivos, N., Beyaert, R., & Tschopp, J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021790 · Cited by 512 · see citing works
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
Baccalà, R., Hoebe, K. H. N., Kono, D. H., Beutler, B., & Theofilopoulos, A. N. (2007) · Nature Medicine · doi:10.1038/nm1590 · Cited by 471 · see citing works
A Deubiquitinase That Regulates Type I Interferon Production
Kayagaki, N., Phung, Q. T., Chan, S. B., Chaudhari, R., Quan, C., O’Rourke, K. M., Eby, M. T., Pietras, E. M., Cheng, G., Bazán, J. F., et al. (2007) · Science · doi:10.1126/science.1145918 · Cited by 452 · see citing works
JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection
Chu, W., Ostertag, D. G., Li, Z.-W., Chang, L., Chen, Y., Hu, Y., Williams, B. R. G., Perrault, J., & Karin, M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80146-6 · Cited by 389 · see citing works
Deubiquitylation and regulation of the immune response
Sun, S. (2008) · Nature reviews. Immunology · doi:10.1038/nri2337 · Cited by 356 · see citing works
PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunit
Tanaka, T., Grusby, M. J., & Kaisho, T. (2007) · Nature Immunology · doi:10.1038/ni1464 · Cited by 326 · see citing works
The NEMO adaptor bridges the nuclear factor-κB and interferon regulatory factor signaling pathways
Zhao, T., Yang, L., Sun, Q., Arguello, M., Ballard, D. W., Hiscott, J. B., & Lin, R. (2007) · Nature Immunology · doi:10.1038/ni1465 · Cited by 317 · see citing works
The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
Shembade, N., Harhaj, N. S., Parvatiyar, K., Copeland, N. G., Jenkins, N. A., Matesic, L. E., & Harhaj, E. W. (2008) · Nature Immunology · doi:10.1038/ni1563 · Cited by 278 · see citing works
Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20
Turer, E. E., Tavares, R. M., Mortier, E., Hitotsumatsu, O., Advincula, R., Lee, B. L., Shifrin, N. T., Malynn, B. A., & Ma, A. I. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071108 · Cited by 267 · see citing works
Immunity by ubiquitylation: a reversible process of modification
Liu, Y., Penninger, J. M., & Karin, M. (2005) · Nature reviews. Immunology · doi:10.1038/nri1731 · Cited by 257 · see citing works
Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1
An, H., Hou, J., Zhou, J., Zhao, W., Xu, H., Zheng, Y., Yu, Y., Liu, S., & Cao, X. (2008) · Nature Immunology · doi:10.1038/ni.1604 · Cited by 250 · see citing works
Self-citation
Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4
Wang, Y., Chen, T., Han, C., He, D., Liu, H., An, H., Cai, Z., & Cao, X. (2007) · Blood · doi:10.1182/blood-2007-01-066027 · Cited by 210 · see citing works
Self-citation
The Tumor Suppressor Cylindromatosis (CYLD) Acts as a Negative Regulator for Toll-like Receptor 2 Signaling via Negative Cross-talk with TRAF6 and TRAF7
Yoshida, H., Jono, H., Kai, H., & Li, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509526200 · Cited by 199 · see citing works
The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
Venuprasad, K., Huang, H., Harada, Y., Elly, C., Subramaniam, M., Spelsberg, T. C., Su, J., & Liu, Y. (2008) · Nature Immunology · doi:10.1038/ni1564 · Cited by 174 · see citing works
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts
Kopp, E. B. (2004) · Medical Entomology and Zoology · Cited by 160 · see citing works
Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3
Qiu, X., & Goldberg, A. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232580999 · Cited by 156 · see citing works
Regulation of IκB Kinase-related Kinases and Antiviral Responses by Tumor Suppressor CYLD
Zhang, M., Wu, X., Lee, A. J., Jin, W., Chang, M., Wright, A., Imaizumi, T., & Sun, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801451200 · Cited by 131 · see citing works
An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels
Diamonti, A. J., Guy, P. M., Ivanof, C., Wong, K., Sweeney, C. A., & Carraway, K. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052709799 · Cited by 126 · see citing works
Nrdp1‐mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis
Qiu, X., Markant, S. L., Yuan, J., & Goldberg, A. L. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600075 · Cited by 125 · see citing works
Neuregulin-Induced ErbB3 Downregulation Is Mediated by a Protein Stability Cascade Involving the E3 Ubiquitin Ligase Nrdp1
Cao, Z., Wu, X., Yen, L., Sweeney, C., & Carraway, K. L. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01245-06 · Cited by 119 · see citing works
E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury
Bachmaier, K., Toya, S. P., Gao, X., Triantafillou, T., Garrean, S. M., Park, G. Y., Frey, R. S., Vogel, S. M., Minshall, R. D., Christman, J. W., et al. (2007) · Nature Medicine · doi:10.1038/nm1607 · Cited by 108 · see citing works
Loss of Nrdp1 Enhances ErbB2/ErbB3–Dependent Breast Tumor Cell Growth
Yen, L., Cao, Z., Wu, X., Ingalla, E., Baron, C. A., Young, L. J. T., Gregg, J. P., Cardiff, R. D., Borowsky, A. D., Sweeney, C. A., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2319 · Cited by 83 · see citing works
Lipopolysaccharide-mediated Interferon Regulatory Factor Activation Involves TBK1-IKKϵ-dependent Lys63-linked Polyubiquitination and Phosphorylation of TANK/I-TRAF
Gatot, J., Gioia, R., Chau, T., Patrascu, F., Warnier, M., Close, P., Chapelle, J.-P., Muraille, É., Brown, K., Siebenlist, U. K., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701690200 · Cited by 82 · see citing works
Impact of macrophage and dendritic cell subset elimination on antiviral immunity, viral clearance and production of type 1 interferon
Ciavarra, R. P., Taylor, L., Greene, A. R., Yousefieh, N., Horeth, D. R., van Rooijen, N., Steel, C., Gregory, B. W., Birkenbach, M. P., & Sekellick, M. J. (2005) · Virology · doi:10.1016/j.virol.2005.07.031 · Cited by 43 · see citing works
FLRF, a Novel Evolutionarily Conserved RING Finger Gene, Is Differentially Expressed in Mouse Fetal and Adult Hematopoietic Stem Cells and Progenitors
Abdullah, J. M., Li, X., Nachtman, R. G., & Jurecic, R. (2001) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2001.0390 · Cited by 22 · see citing works

Flagged first, then by citations

Sorted by citations

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304 · see citing works
Toll-Like Receptor Signaling Pathways
Kawasaki, T., & Kawai, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00461 · Cited by 3,250 · see citing works
Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity
Duan, T., Du, Y., Xing, C., Wang, H. Y., & Wang, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.812774 · Cited by 1,005 · see citing works
The role of ubiquitination in tumorigenesis and targeted drug discovery
Deng, L., Meng, T., Chen, L., Wei, W., & Wang, P. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0107-0 · Cited by 744 · see citing works
Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma
Hou, J., Lin, L., Zhou, W., Wang, Z., Ding, G., Dong, Q., Qin, L., Wu, X., Zheng, Y., Yang, Y. S., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.01.001 · Cited by 690 · see citing works
Self-citation
Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease
Cao, X. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.8 · Cited by 661 · see citing works
Self-citation
The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ
Ma, F., Xu, S., Liu, X., Zhang, Q., Xu, X., Liu, M., Hua, M.-M., Li, N., Yao, H., & Cao, X. (2011) · Nature Immunology · doi:10.1038/ni.2073 · Cited by 647 · see citing works
Self-citation
Post-Translational Modification Control of Innate Immunity
Liu, J., Qian, C., & Cao, X. (2016) · Immunity · doi:10.1016/j.immuni.2016.06.020 · Cited by 632 · see citing works
Self-citation
Ubiquitin signaling in immune responses
Hu, H., & Sun, S. (2016) · Cell Research · doi:10.1038/cr.2016.40 · Cited by 481 · see citing works
Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b
Han, C., Jin, J., Xu, S., Liu, H., Li, N., & Cao, X. (2010) · Nature Immunology · doi:10.1038/ni.1908 · Cited by 458 · see citing works
Self-citation
COVID-19: Drug Targets and Potential Treatments
Gil, C., Ginex, T., Maestro, I., Nozal, V., Barrado-Gil, L., Cuesta-Geijo, M. Á., Urquiza, J., Ramírez, D., Alonso, C., Campillo, N. E., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00606 · Cited by 449 · see citing works
Inducible microRNA-155 Feedback Promotes Type I IFN Signaling in Antiviral Innate Immunity by Targeting Suppressor of Cytokine Signaling 1
Wang, P., Hou, J., Lin, L., Wang, C., Liu, X., Li, D., Ma, F., Wang, Z., & Cao, X. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000491 · Cited by 431 · see citing works
Self-citation
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-RepurposingPreprint
Gordon, D. E., Jang, G. Μ., Bouhaddou, M., Xu, J., Obernier, K., O’Meara, M. J., Guo, J. Z., Swaney, D. L., Tummino, T. A., Hüttenhain, R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.22.002386 · Cited by 419 · see citing works
Toll-Like Receptors (TLRs), NOD-Like Receptors (NLRs), and RIG-I-Like Receptors (RLRs) in Innate Immunity. TLRs, NLRs, and RLRs Ligands as Immunotherapeutic Agents for Hematopoietic Diseases
Wicherska‐Pawłowska, K., Wróbel, T., & Rybka, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413397 · Cited by 412 · see citing works
The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway
Yang, P., An, H., Liu, X., Wen, M., Zheng, Y., Rui, Y., & Cao, X. (2010) · Nature Immunology · doi:10.1038/ni.1876 · Cited by 392 · see citing works
Self-citation
Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid SensorsPreprint
Pandey, S., Kawai, T., & Akira, S. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016246 · Cited by 365 · see citing works
Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production
Li, S., Wang, L., Berman, M. A., Kong, Y., & Dorf, M. E. (2011) · Immunity · doi:10.1016/j.immuni.2011.06.014 · Cited by 334 · see citing works
Mechanisms and pathways of innate immune activation and regulation in health and cancer
Cui, J., Chen, Y., Wang, H. Y., & Wang, R. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/21645515.2014.979640 · Cited by 310 · see citing works
The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling
Mukherjee, A., Morosky, S. A., Delorme‐Axford, E., Dybdahl-Sissoko, N., Oberste, M. S., Wang, T., & Coyne, C. B. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001311 · Cited by 306 · see citing works
NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4
Cui, J., Li, Y., Zhu, L., Liu, D., Songyang, Z., Wang, H. Y., & Wang, R. (2012) · Nature Immunology · doi:10.1038/ni.2239 · Cited by 301 · see citing works
Recognition of viral nucleic acids in innate immunity
Yoneyama, M., & Fujita, T. (2009) · Reviews in Medical Virology · doi:10.1002/rmv.633 · Cited by 303 · see citing works
Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation
Chen, W., Han, C., Xie, B., Hu, X., Yu, Q., Shi, L., Wang, Q., Li, D., Wang, J., Zheng, P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.011 · Cited by 274 · see citing works
Self-citation
MicroRNA-148/152 Impair Innate Response and Antigen Presentation of TLR-Triggered Dendritic Cells by Targeting CaMKIIα
Liu, X.-G., Zhan, Z.-Z., Xu, L., Ma, F., Li, D., Guo, Z.-H., Li, N., & Cao, X.-T. (2010) · Journal of Immunology · doi:10.4049/jimmunol.1001573 · Cited by 286 · see citing works
Self-citation
Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk
Liu, X., Zhan, Z., Li, D., Xu, L., Ma, F., Zhang, P., Yao, H., & Cao, X. (2011) · Nature Immunology · doi:10.1038/ni.2015 · Cited by 261 · see citing works
Self-citation
MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines
Sun, Y., Li, Q., Gui, H., Xu, D.-P., Yang, Y., Su, D., & Liu, X. (2013) · Cell Research · doi:10.1038/cr.2013.116 · Cited by 253 · see citing works
Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1
Tu, D., Zhu, Z., Zhou, A. Y., Yun, C., Lee, K., Toms, A. V., Li, Y., Dunn, G. P., Chan, E. M., Thai, T. C., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.033 · Cited by 215 · see citing works
Ubiquitin in the activation and attenuation of innate antiviral immunity
Heaton, S. M., Borg, N. A., & Dixit, V. M. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20151531 · Cited by 208 · see citing works
E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1
Song, G., Liu, B., Li, Z., Wu, H. M., Wang, P., Zhao, K., Jiang, G., Zhang, L., & Gao, C. (2016) · Nature Immunology · doi:10.1038/ni.3588 · Cited by 201 · see citing works
Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity
Li, X., Zhang, Q., Ding, Y., Liu, Y., Zhao, D., Zhao, K., Shen, Q., Liu, X., Zhu, X., Li, N., et al. (2016) · Nature Immunology · doi:10.1038/ni.3464 · Cited by 202 · see citing works
Self-citation
The RING finger protein family in health and disease
Cai, C., Tang, Y., Zhai, J., & Zheng, C. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01152-2 · Cited by 194 · see citing works
Ubiquitination in the antiviral immune response
Davis-Gardner, M. E., & Gack, M. U. (2015) · Virology · doi:10.1016/j.virol.2015.02.033 · Cited by 188 · see citing works
Inflammatory response of macrophages in infection.
Zhang, L., & Wang, C.-C. (2014) · Hepatobiliary & Pancreatic Diseases International · doi:10.1016/s1499-3872(14)60024-2 · Cited by 189 · see citing works
Self-citation
The Leader Proteinase of Foot-and-Mouth Disease Virus Negatively Regulates the Type I Interferon Pathway by Acting as a Viral Deubiquitinase
Wang, D., Fang, L., Li, P., Sun, L., Fan, J., Zhang, Q., Luo, R., Liu, X., Li, K., Chen, H., et al. (2011) · Journal of Virology · doi:10.1128/jvi.02589-10 · Cited by 188 · see citing works
Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27
Zheng, Q., Hou, J., Zhou, Y., Yang, Y., Xie, B., & Cao, X. (2015) · Cell Research · doi:10.1038/cr.2015.108 · Cited by 187 · see citing works
Self-citation
Sensing and Signaling in Antiviral Innate Immunity
O'Neill, L. A. J., & Bowie, A. (2010) · Current Biology · doi:10.1016/j.cub.2010.01.044 · Cited by 183 · see citing works
Recent insights into the complexity of Tank‐binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1
Helgason, E., Phung, Q. T., & Dueber, E. C. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.01.059 · Cited by 185 · see citing works
Regulation of Virus-triggered Signaling by OTUB1- and OTUB2-mediated Deubiquitination of TRAF3 and TRAF6
Li, S., Zheng, H., Mao, A., Zhong, B., Li, Y., Liu, Y., Gao, Y., Ran, Y., Tien, P., & Shu, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.074971 · Cited by 179 · see citing works
The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis
Roshan, M. H. K., Tambo, A., & Pace, N. P. (2016) · International Journal of Inflammation · doi:10.1155/2016/1532832 · Cited by 177 · see citing works
Regulation of TLR7/9 signaling in plasmacytoid dendritic cells
Bao, M., & Liu, Y.-J. (2012) · Protein & Cell · doi:10.1007/s13238-012-2104-8 · Cited by 172 · see citing works
TAX1BP1 and A20 Inhibit Antiviral Signaling by Targeting TBK1-IKKi Kinases
Parvatiyar, K., Barber, G. N., & Harhaj, E. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.109819 · Cited by 167 · see citing works
Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKKε Kinase-Mediated Antiviral Response
Rajsbaum, R., Versteeg, G. A., Schmid, S., Maestre, A. M., Belicha-Villanueva, A., Martínez-Romero, C., Patel, J. R., Morrison, J., Pisanelli, G., Miorin, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.018 · Cited by 168 · see citing works
Regulation of Toll‐like receptor signaling pathways in innate immune responses
Qian, C., & Cao, X. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06786.x · Cited by 168 · see citing works
Self-citation
Deciphering the complexity of Toll-like receptor signaling
Ostuni, R., Zanoni, I., & Granucci, F. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0464-x · Cited by 154 · see citing works
Myeloid Differentiation Primary Response Protein 88 (MyD88): The Central Hub of TLR/IL-1R Signaling
Chen, L., Zheng, L., Chen, P., & Liang, G. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00884 · Cited by 153 · see citing works
The role of TBK1 in cancer pathogenesis and anticancer immunity
Runde, A. P., Mack, R. M., Breslin, P., & Zhang, J. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02352-y · Cited by 153 · see citing works
Self-citation
Negative regulation of TBK1‐mediated antiviral immunity
Zhao, W. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.01.052 · Cited by 149 · see citing works
TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1
Zhang, M., Wang, L., Zhao, X., Zhao, K., Hong, M., Zhao, W., & Gao, C. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20120024 · Cited by 146 · see citing works
USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome
Lin, M., Zhao, Z., Yang, Z., Meng, Q., Tan, P., Xie, W., Qin, Y., Wang, R., & Cui, J. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.08.029 · Cited by 145 · see citing works
Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Inhibits Beta Interferon Production by Deubiquitinating TRAF3
Wang, S., Wang, K., Li, J., & Zheng, C. (2013) · Journal of Virology · doi:10.1128/jvi.01211-13 · Cited by 141 · see citing works
Post‐translational regulation of antiviral innate signaling
Zhou, Y., He, C., Wang, L., & Ge, B.-X. (2017) · European Journal of Immunology · doi:10.1002/eji.201746959 · Cited by 137 · see citing works
Virus-triggered Ubiquitination of TRAF3/6 by cIAP1/2 Is Essential for Induction of Interferon-β (IFN-β) and Cellular Antiviral Response
Mao, A., Li, S., Zhong, B., Li, Y., Yan, J., Li, Q., Teng, C., & Shu, H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.071043 · Cited by 134 · see citing works
Regulation of innate immune signaling by IRAK proteins
Pereira, M. C. A., & Gazzinelli, R. T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1133354 · Cited by 133 · see citing works
Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS
Liuyu, T., Yu, K., Ye, L., Zhang, Z., Zhang, M., Ren, Y., Cai, Z., Zhu, Q., Lin, D., & Zhong, B. (2018) · Cell Research · doi:10.1038/s41422-018-0107-6 · Cited by 126 · see citing works
E3 Ubiquitin Ligase Tripartite Motif 38 Negatively Regulates TLR-Mediated Immune Responses by Proteasomal Degradation of TNF Receptor-Associated Factor 6 in Macrophages
Zhao, W., Wang, L., Zhang, M., Yuan, C., & Gao, C. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103255 · Cited by 127 · see citing works
MicroRNAs in the regulation of TLR and RIG-I pathways
Li, Y., & Shi, X. (2012) · Cellular and Molecular Immunology · doi:10.1038/cmi.2012.55 · Cited by 125 · see citing works
Toll-like Receptor 4 (TLR4) Is Essential for Hsp70-like Protein 1 (HSP70L1) to Activate Dendritic Cells and Induce Th1 Response
Fang, H., Wu, Y., Huang, X., Wang, W., Ang, B., Cao, X., & Wan, T. Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.266528 · Cited by 122 · see citing works
Self-citation
Autophagy in regulation of Toll-like receptor signaling
Into, T., Inomata, M., Takayama, E., & Takigawa, T. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.020 · Cited by 119 · see citing works
RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation
Wang, W., Jiang, M., Liu, S., Zhang, S., Liu, W., Ma, Y., Zhang, L., Zhang, J., & Cao, X. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604277113 · Cited by 120 · see citing works
Self-citation
Molecular and Cellular Mechanisms Influenced by Postbiotics
Jastrząb, R., Graczyk, D., & Siedlecki, P. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413475 · Cited by 121 · see citing works
Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing
Chathuranga, K., Weerawardhana, A., Dodantenna, N., & Lee, J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00691-y · Cited by 108 · see citing works
Regulation of ERBB3/HER3 signaling in cancer
Mujoo, K., Choi, B.-K., Huang, Z., Zhang, N., & An, Z. (2014) · Oncotarget · doi:10.18632/oncotarget.2655 · Cited by 107 · see citing works
<scp>CD</scp>14 is a key organizer of microglial responses to <scp>CNS</scp> infection and injury
Janova, H., Böttcher, C., Holtman, I. R., Regen, T., van Rossum, D., Götz, A., Ernst, A., Fritsche, C., Gertig, U., Saiepour, N., et al. (2016) · Glia · doi:10.1002/glia.22955 · Cited by 105 · see citing works
TBK1, a central kinase in innate immune sensing of nucleic acids and beyond
Zhou, R., Zhang, Q., & Xu, P. (2020) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa051 · Cited by 104 · see citing works
Toll‐like receptors and liver disease
Kesar, V., & Odin, J. A. (2013) · Liver International · doi:10.1111/liv.12315 · Cited by 104 · see citing works
E3 ubiquitin ligase Cbl-b in innate and adaptive immunity
Qingjun, L., Zhou, H., Langdon, W. Y., & Zhang, J. (2014) · Cell Cycle · doi:10.4161/cc.29213 · Cited by 101 · see citing works
Self-citation
Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein
Jiang, J., & Tang, H. (2010) · Protein & Cell · doi:10.1007/s13238-010-0141-8 · Cited by 101 · see citing works
K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8+ T cell activation
Yang, M., Chen, T., Li, X., Zhou, Y., Tang, S., Wang, C., Gu, Y. H., Liu, Y., Xu, S., Li, W., et al. (2015) · Nature Immunology · doi:10.1038/ni.3258 · Cited by 97 · see citing works
Self-citation
Mechanisms of Antiviral Immune Evasion of SARS-CoV-2
Beyer, D. K., & Forero, A. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167265 · Cited by 93 · see citing works
SARS-CoV-2 NSP13 Inhibits Type I IFN Production by Degradation of TBK1 via p62-Dependent Selective Autophagy
Sui, C., Xiao, T., Zhang, S., Zeng, H., Zheng, Y., Liu, B., Xu, G., Gao, C., & Zhang, Z. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100684 · Cited by 93 · see citing works
E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKCζ
Yang, M., Wang, C., Zhu, X., Tang, S., Shi, L., Cao, X., & Chen, T. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102667 · Cited by 93 · see citing works
Self-citation
TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1
Qin, Y., Liu, Q., Tian, S., Xie, W., Cui, J., & Wang, R. (2016) · Cell Research · doi:10.1038/cr.2016.27 · Cited by 93 · see citing works
ABIN1 Protein Cooperates with TAX1BP1 and A20 Proteins to Inhibit Antiviral Signaling
Gao, L., Coope, H. J., Grant, S. M., Ma, A. I., Ley, S. C., & Harhaj, E. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.283762 · Cited by 88 · see citing works
Inhibition of the Type I Interferon Antiviral Response During Arenavirus Infection
Borrow, P., Martínez‐Sobrido, L., & de la Torre, J. C. (2010) · Viruses · doi:10.3390/v2112443 · Cited by 87 · see citing works
Regulation of MyD88 Aggregation and the MyD88-dependent Signaling Pathway by Sequestosome 1 and Histone Deacetylase 6
Into, T., Inomata, M., Niida, S., Murakami, Y., & Shibata, K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.126904 · Cited by 89 · see citing works
A Structural View of Negative Regulation of the Toll-like Receptor-Mediated Inflammatory Pathway
Guven‐Maiorov, E., Keskin, Ö., Gürsoy, A., & Nussinov, R. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.06.048 · Cited by 87 · see citing works
RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA
Zhang, Z.-D., Xiong, T.-C., Yao, S., Wei, M., Chen, M., Lin, D., & Zhong, B. (2020) · Nature Communications · doi:10.1038/s41467-020-19318-3 · Cited by 87 · see citing works
Comparative Genomic Analysis of Rapidly Evolving SARS-CoV-2 Reveals Mosaic Pattern of Phylogeographical Distribution
Kumar, R., Verma, H., Singhvi, N., Sood, U., Gupta, V., Singh, M., KUMARI, R. R., Hira, P., Nagar, S., Talwar, C., et al. (2020) · mSystems · doi:10.1128/msystems.00505-20 · Cited by 81 · see citing works
The VP3 structural protein of foot‐and‐mouth disease virus inhibits the IFN‐β signaling pathway
Li, D., Yang, W., Yang, F., Liu, H., Zhu, Z., Lian, K., Lei, C., Li, S., Liu, X., Zheng, H., et al. (2016) · The FASEB Journal · doi:10.1096/fj.15-281410 · Cited by 80 · see citing works
Intracellular NAMPT–NAD+–SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors
Wang, P., Du, H., Zhou, C., Song, J., Liu, X., Cao, X., Mehta, J. L., Shi, Y., Su, D., & Miao, C. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu220 · Cited by 76 · see citing works
Self-citation
Kaposi's Sarcoma-Associated Herpesvirus-Encoded Replication and Transcription Activator Impairs Innate Immunity via Ubiquitin-Mediated Degradation of Myeloid Differentiation Factor 88
Zhao, Q., Liang, D., Sun, R., Jia, B., Xia, T., Xiao, H. Q., & Lan, K. (2014) · Journal of Virology · doi:10.1128/jvi.02591-14 · Cited by 73 · see citing works
The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1–IRF3 signaling
Zhang, H., Han, C., Li, T., Li, N., & Cao, X. (2018) · Cellular and Molecular Immunology · doi:10.1038/s41423-018-0057-4 · Cited by 71 · see citing works
Self-citation
PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway
Wang, G., Chen, G., Zheng, D., Cheng, G., & Tang, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017192 · Cited by 70 · see citing works
Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins
Liu, X., Wang, Q., Chen, W., & Wang, C. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.07.002 · Cited by 69 · see citing works
Self-citation
Mitochondrial Ubiquitin Ligase MARCH5 Promotes TLR7 Signaling by Attenuating TANK Action
Shi, H.-X., Liu, X., Wang, Q., Tang, P.-P., Liu, X.-Y., Shan, Y.-F., & Wang, C. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002057 · Cited by 67 · see citing works
Self-citation
Lys29-linkage of ASK1 by Skp1−Cullin 1−Fbxo21 ubiquitin ligase complex is required for antiviral innate response
Zhou, Y., Chen, T., Li, X., Yang, M., Tang, S., Zhu, X., Gu, Y. H., Su, X., Meng, X., Li, W., et al. (2016) · eLife · doi:10.7554/elife.14087 · Cited by 67 · see citing works
Self-citation
Deubiquitinating enzyme USP33 restrains docetaxel-induced apoptosis via stabilising the phosphatase DUSP1 in prostate cancer
Guo, F., Zhang, C., Wang, F., Zhang, W. J., Shi, X., Zhu, Y., Fang, Z., Yang, B., & Sun, Y. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0473-8 · Cited by 66 · see citing works
DYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation
Tai, A., Li, S., Pan, W. D., Tien, P., Zhong, B., Shu, H., & Wu, S. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005179 · Cited by 64 · see citing works
RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding
Wauman, J., Ceuninck, L. D., Vanderroost, N., Lievens, S., & Tavernier, J. H. (2011) · Journal of Cell Science · doi:10.1242/jcs.078055 · Cited by 64 · see citing works
Foot-and-mouth disease virus non-structural protein 3A inhibits the interferon-β signaling pathway
Li, D., Lei, C., Xu, Z.-S., Yang, F., Liu, H., Zhu, Z., Li, S., Liu, X., Shu, H., & Zheng, H. (2016) · Scientific Reports · doi:10.1038/srep21888 · Cited by 65 · see citing works
Ubiquitin-Specific Protease 2b Negatively Regulates IFN-β Production and Antiviral Activity by Targeting TANK-Binding Kinase 1
Zhang, L., Zhao, X., Zhang, M., Zhao, W., & Gao, C. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302634 · Cited by 62 · see citing works
HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection
Li, F., Li, Y., Liang, H., Xu, T., Kong, Y., Huang, M., Xiao, J., Chen, X., Xia, H., Wu, Y., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120406 · Cited by 64 · see citing works
TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination
Deng, M., Tam, J. W., Wang, L., Liang, K., Li, S., Zhang, L., Guo, H., Luo, X., Zhang, Y., Petrucelli, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16014-0 · Cited by 64 · see citing works
A rational roadmap for SARS‐CoV‐2/COVID‐19 pharmacotherapeutic research and development: IUPHAR Review 29
Alexander, S. P. H., Armstrong, J. F., Davenport, A. P., Davies, J. A., Faccenda, E., Harding, S. D., Levi‐Schaffer, F., Maguire, J. J., Pawson, A. J., Southan, C., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15094 · Cited by 60 · see citing works
The tyrosine kinase Src promotes phosphorylation of the kinase TBK1 to facilitate type I interferon production after viral infection
Li, X., Yang, M., Zhou, Y., Tang, S., Wang, L., Cao, X., & Chen, T. (2017) · Science Signaling · doi:10.1126/scisignal.aae0435 · Cited by 62 · see citing works
Self-citation
RING-Domain E3 Ligase-Mediated Host–Virus Interactions: Orchestrating Immune Responses by the Host and Antagonizing Immune Defense by Viruses
Zhang, Y., Li, L.-F., Munir, M., & Qiu, H.-J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01083 · Cited by 62 · see citing works
RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase
Tang, S., Chen, T., Zhou, Y., Zhu, X., Yang, M., Xie, B., Li, N., Cao, X., & Wang, J. (2014) · Nature Communications · doi:10.1038/ncomms5657 · Cited by 60 · see citing works
Self-citation
TANK-binding kinase 1 as a novel therapeutic target for viral diseases
Zhao, C., & Zhao, W. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1601702 · Cited by 61 · see citing works
USP8 protects against lipopolysaccharide-induced cognitive and motor deficits by modulating microglia phenotypes through TLR4/MyD88/NF-κB signaling pathway in mice
Zhao, J., Bi, W., Zhang, J., Xiao, S., Zhou, R., Tsang, C. K., Lu, D., & Zhu, L. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.04.052 · Cited by 64 · see citing works
Self-citation
Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1
Huang, L., Liu, H., Zhang, K., Meng, Q., Hu, L., Zhang, Y., Xiang, Z., Li, J., Yang, Y., Chen, Y., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108044 · Cited by 60 · see citing works
Protein Microarray Characterization of the S-Nitrosoproteome
Lee, Y.-I., Giovinazzo, D., Kang, H. C., Lee, Y., Jeong, J. S., Doulias, P., Xie, Z., Hu, J., Ghasemi, M., Ischiropoulos, H., et al. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.032235 · Cited by 59 · see citing works

E3泛素连接酶Nrdpl“优先”促进TLR介导的I型干扰素的产生
曹雪涛 (2010) · 科学中国人
The role of novel E3 ubiquitin ligase in the regulation of TLR3 signaling pathway
Lin, Y.-S., Chang, Y., Lai, T., Lee, C., Chuang, T., & Hsu, L.-C. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.204.supp.226.26
Transforming Growth Factor-β Differentially Inhibits MyD88-dependent, but Not TRAM- and TRIF-dependent, Lipopolysaccharide-induced TLR4 Signaling
Naiki, Y., Michelsen, K. S., Zhang, W., Chen, S., Doherty, T. M., & Arditi, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400503200 · Cited by 183 · see citing works
N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation
Gitlin, A. D., Maltzman, A., Kanno, Y., Heger, K., Reja, R., Schubert, A. F., Wierciszewski, L. J., Pantua, H., Kapadia, S. B., Harris, S. F., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.04.004 · Cited by 28 · see citing works
Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages
Xu, H., An, H., Hou, J., Han, C., Wang, P., Yu, Y., & Cao, X. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.05.006 · Cited by 99 · see citing works
Self-citation

Authors: Wang, C., Chen, T., Zhang, J., Yang, M., Li, N., Xu, X., & Cao, X.
Affiliations: Second Military Medical University (CN)
Corresponding author: Cao, Xuetao
ORCID: Wang, Chen
Chen, Taoyong
Zhang, Jia
Yang, Mingjin
Li, Nan
Xu, Xiongfei
Cao, Xuetao
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-05-31
Volume: 10
Issue: 7
Pages: 744-752
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni.1742
OpenAlex: W2077995361
Cited by: 317
References: 46
Citations by year: 2026: 10 · 2025: 10 · 2024: 19 · 2023: 13 · 2022: 27 · 2021: 14 · 2020: 35 · 2019: 14 · 2018: 21 · 2017: 11 · 2016: 26 · 2015: 18 · 2014: 22 · 2013: 19 · 2012: 14
FWCI: 8.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: Nrdp1, E3 ubiquitin ligase, Toll-like receptor signaling, type I interferon, interferon-beta, IRF3, NF-κB, AP-1, macrophages, polyubiquitination, vesicular stomatitis virus, endotoxic shock, innate immunity
MeSH terms: Animals, Carrier Proteins, Cell Line, Cells, Cultured, Female, Humans, Interferon Type I, Lipopolysaccharides, Macrophages, Male, Mice, Inbred C57BL, Mice, Transgenic, Protein Binding, Immunoblotting, Protein Serine-Threonine Kinases, Macrophages, Peritoneal, Vesiculovirus, Rhabdoviridae Infections, Sepsis, Reverse Transcriptase Polymerase Chain Reaction, Ubiquitin-Protein Ligases, Toll-Like Receptors, Mice, Myeloid Differentiation Factor 88, Host-Pathogen Interactions

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks