The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
Vitamin effects on the immune system: vitamins A and D take centre stage
Open accessAbstract
Vitamins are essential constituents of our diet that have long been known to influence the immune system. Vitamins A and D have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. We present and discuss our current understanding of the essential roles of vitamins in modulating a broad range of immune processes, such as lymphocyte activation and proliferation, T-helper-cell differentiation, tissue-specific lymphocyte homing, the production of specific antibody isotypes and regulation of the immune response. Finally, we discuss the clinical potential of vitamin A and D metabolites for modulating tissue-specific immune responses and for preventing and/or treating inflammation and autoimmunity.
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“In states of deficiency, the population of hematopoietic stem cells decreases since they cannot remain dormant, leading to imbalances in the immune system [186,214].”
From Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use and Toxicity (2021) · cites this paper as [214]
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Metadata
- Authors
- Mora, J. R., Iwata, M., & von Andrian, U. H.
- Affiliations
- Harvard University (US)
- Tokushima Bunri University (JP)
- Corresponding author
- Mora, J. Rodrigo
- Venue
- Nature Reviews Immunology
- Published
- 2008-09
- Volume
- 8
- Issue
- 9
- Pages
- 685-698
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC2906676
- OpenAlex
- W2018938924
- Cited by
- 1,559
- References
- 170
- Citations by year
- 2026: 46 · 2025: 84 · 2024: 81 · 2023: 75 · 2022: 98 · 2021: 118 · 2020: 123 · 2019: 69 · 2018: 87 · 2017: 88 · 2016: 86 · 2015: 115 · 2014: 89 · 2013: 100 · 2012: 91
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 56949, P01HL056949)
- National Institute of Allergy and Infectious Diseases (R01AI072252, AI061663, R01AI069259, R01AI061663, AI072252, AI-069259)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 43351, P30DK043351)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 42689, P30AR042689)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- vitamins, vitamin A, vitamin D, immune regulation, lymphocyte activation, T helper cell differentiation, lymphocyte homing, antibody isotypes, immune-mediated diseases, autoimmunity, inflammation, immunomodulatory therapy
- MeSH terms
- Animals, Humans, Immune System, Immunotherapy, Lymphocytes, Vitamin A, Vitamin D, Vitamins
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