Cited by 1,559Vitamin D Research StudiesT-cell and B-cell ImmunologyImmune Response and Inflammation

The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.

Vitamin effects on the immune system: vitamins A and D take centre stage

Open access

Mora, J. Rodrigo, Iwata, Makoto, von Andrian, Ulrich H.·2008·Nature Reviews Immunology

Open this paper in CoChat — free account

Abstract

Vitamins are essential constituents of our diet that have long been known to influence the immune system. Vitamins A and D have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. We present and discuss our current understanding of the essential roles of vitamins in modulating a broad range of immune processes, such as lymphocyte activation and proliferation, T-helper-cell differentiation, tissue-specific lymphocyte homing, the production of specific antibody isotypes and regulation of the immune response. Finally, we discuss the clinical potential of vitamin A and D metabolites for modulating tissue-specific immune responses and for preventing and/or treating inflammation and autoimmunity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nri2378

Cites

170 of 170 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Vitamin D Deficiency
Holick, M. F. (2007) · New England Journal of Medicine · doi:10.1056/nejmra070553 · Cited by 13,720
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708
Reciprocal T H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid
Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., & Cheroutre, H. (2007) · Science · doi:10.1126/science.1145697 · Cited by 1,982
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.
Jung, S., Unutmaz, D., Wong, P., Sano, G., Santos, K. D. L., Sparwasser, T., Wu, S., Vuthoori, S., Ko, K., Zavala, F., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00365-5 · Cited by 1,953
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
Sun, C., Hall, J. A., Blank, R. B., Bouladoux, N. J., Oukka, M., Mora, J. R., & Belkaid, Y. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070602 · Cited by 1,880
Self-citation
Retinoic acid imprints gut-homing specificity on T cells
Iwata, M., Hirakiyama, A., Eshima, Y., Kagechika, H., Kato, C., & Song, S.-Y. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.011 · Cited by 1,541
Self-citation
The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
Manel, N., Unutmaz, D., & Littman, D. R. (2008) · Nature Immunology · doi:10.1038/ni.1610 · Cited by 1,328
1α,25-Dihydroxyvitamin D3 Inhibits Differentiation, Maturation, Activation, and Survival of Dendritic Cells Leading to Impaired Alloreactive T Cell Activation
Penna, G., & Adorini, L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.5.2405 · Cited by 1,257
In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines
Barrat, F. J., Cua, D. J., Boonstra, A., Richards, D. F., Crain, C., Savelkoul, H. F. J., Malefyt, R. D. W., Coffman, R. L., Hawrylowicz, C. M., & O’Garra, A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011629 · Cited by 1,161
Modulatory Effects of 1,25-Dihydroxyvitamin D3 on Human B Cell Differentiation
Chen, S., Sims, G. P., Chen, X. X., Gu, Y. Y., Chen, S., & Lipsky, P. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1634 · Cited by 1,119
Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
Mora, J. R., Bono, M. R., Manjunath, N., Weninger, W., Cavanagh, L. L., Rosemblatt, M. S., & von Andrian, U. H. (2003) · Nature · doi:10.1038/nature01726 · Cited by 1,068
Self-citation
Generation of Gut-Homing IgA-Secreting B Cells by Intestinal Dendritic Cells
Mora, J. R., Iwata, M., Eksteen, B., Song, S., Junt, T., Senman, B. C., Otipoby, K. L., Yokota, A., Takeuchi, H., Ricciardi‐Castagnoli, P., et al. (2006) · Science · doi:10.1126/science.1132742 · Cited by 1,014
Self-citation
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses
Denning, T. L., Wang, Y., Patel, S. R., Williams, I. R., & Pulendran, B. (2007) · Nature Immunology · doi:10.1038/ni1511 · Cited by 995
Overview of retinoid metabolism and function
Blomhoff, R., & Blomhoff, H. K. (2006) · Journal of Neurobiology · doi:10.1002/neu.20242 · Cited by 981
Immunoregulation by 1,25-dihydroxyvitamin D3: Basic concepts
van Etten, E., & Mathieu, C. (2005) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2005.06.002 · Cited by 882
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
Benson, M. J., Pino-Lagos, K., Rosemblatt, M., & Noelle, R. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070719 · Cited by 847
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
Uematsu, S., Fujimoto, K., Jang, M. H., Yang, B., Jung, Y.-J., Nishiyama, M., Sato, S., Tsujimura, T., Yamamoto, M., Yokota, Y., et al. (2008) · Nature Immunology · doi:10.1038/ni.1622 · Cited by 769
Intestinal Bacteria Trigger T Cell-Independent Immunoglobulin A2 Class Switching by Inducing Epithelial-Cell Secretion of the Cytokine APRIL
He, B., Xu, W., Santini, P. A., Polydorides, A. D., Chiu, A., Estrella, J. S., Shan, M., Chadburn, A., Villanacci, V., Plebani, A., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.014 · Cited by 748
Regulatory T cells and infection: a dangerous necessity
Belkaid, Y. (2007) · Nature reviews. Immunology · doi:10.1038/nri2189 · Cited by 746
The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis
Malý, P., Thall, A. D., Petryniak, B., Rogers, C. E., Smith, P. L., Marks, R. M., Kelly, R. J., Gersten, K. M., Cheng, G., Saunders, T. L., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80137-3 · Cited by 714
Expression of 1,25-Dihydroxyvitamin D3 Receptor in the Immune System
Veldman, C. M., Cantorna, M. T., & DeLuca, H. F. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1605 · Cited by 712
Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors
Schug, T. T., Berry, D. C., Shaw, N. S., Travis, S. N., & Noy, N. (2007) · Cell · doi:10.1016/j.cell.2007.02.050 · Cited by 680
IMPACT OF VITAMIN A SUPPLEMENTATION ON CHILDHOOD MORTALITY
Sommer, A. H., Djunaedi, E., Loeden, A. A., Tarwotjo, I., West, K., Tilden, R. L., Mele, L., & The Aceh Study Group (1986) · The Lancet · doi:10.1016/s0140-6736(86)91157-8 · Cited by 678
Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.
D’Ambrosio, D., Cippitelli, M., Cocciolo, M., Mazzeo, D., Lucia, P. D., Lang, R., Sinigaglia, F., & Panina‐Bordignon, P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1050 · Cited by 649
Freshly Isolated Peyer's Patch, but Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells
Iwasaki, A., & Kelsall, B. L. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.2.229 · Cited by 636
DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27
Sigmundsdóttir, H., Pan, J., Debes, G. F., Alt, C., Habtezion, A., Soler, D. F., & Butcher, E. C. (2007) · Nature Immunology · doi:10.1038/ni1433 · Cited by 630
Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance
Gregori, S., Casorati, M., Amuchastegui, S., Smiroldo, S., Davalli, A. M., & Adorini, L. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.1945 · Cited by 617
Vitamin D and diabetes
Mathieu, C., Gysemans, C. A., Giulietti, A., & Bouillon, R. (2005) · Diabetologia · doi:10.1007/s00125-005-1802-7 · Cited by 612
Dendritic cell modulation by 1α,25 dihydroxyvitamin D 3 and its analogs: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo
Griffin, M. D., Lutz, W. H., Phan, V., Bachman, L. A., McKEAN, D. J., & Kumar, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121172198 · Cited by 600
Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis
Li, M., Hener, P., Zhang, Z., Kato, S., METZGER, D., & Chambon, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604575103 · Cited by 550
1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells.
Lemire, J. M., Adams, J. S., Sakai, R. S., & Jordan, S. C. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111465 · Cited by 510
Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice
Travis, M. A., Reizis, B., Melton, A. C., Masteller, E., Tang, Q., Proctor, J. M., Wang, Y., Bernstein, X., Huang, X., Reichardt, L. F., et al. (2007) · Nature · doi:10.1038/nature06110 · Cited by 503
Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice
Praticò, D., Tangirala, R. K., Rader, D. J., Rokach, J., & FitzGerald, G. A. (1998) · Nature Medicine · doi:10.1038/2685 · Cited by 501
International Union of Pharmacology. LXIII. Retinoid X receptors
Germain, P., Chambon, P., Eichele, G., Evans, R. M., Lazar, M. A., Leid, M., De Lera, A. R., Lotan, R., Mangelsdorf, D. J., & Gronemeyer, H. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.7 · Cited by 496
1,25-Dihydroxycholecalciferol Prevents and Ameliorates Symptoms of Experimental Murine Inflammatory Bowel Disease
Cantorna, M. T., Munsick, C., Bemiss, C. J., & Mahon, B. D. (2000) · Journal of Nutrition · doi:10.1093/jn/130.11.2648 · Cited by 495
Rapid Acquisition of Tissue-specific Homing Phenotypes by CD4+ T Cells Activated in Cutaneous or Mucosal Lymphoid Tissues
Campbell, D., & Butcher, E. C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011502 · Cited by 490
1,25-dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis.
Lemire, J. M., & Archer, D. C. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115072 · Cited by 473
Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol).
Rigby, W., Stacy, T. P., & Fanger, M. W. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111557 · Cited by 471
Immune Modulatory Treatment of Trinitrobenzene Sulfonic Acid Colitis with Calcitriol Is Associated with a Change of a T Helper (Th) 1/Th17 to a Th2 and Regulatory T Cell Profile
Daniel, C., Sartory, N. A., Zahn, N., Radeke, H. H., & Stein, J. M. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.127209 · Cited by 471
The role of interleukin-6 in mucosal IgA antibody responses in vivo
Ramsay, A. J., Husband, A. J., Ramshaw, L. A., Bao, S., Matthaei, K. I., Koehler, G., & Kopf, M. (1994) · Science · doi:10.1126/science.8160012 · Cited by 454
INCREASED MORTALITY IN CHILDREN WITH MILD VITAMIN A DEFICIENCY
Sommer, A. H., Hussaini, G., Tarwotjo, I., & Susanto, D. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90677-3 · Cited by 453
REDUCTION OF STRESS/ CATECHOLAMINE-INDUCED CARDIAC NECROSIS BY BETA1-SELECTIVE BLOCKADE
Cruickshank, J., Degaute, J.-P., Kuurne, T., Vincent, J., Neil-Dwyer, G., Hayes, Y., Kytta, J., Carruthers, M. E., & Patel, S. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92984-9 · Cited by 453
Selective Generation of Gut Tropic T Cells in Gut-associated Lymphoid Tissue (GALT)
Johansson‐Lindbom, B., Svensson, M., Wurbel, M., MALISSEN, B., Márquez, G., & Agace, W. W. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20031244 · Cited by 450
Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells
Tezuka, H., Abe, Y., Iwata, M., Takeuchi, H., Ishikawa, H., Matsushita, M., Shiohara, T., Akira, S., & Ohteki, T. (2007) · Nature · doi:10.1038/nature06033 · Cited by 421
Self-citation
Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3
Penna, G., Roncari, A., Amuchastegui, S., Daniel, K. C., Berti, E., Colonna, M., & Adorini, L. (2005) · Blood · doi:10.1182/blood-2005-05-2044 · Cited by 412
Transcriptional Repression of the Interleukin-2 Gene by Vitamin D 3 : Direct Inhibition of NFATp/AP-1 Complex Formation by a Nuclear Hormone Receptor
Alroy, I., Towers, T. L., & Freedman, L. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5789 · Cited by 397
1,25-Dihydroxycholecalciferol Inhibits the Progression of Arthritis in Murine Models of Human Arthritis ,
Cantorna, M. T., Hayes, C. E., & DeLuca, H. F. (1998) · Journal of Nutrition · doi:10.1093/jn/128.1.68 · Cited by 376
Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells
手塚, 裕., 安部, 由., & 樗木, 俊. (2008) · 生体の科学 · Cited by 324
1,25-Dihydroxyvitamin D3 suppresses human T helper/inducer lymphocyte activity in vitro.
Lemire, J. M., Adams, J. S., Kermani-Arab, V., Bakke, A. C., Sakai, R. S., & Jordan, S. C. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.5.3032 · Cited by 323
1 alpha,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes.
Reichel, H., Koeffler, H. P., Tobler, A., & Norman, A. W. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3385 · Cited by 322
Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells
手塚, 裕., 安部, 由., & 樗木, 俊. (2008) · 生体の科学 · Cited by 322
BUSPIRONE IN TREATMENT OF AGITATED DEMENTED PATIENT
Colenda, C. C. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91988-5 · Cited by 311
Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues
Mora, J. R., Cheng, G., Picarella, D., Briskin, M., Buchanan, N. M., & von Andrian, U. H. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041645 · Cited by 309
Self-citation
Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors
Iwata, M. (2003) · International Immunology · doi:10.1093/intimm/dxg101 · Cited by 294
Self-citation
Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS)
Littorin, B., Blom, P. J. J., Schölin, A., Arnqvist, H. J., Blohmé, G., Bolinder, J., Ekbom-Schnell, A., Eriksson, J. W., Guðbjörnsdóttir, S., Nyström, L., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0426-x · Cited by 276
Design of selective nuclear receptor modulators: RAR and RXR as a case study
de Lera, Á. R., Bourguet, W., Altucci, L., & Gronemeyer, H. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2398 · Cited by 272
Topically Applied 1,25-Dihydroxyvitamin D3 Enhances the Suppressive Activity of CD4+CD25+ Cells in the Draining Lymph Nodes
Gorman, S., Kuritzky, L. A., Judge, M. A., Dixon, K. M., McGlade, J. P., Mason, R. S., Finlay‐Jones, J. J., & Hart, P. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.6273 · Cited by 266
CD11b+ Peyer’s Patch Dendritic Cells Secrete IL-6 and Induce IgA Secretion from Naive B Cells
Sato, A., Hashiguchi, M., Toda, E., Iwasaki, A., Hachimura, S., & Kaminogawa, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3684 · Cited by 256
Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course.
Racke, M. K., Burnett, D., Pak, S. H., Albert, P. S., Cannella, B., Raine, C. S., McFarlin, D. E., & Scott, D. E. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.1.450 · Cited by 252
Regulation of 25-hydroxyvitamin D3-1α-hydroxylase and production of 1α,25-dihydroxyvitamin D3 by human dendritic cells
Fritsche, J., Mondal, K., Ehrnsperger, A., Andreesen, R., & Kreutz, M. P. (2003) · Blood · doi:10.1182/blood-2002-11-3521 · Cited by 248
Differentiation and homing of IgA-secreting cells
Mora, J. R., & von Andrian, U. H. (2008) · Mucosal Immunology · doi:10.1038/mi.2007.14 · Cited by 246
Self-citation
Differential effects of 1,25-dihydroxyvitamin D3 on human lymphocytes and monocyte/macrophages: Inhibition of interleukin-2 and augmentation of interleukin-1 production
Bhalla, A. K., Amento, E. P., & Krane, S. M. (1986) · Cellular Immunology · doi:10.1016/0008-8749(86)90291-1 · Cited by 241
1,25-Dihydroxyvitamin D 3 Attenuates of Expression of Experimental Murine Lupus of MRL/1 Mice
Lemire, J. M., Ince, A., & Takashima, M. (1992) · Autoimmunity · doi:10.3109/08916939209150321 · Cited by 240
Vitamin D in rheumatoid arthritis
Cutolo, M., Otsa, K., Üprus, M., Paolino, S., & SERIOLO, B. (2007) · Autoimmunity Reviews · doi:10.1016/j.autrev.2007.07.001 · Cited by 234
Increased atherosclerosis in hyperlipidemic mice deficient in α-tocopherol transfer protein and vitamin E
Terasawa, Y., Ladha, Z., Leonard, S. W., Morrow, J. D., Newland, D., Sanan, D. A., Packer, L., Traber, M. G., & Farese, R. V. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240462697 · Cited by 232
Antioxidants inhibit the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 induced by oxidized LDL on human umbilical vein endothelial cells
Cominacini, L., Garbin, U., Pasini, A. F., Davoli, A., Campagnola, M., Contessi, G. B., Pastorino, A. M., & Lo Cascio, V. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00271-7 · Cited by 230
The Immunoglobulin Class Switch: Beyond “Accessibility”
Snapper, C. M., Marcu, K. B., & Zelazowski, P. (1997) · Immunity · doi:10.1016/s1074-7613(00)80324-6 · Cited by 213
IL-10 Signaling Is Essential for 1,25-Dihydroxyvitamin D3-Mediated Inhibition of Experimental Autoimmune Encephalomyelitis
Spach, K. M., Nashold, F. E., Dittel, B. N., & Hayes, C. E. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.6030 · Cited by 207
Effects of retinoic acid on the immune system: Stimulation of T killer cell induction
Dennert, G., & Lotan, R. (1978) · European Journal of Immunology · doi:10.1002/eji.1830080106 · Cited by 192
Intracellular Signaling by 14-hydroxy-4,14- Retro -Retinol
Buck, J., Derguini, F., Levi, E., Nakanishi, K., & Hämmerling, U. (1991) · Science · doi:10.1126/science.1749937 · Cited by 183
Retinoid X receptors
Rowe, A. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(96)00101-x · Cited by 175
A Vitamin D Analog Down-Regulates Proinflammatory Chemokine Production by Pancreatic Islets Inhibiting T Cell Recruitment and Type 1 Diabetes Development
Giarratana, N., Penna, G., Amuchastegui, S., Mariani, R., Daniel, K. C., & Adorini, L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.4.2280 · Cited by 174
Dendritic cells govern induction and reprogramming of polarized tissue‐selective homing receptor patterns of T cells: important roles for soluble factors and tissue microenvironments
Dudda, J. C., Lembo, A., Bachtanian, E., Huehn, J., Siewert, C., Hamann, A., Kremmer, E., Förster, R., & Martin, S. F. (2005) · European Journal of Immunology · doi:10.1002/eji.200425817 · Cited by 168
Vitamin C prevents cigarette smoke-induced leukocyte aggregation and adhesion to endothelium in vivo.
Lehr, H. A., Frei, B., & Arfors, K. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7688 · Cited by 167
Vitamin D and the skin: an ancient friend, revisited
Reichrath, J. (2007) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00570.x · Cited by 166
Gut IgA Class Switch Recombination in the Absence of CD40 Does Not Occur in the Lamina Propria and Is Independent of Germinal Centers
Bergqvist, P. J., Gärdby, E., Stensson, A., Bemark, M., & Lycke, N. Y. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7772 · Cited by 165
In Vitro and In Vivo Analysis of the Immune System of Vitamin D Receptor Knockout Mice
Mathieu, C., van Etten, E., Gysemans, C. A., Decallonne, B., Kato, S., Laureys, J. M., Depovere, J., Valckx, D., Verstuyf, A., & Bouillon, R. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.11.2057 · Cited by 165
Induction of organ‐selective CD4+ regulatory T cell homing
Siewert, C., Menning, A., Dudda, J. C., Siegmund, K., Lauer, U., Floess, S., Campbell, D., Hamann, A., & Huehn, J. (2007) · European Journal of Immunology · doi:10.1002/eji.200636575 · Cited by 161
Retinoids Regulate Survival and Antigen Presentation by Immature Dendritic Cells
Geissmann, F., Revy, P., Brousse, N., Lepelletier, Y., Folli, C., Durandy, A., Chambon, P., & Dy, M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030390 · Cited by 161
Vitamin D3 metabolism in patients with rheumatic diseases: Low serum levels of 25-hydroxyvitamin D3 in patients with systemic lupus erythematosus
Müller, K., Kriegbaum, N. J., Baslund, B., Sørensen, O. H., Thymann, M., & Bentzen, K. (1995) · Clinical Rheumatology · doi:10.1007/bf02207671 · Cited by 157
α-Tocopherol Decreases Interleukin-1β Release From Activated Human Monocytes by Inhibition of 5-Lipoxygenase
Devaraj, S., & Jialal, I. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.4.1125 · Cited by 154
Metabolism of Vitamin A and Its Active Metabolite All-trans-retinoic Acid in Small Intestinal Enterocytes
Lampen, A., Meyer, S., Arnhold, T., & Nau, H. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38997-9 · Cited by 152
1,25‐dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by inhibiting chemokine synthesis and monocyte trafficking
Pedersen, L. B., Nashold, F. E., Spach, K. M., & Hayes, C. E. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21382 · Cited by 145
Treatment of Experimental Autoimmune Prostatitis in Nonobese Diabetic Mice by the Vitamin D Receptor Agonist Elocalcitol
Penna, G., Amuchastegui, S., Cossetti, C., Aquilano, F., Mariani, R., Sanvito, F., Doglioni, C., & Adorini, L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8504 · Cited by 135
Oral Alitretinoin (9-cis-Retinoic Acid) Therapy for Chronic Hand Dermatitis in Patients Refractory to Standard Therapy
Ruzicka, T., Larsen, F. G., Galewicz, D., Horváth, A., Coenraads, P. J., Thestrup‐Pedersen, K., Ortonne, J. P., Zouboulis, C. C., Harsch, M., Brown, T. C., et al. (2004) · Archives of Dermatology · doi:10.1001/archderm.140.12.1453 · Cited by 134
In Vitro Induction of Mucosa-Type Dendritic Cells by All- Trans Retinoic Acid
Saurer, L., McCullough, K. C., & Summerfield, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3504 · Cited by 133
Vitamin A is a key regulator for cell growth, cytokine production, and differentiation in normal B cells.
Blomhoff, H. K., Smeland, E. B., Erikstein, B., Rasmussen, A. M., Skrede, B., Skjønsberg, C., & Blomhoff, R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35934-9 · Cited by 130
Inflammation and Collagenase Production in Rats with Adjuvant Arthritis Reduced with 13- cis -Retinoic Acid
Brinckerhoff, C., Coffey, J. W., & Sullivan, A. C. (1983) · Science · doi:10.1126/science.6308759 · Cited by 121
Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes
Dawson, H. D., Collins, G. D., Pyle, R. S., Key, M. L., Weeraratna, A. T., Deep-Dixit, V., Nadal, C. N., & Taub, D. D. (2006) · BMC Immunology · doi:10.1186/1471-2172-7-27 · Cited by 117
Protection From Oxidized LDL–Induced Leukocyte Adhesion to Microvascular and Macrovascular Endothelium In Vivo by Vitamin C but Not by Vitamin E
Lehr, H., Frei, B. B., Olofsson, A. M., Carew, T. E., & Arfors, K. ‐. (1995) · Circulation · doi:10.1161/01.cir.91.5.1525 · Cited by 116
Vitamin A Deficiency Decreases and High Dietary Vitamin A Increases Disease Severity in the Mouse Model of Asthma
Schuster, G. U., Kenyon, N. J., & Stephensen, C. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1834 · Cited by 115
Retinoic Acid Enhances the T Helper 2 Cell Development That Is Essential for Robust Antibody Responses through Its Action on Antigen-Presenting Cells
Hoag, K. A., Nashold, F. E., Hayes, C. E., & Goverman, J. M. (2002) · Journal of Nutrition · doi:10.1093/jn/132.12.3736 · Cited by 115
Mouse Vitamin D-24-Hydroxylase: Molecular Cloning, Tissue Distribution, and Transcriptional Regulation by 1 ,25-Dihydroxyvitamin D3
Akeno, N., Saikatsu, S., Kawane, T., & Horiuchi, N. (1997) · Endocrinology · doi:10.1210/endo.138.6.5170 · Cited by 110
Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology.
Buck, J., Grün, F., Derguini, F., Chen, Y., Kimura, S., Noy, N., & Hämmerling, U. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.675 · Cited by 100
Retinoic Acid Stimulates the Cell Cycle Machinery in Normal T Cells: Involvement of Retinoic Acid Receptor-Mediated IL-2 Secretion
Ertesvag, A., Engedal, N., Naderi, S., & Blomhoff, H. K. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5555 · Cited by 98
Homing imprinting and immunomodulation in the gut: Role of dendritic cells and retinoids
Mora, R. J. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20280 · Cited by 96
The Effect of α-Tocopherol on Monocyte Proatherogenic Activity
Jialal, I., Devaraj, S., & Kaul, N. (2001) · Journal of Nutrition · doi:10.1093/jn/131.2.389s · Cited by 96
1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells
Shirakawa, A., Nagakubo, D., Hieshima, K., Nakayama, T., Jin, Z. H., & Yoshie, O. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.2786 · Cited by 95
Prevention of immunological disorders in MRL/l mice by a new synthetic analogue of vitamin D3: 22-oxa-1.ALPHA., 25-dihydroxyvitamin D3.
Junko, A. B. E., Nakamura, K., Takita, Y., Nakano, T., Irie, H., & Nishii, Y. (1990) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.36.21 · Cited by 94
Characterization of a helper T lymphocyte defect in vitamin A-deficient mice.
Carman, J., SMITH, S., & Hayes, C. E. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.2.388 · Cited by 93
Delivery of retinoid-based therapies to target tissues
Moise, A. R., Noy, N., Palczewski, K., & Blaner, W. S. (2007) · Biochemistry · doi:10.1021/bi7003069 · Cited by 93
Atherosclerosis and Oxidant Stress: The End of the Road for Antioxidant Vitamin Treatment?
Thomson, M. J. C. B., Püntmann, V. O., & Kaski, J. C. (2007) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-007-6027-1 · Cited by 91
Impaired local immune response in vitamin A-deficient rats.
Sirisinha, S., Darip, M. D., Moongkarndi, P., Ongsakul, M., & Lamb, A. J. (1980) · PubMed Central · Cited by 86
Update on retinoid therapy of psoriasis in: an update on the use of retinoids in dermatology
van de Kerkhof, P. C. M. (2006) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2006.00082.x · Cited by 85
α‐tocopherol protects against expression of adhesion molecules on neutrophils and endothelial cells
Yoshikawa, T., Yoshida, N., Manabe, H., Terasawa, Y., Takemura, T., & Kondo, M. (1998) · BioFactors · doi:10.1002/biof.5520070103 · Cited by 84
1,25-DIHYDROXYVITAMIN D3 PROLONGS GRAFT SURVIVAL WITHOUT COMPROMISING HOST RESISTANCE TO INFECTION OR BONE MINERAL DENSITY1
Cantorna, M. T., Hullett, D. A., Redaelli, C., Brandt, C. R., Humpal-Winter, J., Sollinger, H. W., & DeLuca, H. F. (1998) · Transplantation · doi:10.1097/00007890-199810150-00003 · Cited by 84
Aberrant T-cell function in vitro and impaired T-cell dependent antibody response in vivo in vitamin A-deficient rats.
Wiedermann, U., HANSON, L. Å., Kahu, H., & Dahlgren, U. I. (1993) · PubMed Central · Cited by 83
Effect of periodic vitamin A supplementation on mortality and morbidity of human immunodeficiency virus–infected children in Uganda: A controlled clinical trial
Semba, R. D., Ndugwa, C. M., Perry, R. T., Clark, T. D., Jackson, J. B., Melikian, G., Tielsch, J. M., & Mmiro, F. A. (2005) · Nutrition · doi:10.1016/j.nut.2004.10.004 · Cited by 81
Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death
Li‐Weber, M., Weigand, M. A., Giaisi, M., Süss, D., Treiber, M. K., Baumann, S., Ritsou, E., Breitkreutz, R., & Krammer, P. H. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15073 · Cited by 75
1,25-Dihydroxyvitamin D3 enhances the generation of nonspecific suppressor cells while inhibiting the induction of cytotoxic cells in a human MLR
Meehan, M. A., Kerman, R. H., & Lemire, J. M. (1992) · Cellular Immunology · doi:10.1016/0008-8749(92)90206-5 · Cited by 75
All- trans Retinoic Acid Enhances Murine Dendritic Cell Migration to Draining Lymph Nodes via the Balance of Matrix Metalloproteinases and Their Inhibitors
Darmanin, S., Chen, J., Zhao, S., Cui, H., Shirkoohi, R., Kubo, N., Kuge, Y., Tamaki, N., Nakagawa, K., Hamada, J.-I., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4616 · Cited by 75
Inhibition of Human T Lymphocyte Proliferation and Cytokine Production by 1,25-Dihydroxyvitamin D 3 . Differential Effects on Cd45Ra+ and Cd45R0+ Cells
Müller, K., & Bendtzen, K. (1993) · Autoimmunity · doi:10.3109/08916939309077355 · Cited by 73
Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention
Vlad, A., & Zingg, J.-M. A. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.07.001 · Cited by 71
Vitamin D receptor gene polymorphism associates with graft-versus-host disease and survival in HLA-matched sibling allogeneic bone marrow transplantation
Middleton, P. G., Cullup, H., Dickinson, A., Norden, J., Jackson, G. H., Taylor, P., & Cavet, J. (2002) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1703629 · Cited by 69
The role of monocytes and T cells in 1,25-dihydroxyvitamin D3 mediated inhibition of B cell function in vitro
Müller, K., Heilmann, C. J., Poulsen, L. K., Barington, T., & Bendtzen, K. (1991) · Immunopharmacology · doi:10.1016/0162-3109(91)90015-q · Cited by 69
Modulation of chemokine receptor expression and chemotactic responsiveness during differentiation of human naive T cells into Th1 or Th2 cells
Colantonio, L., Recalde, H. R., Sinigaglia, F., & D’Ambrosio, D. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200205)32:5 · Cited by 69
Vitamin E: Inflammation and Atherosclerosis
Singh, U. S., & Devaraj, S. (2007) · Vitamins and hormones · doi:10.1016/s0083-6729(07)76020-x · Cited by 66
1α,25‐Dihydroxy vitamin D3 (calcitriol) stimulates proliferation of human circulating monocytes in vitro
Ohta, M., Okabe, T., Ozawa, K., Urabe, A., & Takaku, F. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80730-4 · Cited by 61
PROLONGATION OF THE SURVIVAL OF MURINE CARDIAC ALLOGRAFTS BY THE VITAMIN D3 ANALOGUE 1,25-DIHYDROXY-Δ16-CHOLECALCIFEROL
Lemire, J. M., ARCHER, D. C., KHULKARNI, A., Ince, A., Uskoković, M. R., & STEPROWSKI, S. (1992) · Transplantation · doi:10.1097/00007890-199210000-00046 · Cited by 61
Vitamin A Prevents the Decline in Immunoglobulin A and Th2 Cytokine Levels in Small Intestinal Mucosa of Protein-Malnourished Mice
Nikawa, T., Odahara, K., Koizumi, H., Kido, Y., Teshima, S., Rokutan, K., & Kishi, K. (1999) · Journal of Nutrition · doi:10.1093/jn/129.5.934 · Cited by 60
The Regulatory Effects of All-trans-Retinoic Acid on Isotype Switching: Retinoic Acid Induces IgA Switch Rearrangement in Cooperation with IL-5 and Inhibits IgG1 Switching
Tokuyama, H., & Tokuyama, Y. (1999) · Cellular Immunology · doi:10.1006/cimm.1998.1438 · Cited by 59
Vitamin A potentiates CpG-mediated memory B-cell proliferation and differentiation: involvement of early activation of p38MAPK
Ertesvag, A., Aasheim, H., Naderi, S., & Blomhoff, H. K. (2007) · Blood · doi:10.1182/blood-2006-09-046748 · Cited by 59
Intra-arterial vitamin C prevents endothelial dysfunction caused by ischemia-reperfusion
Pleiner, J., Schaller, G., Mittermayer, F., Marsik, C. L., MacAllister, R. J., Kapiotis, S., Ziegler, S., Ferlitsch, A., & Wolzt, M. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.06.011 · Cited by 58
Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression
Yamanaka, K., Dimitroff, C. J., Fuhlbrigge, R. C., Kakeda, M., Kurokawa, I., Mizutani, H., & Kupper, T. S. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.08.014 · Cited by 58
Retro-retinoids in regulated cell growth and death.
O’Connell, M. J., Chua, R. A., Hoyos, B. E., Buck, J., Chen, Y., Derguini, F., & Hämmerling, U. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.549 · Cited by 58
Antioxidant activity of vitamin B6 delays homocysteine-induced atherosclerosis in rats
Endo, N., Nishiyama, K., Otsuka, A., Kanouchi, H., Taga, M., & Oka, T. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061764 · Cited by 57
Retinoic Acid
Mora, J. R., & von Andrian, U. H. (2004) · Immunity · doi:10.1016/j.immuni.2004.10.002 · Cited by 55
Self-citation
Retinoic acid promotes the development of Th2-like human myelin basic protein-reactive T cells
Lovett‐Racke, A. E., & Racke, M. K. (2002) · Cellular Immunology · doi:10.1016/s0008-8749(02)00013-8 · Cited by 55
Vitamin A Deficiency Diminishes the Salivary Immunoglobulin A Response and Enhances the Serum Immunoglobulin G Response to Influenza A Virus Infection in BALB/c Mice
Stephensen, C. B., Moldoveanu, Z., & Gangopadhyay, N. N. (1996) · Journal of Nutrition · doi:10.1093/jn/126.1.94 · Cited by 54
Inhibition of bone resorption by 17β-estradiol in human bone marrow cultures
Sarma, U., Edwards, M. W., Motoyoshi, K., & Flanagan, A. M. (1998) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199804)175:1 · Cited by 54
Neuroprotective Effects of l-Carnitine and Vitamin E Alone or in Combination Against Ischemia-Reperfusion Injury in Rats
Önem, G., Aral, E., Enli, Y., Oğuz, E. O., Çoşkun, E., Aybek, H., Özcan, A. V., Saçar, M., Bir, L. S., Baltalarlı, A., et al. (2006) · Journal of Surgical Research · doi:10.1016/j.jss.2005.12.017 · Cited by 54
Impaired intestinal localization of mesenteric lymphoblasts associated with vitamin A deficiency and protein-calorie malnutrition.
McDermott, M. R., Mark, D. A., Befus, A. D., Baliga, B. S., Suskind, R. M., & Bienenstock, J. (1982) · PubMed · Cited by 52
Loss of ileal IgA+ plasma cells and of CD4+ lymphocytes in ileal Peyer's patches of vitamin A deficient rats
Bjersing, J. L., Telemo, E., Dahlgren, U. I., & Hanson, L. Å. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.02009.x · Cited by 50
Prevention of chronic allograft nephropathy with vitamin D*
Hullett, D. A., Laeseke, P. F., Malin, G., Nessel, R., Sollinger, H. W., & Becker, B. N. (2005) · Transplant International · doi:10.1111/j.1432-2277.2005.00187.x · Cited by 49
Comparison of the effects of 1,25‐dihydroxyvitamin D3 on T lymphocyte subpopulations
Rigby, W. F. C., Yirinec, B. A., Oldershaw, R. L., & Fanger, M. W. (1987) · European Journal of Immunology · doi:10.1002/eji.1830170420 · Cited by 49
Effect of Am-80, a Synthetic Derivative of Retinoid, on Experimental Arthritis in Mice
Nagai, H., Matsuura, S., Bouda, K., Takaoka, Y., Wang, T., Niwa, S., & Shudo, K. (1999) · Pharmacology · doi:10.1159/000028272 · Cited by 47
Inhibition of Acute and Chronic Allograft Rejection in Mouse Models by BXL-628, a Nonhypercalcemic Vitamin D Receptor Agonist
Amuchastegui, S., Daniel, K. C., & Adorini, L. (2005) · Transplantation · doi:10.1097/01.tp.0000164619.49828.7a · Cited by 45
Novel synthetic retinoic acid inhibits rat collagen arthritis and differentially affects serum immunoglobulin subclass levels
Kuwabara, K., Shudo, K., & Hori, Y. (1996) · FEBS Letters · doi:10.1016/0014-5793(95)01440-3 · Cited by 43
1α,25-Dihydroxyvitamin D3Transrepresses Retinoic Acid Transcriptional Activity via Vitamin D Receptor in Myeloid Cells
Bastie, J.-N., Balitrand, N., Guidez, F., Guillemot, I., Larghero, J., Calabresse, C., Chomienne, C., & Delva, L. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0412 · Cited by 43
Supplementation of Atherogenic Diet With B Vitamins Does Not Prevent Atherosclerosis or Vascular Dysfunction in Monkeys
Lentz, S. R., Piegors, D. J., Malinow, M. R., & Heistad, D. D. (2001) · Circulation · doi:10.1161/01.cir.103.7.1006 · Cited by 40
MC1288, a vitamin D analog, prevents acute graft-versus-host disease in rat bone marrow transplantation
Pakkala, I., Taskinen, E., Pakkala, S., & Räisänen-Sokolowski, A. K. (2001) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1702873 · Cited by 39
Effect of calcitriol on the production of T-cell-derived cytokines in psoriasis
BARNA, M., Bos, J. D., Kapsenberg, M. L., & Snijdewint, F. G. M. (1997) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1997.tb02137.x · Cited by 38
The Effects of Iloprost and Vitamin C on Kidney as a Remote Organ After Ischemia/Reperfusion of Lower Extremities
Özcan, A. V., Saçar, M., Aybek, H., Bir, F., Demir, S., Önem, G., Gökşin, İ., Baltalarlı, A., & Çolakoğlu, N. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.04.031 · Cited by 37
Vitamin C and E Suppress Mitogen-Stimulated Peripheral Blood Mononuclear Cells in vitro
Winkler, C., Schroecksnadel, K., Schennach, H., & Fuchs, D. (2006) · International Archives of Allergy and Immunology · doi:10.1159/000096438 · Cited by 36
Effects of long-term administration of vitamin D3 analogs to mice
Smith, E., Frankenburg, E., Goldstein, S., Koshizuka, K., Elstner, E., SAID, J. W., Kubota, T., Uskoković, M. R., & Koeffler, H. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.1650163 · Cited by 36
Effect of 1,25-dihydroxyvitamin D3 on preventing allograft from acute rejection following rat orthotoic liver transplantation
Zhang, A.-B. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i5.1067 · Cited by 34
The effect of Am-80, one of retinoids derivatives on experimental allergic encephalomyelitis in rats
Wang, T., Niwa, S., Bouda, K., Matsuura, S., Homma, T., Shudo, K., & Nagai, H. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00776-1 · Cited by 34
Enhancement of the inducible NO synthase activation by retinoic acid is mimicked by RARα agonist in vivo
Seguin‐Devaux, C., Devaux, Y., Latger‐Cannard, V., Grosjean, S. A., Rochette‐Egly, C., Zannad, F. M., Meistelman, C., Mertès, P., & Longrois, D. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00008.2002 · Cited by 33
Failure of successful renal transplant to produce appropriate levels of 1,25-dihydroxyvitamin D
Fleseriu, M., & Licata, A. (2006) · Osteoporosis International · doi:10.1007/s00198-006-0238-3 · Cited by 31
Retinoic acid activates human inducible nitric oxide synthase gene through binding of RARα/RXRα heterodimer to a novel retinoic acid response element in the promoter
Zou, F., Liu, Y., Liu, L., Wu, K., Wei, W., Zhu, Y., & Wu, J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.178 · Cited by 31
Colonic Patches Direct the Cross-Talk Between Systemic Compartments and Large Intestine Independently of Innate Immunity
Chang, S., Cha, H., Uematsu, S., Akira, S., Igarashi, O., Kiyono, H., & Kweon, M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1609 · Cited by 29
Regulation of 25-hydroxyvitamin D 3 -1-hydroxylase and production of 1,25-dihydroxyvitamin D 3 by human dendritic cells
Fritsche, J., Mondal, K., Ehrnsperger, A., et al. (2017) · Cited by 29
Topical paricalcitol (19-nor-1alpha,25-dihydroxyvitamin D2) is a novel, safe and effective treatment for plaque psoriasis: a pilot study
Durakovic, C., Ray, S., & Holick, M. F. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.06002.x · Cited by 27
Challenges and opportunities in the translation of the science of vitamins
Rosenberg, I. H. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.1.325s · Cited by 26
1, 25-dihydroxyvitamin D3 regulates proliferation of activated T-lymphocyte subsets
Matsui, T., Nakao, Y., Koizumi, T., Nakagawa, T., & Fujita, T. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90630-7 · Cited by 26
Potential Effects of 1,25-Dihydroxyvitamin D(3) in Renal Transplant Recipients
Sezer, S., Uyar, M., Arat, Z., Özdemir, F. N., & Haberal, M. A. (2005) · Transplantation Proceedings · doi:10.1016/j.transproceed.2005.07.026 · Cited by 26
The effects of retinoic acid on immunoglobulin synthesis: Role of interleukin 6
Ballow, M., Xiang, S.-N., Wang, W.-P., & Brodsky, L. (1996) · Journal of Clinical Immunology · doi:10.1007/bf01540916 · Cited by 22
Impaired Vitamin A-Mediated Mucosal IgA Response in IL-5 Receptor-Knockout Mice
Nikawa, T., Ikemoto‐Uezumi, M., Kano, M., Tokuoka, K., Hirasaka, K., Uehara, S., Takatsu, K., Rokutan, K., & Kishi, K. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5138 · Cited by 22
Therapeutic effect of all-trans-retinoic acid (at-RA) on an autoimmune nephritis experimental model: role of the VLA-4 integrin
Escribese, M. M., Conde, E., Martín, A., Sáenz-Morales, D., Sancho, D., de Lema, G. P., Lucio-Cazaña, F. J., Sánchez‐Madrid, F., García‐Bermejo, L., & Mampaso, F. M. (2007) · BMC Nephrology · doi:10.1186/1471-2369-8-3 · Cited by 21
Lymphocyte subpopulations in children with vitamin D deficient rickets
YENER, E., Çöker, C., Cura, A., Keskınoğlu, A., & Mır, S. (1995) · Pediatrics International · doi:10.1111/j.1442-200x.1995.tb03362.x · Cited by 20
Are plasma 1,25-dihydroxyvitamin D3 concentrations appropriate after successful kidney transplantation?
Caravaca, F. (1998) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/13.suppl_3.91 · Cited by 20
Effect of vitamins A and E on ischemia-reperfusion damage in rabbit heart
Llesuy, S., Milei, J., Picone, V., González‐Flecha, B., Beigelman, R., & Boveris, A. (1995) · Molecular and Cellular Biochemistry · doi:10.1007/bf00925712 · Cited by 18
Effect of Am-80, a Retinoid Derivative, on 2,4-Dinitrofluorobenzene-Induced Contact Dermatitis in Mice
Niwa, S., Ochi, T., Hirano, Y., Wang, T., Inagaki, N., Shudo, K., & Nagai, H. (2000) · Pharmacology · doi:10.1159/000028371 · Cited by 17
Influence of vitamin C on the metabolism of arachidonic acid and the development of aortic lesions during experimental atherosclerosis in rabbits.
Beetens, J. R., Mc, C., Verheyen, A., Zonnekeyn, L. L., & Ag, H. (1984) · PubMed · Cited by 13
1,25 Dihydroxyvitamin-D3 regulation of immunoglobulin production in peripheral blood mononuclear cells of patients with Systemic Lupus Erythematosus
Chong, P. J., Matzner, W., Wallace, D. J., Klinenberg, J. R., Toyoda, M., & Jordan, S. C. (1989) · Journal of Autoimmunity · doi:10.1016/0896-8411(89)90012-7 · Cited by 12
A Novel Vitamin E Derivative (TMG) Protects Against Gastric Mucosal Damage Induced by Ischemia and Reperfusion in Rats
Ichikawa, H., Yoshida, N., Takano, H., Ishikawa, T., Handa, O., Takagi, T., Naito, Y., Murase, H., & Yoshikawa, T. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1021778229997 · Cited by 9
Regulation of fucosyltransferase-VII expression in peripheral lymph node high endothelial venules
(1998) · doi:10.1002/(sici)1521-4141(199810)28:10

Sorted by citations

Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385
Human nutrition, the gut microbiome and the immune system
Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588
Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
Jia, W., Xie, G., & Jia, W. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.119 · Cited by 1,924
Inflammatory bowel disease
Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806
Regional specialization within the intestinal immune system
Mowat, A. M., & Agace, W. W. (2014) · Nature reviews. Immunology · doi:10.1038/nri3738 · Cited by 1,882

See all 1,559

Authors: Mora, J. R., Iwata, M., & von Andrian, U. H.
Affiliations: Harvard University (US)
Tokushima Bunri University (JP)
Corresponding author: Mora, J. Rodrigo
ORCID: Mora, J. Rodrigo
Iwata, Makoto
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2008-09
Volume: 8
Issue: 9
Pages: 685-698
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2378
PMC: PMC2906676
OpenAlex: W2018938924
Cited by: 1,559
References: 170
Citations by year: 2026: 46 · 2025: 84 · 2024: 81 · 2023: 75 · 2022: 98 · 2021: 118 · 2020: 123 · 2019: 69 · 2018: 87 · 2017: 88 · 2016: 86 · 2015: 115 · 2014: 89 · 2013: 100 · 2012: 91
FWCI: 8.17
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (HL 56949, P01HL056949)
National Institute of Allergy and Infectious Diseases (R01AI072252, AI061663, R01AI069259, R01AI061663, AI072252, AI-069259)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 43351, P30DK043351)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 42689, P30AR042689)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: vitamins, vitamin A, vitamin D, immune regulation, lymphocyte activation, T helper cell differentiation, lymphocyte homing, antibody isotypes, immune-mediated diseases, autoimmunity, inflammation, immunomodulatory therapy
MeSH terms: Animals, Humans, Immune System, Immunotherapy, Lymphocytes, Vitamin A, Vitamin D, Vitamins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Vitamin effects on the immune system: vitamins A and D take centre stage

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks