The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
Nutrient sensing and inflammation in metabolic diseases
Open accessAbstract
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.
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“One of the hallmarks of metabolic syndrome is low-grade chronic systemic inflammation (155, 156).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [155]
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RetractedAn obesity-associated gut microbiome with increased capacity for energy harvest
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Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
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Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
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Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655
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NF-κB in biology and targeted therapy: new insights and translational implications
Guo, Q., Jin, Y., Chen, X., Ye, X., Shen, X., Lin, M., Zeng, C., Zhou, T., & Zhang, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01757-9 · Cited by 2,405
Metadata
- Authors
- Hotamisligil, G. S., & Erbay, E.
- Affiliations
- Harvard University (US)
- ORCID
- Erbay, Ebru
- Venue
- Nature Reviews Immunology
- Published
- 2008-12
- Volume
- 8
- Issue
- 12
- Pages
- 923-934
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC2814543
- OpenAlex
- W2138816083
- Cited by
- 1,040
- References
- 119
- Citations by year
- 2026: 31 · 2025: 35 · 2024: 45 · 2023: 30 · 2022: 51 · 2021: 63 · 2020: 59 · 2019: 64 · 2018: 69 · 2017: 70 · 2016: 77 · 2015: 67 · 2014: 73 · 2013: 74 · 2012: 76
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL065405, HL 65405)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK52539, DK64360, R01DK064360, R01DK054017, R56DK064360, R01DK056894, R01DK052539)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- nutrient sensing, inflammation, metabolic disorders, type 2 diabetes, atherosclerosis, immune-metabolic crosstalk, metabolic homeostasis, pathogen sensing, immune pathways, chronic metabolic diseases
- MeSH terms
- Animals, Energy Metabolism, Homeostasis, Humans, Inflammation, Metabolic Diseases, Nutritional Status, Signal Transduction
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