Cited by 1,040Adipokines, Inflammation, and Metabolic DiseasesMetabolism, Diabetes, and CancerImmune Response and Inflammation

The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.

Nutrient sensing and inflammation in metabolic diseases

Open access

Hotamisligil, Gökhan S., Erbay, Ebru·2008·Nature Reviews Immunology

DOI 10.1038/nri2449PMC PMC2814543

Open this paper in CoChat — free account

Abstract

The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nri2449

Cites

119 of 119 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance
Tsukumo, D. M. L., Carvalho-Filho, M. A., Carvalheira, J. B. C., Prada, P. O., Hirabara, S. M., Schenka, A. A., Araújo, E. P., Vassallo, J., Curi, R., Velloso, L. A., et al. (2007) · Diabetes · doi:10.2337/db06-1595 · Cited by 826
Retracted
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
Origin and physiological roles of inflammation
Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618
Signal integration in the endoplasmic reticulum unfolded protein response
Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,431
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
AKT/PKB signaling: navigating downstream
Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor
Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., & Mori, K. (2001) · Cell · doi:10.1016/s0092-8674(01)00611-0 · Cited by 4,054
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
Schröder, M., & Kaufman, R. J. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074134 · Cited by 3,099
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.
Urano, F., Wang, X.-Z., Bertolotti, A., Zhang, Y.-H., Chung, P., Harding, H., & Ron, D. (2000) · Science · doi:10.1126/science.287.5453.664 · Cited by 3,081
Critical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525
Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes
Özcan, U., Yilmaz, E., Özcan, L., Furuhashi, M., Vaillancourt, E., Smith, R. O., Görgün, C. Z., & Hotamisligil, G. S. (2006) · Science · doi:10.1126/science.1128294 · Cited by 2,413
Ido expression by dendritic cells: tolerance and tryptophan catabolism
Mellor, A. L., & Munn, D. H. (2004) · Nature Reviews Immunology · doi:10.1038/nri1457 · Cited by 2,341
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234
Self-citation
IKK-β links inflammation to obesity-induced insulin resistance
Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677
Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis
Scheuner, D. L., Song, B., McEwen, E. L., Liu, C., Laybutt, D. R., Gillespie, P. J., Saunders, T. L., Bonner‐Weir, S., & Kaufman, R. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00265-9 · Cited by 1,355
Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity
Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., & Cai, D. (2008) · Cell · doi:10.1016/j.cell.2008.07.043 · Cited by 1,350
Hypothalamic mTOR Signaling Regulates Food Intake
Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J. (2006) · Science · doi:10.1126/science.1124147 · Cited by 1,278
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
Cox, J. S., Shamu, C. E., & Walter, P. (1993) · Cell · doi:10.1016/0092-8674(93)90648-a · Cited by 1,240
Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival
Harding, H. P., Zeng, H., Zhang, Y., Jungries, R., Chung, P., Plesken, H., Sabatini, D. D., & Ron, D. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00264-7 · Cited by 1,217
The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins
Harrington, L. S., Findlay, G. M., Gray, A., Толкачева, Т. А., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N. R., Cheng, S., Shepherd, P. R., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403069 · Cited by 1,123
Survival for Immunity: The Price of Immune System Activation for Bumblebee Workers
Moret, Y., & Schmid‐Hempel, P. (2000) · Science · doi:10.1126/science.290.5494.1166 · Cited by 1,111
Toll-like Receptor 4 Polymorphisms and Atherogenesis
Kiechl, S. J., Lorenz, E., Reindl, M., Wiedermann, C. J., Oberhollenzer, F., Bonora, E., Willeit, J., & Schwartz, D. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012673 · Cited by 1,022
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E
Michelsen, K. S., Wong, M. H., Shah, P. K., Zhang, W., Yano, J., Doherty, T. M., Akira, S., Rajavashisth, T. B., & Arditi, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403249101 · Cited by 1,019
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
Feng, B., Yao, P. M., Li, Y., Devlin, C. M., Zhang, D., Harding, H. P., Sweeney, M., Rong, J. X., Kuriakose, G., Fisher, E. A. A., et al. (2003) · Nature Cell Biology · doi:10.1038/ncb1035 · Cited by 902
A transmembrane protein with a cdc2+CDC28-related kinase activity is required for signaling from the ER to the nucleus
Morl, K., Ma, W., Gething, M.-J. H., & Sambrook, J. (1993) · Cell · doi:10.1016/0092-8674(93)90521-q · Cited by 834
A nutrient sensor mechanism controls Drosophila growth
Colombani, J., Raisin, S., Pantalacci, S., Radimerski, T., Montagne, J., & Léopold, P. (2003) · Cell · doi:10.1016/s0092-8674(03)00713-x · Cited by 809
Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex
Gao, Z., Hwang, D. H., Bataille, F., Lefevre, M., York, D. A., Quon, M. J., & Ye, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209459200 · Cited by 777
Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1α-Mediated NF-κB Activation and Down-Regulation of TRAF2 Expression
Hu, P., Han, Z., Couvillon, A. D., Kaufman, R. J., & Exton, J. H. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.3071-3084.2006 · Cited by 774
Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives
Rodrı́guez, P. C., & Ochoa, A. C. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00608.x · Cited by 743
Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response
Zhang, K., Shen, X., Wu, J., Sakaki, K., Saunders, T., Rutkowski, D. T., Back, S. H., & Kaufman, R. J. (2006) · Cell · doi:10.1016/j.cell.2005.11.040 · Cited by 716
LXR signaling couples sterol metabolism to proliferation in the acquired immune response
Bensinger, S. J., Bradley, M. N., Joseph, S. B., Zelcer, N., Janssen, E. M., Hausner, M. A., Shih, R., Parks, J. S., Edwards, P. A., Jamieson, B. D., et al. (2008) · Cell · doi:10.1016/j.cell.2008.04.052 · Cited by 711
Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors
Schug, T. T., Berry, D. C., Shaw, N. S., Travis, S. N., & Noy, N. (2007) · Cell · doi:10.1016/j.cell.2007.02.050 · Cited by 680
Toll-Like Receptor-4 Is Expressed by Macrophages in Murine and Human Lipid-Rich Atherosclerotic Plaques and Upregulated by Oxidized LDL
Xu, X.-O. H., Shah, P. K., Faure, E., Equils, O., Thomas, L. S., Fishbein, M. C., Luthringer, D., Xu, X., Rajavashisth, T. B., Yano, J., et al. (2001) · Circulation · doi:10.1161/hc5001.100631 · Cited by 676
Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2
Deng, J., Lu, P. D., Zhang, Y., Scheuner, D., Kaufman, R. J., Sonenberg, N., Harding, H. P., & Ron, D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.23.10161-10168.2004 · Cited by 665
Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis
Tabas, I. A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000184783.04864.9f · Cited by 641
IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway
Lee, D., Kuo, H.-P., Chen, C., Hsu, J.-M., Chou, C., Wei, Y., Sun, H., Li, L., Ping, B., Huang, W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.058 · Cited by 639
The endoplasmic reticulum stress response in immunity and autoimmunity
Todd, D. J., Lee, A., & Glimcher, L. H. (2008) · Nature reviews. Immunology · doi:10.1038/nri2359 · Cited by 621
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease
Gregor, M. F., & Hotamisligil, G. S. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700007-jlr200 · Cited by 586
Preadipocyte Conversion to Macrophage
Charrière, G. M., Cousin, B., Arnaud, E., André, M., Bacou, F., Pénicaud, L., & Casteilla, L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210811200 · Cited by 556
JNK1 in Hematopoietically Derived Cells Contributes to Diet-Induced Inflammation and Insulin Resistance without Affecting Obesity
Solinas, G., Vilcu, C., Neels, J. G., Bandyopadhyay, G. K., Luo, J.-L., Naugler, W., Grivennikov, S., Wynshaw-Boris, A., Scadeng, M., Olefsky, J. M., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.011 · Cited by 513
Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription
Tan, N.-S., Shaw, N. S., Vinckenbosch, N., Liu, P., Yasmin, R., Desvergne, B., Wahli, W., & Noy, N. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5114-5127.2002 · Cited by 499
The Ubiquitous Glucose Transporter GLUT-1 Is a Receptor for HTLV
Manel, N., Kim, F. J., Kinet, S., Taylor, N. N., Sitbon, M., & Battini, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00881-x · Cited by 486
Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
Song, M. J., Kim, K. H., Yoon, J. M., & Kim, J. B. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.170 · Cited by 454
Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
Pende, M., Kozma, S. C., Jaquet, M., Oorschot, V. M. J., Burcelin, R., MARCHAND‐BRUSTEL, Y. L., Klumperman, J., Thorens, B., & Thomas, G. W. (2000) · Nature · doi:10.1038/35050135 · Cited by 452
Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis
Özcan, U., Özcan, L., Yılmaz, E., Düvel, K., Şahin, M., Manning, B. D., & Hotamışlıgil, G. S. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.023 · Cited by 449
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
Lipson, K. L., Fonseca, S. G., Ishigaki, S., Nguyen, L. X., Foss, E., Bortell, R., Rossini, A. A., & Urano, F. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.007 · Cited by 439
Obesity and immune function relationships
Martí, A., Marcos, A., & Martínez, J. A. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00025.x · Cited by 418
The Fatty Acid-binding Protein, aP2, Coordinates Macrophage Cholesterol Trafficking and Inflammatory Activity
Makowski, L., Brittingham, K. C., Reynolds, J. M., Suttles, J., & Hotamışlıgil, G. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413788200 · Cited by 413
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
Sinclair, L. V., Finlay, D. K., Feijóo, C. G., Cornish, G. H., Gray, A., Ager, A., Okkenhaug, K., Hagenbeek, T. J., Spits, H., & Cantrell, D. A. (2008) · Nature Immunology · doi:10.1038/ni.1603 · Cited by 400
Psychoneuroimmunology: The interface between behavior, brain, and immunity.
Maier, S. F., Watkins, L. R., & Fleshner, M. (1994) · American Psychologist · doi:10.1037//0003-066x.49.12.1004 · Cited by 398
Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents
Ota, T., Gayet, C., & Ginsberg, H. N. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32752 · Cited by 393
Increased Endoplasmic Reticulum Stress in Atherosclerotic Plaques Associated With Acute Coronary Syndrome
Myoishi, M., Hao, H., Minamino, T., Watanabe, K., Nishihira, K., Hatakeyama, K., Asada, Y., Okada, K.-I., Ishibashi‐Ueda, H., Gabbiani, G., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.682054 · Cited by 370
Metabolic costs of mounting an antigen-stimulated immune response in adult and aged C57BL/6J mice
Demas, G. E., Chefer, V. I., Talan, M. I., & Nelson, R. J. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.5.r1631 · Cited by 367
Tumor Necrosis Factor α (TNFα) Induces the Unfolded Protein Response (UPR) in a Reactive Oxygen Species (ROS)-dependent Fashion, and the UPR Counteracts ROS Accumulation by TNFα*
Xue, X., Piao, J.-H., Nakajima, A., Sakon-Komazawa, S., Kojima, Y., Mori, K., Yagita, H., Okumura, K., Harding, H., & Nakano, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505818200 · Cited by 365
Trafficking and Release of Mycobacterial Lipids from Infected Macrophages
Beatty, W. L., Rhoades, E. R., Ullrich, H., Chatterjee, D., Heuser, J. E., & Russell, D. G. (2000) · Traffic · doi:10.1034/j.1600-0854.2000.010306.x · Cited by 362
Palmitate Activates the NF-κB Transcription Factor and Induces IL-6 and TNFα Expression in 3T3-L1 Adipocytes
Ajuwon, K. M., & Spurlock, M. E. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.8.1841 · Cited by 343
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
Kaneto, H., Nakatani, Y., Miyatsuka, T., Kawamori, D., Matsuoka, T., Matsuhisa, M., Kajimoto, Y., Ichijo, H., Yamasaki, Y., & Hori, M. (2004) · Nature Medicine · doi:10.1038/nm1111 · Cited by 337
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
Davis, J. E., Gabler, N. K., Walker‐Daniels, J., & Spurlock, M. E. (2008) · Obesity · doi:10.1038/oby.2008.210 · Cited by 334
Ser/Thr Phosphorylation of IRS Proteins: A Molecular Basis for Insulin Resistance
Zick, Y. (2005) · Science s STKE · doi:10.1126/stke.2682005pe4 · Cited by 326
The GCN2 eIF2α Kinase Regulates Fatty-Acid Homeostasis in the Liver during Deprivation of an Essential Amino Acid
Guo, F., & Cavener, D. R. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.001 · Cited by 313
Stress and mTORture signaling
Reiling, J. H., & Sabatini, D. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209889 · Cited by 311
Feeding Our Immune System: Impact on Metabolism
Wolowczuk, I., Verwaerde, C., Viltart, O., Delanoye, A., Delacre, M., Pot, B., & Grangette, C. (2008) · Clinical and Developmental Immunology · doi:10.1155/2008/639803 · Cited by 307
Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions
Han, S., Liang, C.-P., Seimon, T. A., Ranalletta, M., Welch, C. L., Collins-Fletcher, K., Accili, D., Tabas, I. A., & Tall, A. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.02.008 · Cited by 278
A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease
Tuncman, G., Erbay, E., Hom, X., Vivo, I. D., Campos, H., Rimm, E. B., & Hotamışlıgil, G. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602178103 · Cited by 277
Self-citation
Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation
Pouysségur, J., Shiu, R. P. C., & Pastan, I. H. (1977) · Cell · doi:10.1016/0092-8674(77)90305-1 · Cited by 274
Microarray Analyses during Adipogenesis: Understanding the Effects of Wnt Signaling on Adipogenesis and the Roles of Liver X Receptor α in Adipocyte Metabolism
Ross, S. E., Erickson, R. L., Gerin, I., DeRose, P. M., Bajnok, L., Longo, K. A., Misek, D. E., Kuick, R. D., Hanash, S., Atkins, K. B., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5989-5999.2002 · Cited by 255
Preadipocytes Mediate Lipopolysaccharide-Induced Inflammation and Insulin Resistance in Primary Cultures of Newly Differentiated Human Adipocytes
Chung, S., LaPoint, K., Martinez, K., Kennedy, A. J., Sandberg, M. B., & McIntosh, M. (2006) · Endocrinology · doi:10.1210/en.2006-0536 · Cited by 254
The immune response of Drosophila melanogaster
Leclerc, V., & Reichhart, J. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.0130.x · Cited by 242
Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus.
Gingras, A., Svitkin, Y. V., Belsham, G. J., Pause, A., & Sonenberg, N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5578 · Cited by 238
Energetic Cost and Preferred Speed of Walking in Obese vs. Normal Weight Women
Browning, R. C., & Kram, R. (2005) · Obesity Research · doi:10.1038/oby.2005.103 · Cited by 235
Inter-organelle membrane contact sites: through a glass, darkly
Levine, T. P., & Loewen, C. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.06.011 · Cited by 235
ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome
Schneider, J. G., Finck, B. N., Ren, J., Standley, K. N., Takagi, M., Maclean, K. H., Bernal‐Mizrachi, C., Muslin, A. J., Kastan, M. B., & Semenkovich, C. F. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.002 · Cited by 234
Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation
Suganami, T., Mieda, T., Itoh, M., Shimoda, Y., Kamei, Y., & Ogawa, Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.190 · Cited by 230
Modulation of the JNK Pathway in Liver Affects Insulin Resistance Status
Nakatani, Y., Kaneto, H., Kawamori, D., Hatazaki, M., Miyatsuka, T., Matsuoka, T., Kajimoto, Y., Matsuhisa, M., Yamasaki, Y., & Hori, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406963200 · Cited by 230
Coordinated Regulation of Nutrient and Inflammatory Responses by STAMP2 Is Essential for Metabolic Homeostasis
Wellen, K. E., Fucho, R., Gregor, M. F., Furuhashi, M., Morgan, C., Lindstad, T., Vaillancourt, E., Gorgun, C. Z., Saatcioglu, F., & Hotamisligil, G. S. (2007) · Cell · doi:10.1016/j.cell.2007.02.049 · Cited by 222
Inducible Toll‐like Receptor and NF‐κB Regulatory Pathway Expression in Human Adipose Tissue
Vitseva, O. I., Tanrıverdi, K., Tchkonia, T., Kirkland, J. L., McDonnell, M. E., Apovian, C. M., Freedman, J. E., & Gokce, N. (2008) · Obesity · doi:10.1038/oby.2008.25 · Cited by 215
The Endoplasmic Reticulum Chaperone Improves Insulin Resistance in Type 2 Diabetes
Ozawa, K., Miyazaki, M., Matsuhisa, M., Takano, K., Nakatani, Y., Hatazaki, M., Tamatani, T., Yamagata, K., Miyagawa, J.-I., Kitao, Y., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.3.657 · Cited by 211
Endoplasmic Reticulum Stress Induces Leptin Resistance
Hosoi, T., Sasaki, M., Miyahara, T., Hashimoto, C., Matsuo, S., Yoshii, M., & Ozawa, K. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.050070 · Cited by 206
Leptin beyond body weight regulation—Current concepts concerning its role in immune function and inflammation
Lago, R., Gómez, R., Lago, F., Gómez-Reino, J. J., & Gualillo, O. (2008) · Cellular Immunology · doi:10.1016/j.cellimm.2007.09.004 · Cited by 188
Expression of macrophage‐selective markers in human and rodent adipocytes
Khazen, W., Mbika, J., Tomkiewicz, C., Benelli, C., Chany, C., Achour, A., & Forest, C. D. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.09.032 · Cited by 175
Vesicular Stomatitis Virus Infection Alters the eIF4F Translation Initiation Complex and Causes Dephosphorylation of the eIF4E Binding Protein 4E-BP1
Connor, J. H., & Lyles, D. S. (2002) · Journal of Virology · doi:10.1128/jvi.76.20.10177-10187.2002 · Cited by 166
Steap Proteins: Implications for Iron and Copper Metabolism
Knutson, M. D. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00311.x · Cited by 165
Reductions in total body fat decrease humoral immunity
Demas, G. E., Drazen, D. L., & Nelson, R. J. (2003) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2003.2341 · Cited by 147
Continuous Nucleocytoplasmic Shuttling Underlies Transcriptional Activation of PPARγ by FABP4
Ayers, S. D., Nedrow, K. L., Gillilan, R. E., & Noy, N. (2007) · Biochemistry · doi:10.1021/bi700047a · Cited by 144
The structure of mononuclear phagocytes differentiating in vivo. I. Sequential fine and histologic studies of the effect of Bacillus Calmette-Guerin (BCG).
Adams, D. O. (1974) · PubMed · Cited by 143
Glucose metabolism in lymphoid and inflammatory cells and tissues
Calder, P. C., Dimitriadis, G., & Newsholme, P. (2007) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3281e72ad4 · Cited by 143 · cited 1×
“Most pathogens can also trigger baseline glucose transport in host cells through the regulation of GLUT1, presumably to meet the energy demands of their replication and synthetic phase”
Background
A Critical Role for Eukaryotic Elongation Factor 1A-1 in Lipotoxic Cell Death
Borradaile, N. M., Buhman, K. K., Listenberger, L. L., Magee, C. J., Morimoto, E., Ory, D. S., & Schaffer, J. E. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-08-0742 · Cited by 143
Acute Modulation of Toll-Like Receptors by Insulin
Ghanim, H., Mohanty, P., Deopurkar, R., Sia, C. L., Korzeniewski, K., Abuaysheh, S., Chaudhuri, A., & Dandona, P. (2008) · Diabetes Care · doi:10.2337/dc08-0561 · Cited by 125
A Predominant Role for Parenchymal c-Jun Amino Terminal Kinase (JNK) in the Regulation of Systemic Insulin Sensitivity
Vallerie, S. N., Furuhashi, M., Fucho, R., & Hotamışlıgil, G. S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003151 · Cited by 110
Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up-regulation of CTP: phosphocholine cytidylyltransferase
Shiratori, Y., Okwu, A. K., & Tabas, I. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78130-7 · Cited by 99
Pathogen–endoplasmic-reticulum interactions: in through the out door
Roy, C. R., Salcedo, S. P., & Gorvel, J. (2006) · Nature reviews. Immunology · doi:10.1038/nri1775 · Cited by 97
Induction of dendritic cell-like phenotype in macrophages during foam cell formation
Cho, H., Shashkin, P. N., Gleissner, C. A., Dunson, D., Jain, N., Lee, J. K., Miller, Y. I., & Ley, K. F. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00051.2006 · Cited by 92
Phagosomes, fatty acids and tuberculosis
Russell, D. G. (2003) · Nature Cell Biology · doi:10.1038/ncb0903-776 · Cited by 86
The source of fatty acids incorporated into proliferating lymphoid cells in immune-stimulated lymph nodes
Pond, C. M., & Mattacks, C. A. (2003) · British Journal Of Nutrition · doi:10.1079/bjn2002784 · Cited by 63
Obesity, innate immunity and gut inflammation
Karagiannides, I., & Pothoulakis, C. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3282c8c8d3 · Cited by 63
Expression of Six Transmembrane Protein of Prostate 2 in Human Adipose Tissue Associates with Adiposity and Insulin Resistance
Arner, P., Stenson, B. M., Dungner, E., Näslund, E. B., Hoffstedt, J., Rydén, M., & Dahlman, I. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0206 · Cited by 62
Energy cost of infection burden: An approach to understanding the dynamics of host–pathogen interactions
Romanyukha, A. A., Rudnev, S. G., & Sidorov, I. A. (2005) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2005.11.004 · Cited by 61
Translational control in virus-infected cells: models for cellular stress responses
Clemens, M. J. (2004) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2004.11.011 · Cited by 51
Glucose intolerance in pulmonary tuberculosis.
Jawad, F., Shera, A. S., Memon, R. A., & Ansari, G. (1995) · PubMed · Cited by 49
Specialized Perinodal Fat Fuels and Fashions Immunity
Knight, S. C. (2008) · Immunity · doi:10.1016/j.immuni.2008.01.003 · Cited by 45
Immune response in overnutrition.
Chandra, R. K. (1981) · PubMed · Cited by 42
Adipocyte/macrophage fatty acid binding proteins in metabolic syndrome
Erbay, E., Cao, H., & Hotamışlıgil, G. S. (2007) · Current Atherosclerosis Reports · doi:10.1007/s11883-007-0023-6 · Cited by 34
Self-citation
Stressing the Brain, Fattening the Body
Yang, L., & Hotamışlıgil, G. S. (2008) · Cell · doi:10.1016/j.cell.2008.09.030 · Cited by 29
Reversal of Type 2 Diabetes in Mice by Products of Malaria Parasites
Elased, K. M., Gumaa, K. A., de Souza, J. B., Rahmoune, H., Playfair, J. H. L., & Rademacher, T. W. (2001) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2001.3186 · Cited by 25
Glucose intolerance in pulmonary tuberculosis.
Bloom, J. D. (1969) · PubMed · doi:10.1164/arrd.1969.100.1.38 · Cited by 12
Hepatitis C Virus-Induced Insulin Resistance: Not All Genotypes Are the Same
Neuschwander‐Tetri, B. A. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.12.041 · Cited by 9

Flagged first, then by citations

Sorted by citations

Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
Tilg, H., & Moschen, A. R. (2010) · Hepatology · doi:10.1002/hep.24001 · Cited by 2,548
NF-κB in biology and targeted therapy: new insights and translational implications
Guo, Q., Jin, Y., Chen, X., Ye, X., Shen, X., Lin, M., Zeng, C., Zhou, T., & Zhang, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01757-9 · Cited by 2,405

See all 1,040

Authors: Hotamisligil, G. S., & Erbay, E.
Affiliations: Harvard University (US)
ORCID: Erbay, Ebru
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2008-12
Volume: 8
Issue: 12
Pages: 923-934
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2449
PMC: PMC2814543
OpenAlex: W2138816083
Cited by: 1,040
References: 119
Citations by year: 2026: 31 · 2025: 35 · 2024: 45 · 2023: 30 · 2022: 51 · 2021: 63 · 2020: 59 · 2019: 64 · 2018: 69 · 2017: 70 · 2016: 77 · 2015: 67 · 2014: 73 · 2013: 74 · 2012: 76
FWCI: 5.55
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: American Diabetes Association
National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL065405, HL 65405)
National Institute of Diabetes and Digestive and Kidney Diseases (DK52539, DK64360, R01DK064360, R01DK054017, R56DK064360, R01DK056894, R01DK052539)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: nutrient sensing, inflammation, metabolic disorders, type 2 diabetes, atherosclerosis, immune-metabolic crosstalk, metabolic homeostasis, pathogen sensing, immune pathways, chronic metabolic diseases
MeSH terms: Animals, Energy Metabolism, Homeostasis, Humans, Inflammation, Metabolic Diseases, Nutritional Status, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nutrient sensing and inflammation in metabolic diseases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks