Cited by 887Immunotherapy and Immune ResponsesAluminum toxicity and tolerance in plants and animalsImmune responses and vaccinations

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

Towards an understanding of the adjuvant action of aluminium

Open access

Marrack, Philippa, McKee, Amy S., Munks, Michael W.·2009·Nature Reviews Immunology

DOI 10.1038/nri2510PMC PMC3147301

Open this paper in CoChat — free account

Abstract

The efficacy of vaccines depends on the presence of an adjuvant in conjunction with the antigen. Of these adjuvants, the ones that contain aluminium, which were first discovered empirically in 1926, are currently the most widely used. However, a detailed understanding of their mechanism of action has only started to be revealed. In this Timeline article, we briefly describe the initial discovery of aluminium adjuvants and discuss historically important advances. We also summarize recent progress in the field and discuss their implications and the remaining questions on how these adjuvants work.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nri2510

Cites

63 of 63 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,553
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658 · cited 1×
“Related reports have shown that other particulate materials, such as silica, asbestos and MSU crystals, also act through the NLRP3 inflammasome to produce IL-1&beta”
How dying cells alert the immune system to danger
Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737
Molecular identification of a danger signal that alerts the immune system to dying cells
Shi, Y., Evans, J. E., & Rock, K. L. (2003) · Nature · doi:10.1038/nature01991 · Cited by 1,684
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
Eisenbarth, S. C., Colegio, O. R., O’Connor, W., Sutterwala, F. S., & Flavell, R. A. (2008) · Nature · doi:10.1038/nature06939 · Cited by 1,542
Toll-like receptors control activation of adaptive immune responses
Schnare, M., Barton, G. M., Czopik, A. K., Takeda, K., Akira, S., & Medzhitov, R. M. (2001) · Nature Immunology · doi:10.1038/ni712 · Cited by 1,364
Disruption of the murine IL-4 gene blocks Th2 cytokine responses
Köpf, M., Gros, G. S. L., Bachmann, M. F., Lamers, M. C., Bluethmann, H., & Köhler, G. (1993) · Nature · doi:10.1038/362245a0 · Cited by 1,202
Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
Kool, M., Soullié, T., van Nimwegen, M., Willart, M. A. M., Muskens, F., Jung, S., Hoogsteden, H. C., Hammad, H., & Lambrecht, B. N. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071087 · Cited by 1,014

Flagged first, then by citations

Show all 63 references

Research works printed but not linked: 1

Ramon, G. Sur le pouvoir floculant et sur les proprietes immunisantes d'une toxine diphtherique rendue anatoxique. C. R. Hebd. Seances Acad. Sci. 177, 1338–1340 (1923).

Sorted by citations

Items 101–200 of 885

The Age of Cyclic Dinucleotide Vaccine Adjuvants
Gogoi, H., Mansouri, S., & Jin, L. (2020) · Vaccines · doi:10.3390/vaccines8030453 · Cited by 100
Kinetics of the inflammatory response following intramuscular injection of aluminum adjuvant
Lu, F., & HogenEsch, H. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.05.107 · Cited by 100
OmpL1 Is an Extracellular Matrix- and Plasminogen-Interacting Protein of Leptospira spp
Fernandes, L. G. V., Vieira, M. L., Kirchgatter, K., Alves, I. J., de Morais, Z. M., Vasconcellos, S. A., Romero, E. C., & Nascimento, A. L. T. O. (2012) · Infection and Immunity · doi:10.1128/iai.00474-12 · Cited by 98
Introduction to the Immune System
McComb, S., Thiriot, A., Krishnan, L., & Stark, F. C. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-589-7_1 · Cited by 99
Adjuvant system AS01: from mode of action to effective vaccines
Roman, F. P., Burny, W., Ceregido, M. A., Laupèze, B., Temmerman, S. T., Warter, L., & Coccia, M. (2024) · Expert Review of Vaccines · doi:10.1080/14760584.2024.2382725 · Cited by 115
Dendrimer-like alpha-d-glucan nanoparticles activate dendritic cells and are effective vaccine adjuvants
Lu, F., Mencía, A., Bi, L., Taylor, A., Yao, Y., & HogenEsch, H. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.002 · Cited by 98
Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology
Li, Y., Leneghan, D. B., Miura, K., Nikolaeva, D., Brian, I. J., Dicks, M. D. J., Fyfe, A. J., Zakutansky, S. E., de Cassan, S., Long, C. A., et al. (2016) · Scientific Reports · doi:10.1038/srep18848 · Cited by 98
Adjuvants in the Driver’s Seat: How Magnitude, Type, Fine Specificity and Longevity of Immune Responses Are Driven by Distinct Classes of Immune Potentiators
Bergmann‐Leitner, E. S., & Leitner, W. W. (2014) · Vaccines · doi:10.3390/vaccines2020252 · Cited by 101
Production and characterization of peptide antibodies.
Trier, N., Hansen, P. R., & Houen, G. (2012) · Methods · doi:10.1016/j.ymeth.2011.12.001 · Cited by 98
Correction of age-associated defects in dendritic cells enables CD4+ T cells to eradicate tumors
Zhivaki, D., Kennedy, S. N., Park, J., Borriello, F., Devant, P., Cao, A., Bahleda, K. M., Murphy, S. M., Aubin, C., Evavold, C. L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.026 · Cited by 102
Mn-based cGAS-STING activation for tumor therapy
Huang, A., & Zhou, W. (2023) · Chinese Journal of Cancer Research · doi:10.21147/j.issn.1000-9604.2023.01.04 · Cited by 102
The role of NOD-like Receptors in shaping adaptive immunity
Williams, A., Flavell, R. A., & Eisenbarth, S. C. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.004 · Cited by 92
Aluminium hydroxide stabilised MnFe2O4 and Fe3O4 nanoparticles as dual-modality contrasts agent for MRI and PET imaging
Cui, X., Belo, S., Krueger, D., Yan, Y., de Rosales, R. T. M., Jauregui-Osoro, M., Ye, H., Su, S. C., Máthé, D., Kovács, N., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.004 · Cited by 90
Zinc ions as effectors of environmental oxidative lung injury
Wu, W., Bromberg, P. A., & Samet, J. M. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.048 · Cited by 89
Clearing Persistent Extracellular Antigen of Hepatitis B Virus: An Immunomodulatory Strategy To Reverse Tolerance for an Effective Therapeutic Vaccination
Zhu, D., Liu, L., Yang, D., Fu, S., Bian, Y., Sun, Z., He, J., Su, L., Zhang, L., Peng, H., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502061 · Cited by 91
Choice and Design of Adjuvants for Parenteral and Mucosal Vaccines
Savelkoul, H. F. J., Ferro, V. A., Strioga, M. M., & Schijns, V. E. C. J. (2015) · Vaccines · doi:10.3390/vaccines3010148 · Cited by 89
Mechanism of immunopotentiation by aluminum-containing adjuvants elucidated by the relationship between antigen retention at the inoculation site and the immune response
Noe, S. M., Green, M. A., HogenEsch, H., & Hem, S. L. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.02.085 · Cited by 89
The spectrum of ASIA: ‘Autoimmune (Auto-inflammatory) Syndrome induced by Adjuvants’
Agmon‐Levin, N., Hughes, G., & Shoenfeld, Y. (2012) · Lupus · doi:10.1177/0961203311429316 · Cited by 88
Calcium phosphate nanoparticles as a new generation vaccine adjuvant
Lin, Y., Wang, X., Huang, X., Zhang, J., Xia, N., & Zhao, Q. (2017) · Expert Review of Vaccines · doi:10.1080/14760584.2017.1355733 · Cited by 88
Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo
Munks, M. W., McKee, A. S., MacLeod, M. K. L., Powell, R. L., Degen, J. L., Reisdorph, N. A., Kappler, J. W., & Marrack, P. (2010) · Blood · doi:10.1182/blood-2010-03-275529 · Cited by 93
Self-citation
Adjuvant strategies to improve vaccination of the elderly population
Weinberger, B. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.03.014 · Cited by 87
IFN-γ produced by CD8 T cells induces T-bet–dependent and –independent class switching in B cells in responses to alum-precipitated protein vaccine
Mohr, E., Cunningham, A. F., Toellner, K., Bobat, S., Coughlan, R. E., Bird, R. A., MacLennan, I. C. M., & Serre, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004879107 · Cited by 85
Aluminium in Allergies and Allergen immunotherapy
Jensen‐Jarolim, E. (2015) · World Allergy Organization Journal · doi:10.1186/s40413-015-0060-5 · Cited by 86
Eosinophils: important players in humoral immunity
Berek, C. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12695 · Cited by 85
Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA syndrome) in commercial sheep
Luján, L., Pérez, M. M., Salazar, E., de Haro, N. Á., Gimeno, M., Pinczowski, P., Irusta, S., Santamaría, J., Insausti, N., Cortés, Y., et al. (2013) · Immunologic Research · doi:10.1007/s12026-013-8404-0 · Cited by 85
Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation
Magalhaes, J. G., Rubino, S. J., Travassos, L. H., Bourhis, L. L., Duan, W., Sellge, G., Geddes, K., Reardon, C., Lechmann, M., Carneiro, L. A. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015063108 · Cited by 83
PLGA Particles in Immunotherapy
Horvath, D. J., & Basler, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020615 · Cited by 88
Therapeutic Applications of Nanomedicine: Recent Developments and Future Perspectives
Rehan, F., Zhang, M., Fang, J. Q., & Greish, K. F. (2024) · Molecules · doi:10.3390/molecules29092073 · Cited by 97
Modulation of Immune Responses by Particulate Materials
Lebre, F., Hearnden, C. H. A., & Lavelle, E. C. (2016) · Advanced Materials · doi:10.1002/adma.201505395 · Cited by 85
Immunization induces activation of bone marrow eosinophils required for plasma cell survival
Chu, V. T., & Berek, C. (2011) · European Journal of Immunology · doi:10.1002/eji.201141953 · Cited by 82
Adjuvants for Leishmania vaccines: from models to clinical application
Raman, V. S., Duthie, M. S., Fox, C. B., Matlashewski, G., & Reed, S. G. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00144 · Cited by 81
Calcium phosphate: a substitute for aluminum adjuvants?
Masson, J.-D., Thibaudon, M., Bélec, L., & Crépeaux, G. (2016) · Expert Review of Vaccines · doi:10.1080/14760584.2017.1244484 · Cited by 82
Efficacy and safety of immunological adjuvants. Where is the cut-off?
Batista-Duharte, A., Téllez-Martínez, D., & Carlos, I. Z. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.026 · Cited by 83
MyD88-Dependent TLR1/2 Signals Educate Dendritic Cells with Gut-Specific Imprinting Properties
Wang, S., Villablanca, E. J., Calisto, J. D., Gomes, D. C. O., Nguyen, D. D., Mizoguchi, E., Kagan, J. C., Reinecker, H., Hacohen, N., Nagler‐Anderson, C., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003740 · Cited by 79
A novel RNA‐based adjuvant combines strong immunostimulatory capacities with a favorable safety profile
Heidenreich, R., Jasny, E., Kowalczyk, A., Lutz, J., Probst, J., Baumhof, P., Scheel, B., Voss, S., Kallen, K., & Fotin‐Mleczek, M. (2014) · International Journal of Cancer · doi:10.1002/ijc.29402 · Cited by 80
Comparison of adaptive and innate immune responses induced by licensed vaccines for human papillomavirus
Herrin, D., Coates, E. E., Costner, P. J. M., Kemp, T. J., Nason, M., Saharia, K., Pan, Y., Sarwar, U. N., Holman, L. A., Yamshchikov, G. V., et al. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.34408 · Cited by 75
Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL‐18, and IFN‐γ
Desbien, A. L., Reed, J., Bailor, H. R., Cauwelaert, N. D., Laurance, J. D., Orr, M. T., Fox, C. B., Carter, D., Reed, S. G., & Duthie, M. S. (2014) · European Journal of Immunology · doi:10.1002/eji.201444543 · Cited by 82
An efficient and safe MUC1-dendritic cell-derived exosome conjugate vaccine elicits potent cellular and humoral immunity and tumor inhibition in vivo
Zhu, H., Wang, K., Wang, Z., Wang, D., Yin, X., Liu, Y., Yu, F. D., & Zhao, W. G. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.10.041 · Cited by 79
Adjuvant-specific regulation of long-term antibody responses by ZBTB20
Wang, Y., & Bhattacharya, D. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131821 · Cited by 80
The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved?
Morris, G., Puri, B. K., & Frye, R. E. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0077-2 · Cited by 82
Clay Nanoparticles Elicit Long‐Term Immune Responses by Forming Biodegradable Depots for Sustained Antigen Stimulation
Chen, W., Zuo, H., Li, B., Duan, C., Rolfe, B. E., Zhang, B., Mahony, T. J., & Xu, Z. P. (2018) · Small · doi:10.1002/smll.201704465 · Cited by 77
Delta inulin-based adjuvants promote the generation of polyfunctional CD4+ T cell responses and protection against Mycobacterium tuberculosis infection
Counoupas, C., Pinto, R., Nagalingam, G., Britton, W. J., Petrovsky, N., & Triccas, J. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-09119-y · Cited by 76
A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine
Hörner, C., Schürmann, C., Auste, A., Ebenig, A., Muraleedharan, S., Dinnon, K. H., Scholz, T., Herrmann, M., Schnierle, B. S., Baric, R. S., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2014468117 · Cited by 80
Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine
Li, D., Martinez, D. R., Schäfer, A., Chen, H., Barr, M., Sutherland, L. L., Lee, E., Parks, R., Mielke, D., Edwards, W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33985-4 · Cited by 70
Advancements in Vaccine Adjuvants: The Journey from Alum to Nano Formulations
Moni, S. S., Abdelwahab, S. İ., Jabeen, A., Elmobark, M. E., Aqaili, D. O., Gohal, G., Oraibi, B., Farasani, A., Jerah, A. A., Alnajai, M. M., et al. (2023) · Vaccines · doi:10.3390/vaccines11111704 · Cited by 81
Hydroxypropyl-β-Cyclodextrin Spikes Local Inflammation That Induces Th2 Cell and T Follicular Helper Cell Responses to the Coadministered Antigen
Onishi, M., Ozasa, K., Kobiyama, K., Ohata, K., Kitano, M., Taniguchi, K., Homma, T., Kobayashi, M., Sato, A., Katakai, Y., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402027 · Cited by 73
Is There an Optimal Formulation and Delivery Strategy for Subunit Vaccines?
Bobbala, S. K. R., & Hook, S. M. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1979-0 · Cited by 73
Adjuvant Properties of Mesoporous Silica Particles Tune the Development of Effector T Cells
Vallhov, H., Kupferschmidt, N., Gabrielsson, S., Paulie, S., Strømme, M., Garcia‐Bennett, A. E., & Scheynius, A. (2012) · Small · doi:10.1002/smll.201102620 · Cited by 72
Inflammasome-Dependent and -Independent IL-18 Production Mediates Immunity to the ISCOMATRIX Adjuvant
Wilson, N. S., Duewell, P., Yang, B., Li, Y., Marsters, S. A., Koernig, S., Latz, E., Maraskovsky, E., Morelli, A. B., Schnurr, M. M., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302011 · Cited by 74
Heterogeneity in the differentiation and function of memory B cells
Taylor, J. J., Jenkins, M. K., & Pape, K. A. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.07.005 · Cited by 75
Simple nanoliposomes encapsulating Lycium barbarum polysaccharides as adjuvants improve humoral and cellular immunity in mice
Bo, R., Sun, Y., Zhou, S., Ou, N., Gu, P., Liu, Z., Hu, Y., Liu, J., & Wang, D. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s136820 · Cited by 72
Carbon nanotubes as vaccine scaffolds
Scheinberg, D. A., McDevitt, M. R., Dao, T., Mulvey, J. J., Feinberg, E. N., & Alidori, S. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.013 · Cited by 71
Exploiting fungal cell wall components in vaccines
Levitz, S. M., Huang, H., Ostroff, G. R., & Specht, C. A. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0460-6 · Cited by 71
Adjuvants are Key Factors for the Development of Future Vaccines: Lessons from the Finlay Adjuvant Platform
Pérez, O., Romeu, B., Cabrera, O., González, E., Batista-Duharte, A., Labrada, A., Pérez-Nicado, R., Reyes, L. M., González, W. R., Sifontes, S., et al. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00407 · Cited by 70
Flagellin Induces Antibody Responses through a TLR5- and Inflammasome-Independent Pathway
López-Yglesias, A. H., Zhao, X., Quarles, E. K., Lai, M. A., VandenBos, T., Strong, R. K., & Smith, K. D. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301893 · Cited by 70
Tumor cell membrane‐based vaccines: A potential boost for cancer immunotherapy
Yang, M., Zhou, J., Lu, L., Deng, D., Huang, J., Tang, Z., Shi, X., Lo, P., Lovell, J. F., Zheng, Y., et al. (2024) · Exploration · doi:10.1002/exp.20230171 · Cited by 74
Plant Virus Particles Carrying Tumour Antigen Activate TLR7 and Induce High Levels of Protective Antibody
Jobsri, J., Allen, A., Rajagopal, D., Shipton, M. J., Kanyuka, K., Lomonossoff, G. P., Ottensmeier, C. H. H., Diebold, S. S., Stevenson, F. K., & Savelyeva, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118096 · Cited by 71
Development of Newborn and Infant Vaccines
Sánchez‐Schmitz, G., & Levy, O. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001880 · Cited by 71
Vaccine adjuvants: current status, research and development, licensing, and future opportunities
Cui, Y., Ho, M., Hu, Y., & Shi, Y. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02861e · Cited by 78
Disparate adjuvant properties among three formulations of “alum”
Cain, D. W., Sanders, S. E., Cunningham, M. M., & Kelsoe, G. H. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.11.044 · Cited by 72
The Effects of Environmental Toxins on Allergic Inflammation
Yang, S., Hsieh, C., Kuo, H., Lee, M., Huang, M., Kuo, C., & Hung, C. (2014) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2014.6.6.478 · Cited by 69
Synthesis and Preclinical Evaluation of QS-21 Variants Leading to Simplified Vaccine Adjuvants and Mechanistic Probes
Chea, E. K., Fernández‐Tejada, A., Damani, P., Adams, M. M., Gardner, J. R., Livingston, P. O., Ragupathi, G., & Gin, D. Y. (2012) · Journal of the American Chemical Society · doi:10.1021/ja305121q · Cited by 68
Size effect of amphiphilic poly(γ-glutamic acid) nanoparticles on cellular uptake and maturation of dendritic cells in vivo
Shima, F., Uto, T., Akagi, T., Baba, M., & Akashi, M. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.06.010 · Cited by 70
Bordetellabiofilms: a lifestyle leading to persistent infections
Cattelan, N., Dubey, P., Arnal, L., Yantorno, O. M., & Deora, R. (2015) · Pathogens and Disease · doi:10.1093/femspd/ftv108 · Cited by 69
Plant-Produced Receptor-Binding Domain of SARS-CoV-2 Elicits Potent Neutralizing Responses in Mice and Non-human Primates
Siriwattananon, K., Manopwisedjaroen, S., Shanmugaraj, B., Rattanapisit, K., Phumiamorn, S., Sapsutthipas, S., Trisiriwanich, S., Prompetchara, E., Ketloy, C., Buranapraditkun, S., et al. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.682953 · Cited by 68
Combination of adjuvants: the future of vaccine design
Mount, A. M., Koernig, S., Silva, A., Drane, D. P., Maraskovsky, E., & Morelli, A. B. (2013) · Expert Review of Vaccines · doi:10.1586/14760584.2013.811185 · Cited by 70
Cancer Vaccine Immunotherapy with RNA-Loaded Liposomes
Sayour, E. J., Méndez‐Gómez, H. R., & Mitchell, D. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102890 · Cited by 67
Adjuvant Systems for vaccines: 13 years of post-licensure experience in diverse populations have progressed the way adjuvanted vaccine safety is investigated and understood
Laupèze, B., Hervé, C., Pasquale, A. D., & Silva, F. T. D. (2019) · Vaccine · doi:10.1016/j.vaccine.2019.07.098 · Cited by 71
The Integrated Consideration of Vaccine Platforms, Adjuvants, and Delivery Routes for Successful Vaccine Development
Kozak, M., & Hu, J. (2023) · Vaccines · doi:10.3390/vaccines11030695 · Cited by 70
Time course study of the antigen-specific immune response to a PLGA microparticle vaccine formulation
Wang, Q., Tan, M. T., Keegan, B. P., Barry, M. A., & Heffernan, M. J. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.05.067 · Cited by 65
Ultrasmall Graphene Oxide Supported Gold Nanoparticles as Adjuvants Improve Humoral and Cellular Immunity in Mice
Cao, Y., Ma, Y., Zhang, M., Wang, H., Tu, X., Shen, H., Dai, J., Guo, H., & Zhang, Z. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201401358 · Cited by 65
Toward understanding the mechanism underlying the strong adjuvant activity of aluminum salt nanoparticles
Ruwona, T. B., Xu, H., Li, X., Taylor, A. N., Shi, Y.-C., & Cui, Z. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.04.081 · Cited by 64
Epicutaneous allergen administration: is this the future of allergen-specific immunotherapy?
Senti, G., Moos, S. C. V., & Kündig, T. M. (2011) · Allergy · doi:10.1111/j.1398-9995.2011.02560.x · Cited by 64
Nanomedicine: de novo design of nanodrugs
Yang, Z., Kang, S.-G., & Zhou, R. (2013) · Nanoscale · doi:10.1039/c3nr04535h · Cited by 63
Adjuvant-enhanced CD4 T Cell Responses are Critical to Durable Vaccine Immunity
Martins, K. A. O., Cooper, C. L., Stronsky, S. M., NORRIS, S. L. W., Kwilas, S. A., Steffens, J. T., Benko, J. G., Tongeren, S. A. V., & Bavari, S. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.11.041 · Cited by 63
Self‐healing encapsulation and controlled release of vaccine antigens from PLGA microparticles delivered by microneedle patches
Mazzara, J. M., Ochyl, L. J., Hong, J. K. Y., Moon, J. J., Prausnitz, M. R., & Schwendeman, S. P. (2018) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10103 · Cited by 63
Evidence for cyclic diguanylate as a vaccine adjuvant with novel immunostimulatory activities
Gray, P. M., Forrest, G., Wısnıewskı, T., Porter, G., Freed, D. C., DeMartino, J. A., Zaller, D. M., Guo, Z., Leone, J. W., Fu, T., et al. (2012) · Cellular Immunology · doi:10.1016/j.cellimm.2012.07.006 · Cited by 63
Self-adjuvanting cancer nanovaccines
Liao, Z., Huang, J., Lo, P., Lovell, J. F., Jin, H., & Yang, K. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01545-z · Cited by 66
The Malarial Metabolite Hemozoin and Its Potential Use as a Vaccine Adjuvant
Coban, C., Yagi, M., Ohata, K., Igari, Y., Tsukui, T., Horii, T., Ishii, K. J., & Akira, S. (2010) · Allergology International · doi:10.2332/allergolint.10-rai-0194 · Cited by 61
“IDEAL” vaccines for resource poor settings
Levine, M. M. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.11.090 · Cited by 64
Sex differences in the vaccine-specific and non-targeted effects of vaccines
Flanagan, K. L., Klein, S. L., Skakkebæk, N. E., Marriott, I., Marchant, A., Selin, L. K., Fish, E. N., Prentice, A. M., Whittle, H. C., & Benn, C. S. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.01.071 · Cited by 62
Innate immune memory: implications for development of pediatric immunomodulatory agents and adjuvanted vaccines
Levy, O., & Netea, M. G. (2013) · Pediatric Research · doi:10.1038/pr.2013.214 · Cited by 61
Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system
Gherardi, R. K., Crépeaux, G., & Authier, F. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.05.006 · Cited by 64
NLRP3 inflammasomes that induce antitumor immunity
Zhivaki, D., & Kagan, J. C. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.05.001 · Cited by 61
Novel adjuvant formulations for delivery of anti-tuberculosis vaccine candidates
Agger, E. M. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.012 · Cited by 60
Cellular networks controlling Th2 polarization in allergy and immunity
Kool, M., Hammad, H., & Lambrecht, B. N. (2012) · F1000 Biology Reports · doi:10.3410/b4-6 · Cited by 60
Immune response to vaccine adjuvants during the first year of life
Levy, O., Goriely, S., & Kollmann, T. R. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.10.016 · Cited by 61
Role of AS04 in human papillomavirus vaccine: mode of action and clinical profile
Garçon, N., Wettendorff, M. A., & Mechelen, M. V. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.573624 · Cited by 59
Particle platforms for cancer immunotherapy
Serda, R. E. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s31756 · Cited by 58
Silica Nanoparticles as the Adjuvant for the Immunisation of Mice Using Hepatitis B Core Virus-Like Particles
Skrastiņa, D., Petrovskis, I., Lieknina, I., Bogans, J., Renhofa, R., Ose, V., Dišlers, A., Dekhtyar, Y., & Pumpens, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114006 · Cited by 58
Equine Influenza Virus and Vaccines
Oladunni, F. S., Oseni, S. O., Martínez‐Sobrido, L., & Chambers, T. M. (2021) · Viruses · doi:10.3390/v13081657 · Cited by 57
The potential of nanoparticles for the immunization against viral infections
Sokolova, V., Westendorf, A. M., Buer, J., Überla, K., & Epple, M. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00618j · Cited by 57
Directing vaccine immune responses to mucosa by nanosized particulate carriers encapsulating NOD ligands
Pavot, V., Climent, N., Rochereau, N., García, F., Genin, C., Tiraby, G., Vernejoul, F., Pérouzel, É., Lioux, T., Verrier, B., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.10.034 · Cited by 57
Safety and potency of BIV1‐CovIran inactivated vaccine candidate for SARS‐CoV‐2: A preclinical study
Abdoli, A., Aalizadeh, R., Aminianfar, H., Kianmehr, Z., Teimoori, A., Azimi, E., Emamipour, N., Eghtedardoost, M., Siavashi, V., Jamshidi, H., et al. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2305 · Cited by 54
Comparative Systems Analyses Reveal Molecular Signatures of Clinically tested Vaccine Adjuvants
Olafsdottir, T. A., Lindqvist, M., Nookaew, I., Andersen, P. L., Maertzdorf, J., Persson, J., Christensen, D., Zhang, Y., Anderson, J., Khoomrung, S., et al. (2016) · Scientific Reports · doi:10.1038/srep39097 · Cited by 56
Soil-Transmitted Helminth Vaccines: Are We Getting Closer?
Zawawi, A., & Else, K. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.576748 · Cited by 55
Mechanistic insight into the impact of nanomaterials on asthma and allergic airway disease
Meldrum, K., Guo, C., Marczylo, E. L., Gant, T. W., Smith, R. R., & Leonard, M. O. (2017) · Particle and Fibre Toxicology · doi:10.1186/s12989-017-0228-y · Cited by 57
Vaccine-induced antigen-specific regulatory T cells attenuate the antiviral immunity against acute influenza virus infection
Lin, P., Wong, W.-I., Wang, Y., Hsieh, M.-P., Lu, C., Liang, C.-Y., Jui, S.-H., Wu, F., Chen, P., & Yang, H. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0004-9 · Cited by 54
Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry
Williams, G. R., Fierens, K., Preston, S. G., Lunn, D., Ryśnik, O., Prijck, S. D., Kool, M., Buckley, H. C., Lambrecht, B. N., O'Hare, D. M., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131768 · Cited by 50
Aluminum (Oxy)Hydroxide Nanosticks Synthesized in Bicontinuous Reverse Microemulsion Have Potent Vaccine Adjuvant Activity
Li, X., Hufnagel, S., Xu, H., Valdes, S. A., Thakkar, S. G., Cui, Z., & Celio, H. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b03965 · Cited by 53

Authors: Marrack, P., McKee, A. S., & Munks, M. W.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Marrack, Philippa
ORCID: Marrack, Philippa
McKee, Amy S.
Munks, Michael W.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-04
Volume: 9
Issue: 4
Pages: 287-293
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2510
PMC: PMC3147301
OpenAlex: W1990954596
Cited by: 887
References: 63
Citations by year: 2026: 44 · 2025: 47 · 2024: 57 · 2023: 47 · 2022: 41 · 2021: 67 · 2020: 50 · 2019: 45 · 2018: 49 · 2017: 65 · 2016: 56 · 2015: 72 · 2014: 44 · 2013: 64 · 2012: 49
FWCI: 3.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institute of Allergy and Infectious Diseases (P01AI022295, R37AI018785)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: alum adjuvant, aluminum salts, vaccine adjuvants, adjuvant mechanisms, vaccine efficacy, immunogenicity
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Adjuvants, Immunologic, Adsorption, Aluminum, Animals, Antibody Formation, Antigen-Presenting Cells, Antigens, Carrier Proteins, Cytoskeletal Proteins, Humans, Immunity, Cellular, Immunity, Innate, Aluminum Compounds, Models, Immunological, Caspase 1, Apoptosis Regulatory Proteins, Mice, CARD Signaling Adaptor Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Towards an understanding of the adjuvant action of aluminium

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks