Cited by 887Immunotherapy and Immune ResponsesAluminum toxicity and tolerance in plants and animalsImmune responses and vaccinations

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Towards an understanding of the adjuvant action of aluminium

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Marrack, Philippa, McKee, Amy S., Munks, Michael W.·2009·Nature Reviews Immunology

DOI 10.1038/nri2510PMC PMC3147301

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Abstract

The efficacy of vaccines depends on the presence of an adjuvant in conjunction with the antigen. Of these adjuvants, the ones that contain aluminium, which were first discovered empirically in 1926, are currently the most widely used. However, a detailed understanding of their mechanism of action has only started to be revealed. In this Timeline article, we briefly describe the initial discovery of aluminium adjuvants and discuss historically important advances. We also summarize recent progress in the field and discuss their implications and the remaining questions on how these adjuvants work.

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Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,553
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658 · cited 1×
“Related reports have shown that other particulate materials, such as silica, asbestos and MSU crystals, also act through the NLRP3 inflammasome to produce IL-1&beta”
How dying cells alert the immune system to danger
Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737
Molecular identification of a danger signal that alerts the immune system to dying cells
Shi, Y., Evans, J. E., & Rock, K. L. (2003) · Nature · doi:10.1038/nature01991 · Cited by 1,684
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
Eisenbarth, S. C., Colegio, O. R., O’Connor, W., Sutterwala, F. S., & Flavell, R. A. (2008) · Nature · doi:10.1038/nature06939 · Cited by 1,542
Toll-like receptors control activation of adaptive immune responses
Schnare, M., Barton, G. M., Czopik, A. K., Takeda, K., Akira, S., & Medzhitov, R. M. (2001) · Nature Immunology · doi:10.1038/ni712 · Cited by 1,364
Disruption of the murine IL-4 gene blocks Th2 cytokine responses
Köpf, M., Gros, G. S. L., Bachmann, M. F., Lamers, M. C., Bluethmann, H., & Köhler, G. (1993) · Nature · doi:10.1038/362245a0 · Cited by 1,202
Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
Kool, M., Soullié, T., van Nimwegen, M., Willart, M. A. M., Muskens, F., Jung, S., Hoogsteden, H. C., Hammad, H., & Lambrecht, B. N. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071087 · Cited by 1,014

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Ramon, G. Sur le pouvoir floculant et sur les proprietes immunisantes d'une toxine diphtherique rendue anatoxique. C. R. Hebd. Seances Acad. Sci. 177, 1338–1340 (1923).

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Authors: Marrack, P., McKee, A. S., & Munks, M. W.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Marrack, Philippa
ORCID: Marrack, Philippa
McKee, Amy S.
Munks, Michael W.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-04
Volume: 9
Issue: 4
Pages: 287-293
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2510
PMC: PMC3147301
OpenAlex: W1990954596
Cited by: 887
References: 63
Citations by year: 2026: 44 · 2025: 47 · 2024: 57 · 2023: 47 · 2022: 41 · 2021: 67 · 2020: 50 · 2019: 45 · 2018: 49 · 2017: 65 · 2016: 56 · 2015: 72 · 2014: 44 · 2013: 64 · 2012: 49
FWCI: 3.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institute of Allergy and Infectious Diseases (P01AI022295, R37AI018785)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: alum adjuvant, aluminum salts, vaccine adjuvants, adjuvant mechanisms, vaccine efficacy, immunogenicity
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Adjuvants, Immunologic, Adsorption, Aluminum, Animals, Antibody Formation, Antigen-Presenting Cells, Antigens, Carrier Proteins, Cytoskeletal Proteins, Humans, Immunity, Cellular, Immunity, Innate, Aluminum Compounds, Models, Immunological, Caspase 1, Apoptosis Regulatory Proteins, Mice, CARD Signaling Adaptor Proteins

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