Cited by 2,780interferon and immune responsesImmune Response and InflammationCytokine Signaling Pathways and Interactions

The DOI matches its Crossref record; 238 of the 238 references it cites were found in a registry or an index.

Type I interferons in infectious disease

Open access

McNab, Finlay, Mayer-Barber, Katrin, Sher, Alan, Wack, Andreas, O'Garra, Anne·2015·Nature Reviews Immunology

DOI 10.1038/nri3787PMC PMC7162685

Open this paper in CoChat — free account Open PDF

Abstract

Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the induction of other mediators. Type I IFNs are important for host defence against viruses. However, recently, they have been shown to cause immunopathology in some acute viral infections, such as influenza virus infection. Conversely, they can lead to immunosuppression during chronic viral infections, such as lymphocytic choriomeningitis virus infection. During bacterial infections, low levels of type I IFNs may be required at an early stage, to initiate cell-mediated immune responses. High concentrations of type I IFNs may block B cell responses or lead to the production of immunosuppressive molecules, and such concentrations also reduce the responsiveness of macrophages to activation by IFNγ, as has been shown for infections with Listeria monocytogenes and Mycobacterium tuberculosis. Recent studies in experimental models of tuberculosis have demonstrated that prostaglandin E2 and interleukin-1 inhibit type I IFN expression and its downstream effects, demonstrating that a cross-regulatory network of cytokines operates during infectious diseases to provide protection with minimum damage to the host.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nri3787

Cites

238 of 238 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Role of the microbiota in immunity and inflammation.
Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
Gerold, G., & Pietschmann, T. (2014) · Digestive Diseases · doi:10.1159/000360830 · Cited by 4,871
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
Ge, D., Fellay, J., Thompson, A. J. V., Simon, J. S., Shianna, K. V., Urban, T. J., Heinzen, E. L., Qiu, P., Bertelsen, A. H., Muir, A. J., et al. (2009) · Nature · doi:10.1038/nature08309 · Cited by 3,533
Regulation of type I interferon responses
Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,442
Functional Role of Type I and Type II Interferons in Antiviral Defense
Müller, U., Steinhoff, U., Reis, L. F. L., Hemmi, S., Pavlovic, J., Zinkernagel, R. M., & Aguet, M. (1994) · Science · doi:10.1126/science.8009221 · Cited by 2,453
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
Thomas, D. L., Thio, C. L., Martin, M. P., Qi, Y., Ge, D., Ó’hUigín, C., Kidd, J. R., Kídd, K. K., Khakoo, S. I., Alexander, G., et al. (2009) · Nature · doi:10.1038/nature08463 · Cited by 2,147
Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C
Tanaka, Y., Nishida, N., Sugiyama, M., Kurosaki, M., Matsuura, K., Sakamoto, N., Nakagawa, M., Korenaga, M., Hino, K., Hige, S., et al. (2009) · Nature Genetics · doi:10.1038/ng.449 · Cited by 2,141
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
Berry, M. P. R., Graham, C. M., McNab, F. W., Xu, Z., Bloch, S. A. A., Oni, T., Wilkinson, K. A., Banchereau, R., Skinner, J., Wilkinson, R. J., et al. (2010) · Nature · doi:10.1038/nature09247 · Cited by 1,898
Self-citation
Interferons, interferon‐like cytokines, and their receptors
Pestka, S., Krause, C. D., & Walter, M. R. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00204.x · Cited by 1,845
IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy
Study, F. T. H. C., Suppiah, V., Moldovan, M. V., Ahlenstiel, G., Berg, T., Weltman, M., Abate, M. L., Bassendine, M. F., Spengler, U., Dore, G. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.447 · Cited by 1,829

Flagged first, then by citations

Show all 238 references

Sorted by citations

Items 201–300 of 1,004

RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation
Wilson, J. A. C., Prow, N. A., Schroder, W. A., Ellis, J. J., Cumming, H. E., Gearing, L. J., Poo, Y. S., Taylor, A., Hertzog, P. J., Giallonardo, F. D., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006155 · Cited by 116
Stimulation of Innate Immunity by Host and Viral RNAs
Streicher, F., & Jouvenet, N. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.10.009 · Cited by 111
Trial Watch—Oncolytic viruses and cancer therapy
Pol, J. G., Buqué, A., Aranda, F., Bloy, N., Cremer, I., Eggermont, A. M. M., Erbs, P., Fucikova, J. P., Galon, J., Limacher, J., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1117740 · Cited by 111
Renal Replacement Techniques in Septic Shock
Hellman, T., Uusalo, P., & Järvisalo, M. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910238 · Cited by 111
Microbiota regulation of viral infections through interferon signaling
Wirusanti, N. I., Baldridge, M. T., & Harris, V. (2022) · Trends in Microbiology · doi:10.1016/j.tim.2022.01.007 · Cited by 113
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity
Qin, Z., Fang, X., Sun, W., Ma, Z., Dai, T., Wang, S., Zong, Z., Huang, H., Ru, H., Lu, H., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01269-0 · Cited by 113
p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β
Rackov, G., Hernández-Jiménez, E., Shokri, R., Carmona‐Rodríguez, L., Mañes, S., Álvarez‐Mon, M., López‐Collazo, E., Martínez‐A, C., & Balomenos, D. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83404 · Cited by 110
Safe Recombinant Outer Membrane Vesicles that Display M2e Elicit Heterologous Influenza Protection
Watkins, H. C., Rappazzo, C. G., Higgins, J. S., Sun, X., Brock, N., Chau, A., Misra, A., Cannizzo, J. P. B., King, M. R., Maines, T. R., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.01.010 · Cited by 109
A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection
Hou, P., Yang, K., Jia, P., Liu, L., Lin, Y., Li, Z., Li, J., Chen, S., Guo, S., Pan, J., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0362-1 · Cited by 110
Trial Watch: experimental TLR7/TLR8 agonists for oncological indications
Frega, G., Wu, Q., Le Naour, J., Vacchelli, E., Galluzzi, L., Kroemer, G., & Kepp, O. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1796002 · Cited by 108
Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens
Afkhami, S., Yao, Y., & Xing, Z. (2016) · Molecular Therapy — Methods & Clinical Development · doi:10.1038/mtm.2016.30 · Cited by 108
Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation
Man, S. M., Place, D. E., Kuriakose, T., & Kanneganti, T. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4mr0516-223r · Cited by 111
Clinical, Laboratory, and Interferon-Alpha Response Characteristics of Patients With Chilblain-like Lesions During the COVID-19 Pandemic
Hubiche, T., Cardot‐Leccia, N., Duff, F. L., Seitz‐Polski, B., Giordana, P., Chiavérini, C., Giordanengo, V., Gonfrier, G., Raimondi, V. P., Bausset, O., et al. (2020) · JAMA Dermatology · doi:10.1001/jamadermatol.2020.4324 · Cited by 109
Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway
Meyts, I., & Casanova, J. (2021) · European Journal of Immunology · doi:10.1002/eji.202048793 · Cited by 112
Proinflammatory Cytokines and Skin Wound Healing in Mice
Nosenko, M. A., Ambaryan, S. G., & Drutskaya, M. S. (2019) · Molecular Biology · doi:10.1134/s0026893319050121 · Cited by 110
Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation
Mitchell, G., & Isberg, R. R. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.07.005 · Cited by 109
Examining Chronic Inflammation, Immune Metabolism, and T Cell Dysfunction in HIV Infection
Mu, W., Patankar, V., Kitchen, S. G., & Zhen, A. (2024) · Viruses · doi:10.3390/v16020219 · Cited by 116
Rift Valley fever virus NSs protein functions and the similarity to other bunyavirus NSs proteins
Ly, H. J., & Ikegami, T. (2016) · Virology Journal · doi:10.1186/s12985-016-0573-8 · Cited by 110
SARS-CoV-2 Antiviral Therapy
Tao, K., Tzou, P. L., Nouhin, J., Bonilla, H. F., Jagannathan, P., & Shafer, R. W. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00109-21 · Cited by 109
“The NET effect”: Neutrophil extracellular traps—a potential key component of the dysregulated host immune response in sepsis
Retter, A., Singer, M., & Annane, D. (2025) · Critical Care · doi:10.1186/s13054-025-05283-0 · Cited by 114
Characterization of Glycoprotein-Mediated Entry of Severe Fever with Thrombocytopenia Syndrome Virus
Tani, H., Shimojima, M., Fukushi, S., Yoshikawa, T., Fukuma, A., Taniguchi, S., Morikawa, S., & Saijo, M. (2016) · Journal of Virology · doi:10.1128/jvi.00110-16 · Cited by 103
Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a–LCOR axis
Celià-Terrassa, T., Liu, D. D., Choudhury, A., Hang, X., Wei, Y., Zamalloa, J., Alfaro‐Aco, R., Chakrabarti, R., Jiang, Y., Koh, B. I., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3533 · Cited by 105
Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads
Zanin, N., de Lesegno, C. V., Lamaze, C., & Blouin, C. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.615603 · Cited by 111
Serious Non-AIDS Events: Therapeutic Targets of Immune Activation and Chronic Inflammation in HIV Infection
Hsu, D. C., & Sereti, I. (2016) · Drugs · doi:10.1007/s40265-016-0546-7 · Cited by 102
Interferon-Related Depression: A Primer on Mechanisms, Treatment, and Prevention of a Common Clinical Problem
Pinto, E. F., & Andrade, C. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160106155129 · Cited by 101
Phleboviruses and the Type I Interferon Response
Wuerth, J. D., & Weber, F. (2016) · Viruses · doi:10.3390/v8060174 · Cited by 104
Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection
de, M. M., Kumar, R., Rivera, F. D. L., Amante, F. H., Sheel, M., Faleiro, R. J., Bunn, P. T., Best, S. E., Beattie, L., Ng, S. S., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.015 · Cited by 102
Chikungunya virus antagonizes cGAS-STING mediated type-I interferon responses by degrading cGAS
Webb, L. G., Veloz, J., Silva, J. P., Zhu, T., Rangel, M. V., Mutetwa, T., Zhang, L., Bernal‐Rubio, D., Figueroa, D., Carrau, L., et al. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008999 · Cited by 105
Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons
Ji, D. X., Witt, K. C., Kotov, D. I., Margolis, S. R., Louie, A., Chevée, V., Chen, K. J., Gaidt, M. M., Dhaliwal, H. S., Lee, A. Y., et al. (2021) · eLife · doi:10.7554/elife.67290 · Cited by 106
The crucial regulatory role of type I interferon in inflammatory diseases
Ji, L., Li, T., Chen, H., Yang, Y., Liu, J., Liu, J., Qiao, W., & Chen, H. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01188-z · Cited by 107
Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity
Zahid, A., Ismail, H., Li, B., & Jin, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.613039 · Cited by 100
Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis
Lu, Q., Yokoyama, C. C., Williams, J. W., Baldridge, M. T., Jin, X., DesRochers, B. L., Bricker, T. L., Wilen, C. B., Bagaitkar, J., Loginicheva, E., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2015.12.011 · Cited by 103
Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling
Moreira-Teixeira, L., Sousa, J., McNab, F. W., Torrado, E., Cardoso, F., Machado, H., Castro, F., Cardoso, V., Gaifem, J., Wu, X., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600584 · Cited by 99
Self-citation
The metabolic enzyme fructose-1,6-bisphosphate aldolase acts as a transcriptional regulator in pathogenic Francisella
Ziveri, J., Tros, F., Guerrera, I. C., Chhuon, C., Audry, M., Dupuis, M., Barel, M., Korniotis, S., Fillatreau, S., Gales, L., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00889-7 · Cited by 102
Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection
Li, Y., Guo, X., Hu, C., Du, Y., Guo, C., Wang, D., Zhao, W., Huang, G., Li, C., Lu, Q., et al. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-017-0041-z · Cited by 102
Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome
Liu, M.-M., Lei, X.-Y., Yu, H., Zhang, J.-Z., & Yu, X.-J. (2017) · Virology Journal · doi:10.1186/s12985-016-0677-1 · Cited by 84
Type I interferon dysregulation in Systemic Sclerosis
Skaug, B. A., & Assassi, S. (2019) · Cytokine · doi:10.1016/j.cyto.2018.12.018 · Cited by 98
Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins
Zhou, Q., Chi, X., Lee, M. S., Hsieh, W. Y., Mkrtchyan, J. J., Feng, A., He, C. H., York, A. G., Bui, V. L., Kronenberger, E. B., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0695-4 · Cited by 101
A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood
Ng, D., Granados, A. C., Santos, Y. A., Servellita, V., Goldgof, G. M., Meydan, C., Sotomayor-González, A., Levine, A. G., Balcerek, J., Han, L. M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe5984 · Cited by 103
Unraveling the Link Between Mitochondrial Dynamics and Neuroinflammation
de Oliveira, L. G., Angelo, Y. D. S., Iglesias, A. H., & Peron, J. P. S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.624919 · Cited by 100
Expression characteristics of interferon-stimulated genes and possible regulatory mechanisms in lupus patients using transcriptomics analyses
Deng, Y., Zheng, Y., Li, D., Hong, Q., Zhang, M., Li, Q., Fu, B., Wu, L., Wang, X., Shen, W., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103477 · Cited by 98
Oral Ritlecitinib and Brepocitinib for Moderate-to-Severe Ulcerative Colitis: Results From a Randomized, Phase 2b Study
Sandborn, W. J., Danese, S., Leszczyszyn, J., Romatowski, J. A., Altıntaşž, E., Peeva, E., Hassan‐Zahraee, M., Vincent, M. S., Reddy, P. S., Banfield, C. R., et al. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2022.12.029 · Cited by 98
Cause and consequences of the activated type I interferon system in SLE
Eloranta, M., & Rönnblom, L. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1421-4 · Cited by 98
Cytokine Storm in Domestic Pigs Induced by Infection of Virulent African Swine Fever Virus
Wang, S., Zhang, J., Zhang, Y., Yang, J., Wang, L., Qi, Y., Han, X., Zhou, X., Miao, F., Chen, T., et al. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.601641 · Cited by 96
Battle Royale: Innate Recognition of Poxviruses and Viral Immune Evasion
Yu, H., Bruneau, R. C., Brennan, G., & Rothenburg, S. (2021) · Biomedicines · doi:10.3390/biomedicines9070765 · Cited by 97
MTBVAC: Attenuating the Human Pathogen of Tuberculosis (TB) Toward a Promising Vaccine against the TB Epidemic
Gonzalo‐Asensio, J., Marinova, D., Martı́n, C., & Aguiló, N. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01803 · Cited by 103
CD8 + T cell exhaustion in anti‐tumour immunity: The new insights for cancer immunotherapy
Huang, Y., Jia, A., Wang, Y., & Liu, G. (2022) · Immunology · doi:10.1111/imm.13588 · Cited by 96
Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics
Banchereau, R., Cepika, A., Banchereau, J., & Pascual, V. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052225 · Cited by 98
Infections in Patients Receiving Multiple Sclerosis Disease-Modifying Therapies
Grebenciucova, E., & Pruitt, A. A. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0800-8 · Cited by 100
Outcomes of Congenital Zika Disease Depend on Timing of Infection and Maternal-Fetal Interferon Action
Chen, J., Liang, Y., Yi, P., Xu, L., Hawkins, H. K., Rossi, S. L., Soong, L., Cai, J., Menon, R., & Sun, J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.059 · Cited by 98
Infant Immune Response to Respiratory Viral Infections
Heinonen, S., Fernández, R. R., Díaz, A., Rodríguez-Pastor, S. O., Ramilo, O., & Mejías, A. (2019) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2019.03.005 · Cited by 100
Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity
Zhang, Z., Fang, X., Wu, X., Li, L., Chu, F., Li, J., Wang, S., Zang, J., Zhang, B., Ye, S., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.06.020 · Cited by 96
Innate Immune Responses to Influenza Virus Infections in the Upper Respiratory Tract
Mifsud, E. J., Kuba, M., & Barr, I. (2021) · Viruses · doi:10.3390/v13102090 · Cited by 102
Translation stress and collided ribosomes are co-activators of cGAS
Wan, L., Juszkiewicz, S., Blears, D., Bajpe, P. K., Han, Z., Faull, P. A., Mitter, R., Stewart, A., Snijders, A. P., Hegde, R. S., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.05.018 · Cited by 94
The Relationship between Reactive Oxygen Species and the cGAS/STING Signaling Pathway in the Inflammaging Process
Andrade, B., Jara‐Gutiérrez, C., Paz-Araos, M., Vázquez, M. C., Díaz, P., & Murgas, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315182 · Cited by 96
Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPs
Francica, J. R., Zak, D. E., Linde, C., Siena, E., Johnson, C. D., Juraska, M., Yates, N. L., Gunn, B. M., Gregorio, E. D., Flynn, B. J., et al. (2017) · Blood Advances · doi:10.1182/bloodadvances.2017011411 · Cited by 91
Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity
Duncan, C. J. A., Randall, R. E., & Hambleton, S. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.08.017 · Cited by 97
Lnc-ISG20 Inhibits Influenza A Virus Replication by Enhancing ISG20 Expression
Chai, W., Li, J., Shangguan, Q., Liu, Q., Li, X., Qi, D., Tong, X., Liu, W., & Ye, X. (2018) · Journal of Virology · doi:10.1128/jvi.00539-18 · Cited by 90
Gut microbiota-mediated protection against influenza virus subtype H9N2 in chickens is associated with modulation of the innate responses
Yitbarek, A., Taha-Abdelaziz, K., Hodgins, D. C., Read, L. R., Nagy, É., Weese, J. S., Caswell, J., Parkinson, J., & Sharif, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-31613-0 · Cited by 91
Interferons as Essential Modulators of Atherosclerosis
Boshuizen, M. C. S., & de Winther, M. P. J. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305464 · Cited by 90
Dysregulated Interferon Response Underlying Severe COVID-19
Lopez, L., Sang, P. C., Tian, Y., & Sang, Y. (2020) · Viruses · doi:10.3390/v12121433 · Cited by 92
Cytokines and Chemokines in HBV Infection
Zhong, S., Zhang, T., Tang, L., & Li, Y. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.805625 · Cited by 90
Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions
Cascarina, S. M., & Ross, E. D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101677 · Cited by 91
RNA viruses and the cGAS-STING pathway: reframing our understanding of innate immune sensing
Webb, L. G., & Fernandez-Sesma, A. (2022) · Current Opinion in Virology · doi:10.1016/j.coviro.2022.101206 · Cited by 91
The interferon-inducible isoform of NCOA7 inhibits endosome-mediated viral entry
Doyle, T., Moncorgé, O., Bonaventure, B., Pollpeter, D., Lussignol, M., Tauziet, M., Apolonia, L., Catanese, M. T., Goujon, C., & Malim, M. H. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0273-9 · Cited by 87
Cytokine Networks Dysregulation during HTLV-1 Infection and Associated Diseases
Futsch, N., Prates, G. D. S., Mahieux, R., Casseb, J., & Dutartre, H. (2018) · Viruses · doi:10.3390/v10120691 · Cited by 89
Ebola Virus: Pathogenesis and Countermeasure Development
Furuyama, W., & Marzi, A. (2019) · Annual Review of Virology · doi:10.1146/annurev-virology-092818-015708 · Cited by 87
Shedding the Light on Post-Vaccine Myocarditis and Pericarditis in COVID-19 and Non-COVID-19 Vaccine Recipients
Hajjo, R., Sabbah, D. A., Bardaweel, S. K., & Tropsha, A. (2021) · Vaccines · doi:10.3390/vaccines9101186 · Cited by 87
SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation
Zhang, X., Choi, J., Dai, D. L., Luo, J., Ladak, R. J., Li, Q., Wang, Y., Zhang, C., Wiebe, S. A., Liu, A. C. H., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204539119 · Cited by 99
Manganese( ii ) complexes stimulate antitumor immunity via aggravating DNA damage and activating the cGAS-STING pathway
Cai, L., Wang, Y., Chen, Y., Chen, H., Yang, T., Zhang, S., Guo, Z., & Wang, X. (2023) · Chemical Science · doi:10.1039/d2sc06036a · Cited by 88
Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection
Ivin, M., Dumigan, A., Vasconcelos, F., Ebner, F., Borroni, M., Kavirayani, A. M., Przybyszewska, K., Ingram, R. J., Lienenklaus, S., Kalinke, U., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006696 · Cited by 85
Immunomodulatory Role of Interferons in Viral and Bacterial Infections
Mertowska, P., Smolak, K., Mertowski, S., & Grywalska, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210115 · Cited by 91
Host Protein Moloney Leukemia Virus 10 (MOV10) Acts as a Restriction Factor of Influenza A Virus by Inhibiting the Nuclear Import of the Viral Nucleoprotein
Zhang, J., Huang, F., Tan, L., Bai, C., Chen, B., Liu, J., Liang, J., Liu, C., Zhang, S., Lu, G., et al. (2016) · Journal of Virology · doi:10.1128/jvi.03137-15 · Cited by 86
Cytokine Profiling of Primary Human Macrophages Exposed to Endotoxin‐Free Graphene Oxide: Size‐Independent NLRP3 Inflammasome Activation
Mukherjee, S. P., Kostarelos, K., & Fadeel, B. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700815 · Cited by 84
Toll-like receptor-induced cytokines as immunotherapeutic targets in cancers and autoimmune diseases
Patra, M. C., Shah, M., & Choi, S. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.05.002 · Cited by 84
Immunogenic cell death: The cornerstone of oncolytic viro-immunotherapy
Palanivelu, L., Liu, C., & Lin, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1038226 · Cited by 86
Transcriptional profile and Epstein-Barr virus infection status of laser-cut immune infiltrates from the brain of patients with progressive multiple sclerosis
Veroni, C., Serafini, B., Rosicarelli, B., Fagnani, C., & Aloisi, F. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1049-5 · Cited by 84
Type I interferons and endoplasmic reticulum stress in health and disease
(2020) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.10.004 · Cited by 83
E2F/Rb Family Proteins Mediate Interferon Induced Repression of Adenovirus Immediate Early Transcription to Promote Persistent Viral Infection
Zheng, Y., Stamminger, T., & Hearing, P. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005415 · Cited by 83
Epithelial-derived TGF-β1 acts as a pro-viral factor in the lung during influenza A infection
Denney, L., Branchett, W. J., Gregory, L. G., Oliver, R. A., & Lloyd, C. M. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.77 · Cited by 83
MicroRNA-155 and antiviral immune responses
Jafarzadeh, A., Naseri, A., Shojaie, L., Nemati, M., Jafarzadeh, S., Baghi, H. B., Hamblin, M. R., Akhlagh, S. A., & Mirzaei, H. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108188 · Cited by 83
Architects of immunity: How dendritic cells shape CD8 + T cell fate in cancer
Bhandarkar, V., Dinter, T., & Spranger, S. (2025) · Science Immunology · doi:10.1126/sciimmunol.adf4726 · Cited by 88
Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection
Beyer, M., Abdullah, Z., Chemnitz, J. M., Maisel, D., Sander, J., Lehmann, C., Thabet, Y., Shinde, P. V., Schmidleithner, L., Köhne, M., et al. (2016) · Nature Immunology · doi:10.1038/ni.3399 · Cited by 86
STING directly recruits WIPI2 for autophagosome formation during STING‐induced autophagy
Wan, W., Qian, C., Wang, Q., Li, J., Zhang, H., Wang, L., Pu, M., Huang, Y., He, Z., Zhou, T., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022112387 · Cited by 84
The Structural Basis for Class II Cytokine Receptor Recognition by JAK1
Ferrao, R., Wallweber, H. J. A., Ho, H., Tam, C., Franke, Y., Quinn, J. G., & Lupardus, P. J. (2016) · Structure · doi:10.1016/j.str.2016.03.023 · Cited by 82
C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells
Troegeler, A., Mercier, I., Cougoule, C., Pietretti, D., Colom, A., Duval, C., Manh, T. V., Capilla, F., Poincloux, R., Pingris, K., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613254114 · Cited by 88
Lysosomal rupture induced by structurally distinct chitosans either promotes a type 1 IFN response or activates the inflammasome in macrophages
Fong, D. W. F., Grégoire-Gélinas, P., Cheng, A. P., Mezheritsky, T., Lavertu, M., Sato, S., & Hoemann, C. D. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.022 · Cited by 83
Inflammatory Ly6Chigh Monocytes Protect against Candidiasis through IL-15-Driven NK Cell/Neutrophil Activation
Domínguez‐Andrés, J., Feo-Lucas, L., de la Escalera, M. M., González, L., López‐Bravo, M., & Ardavı́n, C. (2017) · Immunity · doi:10.1016/j.immuni.2017.05.009 · Cited by 86
Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues
Kadoki, M., Patil, A., Thaiss, C. C., Brooks, D., Pandey, S., Deep, D., Álvarez, D., von Andrian, U. H., Wagers, A. J., Nakai, K., et al. (2017) · Cell · doi:10.1016/j.cell.2017.08.024 · Cited by 85
Therapeutic applications of TRAIL receptor agonists in cancer and beyond
Amarante-Mendes, G. P., & Griffith, T. S. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.09.001 · Cited by 83
Improvement of In Vivo Expression of Genes Delivered by Self-Amplifying RNA Using Vaccinia Virus Immune Evasion Proteins
Beißert, T., Koste, L., Perković, M., Walzer, K. C., Erbar, S., Selmi, A., Diken, M., Kreiter, S., Türeci, Ö., & Şahin, U. (2017) · Human Gene Therapy · doi:10.1089/hum.2017.121 · Cited by 81
Metabolic Programming of Macrophages: Implications in the Pathogenesis of Granulomatous Disease
Wilson, J. L., Mayr, H. K., & Weichhart, T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02265 · Cited by 85
AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity
Schmid, E. T., Pang, I. K., Silva, E. A. C., Bosurgi, L., Miner, J. J., Diamond, M., Iwasaki, A., & Rothlin, C. V. (2016) · eLife · doi:10.7554/elife.12414 · Cited by 83
The biology of JC polyomavirus
Assetta, B., & Atwood, W. J. (2017) · Biological Chemistry · doi:10.1515/hsz-2016-0345 · Cited by 81
Expansion of amphibian intronless interferons revises the paradigm for interferon evolution and functional diversity
Sang, Y., Liu, Q., Lee, J., Ma, W., McVey, D. S., & Blecha, F. (2016) · Scientific Reports · doi:10.1038/srep29072 · Cited by 81
Nucleic Acid Sensors and Programmed Cell Death
Maelfait, J., Liverpool, L., & Rehwinkel, J. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.11.016 · Cited by 85
Epstein-Barr Virus (EBV) Tegument Protein BGLF2 Suppresses Type I Interferon Signaling To Promote EBV Reactivation
Liu, X., Sadaoka, T., Krogmann, T. A., & Cohen, J. I. (2020) · Journal of Virology · doi:10.1128/jvi.00258-20 · Cited by 82
Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING
Brown Harding, H., Kwaku, G. N., Reardon, C. M., Khan, N. S., Zamith-Miranda, D., Zarnowski, R., Tam, J. M., Bohaen, C. K., Richey, L., Mosallanejad, K., et al. (2024) · Nature Microbiology · doi:10.1038/s41564-023-01546-0 · Cited by 82
Type I interferon is required for T helper (Th) 2 induction by dendritic cells
Webb, L. M., Lundie, R. J., Borger, J. G., Brown, S. L., Connor, L. M., Cartwright, A. N. R., Dougall, A. M., Wilbers, R. H. P., Cook, P. C., Jackson-Jones, L. H., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201695345 · Cited by 82
Mutations of deubiquitinase OTUD1 are associated with autoimmune disorders
Lü, D., Song, J., Sun, Y., Fang, Q., Liu, L., Jin, Y., McNutt, M. A., & Yin, Y. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.07.019 · Cited by 79

Authors: McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A.
Affiliations: GlaxoSmithKline (United Kingdom) (GB)
National Institutes of Health (US)
National Institute for Medical Research (GB)
ORCID: Mayer-Barber, Katrin
Sher, Alan
Wack, Andreas
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2015-01-23
Volume: 15
Issue: 2
Pages: 87-103
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3787
PMC: PMC7162685
OpenAlex: W2091129202
Cited by: 2,780
References: 238
Citations by year: 2026: 263 · 2025: 333 · 2024: 364 · 2023: 330 · 2022: 330 · 2021: 307 · 2020: 194 · 2019: 160 · 2018: 166 · 2017: 169 · 2016: 119 · 2015: 44
FWCI: 15.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Wellcome Trust (FC001126)
Francis Crick Institute (10206, 10126)
Cancer Research UK (FC001126)
National Institutes of Health
Medical Research Council (U117597139, U117565642)
National Institute of Allergy and Infectious Diseases
FP7 Ideas: European Research Council (294682)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: type I interferon, innate immunity, viral infection, bacterial infection, parasitic infection, fungal infection, immunopathology, influenza virus, lymphocytic choriomeningitis virus, chronic viral infection, immunosuppression, B cell response, macrophage activation, Listeria monocytogenes, Mycobacterium tuberculosis, prostaglandin E2, interleukin-1, host defense
MeSH terms: Animals, Bacterial Infections, Communicable Diseases, Humans, Interferon Type I, Mycoses, Parasitic Diseases, Virus Diseases, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Type I interferons in infectious disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks