Molecular and Structural Basis of DNA Sensors in Antiviral Innate Immunity

A Toll-like receptor recognizes bacterial DNA

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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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Immunogenic cell death in cancer and infectious disease

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Interferon-stimulated genes: A complex web of host defenses

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DNA methylation: roles in mammalian development

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Type I interferons in infectious disease

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

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Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

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Toll-like Receptors and the Control of Immunity

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Regulation of Adaptive Immunity by the Innate Immune System

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Mitochondrial DNA stress primes the antiviral innate immune response

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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

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STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

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DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

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cGAS surveillance of micronuclei links genome instability to innate immunity

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DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

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CGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING.

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IFI16 is an innate immune sensor for intracellular DNA

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Chromosomal instability drives metastasis through a cytosolic DNA response

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STING is a direct innate immune sensor of cyclic di-GMP

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Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

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Mitotic progression following DNA damage enables pattern recognition within micronuclei

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DNA sensing by the cGAS–STING pathway in health and disease

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Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

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Type I interferons in anticancer immunity

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Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

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Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells

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RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

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Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

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Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

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An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

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cGAS in action: Expanding roles in immunity and inflammation

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BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

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DNA-induced liquid phase condensation of cGAS activates innate immune signaling

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Programmed cell death as a defence against infection

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The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

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RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

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Structural mechanism of cytosolic DNA sensing by cGAS

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The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

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Correction: Corrigendum: Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

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Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

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The innate immune DNA Sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.

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Leucine-rich repeats and pathogen recognition in Toll-like receptors

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Immune Sensing of DNA

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Ordered Recruitment of Chromatin Modifying and General Transcription Factors to the IFN-β Promoter

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The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

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Activation of STING requires palmitoylation at the Golgi

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Mitochondria: master regulators of danger signalling

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IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

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Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9

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Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor- viral RNA interactions

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Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

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The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

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The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

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TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

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TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to <i>Mycobacterium tuberculosis</i>

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Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

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Recognition of Endogenous Nucleic Acids by the Innate Immune System

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The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

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cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders

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The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

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Toll‐like receptor 9 binds single‐stranded CpG‐DNA in a sequence‐ and pH‐dependent manner

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Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

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Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

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Herpes simplex virus type-1 induces IFN-α production via Toll-like receptor 9-dependent and -independent pathways

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Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

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DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

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Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors

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Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

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TLR9 Expression and Function Is Abolished by the Cervical Cancer-Associated Human Papillomavirus Type 16

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The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum

Srikanth, S., Woo, J. S., Wu, B., El-Sherbiny, Y. M., Leung, J., Chupradit, K., Rice, L., Seo, G. J., Calmettes, G., Ramakrishna, C., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0287-8 · Cited by 380 · see citing works

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

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DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells

Zhang, Z., Kim, T., Bao, M., Facchinetti, V., Jung, S. Y., Ghaffari, A. A., Qin, J., Cheng, G., & Liu, Y. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.027 · Cited by 376 · see citing works

Correction: Corrigendum: Antigen distribution of TMUV and GPV are coincident with the expression profiles of CD8α-positive cells and goose IFNγ

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Intracellular DNA recognition

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Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

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Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

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IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

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Inborn Error of Immunity: A Journey Through Novel Genes and Clinical Presentation

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Polymer Nanocomposites of 2D Nanomaterials for Biosensing and Imaging Applications

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Circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis: a new association

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The DAMP-Driven Host Immune Defense Program Against Pathogens

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Type I IFN expression is inhibited during cell division by CDK4/6Preprint

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Sensors of Intracellular Nucleic Acids Activating STING-Dependent Production of Interferons in Immunocompetent Cells

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Sensors of Intracellular Nucleic Acids Activating STING-Dependent Production of Interferons in Immunocompetent Cells

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Understanding the Mode of Action of Several Active Ingredients from the Micro-Immunotherapy Medicine 2LZONA®

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Role of NLRC3 in modulating inflammatory responses in neonates

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Varicellovirus bovinealpha 1 UL42 targets host IRF3 to inhibit type I interferon β production

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The DNA Vaccines for the Gn and Gc Heterologous Polymer of Severe Fever with Thrombocytopenia Syndrome Virus Induce Potent Immunogenicity in Mice

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MRE11A Regulates Sepsis Through the mtDNA/STING Pathway of T Lymphocyte ApoptosisPreprint

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Epigenetic regulation of transgenes

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Enterovirus infections in children

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The 4EHP/GIGYF2 translation repressor complex is co-opted by the vaccinia virus K3L protein as a potential mechanism of immunoevasion

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ZBP1 and IFI16: novel innate sensors and inflammation regulation under infection stress

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Stealthy lentiviral vectors: Breaking the barriers to systemic in vivo gene delivery

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Taming Mre11–Rad50 at Telomeres: Convergent Strategies for Chromosome‐End Protection Across Evolution

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The Interplay between Viruses and Host DNA Sensors

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