IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works

<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data

Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works

limma powers differential expression analyses for RNA-sequencing and microarray studies

Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829 · see citing works

Near-optimal probabilistic RNA-seq quantification

Bray, N. L., Pimentel, H., Melsted, P., & Pachter, L. (2016) · Nature Biotechnology · doi:10.1038/nbt.3519 · Cited by 9,723 · see citing works

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

Eden, E., Navon, R., Steinfeld, I., Lipson, D., & Yakhini, Z. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-48 · Cited by 3,356 · see citing works

European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease

Husby, S., Koletzko, S., Korponay‐Szabó, I. R., Mearin, M. L., Phillips, A., Shamir, R., Troncone, R., Giersiepen, K., Branski, D., Catassi, C., et al. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31821a23d0 · Cited by 2,683 · see citing works

Celiac Disease

Green, P. H. R., & Jones, R. (2006) · Cited by 2,453 · see citing works

lumi : a pipeline for processing Illumina microarray

Du, P., Kibbe, W. A., & Lin, S. M. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn224 · Cited by 2,028 · see citing works

Identification of tissue transglutaminase as the autoantigen of celiac disease

Dieterich, W., Ehnis, T., Bauer, M., Donner, P., Volta, U., Riecken, E. O., & Schuppan, D. (1997) · Nature Medicine · doi:10.1038/nm0797-797 · Cited by 2,021 · see citing works

Celiac Disease

Green, P. H. R., & Cellier, C. (2007) · New England Journal of Medicine · doi:10.1056/nejmra071600 · Cited by 1,617 · see citing works

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design

Waldmann, T. A. (2006) · Nature reviews. Immunology · doi:10.1038/nri1901 · Cited by 1,178 · see citing works

Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease

Molberg, Ø., McAdam, S. N., Körner, R., Quarsten, H., Kristiansen, C., Madsen, L. S., Fugger, L. H., Scott, H., Norén, O., Roepstorff, P., et al. (1998) · Nature Medicine · doi:10.1038/nm0698-713 · Cited by 1,166 · see citing works

Coordinated Induction by IL15 of a TCR-Independent NKG2D Signaling Pathway Converts CTL into Lymphokine-Activated Killer Cells in Celiac Disease

Meresse, B., Chen, Z., Ciszewski, C., Tretiakova, M., Bhagat, G., Krausz, T. N., Raulet, D. H., Lanier, L. L., Groh, V., Spies, T. A., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.020 · Cited by 853 · see citing works

A Direct Role for NKG2D/MICA Interaction in Villous Atrophy during Celiac Disease

Hüe, S., Mention, J., Monteiro, R. C., Zhang, S., Cellier, C., Schmitz, J., Verkarre, V., Fodil, N., Bahram, S., Cerf–Bensussan, N., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.018 · Cited by 758 · see citing works

Model-based variance-stabilizing transformation for Illumina microarray data

Lin, S. M., Du, P., Huber, W. K., & Kibbe, W. A. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkm1075 · Cited by 515 · see citing works

Integration of Genetic and Immunological Insights into a Model of Celiac Disease Pathogenesis

Abadie, V., Sollid, L. M., Barreiro, L. B., & Jabrì, B. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-040210-092915 · Cited by 512 · see citing works

Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity.

van de Wal, Y., Kooy, Y. M. C., van Veelen, P. A., Peña, S., Mearin, L., Papadopoulos, G. K., & Koning, F. (1998) · PubMed · Cited by 490 · see citing works

Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease

Nilsen, E. M., Jahnsen, F. L., Lundin, K. E. A., Johansen, F., FAUSA, O., Sollid, L. M., Jahnsen, J., Scott, H., & Brandtzaeg, P. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70134-9 · Cited by 471 · see citing works

Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease

Bouziat, R., Hinterleitner, R., Brown, J. J., Stencel-Baerenwald, J., Ikizler, M. R., Mayassi, T., Meisel, M., Kim, S. M., Discepolo, V., Pruijssers, A. J. P., et al. (2017) · Science · doi:10.1126/science.aah5298 · Cited by 447 · see citing works

Cutting Edge: Selective Deamidation by Tissue Transglutaminase Strongly Enhances Gliadin-Specific T Cell Reactivity

van de Wal, Y., Kooy, Y. M. C., van Veelen, P. A., Peña, A. S., Mearin, M. L., Papadopoulos, G. K., & Koning, F. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.4.1585 · Cited by 430 · see citing works

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens

DePaolo, R. W., Abadie, V., Tang, F., Fehlner-Peach, H., Hall, J. A., Wang, W., Marietta, E. V., Kasarda, D. D., Waldmann, T. A., Murray, J. A., et al. (2011) · Nature · doi:10.1038/nature09849 · Cited by 389 · see citing works

Reprogramming of CTLs into natural killer–like cells in celiac disease

Meresse, B., Curran, S. A., Ciszewski, C., Orbelyan, G., Setty, M., Bhagat, G., Lee, L., Tretiakova, M., Semrad, C., Kistner, E., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060028 · Cited by 322 · see citing works

IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction

Jabri, B., & Abadie, V. (2015) · Nature Reviews Immunology · doi:10.1038/nri3919 · Cited by 315 · see citing works

Tissue-mediated control of immunopathology in coeliac disease

Jabrì, B., & Sollid, L. M. (2009) · Nature reviews. Immunology · doi:10.1038/nri2670 · Cited by 305 · see citing works

High abundance of plasma cells secreting transglutaminase 2–specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions

Niro, R. D., Mesin, L., Zheng, N., Stamnæs, J., Michael, M., Lee, J.-H., Huang, M., Iversen, R., du Pré, M. F., Qiao, S., et al. (2012) · Nature Medicine · doi:10.1038/nm.2656 · Cited by 211 · see citing works

Isolation of Mouse Small Intestinal Intraepithelial Lymphocytes, Peyer's Patch, and Lamina Propria Cells

Lefrançois, L., & Lycke, N. Y. (1996) · Current Protocols in Immunology · doi:10.1002/0471142735.im0319s17 · Cited by 207 · see citing works

Mechanisms of Disease: immunopathogenesis of celiac disease

Jabrì, B., & Sollid, L. M. (2006) · Nature Clinical Practice Gastroenterology &#38 Hepatology · doi:10.1038/ncpgasthep0582 · Cited by 187 · see citing works

HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22

Bodd, M., Ráki, M., Tollefsen, S., Fallang, L.-E., Bergseng, E., Lundin, K. E. A., & Sollid, L. M. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.36 · Cited by 155 · see citing works

HLA-DQ Determines the Response to Exogenous Wheat Proteins: A Model of Gluten Sensitivity in Transgenic Knockout Mice

Black, K. E., Murray, J. A., & David, C. S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5595 · Cited by 152 · see citing works

Regulatory Sequences of the Mouse Villin Gene That Efficiently Drive Transgenic Expression in Immature and Differentiated Epithelial Cells of Small and Large Intestines

Pinto, D., Robine, S., Jaisser, F., Marjou, F. E., & Louvard, D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6476 · Cited by 134 · see citing works

Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease

Setty, M., Discepolo, V., Abadie, V., Kamhawi, S., Mayassi, T., Kent, A., Ciszewski, C., Maglio, M., Kistner, E., Bhagat, G., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.05.013 · Cited by 119 · see citing works

Interleukin-15 promotes intestinal dysbiosis with butyrate deficiency associated with increased susceptibility to colitis

Meisel, M., Mayassi, T., Fehlner-Peach, H., Koval, J., O'Brien, S. L., Hinterleitner, R., Lesko, K., Kim, S. M., Bouziat, R., Chen, L., et al. (2016) · The ISME Journal · doi:10.1038/ismej.2016.114 · Cited by 91 · see citing works

Interleukin 15 and CD4+ T Cells Cooperate to Promote Small Intestinal Enteropathy in Response to Dietary Antigen

Korneychuk, N., Ramiro‐Puig, E., Ettersperger, J., Schulthess, J., Montcuquet, N., Kiyono, H., Meresse, B., & Cerf–Bensussan, N. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.12.023 · Cited by 69 · see citing works

Association Between Celiac Disease and Cancer

Marafini, I., Monteleone, G., & Stolfi, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114155 · Cited by 67 · see citing works

Elevated Transglutaminase 2 Activity Is Associated with Hypoxia-Induced Experimental Pulmonary Hypertension in Mice

DiRaimondo, T. R., Klöck, C., Warburton, R. R., Herrera, Z., Penumatsa, K. C., Toksoz, D., Hill, N. S., Khosla, C., & Fanburg, B. L. (2013) · ACS Chemical Biology · doi:10.1021/cb4006408 · Cited by 60 · see citing works

Therapeutic approaches for celiac disease

Plugis, N. M., & Khosla, C. (2015) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2015.04.005 · Cited by 59 · see citing works

Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice

Freitag, T. L., Rietdijk, S. T., Junker, Y., Popov, Y. V., Bhan, A. K., Kelly, C. P., Terhorst, C., & Schuppan, D. (2009) · Gut · doi:10.1136/gut.2009.186361 · Cited by 59 · see citing works

Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity

Scherf, K. A., Catassi, C., Chirdo, F. G., Ciclitira, P. J., Feighery, C., Gianfrani, C., Koning, F., Lundin, K. E. A., Schuppan, D., SMULDERS, M. J. M., et al. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00029 · Cited by 58 · see citing works

Discovery of Potent and Specific Dihydroisoxazole Inhibitors of Human Transglutaminase 2

Klöck, C., Herrera, Z., Albertelli, M. A., & Khosla, C. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501145a · Cited by 55 · see citing works

An Untargeted Metabolomics Investigation of Jiulong Yak (Bos grunniens) Meat by 1H-NMR

Zhu, C., Petracci, M., Li, C., Fiore, E., & Laghi, L. (2020) · Foods · doi:10.3390/foods9040481 · Cited by 25 · see citing works

Interplay between Type 2 Transglutaminase (TG2), Gliadin Peptide 31-43 and Anti-TG2 Antibodies in Celiac Disease

Martucciello, S., Sposito, S., Esposito, C., Paolella, G., & Caputo, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103673 · Cited by 18 · see citing works

Whole exome sequencing of a Saudi family and systems biology analysis identifies CPED1 as a putative causative gene to Celiac Disease

Bokhari, H. A., Shaik, N. A., Banaganapalli, B., Nasser, K. K., Ageel, H. I., Shamrani, A. S. A., Rashidi, O. M., Ghubayshi, O. Y. A., Shaik, J. P., Ahmad, A., et al. (2020) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.04.011 · Cited by 12 · see citing works

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works

KIR ⁺ CD8 ⁺ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

Li, J., Zaslavsky, M., Su, Y., Guo, J., Sikora, M. J., van Unen, V., Christophersen, A., Chiou, S.-H., Chen, L., Li, J., et al. (2022) · Science · doi:10.1126/science.abi9591 · Cited by 249 · see citing works

A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease

Schuppan, D., Mäki, M., Lundin, K. E. A., Isola, J. J., Friesing-Sosnik, T., Taavela, J., Popp, A., Koskenpato, J., Langhorst, J., Hovde, Ø., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2032441 · Cited by 234 · see citing works

The Immunobiology and Pathogenesis of Celiac Disease

Iversen, R., & Sollid, L. M. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-032634 · Cited by 222 · see citing works

Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation

Lamas, B., Hernandez-Galan, L., Galipeau, H. J., Constante, M., Clarizio, A., Jury, J., Breyner, N. M., Caminero, A., Rueda, G., Hayes, C. L., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aba0624 · Cited by 179 · see citing works

De causis linguae latinae

Álvarez, J. V. (2004) · Revista de estudios latinos: RELat · Cited by 128 · see citing works

Current and emerging therapies for coeliac disease

Kivelä, L., Caminero, A., Leffler, D. A., Pinto-Sánchez, M. I., Tye–Din, J. A., & Lindfors, K. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00378-1 · Cited by 124 · see citing works

Gut Dysbiosis and Fecal Microbiota Transplantation in Autoimmune Diseases

Belvončíková, P., Marônek, M., & Gardlík, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810729 · Cited by 108 · see citing works

Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract

Fenneman, A. C., Weidner, M., Chen, L. A., Nieuwdorp, M., & Blaser, M. J. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00685-9 · Cited by 108 · see citing works

Immunopathogenesis and environmental triggers in coeliac disease

Levescot, A., Malamut, G., & Cerf–Bensussan, N. (2022) · Gut · doi:10.1136/gutjnl-2021-326257 · Cited by 95 · see citing works

iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies

Palasantzas, V. E. J. M., Tamargo-Rubio, I., Le, K. T. T., Slager, J., Wijmenga, C., Jonkers, I. H., Kumar, V., Fu, J., & Withoff, S. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.01.002 · Cited by 88 · see citing works

Intraepithelial Lymphocytes of the Intestine

Lockhart, A. A. K., Mucida, D., & Bilate, A. M. B. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090222-100246 · Cited by 88 · see citing works

Human organoids as 3D in vitro platforms for drug discovery: opportunities and challenges

Wang, D., Villenave, R., Stokar‐Regenscheit, N., & Clevers, H. C. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01317-y · Cited by 98 · see citing works

Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease

Pinto-Sánchez, M. I., Silvester, J. A., Lebwohl, B., Leffler, D. A., Anderson, R. P., Therrien, A., Kelly, C. P., & Verdu, E. F. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00511-8 · Cited by 109 · see citing works

Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder

Dunne, M. R., Byrne, G., Chirdo, F. G., & Feighery, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01374 · Cited by 85 · see citing works

Genome-Wide Transcriptomic Analysis of Intestinal Mucosa in Celiac Disease Patients on a Gluten-Free Diet and Postgluten Challenge

Dotsenko, V., Oittinen, M., Taavela, J., Popp, A., Peräaho, M., Staff, S. M., Sarin, J., León, F., Isola, J. J., Mäki, M., et al. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.07.010 · Cited by 77 · see citing works

A human autoimmune organoid model reveals IL-7 function in coeliac disease

Santos, A. J. M., van Unen, V., Lin, Z., Chirieleison, S. M., Ha, N., Batish, A., Chan, J. E., Cedano, J., Zhang, E., Mu, Q., et al. (2024) · Nature · doi:10.1038/s41586-024-07716-2 · Cited by 79 · see citing works

New Insights on Genes, Gluten, and Immunopathogenesis of Celiac Disease

Abadie, V., Han, A. S., Jabrì, B., & Sollid, L. M. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.03.042 · Cited by 75 · see citing works

Interplay Between Gluten, HLA, Innate and Adaptive Immunity Orchestrates the Development of Coeliac Disease

Voisine, J., & Abadie, V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.674313 · Cited by 74 · see citing works

Co-factors, Microbes, and Immunogenetics in Celiac Disease to Guide Novel Approaches for Diagnosis and Treatment

Verdu, E. F., & Schuppan, D. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.08.016 · Cited by 72 · see citing works

Association Between Celiac Disease and Cancer

Marafini, I., Monteleone, G., & Stolfi, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114155 · Cited by 67 · see citing works

Tissue transglutaminase: a multifunctional and multisite regulator in health and disease

Yao, Z., Fan, Y., Lin, L., Kellems, R. E., & Xia, Y. (2023) · Physiological Reviews · doi:10.1152/physrev.00003.2023 · Cited by 58 · see citing works

Shape morphing of hydrogels by harnessing enzyme enabled mechanoresponse

Zhang, K., Zhou, Y. J., Zhang, J., Liu, Q., Hanenberg, C., Mourran, A., Wang, X., Gao, X., Cao, Y., Herrmann, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44607-y · Cited by 58 · see citing works

Celiac Disease in Children

Jimenez, J., Loveridge‐Lenza, B., & Horváth, K. (2021) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2021.07.007 · Cited by 58 · see citing works

Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity

Scherf, K. A., Catassi, C., Chirdo, F. G., Ciclitira, P. J., Feighery, C., Gianfrani, C., Koning, F., Lundin, K. E. A., Schuppan, D., SMULDERS, M. J. M., et al. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00029 · Cited by 58 · see citing works

Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells

Olazagoitia‐Garmendia, A., Zhang, L., Mera, P., Godbout, J. K., Sebastian‐delaCruz, M., García‐Santisteban, I., Mendoza, L. M., Huerta, A., Irastorza, I., Bhagat, G., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-322566 · Cited by 52 · see citing works

The Role of Gluten in Food Products and Dietary Restriction: Exploring the Potential for Restoring Immune Tolerance

Li, Y., Zheng, W., Li, X., Han, W., Shen, J.-L., Lin, Q., Hou, L., Liao, L., & Zeng, X. (2023) · Foods · doi:10.3390/foods12224179 · Cited by 51 · see citing works

The Gluten Gene: Unlocking the Understanding of Gluten Sensitivity and Intolerance

Asri, N., Rostami‐Nejad, M., Anderson, R. P., & Rostami, K. (2021) · The Application of Clinical Genetics · doi:10.2147/tacg.s276596 · Cited by 53 · see citing works

New Developments in Celiac Disease Treatment

Machado, M. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020945 · Cited by 52 · see citing works

Pivotal Role of Inflammation in Celiac Disease

Barone, M. V., Auricchio, R., Nanayakkara, M., Greco, L., Troncone, R., & Auricchio, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137177 · Cited by 47 · see citing works

An efficient urine peptidomics workflow identifies chemically defined dietary gluten peptides from patients with celiac disease

Palanski, B. A., Weng, N., Zhang, L., Hilmer, A. J., Fall, L. A., Swaminathan, K., Jabrì, B., Sousa, C., Fernandez‐Becker, N., Khosla, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28353-1 · Cited by 45 · see citing works

Dynamics of the gut microbiome, IgA response, and plasma metabolome in the development of pediatric celiac disease

Girdhar, K., Dogru, Y. D., Huang, Q., Yang, Y., Tolstikov, V., Raisingani, A., Chrudinová, M., Oh, J., Kelley, K., Ludvigsson, J. F., et al. (2023) · Microbiome · doi:10.1186/s40168-022-01429-2 · Cited by 45 · see citing works

Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease

Kornberg, A. E., Botella, T., Moon, C. S., Rao, S., Gelbs, J., Cheng, L., Miller, J. D., Baccarella, A., Garcia‐Vilas, J. A., Vargas, J., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.adf4312 · Cited by 45 · see citing works

Substrates, inhibitors, and probes of mammalian transglutaminase 2

Zhuang, R., & Khosla, C. (2019) · Analytical Biochemistry · doi:10.1016/j.ab.2019.113560 · Cited by 44 · see citing works

Celiac disease: mechanisms and emerging therapeutics

Besser, H. A., & Khosla, C. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.09.006 · Cited by 47 · see citing works

Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells

Lockhart, A. A. K., Reed, A. C., Castro, T. B. R., Herman, C., Canesso, M. C. C., & Mucida, D. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221816 · Cited by 40 · see citing works

How Future Pharmacologic Therapies for Celiac Disease Will Complement the Gluten-Free Diet

Discepolo, V., Kelly, C. P., Koning, F., & Schuppan, D. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.02.050 · Cited by 39 · see citing works

Epigenetics in autoimmune diseases: Unraveling the hidden regulators of immune dysregulation

Bagni, G., Biancalana, E., Chiara, E., Costanzo, I., Malandrino, D., Lastraioli, E., Palmerini, M., Silvestri, E., Urban, M. L., & Emmi, G. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103784 · Cited by 39 · see citing works

Gluten-Dependent Activation of CD4+ T Cells by MHC Class II–Expressing Epithelium

Rahmani, S., Galipeau, H. J., Clarizio, A. V., Wang, X., Hann, A., Rueda, G. H., Kirtikar, U., Constante, M., Wulczynski, M., Su, H., et al. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.07.008 · Cited by 38 · see citing works

Autologous organoid co-culture model reveals T cell-driven epithelial cell death in Crohn’s Disease

Hammoudi, N., Hamoudi, S., Bonnereau, J., Bottois, H., Pérez, K., Bezault, M., Hassid, D., Chardiny, V., Grand, C., Gergaud, B., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1008456 · Cited by 37 · see citing works

GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology

Earley, Z. M., Lisicka, W., Sifakis, J. J., Aguirre‐Gamboa, R., Kowalczyk, A., Barlow, J. T., Shaw, D. G., Discepolo, V., Tan, I. L., Gona, S., et al. (2023) · Immunity · doi:10.1016/j.immuni.2022.12.009 · Cited by 37 · see citing works

The gliadin p31–43 peptide: Inducer of multiple proinflammatory effects

Chirdo, F. G., Auricchio, S., Troncone, R., & Barone, M. V. (2020) · International review of cytology · doi:10.1016/bs.ircmb.2020.10.003 · Cited by 34 · see citing works

IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes

James, O. J., Vandereyken, M., Marchingo, J. M., Singh, F., Bray, S. E., Wilson, J., Love, A. G., & Swamy, M. (2021) · Nature Communications · doi:10.1038/s41467-021-24473-2 · Cited by 33 · see citing works

Type 2 Transglutaminase in Coeliac Disease: A Key Player in Pathogenesis, Diagnosis and Therapy

Paolella, G., Sposito, S., Romanelli, A. M., & Caputo, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147513 · Cited by 34 · see citing works

Autoimmunity provoked by foreign antigens

Iversen, R., & Sollid, L. M. (2020) · Science · doi:10.1126/science.aay3037 · Cited by 32 · see citing works

Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease

Perez, F., Ruera, C. N., Miculán, E., Carasi, P., & Chirdo, F. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147426 · Cited by 33 · see citing works

Inflammatory response in traumatic brain and spinal cord injury: The role of <scp>XCL</scp>1‐<scp>XCR</scp>1 axis and T cells

Zhang, M., Han, X., Yan, L., Fu, Y., Kou, H., Shang, C., Wang, J., Liu, H., Jiang, C., Wang, J., et al. (2024) · CNS Neuroscience &amp; Therapeutics · doi:10.1111/cns.14781 · Cited by 32 · see citing works

B Lymphocytes Contribute to Celiac Disease Pathogenesis

Lejeune, T., Meyer, C., & Abadie, V. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.02.063 · Cited by 29 · see citing works

Exploring celiac disease candidate pathways by global gene expression profiling and gene network cluster analysis

Banaganapalli, B., Mansour, H., Mohammed, A., Alharthi, A. M., Aljuaid, N. M., Nasser, K. K., Ahmad, A., Saadah, O. I., Al-Aama, J. Y., Elango, R., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-73288-6 · Cited by 28 · see citing works

An updated overview on celiac disease: from immuno-pathogenesis and immuno-genetics to therapeutic implications

D’Avino, P., Serena, G., Kenyon, V., & Fasano, A. (2021) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1880320 · Cited by 29 · see citing works

The double-edged sword of gut bacteria in celiac disease and implications for therapeutic potential

Galipeau, H. J., & Verdu, E. F. (2022) · Mucosal Immunology · doi:10.1038/s41385-021-00479-3 · Cited by 30 · see citing works

The implications of IL-15 trans-presentation on the immune response

Waldmann, T. A., WALDMANN, R. J., Lin, J., & Leonard, W. J. (2022) · Advances in immunology · doi:10.1016/bs.ai.2022.09.002 · Cited by 25 · see citing works

Non-Host Factors Influencing Onset and Severity of Celiac Disease

Galipeau, H. J., Hinterleitner, R., Leonard, M. M., & Caminero, A. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.01.030 · Cited by 28 · see citing works

An Untargeted Metabolomics Investigation of Jiulong Yak (Bos grunniens) Meat by 1H-NMR

Zhu, C., Petracci, M., Li, C., Fiore, E., & Laghi, L. (2020) · Foods · doi:10.3390/foods9040481 · Cited by 25 · see citing works

Celiac Disease: Beyond Diet and Food Awareness

Herrera‐Quintana, L., Navajas-Porras, B., Vázquez‐Lorente, H., Hinojosa-Nogueira, D., Corrales-Borrego, F. J., López-Garzón, M., & Plaza‐Díaz, J. (2025) · Foods · doi:10.3390/foods14030377 · Cited by 26 · see citing works

How the Microbiota May Affect Celiac Disease and What We Can Do

Matera, M., & Guandalini, S. (2024) · Nutrients · doi:10.3390/nu16121882 · Cited by 23 · see citing works

Elevated inflammatory fecal immune factors in men who have sex with men with HIV associate with microbiome composition and gut barrier function

Littlefield, K. M., Schneider, J. M., Neff, C. P., Soesanto, V., Siebert, J., Nusbacher, N. M., Moreno-Huizar, N., Cartwright, I. M., Armstrong, A. J. S., Colgen, S. P., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1072720 · Cited by 21 · see citing works

Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis

Lisicka, W., Earley, Z. M., Sifakis, J. J., Erickson, S. A., Mattingly, J. R., Wu-Woods, N. J., Krishnamurthy, S. R., Belkaid, Y., Ismagilov, R. F., Cyster, J. G., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.03.004 · Cited by 20 · see citing works

Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease

FitzPatrick, M. E. B., Antanaviciute, A., Dunstan, M. L., Künnapuu, K., Trzupek, D., Provine, N. M., Dooley, K., Zhang, J., Irwin, S. L., Garner, L. C., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02146-2 · Cited by 22 · see citing works

The Nutritional Intervention of Resveratrol Can Effectively Alleviate the Intestinal Inflammation Associated With Celiac Disease Induced by Wheat Gluten

Tian, Y., Xie, Y., Yuan, J., Gao, J., Xiao, Z., Wu, Y., & Chen, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.878186 · Cited by 20 · see citing works

Review article: Diagnosis of coeliac disease: a perspective on current and future approaches

Anderson, R. P. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16840 · Cited by 21 · see citing works

Nutritional Deficiencies in Celiac Disease: Current Perspectives

Verma, A. K. (2021) · Nutrients · doi:10.3390/nu13124476 · Cited by 19 · see citing works

Regulatory CD8 + T cells suppress disease

Levescot, A., & Cerf–Bensussan, N. (2022) · Science · doi:10.1126/science.abp8243 · Cited by 19 · see citing works

Tolerance-inducing therapies in coeliac disease — mechanisms, progress and future directions

Sollid, L. M. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00895-3 · Cited by 19 · see citing works

New developments in celiac disease treatments

Buriánek, F., Gege, C., & Marinković, P. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.104113 · Cited by 18 · see citing works

Human gut M cells resemble dendritic cells and present gluten antigen

Wang, D., Lim, S., van de Wetering, W. J., López‐Iglesias, C., Okura, Y., Teranishi-Ikawa, Y., Mizoroki, A., Spoelstra, W. K., Dayton, T. L., van Son, G. J. F., et al. (2025) · Nature · doi:10.1038/s41586-025-09829-8 · Cited by 18 · see citing works

Advances in quantification and analysis of the celiac‐related immunogenic potential of gluten

Ribeiro, M., de Sousa, T., Sabença, C., Poeta, P. A. C. Q. D., Bagulho, A. S., & Igrejas, G. (2021) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12828 · Cited by 18 · see citing works

LRP-1 links post-translational modifications to efficient presentation of celiac disease-specific T cell antigens

Loppinet, E., Besser, H. A., Sewa, A. S., Yang, F.-C., Jabrì, B., & Khosla, C. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2022.12.002 · Cited by 19 · see citing works

Assessing the Prevalence of HLA-DQ2 and HLA-DQ8 in Lipedema Patients and the Potential Benefits of a Gluten-Free Diet

Amato, A. C. M., Amato, L. L., Benitti, D. A., & Amato, J. L. S. (2023) · Cureus · doi:10.7759/cureus.41594 · Cited by 18 · see citing works

The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes

Yomogida, K., Tršan, T., Sudan, R., Rodrigues, P. F., Antonova, A. U., Ingle, H., Luccia, B. D., Collins, P. L., Cella, M., Gilfillan, S., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01693-w · Cited by 18 · see citing works

Interplay between Type 2 Transglutaminase (TG2), Gliadin Peptide 31-43 and Anti-TG2 Antibodies in Celiac Disease

Martucciello, S., Sposito, S., Esposito, C., Paolella, G., & Caputo, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103673 · Cited by 18 · see citing works

The use of peripheral blood mononuclear cells in celiac disease diagnosis and treatment

Kurki, A., Kemppainen, E., Laurikka, P., Kaukinen, K., & Lindfors, K. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2021.1850262 · Cited by 18 · see citing works

Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state

Sewa, A. S., Besser, H. A., Mathews, I. I., & Khosla, C. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2407066121 · Cited by 17 · see citing works

Advances in the pathophysiology, diagnosis, and management of celiac disease

Doyle, J. B., Silvester, J. A., Ludvigsson, J. F., & Lebwohl, B. (2025) · BMJ · doi:10.1136/bmj-2024-081353 · Cited by 19 · see citing works

A Combined mRNA- and miRNA-Sequencing Approach Reveals miRNAs as Potential Regulators of the Small Intestinal Transcriptome in Celiac Disease

Tan, I. L., Barisani, D., Panceri, R., Modderman, R., Visschedijk, M. C., Weersma, R. K., Wijmenga, C., Jonkers, I. H., de Almeida, R. C., & Withoff, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111382 · Cited by 17 · see citing works

Selective Targeting of IL-15Rα Is Sufficient to Reduce Inflammation

Meghnem, D., Maillasson, M., Barbieux, I., Morisseau, S., Keita, D., Jacques, Y., Quéméner, A., & Mortier, E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.886213 · Cited by 16 · see citing works

Innate Lymphoid Cells and Celiac Disease: Current Perspective

Yu, X. B., Vargas, J., Green, P. H. R., & Bhagat, G. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.12.002 · Cited by 16 · see citing works

Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease

Lindeman, I., Høydahl, L. S., Christophersen, A. O., Risnes, L. F., Jahnsen, J., Lundin, K. E. A., Sollid, L. M., & Iversen, R. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114045 · Cited by 16 · see citing works

Pharmacological targeting of the JAK–STAT pathway: new concepts and emerging indications

Haikarainen, T., Virtanen, A. T., Cravatt, B. F., & Silvennoinen, O. (2026) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01336-9 · Cited by 17 · see citing works

Novel Drug Therapeutics in Celiac Disease: A Pipeline Review

Varma, S., & Krishnareddy, S. (2022) · Drugs · doi:10.1007/s40265-022-01784-2 · Cited by 14 · see citing works

A Snapshot of Cytokine Dynamics: A Fine Balance Between Health and Disease

Mallick, S., Duttaroy, A. K., & Bose, B. (2024) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30680 · Cited by 15 · see citing works

A Mouse Model of Celiac Disease

Abadie, V., Khosla, C., & Jabrì, B. (2022) · Current Protocols · doi:10.1002/cpz1.515 · Cited by 14 · see citing works

Emergence of an adaptive immune paradigm to explain celiac disease: a perspective on new evidence and implications for future interventions and diagnosis

Anderson, R. P. (2021) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.2006636 · Cited by 13 · see citing works

Sterile inflammation drives multiple programmed cell death pathways in the gut

Ruera, C. N., Miculán, E., Pérez, F., Ducca, G., Carasi, P., & Chirdo, F. G. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ma0820-660r · Cited by 13 · see citing works

Co-Silencing of Tissue Transglutaminase-2 and Interleukin-15 Genes in a Celiac Disease Mimetic Mouse Model Using a Nanoparticle-in-Microsphere Oral System

Attarwala, H. Z., Suri, K., & Amiji, M. M. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00322 · Cited by 13 · see citing works

TG6 Auto-Antibodies in Dermatitis Herpetiformis

Hadjivassiliou, M., Reunala, T. L., Hervonen, K., Aeschlimann, P. C., & Aeschlimann, D. P. (2020) · Nutrients · doi:10.3390/nu12092884 · Cited by 12 · see citing works

Wheat Amylase Trypsin Inhibitors Aggravate Intestinal Inflammation Associated with Celiac Disease Mediated by Gliadin in BALB/c Mice

Tian, Y., Hu, S., Min, F., Li, J., Shen, Y., Yuan, J., Gao, J., Wu, Y., & Chen, H. (2022) · Foods · doi:10.3390/foods11111559 · Cited by 12 · see citing works

Whole exome sequencing of a Saudi family and systems biology analysis identifies CPED1 as a putative causative gene to Celiac Disease

Bokhari, H. A., Shaik, N. A., Banaganapalli, B., Nasser, K. K., Ageel, H. I., Shamrani, A. S. A., Rashidi, O. M., Ghubayshi, O. Y. A., Shaik, J. P., Ahmad, A., et al. (2020) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.04.011 · Cited by 12 · see citing works

Intraepithelial Lymphogram in the Diagnosis of Celiac Disease in Adult Patients: A Validation Cohort

García‐Hoz, C., Crespo, L., Pariente, R., Andrés, A. D., Rodríguez-Ramos, R., & Roy, G. (2024) · Nutrients · doi:10.3390/nu16081117 · Cited by 13 · see citing works

Targeting γc family cytokines with biologics: current status and future prospects

Bick, F., Blanchetot, C., Lambrecht, B. N., & Schuijs, M. J. (2025) · mAbs · doi:10.1080/19420862.2025.2468312 · Cited by 12 · see citing works

Innate and adaptive immunity in celiac disease

Anderson, R. P. (2020) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000672 · Cited by 11 · see citing works

Functional implications of the CpG island methylation in the pathogenesis of celiac disease

Ghosh, S., Khetarpal, P., & Senapati, S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07585-w · Cited by 11 · see citing works

Translation of cell therapies to treat autoimmune disorders

Mehta, J. M., Hiremath, S. C., Chilimba, C., Ghasemi, A., & Weaver, J. D. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115161 · Cited by 11 · see citing works

The expression levels of CHI3L1 and IL15Rα correlate with TGM2 in duodenum biopsies of patients with celiac disease

Catrogiovanni, P., Musumeci, G., Giunta, S., Imbesi, R., & Rosa, M. D. (2020) · Inflammation Research · doi:10.1007/s00011-020-01371-9 · Cited by 11 · see citing works

Celiac disease: Hope for new treatments beyond a gluten-free diet

D’heedene, M., Vanuytsel, T., & Wauters, L. I. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.04.014 · Cited by 11 · see citing works

Interferon-gamma induces epithelial reprogramming driving CXCL11-mediated T-cell migration

Cutilli, A., Jansen, S. A., Paolucci, F., van Hoesel, M., Frederiks, C. L., Mulder, T. A. M., Chalkiadakis, T., Mokrý, M., Preković, S., Mocholí, E., et al. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae205 · Cited by 10 · see citing works

Celiac Disease: A Transitional Point of View

Aitella, E., Cozzolino, D., Ginaldi, L., & Romano, C. P. (2025) · Nutrients · doi:10.3390/nu17020234 · Cited by 11 · see citing works

Host immune interactions in chronic inflammatory gastrointestinal conditions

Caminero, A., & Pinto-Sánchez, M. I. (2020) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000673 · Cited by 10 · see citing works

Evaluating the Potential of Casein Glycomacropeptide in Adult Irritable Bowel Syndrome Management: A Pilot Study

Qu, Y., Park, S. H., & Dallas, D. C. (2023) · Nutrients · doi:10.3390/nu15194174 · Cited by 10 · see citing works

A long journey to the colon: The role of the small intestine microbiota in intestinal disease

Shealy, N. G., Baltagulov, M., & Byndloss, M. X. (2024) · Molecular Microbiology · doi:10.1111/mmi.15270 · Cited by 10 · see citing works

Mimicking coeliac disease in mice

Ray, K. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0285-9

Concerns about the histological assessment in a mouse model of human celiac disease

Freitag, T. L., Andersson, L. C., & Kipar, A. (2024) · Scandinavian Journal of Immunology · doi:10.1111/sji.13351

Tissue Stress and Posttranslational Modifications of Gluten Drive the Development of Tissue Destruction in Celiac Disease

Kim, S. M. (2019) · Knowledge@UChicago (University of Chicago) · doi:10.6082/b5ms9-75448

Ein Mausmodell bildet die komplexe Interaktion zwischen Immunologie, Genetik und Gluten bei der Sprue exakt ab!

Reinshagen, M. (2020) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1186-3792

Interleukin-15, a Master Piece in the Immunological Jigsaw of Celiac Disease

Meresse, B., Korneychuk, N., Malamut, G., & Cerf–Bensussan, N. (2015) · Digestive Diseases · doi:10.1159/000369521 · Cited by 40 · see citing works