Cited by 134T-cell and B-cell ImmunologyImmune Response and InflammationImmunotherapy and Immune Responses

Significance of bystander T cell activation in microbial infection

Lee, Hoyoung, Jeong, Seongju, Shin, Eui-Cheol·2022·Nature Immunology

Abstract

During microbial infection, pre-existing memory CD8+ T cells that are not specific for the infecting pathogens can be activated by cytokines without cognate antigens, termed bystander activation. Studies in mouse models and human patients demonstrate bystander activation of memory CD8+ T cells, which exerts either protective or detrimental effects on the host, depending on the infection model or disease. Research has elucidated mechanisms underlying the bystander activation of CD8+ T cells in terms of the responsible cytokines and the effector mechanisms of bystander-activated CD8+ T cells. In this Review, we describe the history of research on bystander CD8+ T cell activation as well as evidence of bystander activation. We also discuss the mechanisms and immunopathological roles of bystander activation in various microbial infections.

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Crossref · 10.1038/s41590-021-00985-3

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  • All skin-resident T cells are pre-activated T cells with effector/memory-like phenotypes, which could be activated in an innate fashion by alterations of molecular cues of the local tissue they reside in.

    “All skin-resident T cells are pre-activated T cells with effector/memory-like phenotypes, which could be activated in an innate fashion by alterations of molecular cues of the local tissue they reside in.26,27,28,29,30,31,32”

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Authors
Lee, H., Jeong, S., & Shin, E.-C.
Affiliations
Korea Advanced Institute of Science and Technology (KR)
Corresponding author
Shin, Eui-Cheol
Venue
Nature Immunology
Published
2021-08-05
Volume
23
Issue
1
Pages
13-22
ISSN
  • 1529-2908 (ISSN-L)
  • 1529-2916
OpenAlex
W3189438345
Cited by
134
References
139
Citations by year
2026: 22 · 2025: 25 · 2024: 38 · 2023: 32 · 2022: 15 · 2021: 2
FWCI
2.23
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Samsung Science and Technology Foundation
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
bystander T cell activation, memory CD8+ T cells, microbial infection, immunopathology
MeSH terms
Animals, Antigens, Humans, Immunologic Memory, Inflammation, Lymphocyte Activation, Cytokines, CD8-Positive T-Lymphocytes, Bystander Effect, Microbiota

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