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Chemokines: agents for the immunotherapy of cancer?
Abstract
Chemokines, a superfamily of small cytokine-like molecules, regulate leukocyte transport in the body. In recent years, we have witnessed the transition of immunotherapeutic strategies from the laboratory to the bedside. Here, we review the role of chemokines in tumour biology and the development of the host's anti-tumour defence. We summarize the current knowledge of chemokine-receptor expression by relevant cellular components of the immune system and the role of their ligands in the organization of the antitumour immune response. Finally, we discuss recent findings which indicate that chemokines have therapeutic potential as adjuvants or treatments in antitumour immunotherapy, as well as remaining questions and perspectives for translating experimental evidence into clinical practice.
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“VEGF-A in turn upregulates CXCR4 on endothelial cells7.”
From Inflammation and cancer (2002) · cites this paper as [7]
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“In contrast, stromal-cell-derived factor 1 (SDF-1/CXCL12) induces endothelial expression of VEGF-A;”
From Inflammation and cancer (2002) · cites this paper as [7]
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Metadata
- Authors
- Homey, B., Müller, A., & Zlotnik, A.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Corresponding author
- Homey, Bernhard
- Venue
- Nature Reviews Immunology
- Published
- 2002-03
- Volume
- 2
- Issue
- 3
- Pages
- 175-184
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2095354110
- Cited by
- 398
- References
- 88
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 7 · 2020: 14 · 2019: 10 · 2018: 9 · 2017: 18 · 2016: 17 · 2015: 17 · 2014: 16 · 2013: 12 · 2012: 16
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- chemokines, chemokine receptors, cancer immunotherapy, antitumor immunity, tumor biology, leukocyte migration, clinical translation
- MeSH terms
- Animals, Humans, Immunotherapy, Neoplasm Metastasis, Neoplasms, Cytokines, Chemokines
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