Chemokines: agents for the immunotherapy of cancer?

Dendritic cells and the control of immunity

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Inflammation and cancer: back to Virchow?

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Involvement of chemokine receptors in breast cancer metastasis

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Chemokines

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The microenvironment of the tumour–host interface

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Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

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A chemokine-driven positive feedback loop organizes lymphoid follicles

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Inflammation and cancer

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The senescence-associated secretory phenotype: the dark side of tumor suppression

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Dissemination and growth of cancer cells in metastatic sites

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Cancer and the chemokine network

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Chemokines in the cancer microenvironment and their relevance in cancer immunotherapy

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Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis

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Lymphangiogenesis and cancer metastasis

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Macrophage inflammatory protein-1

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An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Receptor for Platelet Factor 4

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CXCR4–SDF-1 Signalling, Locomotion, Chemotaxis and Adhesion

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Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells

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Senescent cells as a source of inflammatory factors for tumor progression

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Cancer Immunotherapy: A Treatment for the Masses

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Axis of evil: molecular mechanisms of cancer metastasis

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Redirecting In vivo Elicited Tumor Infiltrating Macrophages and Dendritic Cells towards Tumor Rejection

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NF-κB, chemokine gene transcription and tumour growth

Richmond, A. J. (2002) · Nature reviews. Immunology · doi:10.1038/nri887 · Cited by 523

Cancer as a robust system: implications for anticancer therapy

Kitano, H. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1300 · Cited by 456

Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression

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The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression

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CXC chemokines: the regulatory link between inflammation and angiogenesis

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CXCR4 Is a Major Chemokine Receptor on Glioma Cells and Mediates Their Survival

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Increased Survival, Proliferation, and Migration in Metastatic Human Pancreatic Tumor Cells Expressing Functional CXCR4

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The New Era of Cancer Immunotherapy: Targeting Myeloid-Derived Suppressor Cells to Overcome Immune Evasion

Cicco, P. D., Ercolano, G., & Ianaro, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01680 · Cited by 341

Immunotherapy and tumor microenvironment

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Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment

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CXCR3 Ligands in Cancer and Autoimmunity, Chemoattraction of Effector T Cells, and Beyond

Karin, N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00976 · Cited by 285

CXCL8/IL‐8 and CXCL12/SDF‐1α co‐operatively promote invasiveness and angiogenesis in pancreatic cancer

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Blockade of the EGF Receptor Induces a Deranged Chemokine Expression in Keratinocytes Leading to Enhanced Skin Inflammation

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Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis

Robben, P. M., LaRegina, M. C., Kuziel, W. A., & Sibley, L. D. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050054 · Cited by 277

Role of Chemokines and Chemokine Receptors in Shaping the Effector Phase of the Antitumor Immune Response

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Smart Injectable Hydrogels for Cancer Immunotherapy

Chao, Y., Chen, Q., & Liu, Z. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201902785 · Cited by 274

Lymphatic or Hematogenous Dissemination: How Does a Metastatic Tumor Cell Decide?

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The natural course of cutaneous melanoma

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Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors

Muller, A. J., & Scherle, P. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1929 · Cited by 266

Organ selectivity in metastasis: regulation by chemokines and their receptors

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Epithelial-Mesenchymal Transition Induced by Senescent Fibroblasts

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The chemokine system – a major regulator of angiogenesis in health and disease

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Hyperplastic gastric tumors induced by activated macrophages in COX‐2/mPGES‐1 transgenic mice

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BRAK/CXCL14 Is a Potent Inhibitor of Angiogenesis and a Chemotactic Factor for Immature Dendritic Cells

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Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells

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Tumor-Derived Chemokine CCL5 Enhances TGF-β–Mediated Killing of CD8+ T Cells in Colon Cancer by T-Regulatory Cells

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Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response

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Gene expression profiling in follicular lymphoma to assess clinical aggressiveness and to guide the choice of treatment

Glas, A. M. (2004) · Blood · doi:10.1182/blood-2004-06-2298 · Cited by 226

Chemokines beyond chemo-attraction: CXCL10 and its significant role in cancer and autoimmunity

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The multiple faces of CXCL12 (SDF-1α) in the regulation of immunity during health and disease

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Chemokine receptor CXCR4 and early-stage non-small cell lung cancer: pattern of expression and correlation with outcome

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Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC

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CCR5+ Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions

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Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion

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CXCL12 (SDF-1α) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells

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NK- and B-Cell Infiltration Correlates With Worse Outcome in Metastatic Ovarian Carcinoma

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Rosacea: the Cytokine and Chemokine Network

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Supernatural T cells: genetic modification of T cells for cancer therapy

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Chemokines as adjuvants for immunotherapy: implications for immune activation with CCL3

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Physical plasma-treated saline promotes an immunogenic phenotype in CT26 colon cancer cells in vitro and in vivo

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The chemokine CCL20 and its receptor CCR6 in human malignancy with focus on colorectal cancer

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Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis

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Protein Nanocapsule Weaved with Enzymatically Degradable Polymeric Network

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CCR5 Expression Influences the Progression of Human Breast Cancer in a p53-dependent Manner

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Targeting myeloid-derived suppressor cells to enhance natural killer cell-based immunotherapy

Joshi, S., & Sharabi, A. B. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108114 · Cited by 143

Stromal Cell-Derived Factor-1α Promotes Melanoma Cell Invasion across Basement Membranes Involving Stimulation of Membrane-Type 1 Matrix Metalloproteinase and Rho GTPase Activities

Bartolomé, R. A., Gálvez, B. G., Longo, N., Baleux, F., van Muijen, G. N. P., Sánchez‐Mateos, P., Arroyo, A. G., & Teixidó, J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3398 · Cited by 137

Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies

Quail, D. F., & Joyce, J. A. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0133 · Cited by 135

The CXCR3 Targeting Chemokine CXCL11 Has Potent Antitumor Activity In Vivo Involving Attraction of CD8+ T Lymphocytes But Not Inhibition of Angiogenesis

Hensbergen, P. J., Wijnands, P. G. J. T. B., Schreurs, M. W. J., Scheper, R. J., Willemze, R., & Tensen, C. P. (2005) · Journal of Immunotherapy · doi:10.1097/01.cji.0000165355.26795.27 · Cited by 135

Tumor immune escape by the loss of homeostatic chemokine expression

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Blocking Programmed Death-1 Ligand-PD-1 Interactions by Local Gene Therapy Results in Enhancement of Antitumor Effect of Secondary Lymphoid Tissue Chemokine

He, Y., Zhang, G., Wang, X., Zhang, H., Yuan, Y., Li, D., & Feng, Z. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.8.4919 · Cited by 125

CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway

Rousseau, S., Dolado, I., Beardmore, V. A., Shpiro, N., Márquez, R., Nebreda, Á. R., Arthur, J. S. C., Case, L. C., Tessier‐Lavigne, M., Gaestel, M., et al. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.02.006 · Cited by 124

DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade

Chew, G.-L., Campbell, A. E., Neef, E. D., Sutliff, N. A., Shadle, S. C., Tapscott, S. J., & Bradley, R. K. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.06.011 · Cited by 132

PKB/Akt-dependent regulation of inflammation in cancer

Tang, F., Wang, Y., Hemmings, B. A., Rüegg, C., & Xue, G. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.04.018 · Cited by 120

Fractalkine mediates natural killer-dependent antitumor responses in vivo.

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The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It

Armstrong, H., Bording‐Jorgensen, M., Dijk, S., & Wine, E. (2018) · Cancers · doi:10.3390/cancers10030083 · Cited by 122

Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice

Beider, K., Nagler, A., Wald, O., Franitza, S., Dagan‐Berger, M., Wald, H., Giladi, H., Brocke, S., Hanna, J. H., Mandelboim, O., et al. (2003) · Blood · doi:10.1182/blood-2002-10-3293 · Cited by 117

Immune restoration following hematopoietic stem cell transplantation: an evolving target

Auletta, J. J., & Lazarus, H. M. (2005) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704966 · Cited by 117

Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant

Wan, T. Y., Zhou, X., Chen, G., An, H., Chen, T., Zhang, W., Liu, S., Jiang, Y., Yang, F., Wu, Y., et al. (2003) · Blood · doi:10.1182/blood-2003-08-2828 · Cited by 115

Soluble Mediators of Inflammation During Tumor Development

Robinson, S. C., & Coussens, L. M. (2005) · Advances in cancer research · doi:10.1016/s0065-230x(05)93005-4 · Cited by 112

The Innate Immune System Is Activated by Stimulation of Vaginal Epithelial Cells withStaphylococcus aureusand Toxic Shock Syndrome Toxin 1

Peterson, M. L., Ault, K. A., Kremer, M. J., Klingelhutz, A. J., Davis, C., Squier, C. A., & Schlievert, P. M. (2005) · Infection and Immunity · doi:10.1128/iai.73.4.2164-2174.2005 · Cited by 108

Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal

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Favorable prognosis of renal cell carcinoma with increased expression of chemokines associated with a Th1‐type immune response

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Regulation and biological functions of the CX3CL1-CX3CR1 axis and its relevance in solid cancer: A mini-review

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Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer

Leung, S. Y., Yuen, S. T., Chu, K., Mathy, J. A., Li, R., Chan, A. S. Y., Law, S. Y.-K., Wong, J., Chen, X., & So, S. K. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.031 · Cited by 104

Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression

Yang, X., Lu, P., Fujii, C., Nakamoto, Y., Gao, J., Kaneko, S., Murphy, P. M., & Mukaida, N. (2005) · International Journal of Cancer · doi:10.1002/ijc.21596 · Cited by 99

Chemokine Receptor-Specific Antibodies in Cancer Immunotherapy: Achievements and Challenges

Vela, M., Aris, M., Llorente, M., García‐Sanz, J. A., & Kremer, L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00012 · Cited by 101

Characterization of an adaptive immune response in microsatellite-instable colorectal cancer

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Cathepsin D Specifically Cleaves the Chemokines Macrophage Inflammatory Protein-1α, Macrophage Inflammatory Protein-1β, and SLC That Are Expressed in Human Breast Cancer

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Regulation of Blastocyst Migration, Apposition, and Initial Adhesion by a Chemokine, Interferon γ-inducible Protein 10 kDa (IP-10), during Early Gestation

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