Cited by 45Chemokine receptors and signalingProstate Cancer Treatment and ResearchProtease and Inhibitor Mechanisms

Role of chemokines and chemokine receptors in prostate cancer development and progression.

Open access
Singh, Rajendra K, Sudhakar, Akulapalli, Lokeshwar, Bal L·2010·Journal of Cancer Science & Therapy

Abstract

Prostate cancer (PC) is the second leading cause of cancer deaths in men in America and Western Europe. Epidemiological studies suggest that prostate cancer incidences increased in last few years in Asian. The causes or consequences of increasing trend of prostate cancer incidence are not completely known. Emerging evidences suggest that among the many risk factors, inflammation is the major risk factor for developing prostate cancer and its progression to metastasis. It is proposed that exposure to environmental factors such as infectious agents, dietary agents and saturated lipids leads to injury of the prostate due to chronic inflammation and regenerative risk factor lesions referred to as proliferative inflammatory atrophy (PIA). These phenomena predominantly control by a number of proinflammatory macro molecules such as chemokines, and their receptors. Some recent studies suggest that many of these pro-inflammatory chemokines and their receptors are the products of protooncogenes in many cancers including that of the prostate. This review will focus on the current biology of chemokines and chemokine receptors in prostate cancer. An understanding of this axis may enable researchers to develop targeted strategies for prostate cancer.

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Crossref · 10.4172/1948-5956.1000030

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  • Chronic local inflammation in the prostate (proliferative inflammatory atrophy) can promote up-regulation of inflammatory signaling factors that can drive the development and progression of prostate tumors.

    “Chronic local inflammation in the prostate (proliferative inflammatory atrophy) can promote up-regulation of inflammatory signaling factors that can drive the development and progression of prostate tumors.”

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  1. Koukourakis G, Kelekis N, Armonis V, Kouloulias V (2009) Brachytherapy for prostatecancer: a systematic review. Adv Urol 2009: 327945.

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Authors
Singh, R. K., Sudhakar, A., & Lokeshwar, B. L.
Affiliations
  • University of Miami (US)
  • Creighton University (US)
  • United States Department of Veterans Affairs (US)
Venue
Journal of Cancer Science & Therapy
Published
2010
Volume
02
Issue
04
Pages
89-94
ISSN
1948-5956 (ISSN-L)
OpenAlex
W2045135900
Cited by
45
References
81
Citations by year
2024: 1 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 9 · 2014: 1 · 2013: 9 · 2012: 4
FWCI
3.96
Type
journal article
Language
en
Open access
Locations
  • Journal of Cancer Science & Therapy (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Flight Attendant Medical Research Institute
  • National Cancer Institute (R01CA143128)
Topics
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords
prostate cancer, chemokines, chemokine receptors, tumor progression, inflammation, proliferative inflammatory atrophy, metastasis, proto-oncogenes, risk factors, targeted therapy

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