Cited by 398Chemokine receptors and signalingCancer Immunotherapy and BiomarkersImmune cells in cancer

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Chemokines: agents for the immunotherapy of cancer?

Homey, Bernhard, Müller, Anja, Zlotnik, Albert·2002·Nature Reviews Immunology

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Abstract

Chemokines, a superfamily of small cytokine-like molecules, regulate leukocyte transport in the body. In recent years, we have witnessed the transition of immunotherapeutic strategies from the laboratory to the bedside. Here, we review the role of chemokines in tumour biology and the development of the host's anti-tumour defence. We summarize the current knowledge of chemokine-receptor expression by relevant cellular components of the immune system and the role of their ligands in the organization of the antitumour immune response. Finally, we discuss recent findings which indicate that chemokines have therapeutic potential as adjuvants or treatments in antitumour immunotherapy, as well as remaining questions and perspectives for translating experimental evidence into clinical practice.

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Authors: Homey, B., Müller, A., & Zlotnik, A.
Affiliations: Heinrich Heine University Düsseldorf (DE)
Corresponding author: Homey, Bernhard
ORCID: Homey, Bernhard
Müller, Anja
Zlotnik, Albert
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2002-03
Volume: 2
Issue: 3
Pages: 175-184
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri748
OpenAlex: W2095354110
Cited by: 398
References: 88
Citations by year: 2026: 1 · 2025: 1 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 7 · 2020: 14 · 2019: 10 · 2018: 9 · 2017: 18 · 2016: 17 · 2015: 17 · 2014: 16 · 2013: 12 · 2012: 16
FWCI: 3.81
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: chemokines, chemokine receptors, cancer immunotherapy, antitumor immunity, tumor biology, leukocyte migration, clinical translation
MeSH terms: Animals, Humans, Immunotherapy, Neoplasm Metastasis, Neoplasms, Cytokines, Chemokines

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Chemokines: agents for the immunotherapy of cancer?

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