Cited by 190T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

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Tracking T cells with tetramers: new tales from new tools

Klenerman, Paul, Cerundolo, Vincenzo, Dunbar, P. Rod·2002·Nature Reviews Immunology

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Abstract

To understand the success or failure of immune responses against pathogens or tumours requires the direct measurement of specific lymphocytes. Recently, there has been an explosion of data in this field through the use of several new tools for measuring the number and function of T cells. This has allowed immunologists who study human disease and mouse models of infection and cancer to readily track specific T cells--in both time and space. Although there are common patterns, over time, each host-pathogen relationship seems to develop unique characteristics, as reflected in the quality of the T-cell response.

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Authors: Klenerman, P., Cerundolo, V., & Dunbar, P. R.
Affiliations: University of Oxford (GB)
John Radcliffe Hospital (GB)
Corresponding author: Klenerman, Paul
ORCID: Klenerman, Paul
Cerundolo, Vincenzo
Dunbar, P. Rod
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2002-04-01
Volume: 2
Issue: 4
Pages: 263-272
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri777
OpenAlex: W1974562087
Cited by: 190
References: 109
Citations by year: 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 6 · 2012: 4
FWCI: 1.62
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Cancer Research UK
Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: T cell tracking, tetramer, T cell response, host-pathogen interaction, infection, tumor immunology, T cell function, mouse model
MeSH terms: Animals, beta 2-Microglobulin, Disease Models, Animal, Humans, Immunity, Cellular, Indicators and Reagents, Neoplasms, Peptides, Receptors, Antigen, T-Cell, T-Lymphocytes, Virus Diseases, Histocompatibility Antigens Class I, Lymphocyte Count, Streptavidin, Macromolecular Substances

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Tracking T cells with tetramers: new tales from new tools

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