Tracking T cells with tetramers: new tales from new tools

Phenotypic Analysis of Antigen-Specific T Lymphocytes

Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

Nestle, F. O., Alijagic, S., Gilliet, M., Sun, Y., Grabbe, S., Dummer, R., Burg, G., & Schadendorf, D. (1998) · Nature Medicine · doi:10.1038/nm0398-328 · Cited by 2,862

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2205 · Cited by 1,978

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

Murali‐Krishna, K., Altman, J. D., Suresh, M., Sourdive, D. J. D., Zajac, A. J., Miller, J. D., Slansky, J. E., & Ahmed, R. (1998) · Immunity · doi:10.1016/s1074-7613(00)80470-7 · Cited by 1,918

Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma

Rosenberg, S. A., Yang, J. C., Schwartzentruber, D. J., Hwu, P., Marincola, F. M., Topalian, S. L., Restifo, N. P., Dudley, M. E., Schwarz, S. L., Spiess, P. J., et al. (1998) · Nature Medicine · doi:10.1038/nm0398-321 · Cited by 1,786

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

Appay, V., Dunbar, P. R., Callan, M. F. C., Klenerman, P., Gillespie, G. M. A., Papagno, L., Ogg, G. S., King, A., Lechner, F., Spina, C. A., et al. (2002) · Nature Medicine · doi:10.1038/nm0402-379 · Cited by 1,556

Analysis of Successful Immune Responses in Persons Infected with Hepatitis C Virus

Lechner, F., Wong, D., Dunbar, P. R., Chapman, R. W., Chung, R. T., Dohrenwend, P. B., Robbins, G. K., Phillips, R., Klenerman, P., & Walker, B. D. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.9.1499 · Cited by 1,269

Determinants of Viral Clearance and Persistence during Acute Hepatitis C Virus Infection

Thimme, R., Oldach, D., Chang, K., Steiger, C., Ray, S. C., & Chisari, F. V. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.10.1395 · Cited by 1,208

Escape of Human Solid Tumors from T–Cell Recognition: Molecular Mechanisms and Functional Significance

Marincola, F. M., Jaffee, E. M., Hicklin, D. J., & Ferrone, S. (1999) · Advances in immunology · doi:10.1016/s0065-2776(08)60911-6 · Cited by 1,185

The use of dendritic cells in cancer immunotherapy

Schuler, G., Schuler‐Thurner, B., & Steinman, R. M. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(03)00015-3 · Cited by 633

Memory Inflation: Continuous Accumulation of Antiviral CD8+ T Cells Over Time

Karrer, U. W., Sierro, S. R., Wagner, M., Oxenius, A., Hengel, H., Koszinowski, U. H., Phillips, R. E., & Klenerman, P. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.2022 · Cited by 444

Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications

Krutzik, P. O., Irish, J. M., Nolan, G. P., & Perez, O. D. (2004) · Clinical Immunology · doi:10.1016/j.clim.2003.11.009 · Cited by 336

A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles

Chattopadhyay, P. K., Yu, J., & Roederer, M. (2005) · Nature Medicine · doi:10.1038/nm1293 · Cited by 321

Dynamic Relationship between IFN-γ and IL-2 Profile of Mycobacterium tuberculosis -Specific T Cells and Antigen Load

Millington, K. A., Innes, J. A., Hackforth, S., Hinks, T., Deeks, J. J., Dosanjh, D. P. S., Revol, V., Gunatheesan, R., Klenerman, P., & Lalvani, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5217 · Cited by 294

CD8+ T-Cell Responses to Trypanosoma cruzi Are Highly Focused on Strain-Variant trans-Sialidase Epitopes

Martin, D. L., Weatherly, D. B., Laucella, S. A., Cabinian, M. A., Crim, M. T., Sullivan, S., Heiges, M., Craven, S. H., Rosenberg, C. S., Collins, M. H., et al. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020077 · Cited by 228

Immunogenic Cell Death Amplified by Co-localized Adjuvant Delivery for Cancer Immunotherapy

Fan, Y., Kuai, R., Xu, Y., Ochyl, L. J., Irvine, D. J., & Moon, J. J. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b03218 · Cited by 222

Dynamic Antigen-specific T-Cell Responses after Point-Source Exposure to Mycobacterium tuberculosis

Ewer, K., Millington, K. A., Deeks, J. J., Alvarez, L., Bryant, G., & Lalvani, A. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200511-1783oc · Cited by 214

The Peptide Vaccine of the Future

Nelde, A., Rammensee, H.-G., & Walz, J. S. (2021) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r120.002309 · Cited by 205

The VITAL assay: a versatile fluorometric technique for assessing CTL- and NKT-mediated cytotoxicity against multiple targets in vitro and in vivo

Hermans, I. F., Silk, J. D., Yang, J., Palmowski, M. J., Gileadi, U., McCarthy, C., Salio, M., Ronchese, F., & Cerundolo, V. (2003) · Journal of Immunological Methods · doi:10.1016/j.jim.2003.10.017 · Cited by 178

Role of Specific CD8+ T Cells in the Severity of a Fulminant Zoonotic Viral Hemorrhagic Fever, Hantavirus Pulmonary Syndrome

Kilpatrick, E. D., Terajima, M., Koster, F. T., Catalina, M. D., Cruz, J., & Ennis, F. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.3297 · Cited by 174

Interaction between the CD8 Coreceptor and Major Histocompatibility Complex Class I Stabilizes T Cell Receptor-Antigen Complexes at the Cell Surface

Wooldridge, L., van den Berg, H. A., Glick, M., Emma Gostick, D., Laugel, B., Hutchinson, S., Milicic, A., Brenchley, J. M., Douek, D. C., Price, D. A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500555200 · Cited by 168

Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients

Ráki, M., Fallang, L.-E., Brottveit, M., Bergseng, E., Quarsten, H., Lundin, K. E. A., & Sollid, L. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608610104 · Cited by 156

T cell antigen discovery via signaling and antigen-presenting bifunctional receptors

Joglekar, A. V., Leonard, M. T., Jeppson, J. D., Swift, M., Li, G., Wong, S. K., Peng, S., Zaretsky, J. M., Heath, J. R., Ribas, A., et al. (2019) · Nature Methods · doi:10.1038/s41592-018-0304-8 · Cited by 151

CD8+ immunodominance among Epstein-Barr virus lytic cycle antigens directly reflects the efficiency of antigen presentation in lytically infected cells

Pudney, V. A., Leese, A. M., Rickinson, A. B., & Hislop, A. D. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041542 · Cited by 154

T cell antigen discovery

Joglekar, A. V., & Li, G. (2020) · Nature Methods · doi:10.1038/s41592-020-0867-z · Cited by 152

More tricks with tetramers: a practical guide to staining T cells with peptide– MHC multimers

Dolton, G. M., Tungatt, K., Lloyd, A., Bianchi, V., Theaker, S. M., Trimby, A., Holland, C. J., Donia, M., Godkin, A. J., Cole, D. K., et al. (2015) · Immunology · doi:10.1111/imm.12499 · Cited by 137

CD4 T Cell-Dependent CD8 T Cell Maturation

Khanolkar, A., Fuller, M. J., & Zajac, A. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2834 · Cited by 136

Mouse phenotyping

Fuchs, H., Gailus‐Durner, V., Adler, T., Aguilar‐Pimentel, J. A., Becker, L., Calzada‐Wack, J., da Silva‐Buttkus, P., Neff, F., Götz, A. A., Hans, W., et al. (2010) · Methods · doi:10.1016/j.ymeth.2010.08.006 · Cited by 135

Clinical immune‐monitoring strategies for predicting infection risk in solid organ transplantation

Fernández‐Ruiz, M., Kumar, D., & Humar, A. (2014) · Clinical & Translational Immunology · doi:10.1038/cti.2014.3 · Cited by 123

T cell response in hepatitis C virus infection.

Neumann-Haefelin, C., Blum, H. E., Chisari, F., & Thimme, R. (2005) · Journal of Clinical Virology · doi:10.1016/j.jcv.2004.05.008 · Cited by 139

Immune control of Babesia bovis infection

Brown, W. C., Norimine, J., Knowles, D. P., & Goff, W. L. (2006) · Veterinary Parasitology · doi:10.1016/j.vetpar.2006.01.041 · Cited by 121

Effect of Treatment of Latent Tuberculosis Infection on the T Cell Response toMycobacterium tuberculosisAntigens

Wilkinson, K. A., Kon, O. M., Newton, S. M., Meintjes, G., Davidson, R. N., Pasvol, G., & Wilkinson, R. J. (2006) · The Journal of Infectious Diseases · doi:10.1086/499311 · Cited by 121

Management of cytomegalovirus infection in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations

Torre‐Cisneros, J., Aguado, J. M., Castón, J. J., Almenar, L., Alonso, A., Cantisán, S., Carratalà, J., Cervera, C., Cordero, E., Fariñas, M. C., et al. (2016) · Transplantation Reviews · doi:10.1016/j.trre.2016.04.001 · Cited by 123

Is immunosenescence influenced by our lifetime “dose” of exercise?

Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112

Phase I/II trial of immunogenicity of a human papillomavirus (HPV) type 16 E7 protein?based vaccine in women with oncogenic HPV-positive cervical intraepithelial neoplasia

Hallez, S., Simon, P., Maudoux, F., Doyen, J., No�l, J.-C., Beliard, A., Capelle, X., Buxant, F., Fayt, I., Lagrost, A.-C., et al. (2004) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-004-0501-4 · Cited by 110

Epstein-barr virus (EBV) reactivation in allogeneic stem-cell transplantation: relationship between viral load, EBV-specific T-cell reconstitution and rituximab therapy

Clave, E., Agbalika, F., Bajzik, V., de Latour, R. P., Trillard, M., Rabian, C., Scieux, C., Devergié, A., Socié, G., Ribaud, P., et al. (2004) · Transplantation · doi:10.1097/01.tp.0000093997.83754.2b · Cited by 109

Nanosystems for simultaneous imaging and drug delivery to T cells

Fahmy, T. M., Fong, P., Park, J. Y., Constable, R. T., & Saltzman, W. M. (2007) · The AAPS Journal · doi:10.1208/aapsj0902019 · Cited by 105

T Cell Recognition Patterns of Immunodominant Cytomegalovirus Antigens in Primary and Persistent Infection

Khan, N., Best, D., Bruton, R. K., Nayak, L., Rickinson, A. B., & Moss, P. A. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4455 · Cited by 95

Quantitative analysis of EBV-specific CD4/CD8 T cell numbers, absolute CD4/CD8 T cell numbers and EBV load in solid organ transplant recipients with PLTD

Sebelin, K., Nguyen, T. D., Oertel, S. H. K., Papp‐Váry, M., Trappe, R. U., Schulzki, A., Pezzutto, A., Riess, H. B., & Subklewe, M. S. (2006) · Transplant Immunology · doi:10.1016/j.trim.2006.10.006 · Cited by 94

Prospects for recombinant vaccines against Babesia bovis and related parasites

Brown, W. C., Norimine, J., Goff, W. L., Suarez, C. E., & McElwain, T. F. (2006) · Parasite Immunology · doi:10.1111/j.1365-3024.2006.00849.x · Cited by 94

Enteritis induction by soybean meal in Totoaba macdonaldi diets: Effects on growth performance, digestive capacity, immune response and distal intestine integrity

Fuentes‐Quesada, J. P., Viana, M. T., Rombenso, A., Guerrero‐Rentería, Y., Nomura, M., Gomez-Calle, V., Lazo, J. P., & Mata-Sotres, J. A. (2018) · Aquaculture · doi:10.1016/j.aquaculture.2018.05.025 · Cited by 92

Counting Antigen‐Specific T Cells: A New Approach for Monitoring Response to Tuberculosis Treatment?

Lalvani, A. (2004) · Clinical Infectious Diseases · doi:10.1086/381763 · Cited by 90

Comparison of peptide–major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

Dolton, G. M., Lissina, A., Skowera, A., Ladell, K., Tungatt, K., Jones, E., Kronenberg‐Versteeg, D., Akpovwa, H., Pentier, J. M., Holland, C. J., et al. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12339 · Cited by 88

Population analysis of antiviral T cell responses using MHC class I-peptide tetramers

Komatsu, H., Sierro, S. R., Cuero, A., & Klenerman, P. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02266.x · Cited by 86

Recombinant modified vaccinia Ankara primes functionally activated CTL specific for a melanoma tumor antigen epitope in melanoma patients with a high risk of disease recurrence

Smith, C. S., Dunbar, P. R., Mirza, F., Palmowski, M. J., Shepherd, D., Gilbert, S. C., Coulie, P. G., Schneider, J., Hoffman, E. W., Hawkins, R. E., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20569 · Cited by 86

Identification of a β-Cell-Specific HLA Class I Restricted Epitope in Type 1 Diabetes

Panagiotopoulos, C., Qin, H., Tan, R., & Verchere, C. B. (2003) · Diabetes · doi:10.2337/diabetes.52.11.2647 · Cited by 86

Pathogenic T‐Cell Clones in Autoimmune Diabetes: More Lessons from the NOD Mouse

HASKINS, K. M. (2005) · Advances in immunology · doi:10.1016/s0065-2776(05)87004-x · Cited by 84

Systemic First-Line Phenotyping

Gailus‐Durner, V., Fuchs, H., Adler, T., Aguilar‐Pimentel, J. A., Becker, L., Bolle, I., Calzada‐Wack, J., Dalke, C., Ehrhardt, N., Ferwagner, B., et al. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-471-1_25 · Cited by 82

Regulatory T-cell response and tumor vaccine-induced cytotoxic T lymphocytes in human melanoma

Chakraborty, N. G., Chattopadhyay, S., Mehrotra, S., Chhabra, A., & Mukherji, B. (2004) · Human Immunology · doi:10.1016/j.humimm.2004.05.012 · Cited by 82

Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy

Portevin, D., Poupot, M., Rolland, O., Turrin, C., Fournié, J., Majoral, J., Caminade, A., & Poupot, R. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-82 · Cited by 78

Efficient Culture of Human Naive and Memory B Cells for Use as APCs

Su, K., Watanabe, A., Yeh, C., Kelsoe, G. H., & Kuraoka, M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502193 · Cited by 83

Discovery of CD8 + T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers

Grotenbreg, G. M., Roan, N. R., Guillén, E., Meijers, R., Wang, J., Bell, G. W., Starnbach, M. N., & Ploegh, H. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711504105 · Cited by 73

Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region

Wooldridge, L., Lissina, A., Vernazza, J., Emma Gostick, D., Laugel, B., Hutchinson, S., Mirza, F., Dunbar, P. R., Boulter, J. M., Glick, M., et al. (2007) · European Journal of Immunology · doi:10.1002/eji.200636765 · Cited by 72

Label-free Electronic Detection of the Antigen-Specific T-Cell Immune Response

Stern, E., Steenblock, E. R., Reed, M. A., & Fahmy, T. M. (2008) · Nano Letters · doi:10.1021/nl801693k · Cited by 70

Phenotypic and functional analysis of EBV-specific memory CD8 cells in SLE

Berner, B. R., Tary‐Lehmann, M., Yonkers, N. L., Askari, A., Lehmann, P., & Anthony, D. D. (2005) · Cellular Immunology · doi:10.1016/j.cellimm.2005.06.010 · Cited by 69

Dextramers: New generation of fluorescent MHC class I/peptide multimers for visualization of antigen-specific CD8+ T cells

Batard, P., Peterson, D. A., Devêvre, E., Guillaume, P., Cerottini, J., Rimoldi, D., Speiser, D. E., Winther, L., & Romero, P. J. (2006) · Journal of Immunological Methods · doi:10.1016/j.jim.2006.01.006 · Cited by 61

Antibody Stabilization of Peptide–MHC Multimers Reveals Functional T Cells Bearing Extremely Low-Affinity TCRs

Tungatt, K., Bianchi, V., Crowther, M. D., Powell, W. E., Schauenburg, A. J. A., Trimby, A., Donia, M., Miles, J. J., Holland, C. J., Cole, D. K., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401785 · Cited by 60

Vaccination with hybrids of tumor and dendritic cells induces tumor‐specific T‐cell and clinical responses in melanoma stage III and IV patients

Trefzer, U., Herberth, G., Wohlan, K. A., Milling, A., Thiemann, M., Sherev, T., Sparbier, K., Sterry, W., & Walden, P. (2004) · International Journal of Cancer · doi:10.1002/ijc.20191 · Cited by 58

DETECTION OF VIMENTIN-SPECIFIC AUTOREACTIVE CD8+ T CELLS IN CARDIAC TRANSPLANT PATIENTS

Barber, L. D., Whitelegg, A. M. E., Madrigal, J. A., Banner, N. R., & Rose, M. L. (2004) · Transplantation · doi:10.1097/01.tp.0000129068.03900.25 · Cited by 56

Cytomegalovirus (CMV) Epitope–Specific CD4+ T Cells Are Inflated in HIV+ CMV+ Subjects

Abana, C. O., Pilkinton, M. A., Gaudieri, S., Chopra, A., McDonnell, W. J., Wanjalla, C. N., Barnett, L. D., Gangula, R., Hager, C. C., Jung, D. K., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700851 · Cited by 56

Amplification of virus-induced antimelanoma T-cell reactivity by high-dose interferon-alpha2b: implications for cancer vaccines.

Astsaturov, I. A., Petrella, T. M., Bağrıaçık, E. Ü., de Benedette, M., Uger, R. A., Lumber, G., Berinstein, N. L., Elias, I., Iscoe, N., Hammond, C., et al. (2003) · PubMed · Cited by 48

The MegaPool Approach to Characterize Adaptive CD4+ and CD8+ T Cell Responses

Antunes, R. D. S., Weiskopf, D., Sidney, J., Rubiro, P., Peters, B., Arlehamn, C. S. L., Grifoni, A., & Sette, A. (2023) · Current Protocols · doi:10.1002/cpz1.934 · Cited by 44

Regulation of T‐cell migration and effector functions: insights from in vivo imaging studies

Pittet, M. J., & Mempel, T. R. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00584.x · Cited by 46

Promoting the accumulation of tumor-specific T cells in tumor tissues by dendritic cell vaccines and chemokine-modulating agents

Obermajer, N., Urban, J. A., Wieckowski, E. U., Muthuswamy, R., Ravindranathan, R., Bartlett, D. L., & Kaliński, P. (2018) · Nature Protocols · doi:10.1038/nprot.2017.130 · Cited by 42

Antigen-specificity measurements are the key to understanding T cell responses

Tippalagama, R., Chihab, L. Y., Kearns, K., Lewis, S. A., Panda, S., Willemsen, L., Burel, J. G., & Arlehamn, C. S. L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1127470 · Cited by 43

Validation of T-Track® CMV to assess the functionality of cytomegalovirus-reactive cell-mediated immunity in hemodialysis patients

Banas, B., Böger, C. A., Lückhoff, G., Krüger, B., Barabas, S., Batzilla, J., Schemmerer, M., Köstler, J., Bendfeldt, H., Rascle, A., et al. (2017) · BMC Immunology · doi:10.1186/s12865-017-0194-z · Cited by 41

Immune Cell Recruitment and Cell-Based System for Cancer Therapy

Gao, J., Okada, N., Mayumi, T., & Nakagawa, S. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9443-9 · Cited by 41

High-Throughput Functional Screening of Antigen-Specific T Cells Based on Droplet Microfluidics at a Single-Cell Level

Wang, S., Liu, Y., Li, Y., Lv, M., Gao, K., He, Y., Wei, W., Zhu, Y., Dong, X., Xu, X., et al. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c03678 · Cited by 38

Critical parameters in blood processing for T-cell assays: Validation on ELISpot and tetramer platforms

Afonso, G., Scotto, M., Renand, A., Arvastsson, J., Vassilieff, D., Cilio, C., & Mallone, R. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2010.05.005 · Cited by 39

Ex Vivo Analysis of Human Antigen-Specific CD8+ T-Cell Responses: Quality Assessment of Fluorescent HLA-A2 Multimer and Interferon-γ ELISPOT Assays for Patient Immune Monitoring

Speiser, D. E., Pittet, M. J., Guillaume, P., Lübenow, N., Hoffman, E. W., Cerottini, J., & Romero, P. J. (2004) · Journal of Immunotherapy · doi:10.1097/00002371-200407000-00006 · Cited by 39

Multiparameter precursor analysis of T-cell responses to antigen

Bercovici, N., Givan, A. L., Waugh, M., Fisher, J. L., Vernel-Pauillac, F., Ernstoff, M. S., Abastado, J., & Wallace, P. K. (2003) · Journal of Immunological Methods · doi:10.1016/s0022-1759(03)00059-0 · Cited by 39

International progress in cancer gene therapy

Guinn, B.-A., & Mulherkar, R. (2008) · Cancer Gene Therapy · doi:10.1038/cgt.2008.66 · Cited by 41

Clinical validation of a novel enzyme-linked immunosorbent spot assay-basedin vitrodiagnostic assay to monitor cytomegalovirus-specific cell-mediated immunity in kidney transplant recipients: a multicenter, longitudinal, prospective, observational study

Banas, B., Steubl, D., Renders, L., Chittka, D., Banas, M. C., Wekerle, T., Koch, M., Witzke, O., Mühlfeld, A., Sommerer, C., et al. (2017) · Transplant International · doi:10.1111/tri.13110 · Cited by 38

Detection of low avidity CD8+ T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers

Melenhorst, J. J., Scheinberg, P., Chattopadhyay, P. K., Lissina, A., Emma Gostick, D., Cole, D. K., Wooldridge, L., van den Berg, H. A., Bornstein, E. R., Hensel, N. F., et al. (2008) · Journal of Immunological Methods · doi:10.1016/j.jim.2008.07.008 · Cited by 37

Mucosal arenavirus infection of primates can protect them from lethal hemorrhagic fever

Rodas, J. D., Lukashevich, I. S., Zapata, J. C., Cairo, C., Tikhonov, I., Djavani, M. M., Pauza, C. D., & Salvato, M. S. (2004) · Journal of Medical Virology · doi:10.1002/jmv.20000 · Cited by 37

Direct Measurement of Peptide-Specific CD8+ T Cells Using HLA-A2:Ig Dimer for Monitoring the In Vivo Immune Response to a HER2/neu Vaccine in Breast and Prostate Cancer Patients

Woll, M. M., Fisher, C. M., Ryan, G. B., Gurney, J. M., Storrer, C. E., Ioannides, C. G., Shriver, C. D., Moul, J. W., McLeod, D. G., Ponniah, S., et al. (2004) · Journal of Clinical Immunology · doi:10.1023/b:joci.0000029117.10791.98 · Cited by 37

Immunesurveillance by dendritic cells: potential implication for immunotherapy of endocrine cancers

Schott, M. (2006) · Endocrine Related Cancer · doi:10.1677/erc.1.01133 · Cited by 39

An immunodominant SSX-2–derived epitope recognized by CD4+ T cells in association with HLA-DR

Ayyoub, M., Hesdorffer, C. S., Montes, M., Merlo, A. C., Speiser, D. E., Rimoldi, D., Cerottini, J., Ritter, G., Scanlan, M. J., Old, L. J., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20667 · Cited by 37

Decay Kinetics of an Interferon Gamma Release Assay with Anti-Tuberculosis Therapy in Newly Diagnosed Tuberculosis Cases

Adetifa, I., Ota, M. O. C., Walther, B., Hammond, A. S., Lugos, M. D., Jeffries, D. J., Donkor, S. A., Adegbola, R. A., & Hill, P. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012502 · Cited by 36

The HIV-1 Tat Protein Induces the Activation of CD8+ T Cells and Affects In Vivo the Magnitude and Kinetics of Antiviral Responses

Nicoli, F., Finessi, V., Sicurella, M., Rizzotto, L., Gallerani, E., Destro, F., Cafaro, A., Marconi, P., Caputo, A., Ensoli, B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077746 · Cited by 36

Measuring Cellular Immunity to Influenza: Methods of Detection, Applications and Challenges

Coughlan, L., & Lambe, T. (2015) · Vaccines · doi:10.3390/vaccines3020293 · Cited by 35

Regulation of melanoma epitope-specific cytolytic T lymphocyte response by immature and activated dendritic cells, in vitro.

Mehrotra, S., Stevens, R., Zengou, R., Chakraborty, N. G., Butterfield, L. H., Economou, J. S., Dorsky, D. I., & Mukherji, B. (2003) · PubMed · Cited by 33

Single Cell Assessment of Allergen-Specific T Cell Responses with MHC Class II Peptide Tetramers: Methodological Aspects

Wambre, E. R., Overtvelt, L. V., Maillère, B., Humphreys, R., Hofe, E. V., Ferhat, L., Ebo, D. G., & Moingeon, P. E. (2008) · International Archives of Allergy and Immunology · doi:10.1159/000113513 · Cited by 34

Immune Monitoring in Cancer Vaccine Clinical Trials: Critical Issues of Functional Flow Cytometry-Based Assays

Macchia, I., Urbani, F., & Proietti, E. (2013) · BioMed Research International · doi:10.1155/2013/726239 · Cited by 34

Class II major histocompatibility complex–peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4+ T cell response to a rheumatoid arthritis–associated antigen

Falta, M. T., Fontenot, A. P., Rosloniec, E. F., Crawford, F., Roark, C. L., Bill, J. R., Marrack, P., Kappler, J. W., & Kotzin, B. L. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21098 · Cited by 34

Direct Ex Vivo Evaluation of Long‐Lived Protective Antiviral Memory B Cell Responses against Hepatitis B Virus

Ward, S. M., Phalora, P. K., Bradshaw, D., Leyendeckers, H., & Klenerman, P. (2008) · The Journal of Infectious Diseases · doi:10.1086/591094 · Cited by 34

Virus‐specific CD8+ T lymphocytes within the normal human liver

Ward, S. M., Jonsson, J. R., Sierro, S. R., Clouston, A. D., Lucas, M., Vargas, A., Powell, E. E., & Klenerman, P. (2004) · European Journal of Immunology · doi:10.1002/eji.200324275 · Cited by 32

HCV immunology–Death and the maiden T cell

Willberg, C. B., Barnes, E. J., & Klenerman, P. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401122 · Cited by 32

Rapid Development of Analytical Methods for Evaluating Pandemic Vaccines: A Covid-19 Perspective

Baldwin, J., Piplani, S., Sakala, I. G., Honda‐Okubo, Y., Li, L., & Petrovsky, N. (2021) · Bioanalysis · doi:10.4155/bio-2021-0096 · Cited by 33

Major Histocompatibility Complex and T Cell Interactions of a Universal T Cell Epitope from Plasmodium falciparum Circumsporozoite Protein

Parra-López, C., Calvo‐Calle, J. M., Cameron, T. O., Vargas, L. E., Salazar, L. M., Patarroyo, M. E., Nardin, E. H., & Stern, L. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511571200 · Cited by 30

A chaperone-assisted high yield system for the production of HLA-DR4 tetramers in insect cells

Fourneau, J., Cohen, H., & Endert, P. V. (2004) · Journal of Immunological Methods · doi:10.1016/j.jim.2003.11.011 · Cited by 30

An immune edited tumour versus a tumour edited immune system: prospects for immune therapy of acute myeloid leukaemia

Chan, L., Hardwick, N. R., Guinn, B., Darling, D., Gäken, J. A., Galea‐Lauri, J., Ho, A. Y. L., Mufti, G. J., & Farzaneh, F. (2006) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-006-0129-7 · Cited by 30

Tuberculin Skin Testing and Treatment Modulates Interferon-Gamma Release Assay Results for Latent Tuberculosis in Migrants

O’Shea, M. K., Fletcher, T. E., Beeching, N. J., Dedicoat, M. J., Spence, D., McShane, H., Cunningham, A. F., & Wilson, D. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097366 · Cited by 29

A Molecular Assay for Sensitive Detection of Pathogen-Specific T-Cells

Kasprowicz, V. O., Mitchell, J. E., Chetty, S., Govender, P., Huang, K. G., Fletcher, H. A., Webster, D. P., Brown, S., Kasmar, A. G., Millington, K. A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020606 · Cited by 29

A nanoscopic multivalent antigen-presenting carrier for sensitive detection and drug delivery to T Cells

Fahmy, T. M., Schneck, J. P., & Saltzman, W. M. (2007) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2006.11.010 · Cited by 29

Specific CD8 T Cells in IgE-mediated Allergy Correlate with Allergen Dose and Allergic Phenotype

Aguilar‐Pimentel, J. A., Alessandrini, F., Huster, K. M., Jakob, T., Schulz, H., Behrendt, H., Ring, J., de Angelis, M. H., Busch, D. H., Mempel, M., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200902-0190oc · Cited by 29

De novo identification of CD4+ T cell epitopes

Zdinak, P. M., Trivedi, N., Grebinoski, S., Torrey, J., Martinez, E. Z., Martínez, S., Hicks, L., Ranjan, R., Makani, V. K. K., Roland, M. M., et al. (2024) · Nature Methods · doi:10.1038/s41592-024-02255-0 · Cited by 26

Enumerating autoreactive T cells in peripheral blood: a big step in diabetes prediction

Eisenbarth, G. S., & Kotzin, B. L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17621 · Cited by 26

Comprehensive analysis of MHC‐II expression in healthy human skin

Angel, C. E., George, E., Ostrovsky, L. L., & Dunbar, P. R. (2007) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100047 · Cited by 26

Anti‐coreceptor antibodies profoundly affect staining with peptide‐MHC class I and class II tetramers

Wooldridge, L., Scriba, T. J., Milicic, A., Laugel, B., Emma Gostick, D., Price, D. A., Phillips, R. E., & Sewell, A. K. (2006) · European Journal of Immunology · doi:10.1002/eji.200635886 · Cited by 25

Analytical performance of a standardized single‐platform MHC tetramer assay for the identification and enumeration of CMV‐specific CD8+ T lymphocytes

Brooimans, R. A., Boyce, C. S., Popma, J., Broyles, D. A., Gratama, J. W., Southwick, P. C., & Keeney, M. (2008) · Cytometry Part A · doi:10.1002/cyto.a.20641 · Cited by 25

The use of HLA class I tetramers to design a vaccination strategy for melanoma patients

Palmowski, M. J., Salio, M., Dunbar, P. R., & Cerundolo, V. (2002) · Immunological Reviews · doi:10.1034/j.1600-065x.2002.18814.x · Cited by 25

Identification of Immunogenic Epitopes by MS/MS

Marco, M. D., Peper-Gabriel, J. K., & Rammensee, H. (2017) · The Cancer Journal · doi:10.1097/ppo.0000000000000252 · Cited by 23

An extrafollicular pathway for the generation of effector CD8+ T cells driven by the proinflammatory cytokine, IL-12

Shah, S. M., Grotenbreg, G. M., Rivera, A., & Yap, G. S. (2015) · eLife · doi:10.7554/elife.09017 · Cited by 24

Intestinal impairment of the California yellowtail, Seriola dorsalis, using soybean meal in the diet

Viana, M. T., Rombenso, A., del Río-Zaragoza, O. B., Nomura, M., Díaz-Argüello, R., & Mata-Sotres, J. A. (2019) · Aquaculture · doi:10.1016/j.aquaculture.2019.734443 · Cited by 23

Single-Cell TCR and Transcriptome Analysis: An Indispensable Tool for Studying T-Cell Biology and Cancer Immunotherapy

Pasetto, A., & Lu, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.689091 · Cited by 24

T-Cell Receptor-Like Antibodies: Targeting the Intracellular Proteome Therapeutic Potential and Clinical Applications

Cohen, M., & Reiter, Y. (2013) · Antibodies · doi:10.3390/antib2030517 · Cited by 23

Linear Fidelity in Quantification of Anti-Viral CD8+ T Cells

Flesch, I. E. A., Hollett, N. A., Wong, Y. C., & Tscharke, D. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039533 · Cited by 22

Dynamics of Dengue Virus (DENV)–Specific B Cells in the Response to DENV Serotype 1 Infections, Using Flow Cytometry With Labeled Virions

Woda, M., Friberg, H., Currier, J. R., Srikiatkhachorn, A., Macareo, L. R., Green, S., Jarman, R. G., Rothman, A. L., & Mathew, A. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw308 · Cited by 22

In vivo tracking of tumor-specific T cells

Yee, C., Riddell, S. R., & Greenberg, P. D. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00196-5 · Cited by 58

Modulating T-cell immunity to tumours: new strategies for monitoring T-cell responses

Yee, C., & Greenberg, P. D. (2002) · Nature reviews. Cancer · doi:10.1038/nrc820 · Cited by 70

Measuring human T-lymphocyte function

Hickling, J. (1998) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399498000313 · Cited by 21

Molecular tracking of antigen-specific T-cell clones during immune responses

Rufer, N. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.06.003 · Cited by 21

Determining T-cell specificity to understand and treat disease

Hadrup, S. R., & Newell, E. W. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0143-4 · Cited by 15