Cited by 1,743Circular RNAs in diseasesRNA Research and SplicingCancer-related molecular mechanisms research

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The biogenesis and emerging roles of circular RNAs

Chen, Ling-Ling·2016·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm.2015.32

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Abstract

Circular RNAs (circRNAs) are produced from precursor mRNA (pre-mRNA) back-splicing of thousands of genes in eukaryotes. Although circRNAs are generally expressed at low levels, recent findings have shed new light on their cell type-specific and tissue-specific expression and on the regulation of their biogenesis. Furthermore, the data indicate that circRNAs shape gene expression by titrating microRNAs, regulating transcription and interfering with splicing, thus effectively expanding the diversity and complexity of eukaryotic transcriptomes.

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Authors: Chen, L.-L.
Affiliations: Chinese Academy of Sciences (CN)
Corresponding author: Chen, Ling-Ling
ORCID: Chen, Ling-Ling
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2016-02-24
Volume: 17
Issue: 4
Pages: 205-211
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm.2015.32
OpenAlex: W2284415752
Cited by: 1,743
References: 63
Citations by year: 2026: 69 · 2025: 109 · 2024: 149 · 2023: 153 · 2022: 227 · 2021: 317 · 2020: 282 · 2019: 185 · 2018: 135 · 2017: 89 · 2016: 25
FWCI: 13.06
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China
Chinese Academy of Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: circular RNA, circRNA biogenesis, back-splicing, microRNA sequestration, cell type-specific gene expression, tissue-specific gene expression, transcriptional regulation, splicing regulation
MeSH terms: RNA, Circular, Animals, Gene Expression Regulation, Humans, Models, Molecular, Organ Specificity, RNA, RNA Splicing, MicroRNAs

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The biogenesis and emerging roles of circular RNAs

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