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Ras proteins: different signals from different locations

Hancock, John F.·2003·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm1105
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Abstract

Ras signalling has classically been thought to occur exclusively at the inner surface of a relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact dynamically with specific microdomains of the plasma membrane as well as with other internal cell membranes. These different membrane microenvironments modulate Ras signal output and highlight the complex interplay between Ras location and function.

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    “When cells expressing wild-type H-ras are stimulated with EGF, GFP–Raf-RBD is initially recruited to the plasma membrane and then progressively to the Golg”
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Cited by

See all 756

Metadata

Authors
Hancock, J. F.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2003-05
Volume
4
Issue
5
Pages
373-385
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm1105
Cited by
756
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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