Cited by 395Protein Kinase Regulation and GTPase SignalingUbiquitin and proteasome pathwaysProtein Tyrosine Phosphatases

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The Cbl interactome and its functions

Schmidt, Mirko H.H., Dikic, Ivan·2005·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm1762

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Abstract

Cbl proteins are ubiquitin ligases and multifunctional adaptor proteins that are implicated in the regulation of signal transduction in various cell types and in response to different stimuli. Cbl-associated proteins can assemble together at a given time or space inside the cell, and such an interactome can form signal competent networks that control many physiological processes. Dysregulation of spatial or temporal constraints in the Cbl interactome results in the development of human pathologies such as immune diseases, diabetes and cancer.

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Cbl Suppresses B Cell Receptor–Mediated Phospholipase C (Plc)-γ2 Activation by Regulating B Cell Linker Protein–Plc-γ2 Binding
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Self-citation
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Authors: Schmidt, M. H. H., & Dikic, I.
Affiliations: Goethe University Frankfurt (DE)
ORCID: Schmidt, Mirko H.H.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2005-10-14
Volume: 6
Issue: 12
Pages: 907-919
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm1762
OpenAlex: W2059037016
Cited by: 395
References: 126
Citations by year: 2026: 6 · 2025: 8 · 2024: 8 · 2023: 15 · 2022: 15 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 12 · 2017: 13 · 2016: 21 · 2015: 23 · 2014: 24 · 2013: 34 · 2012: 38
FWCI: 1.54
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: European Molecular Biology Organization
Deutsche Forschungsgemeinschaft
Boehringer Ingelheim Stiftung
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: ubiquitin ligase, protein-protein interaction network, adaptor proteins, signal transduction regulation, protein complex formation, immune disorders, diabetes mellitus, cancer
MeSH terms: Actins, Animals, Endocytosis, Humans, Lymphocytes, Signal Transduction, Receptor Protein-Tyrosine Kinases, Multiprotein Complexes, Proto-Oncogene Proteins c-cbl

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The Cbl interactome and its functions

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