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Allosteric activation of the protein kinase PDK1 with low molecular weight compounds

Engel, M., Hindie, V., Lopez-Garcia, L. A., Stroba, A., Schaeffer, F., Adrian, I., Imig, J., Idrissova, L., Nastainczyk, W., Zeuzem, S., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601416 · Cited by 110 · see citing works

mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif

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Interaction between the AMP-Activated Protein Kinase and mTOR Signaling Pathways

Kimball, S. R. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000233796.16411.13 · Cited by 109 · see citing works

Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation

Biondi, R. M. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.01.005 · Cited by 109 · see citing works

Differential roles of PDK1- and PDK2-phosphorylation sites in the yeast AGC kinases Ypk1, Pkc1 and Sch9

Roelants, F. M. (2004) · Microbiology · doi:10.1099/mic.0.27286-0 · Cited by 107 · see citing works

PDK1: The Major Transducer of PI 3-Kinase Actions

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Elevated Corticosterone Associated with Food Deprivation Upregulates Expression in Rat Skeletal Muscle of the mTORC1 Repressor, REDD1

McGhee, N. K., Jefferson, L. S., & Kimball, S. R. (2009) · Journal of Nutrition · doi:10.3945/jn.108.099846 · Cited by 102 · see citing works

Exercise‐induced alterations in extracellular signal‐regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle

Williamson, D. L., Kubica, N., Kimball, S. R., & Jefferson, L. S. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.103481 · Cited by 96 · see citing works

The Structure of G Protein-coupled Receptor Kinase (GRK)-6 Defines a Second Lineage of GRKs

Lodowski, D. T., Tesmer, V. M., Benovic, J., & Tesmer, J. J. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601327200 · Cited by 95 · see citing works

Mitotic Raptor Promotes mTORC1 Activity, G2/M Cell Cycle Progression, and Internal Ribosome Entry Site-Mediated mRNA Translation

Ramírez‐Valle, F., Badura, M. L., Braunstein, S. E., Narasimhan, M., & Schneider, R. J. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00322-09 · Cited by 93 · see citing works

A survey of the year 2002 commercial optical biosensor literature

Rich, R. L., & Myszka, D. G. (2003) · Journal of Molecular Recognition · doi:10.1002/jmr.649 · Cited by 93 · see citing works

SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular Target and Strategy for Inhibition

Talarico, C., Dattilo, V., D’Antona, L., Menniti, M., Bianco, C., Ortuso, F., Alcaro, S., Schenone, S., Perrotti, N., & Amato, R. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000447885 · Cited by 90 · see citing works

Atypical protein kinase C (PKCζ/λ) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways

Kanzaki, M., Mora, S., Hwang, J., Saltiel, A. R., & Pessin, J. E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200306152 · Cited by 88 · see citing works

Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock.

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Characterization of the Mechanisms Controlling Greatwall Activity

Vigneron, S., Gharbi-Ayachi, A., Raymond, A., Burgess, A., Labbé, J., Labesse, G., Monsarrat, B., Lorca, T., & Castro, A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.00753-10 · Cited by 87 · see citing works

Evolutionary Adaptations of Plant AGC Kinases: From Light Signaling to Cell Polarity Regulation

Rademacher, E. H., & Offringa, R. (2012) · Frontiers in Plant Science · doi:10.3389/fpls.2012.00250 · Cited by 81 · see citing works

Phosphoinositide-Dependent Phosphorylation of PDK1 Regulates Nuclear Translocation

Scheid, M. P., Parsons, M., & Woodgett, J. R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.6.2347-2363.2005 · Cited by 86 · see citing works

Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase

Schulze, J. O., Saladino, G., Busschots, K., Neimanis, S., Süß, E., Odadzic, D., Zeuzem, S., Hindie, V., Herbrand, A. K., Lisa, M., et al. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2016.06.017 · Cited by 84 · see citing works

Chromatin kinases act on transcription factors and histone tails in regulation of inducible transcription

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mTORC1 senses stresses: Coupling stress to proteostasis

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Substrate-Selective Inhibition of Protein Kinase PDK1 by Small Compounds that Bind to the PIF-Pocket Allosteric Docking Site

Busschots, K., Lopez-Garcia, L. A., Lammi, C., Stroba, A., Zeuzem, S., Piiper, A., Alzari, P. M., Neimanis, S., Arencibia, J. M., Engel, M., et al. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.07.017 · Cited by 83 · see citing works

AKT-independent PI3-K signaling in cancer – emerging role for SGK3

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Modulation of the voltage-gated potassium channel Kv1.5 by the SGK1 protein kinase involves inhibition of channel ubiquitination

Boehmer, C., Laufer, J., Jeyaraj, S., Klaus, F., Lindner, R., Lang, F., & Palmada, M. (2008) · Cellular Physiology and Biochemistry · doi:10.1159/000185543 · Cited by 82 · see citing works

Molecular structure and regulation of phototropin kinase by blue light

Tokutomi, S., Matsuoka, D., & Zikihara, K. (2007) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2007.09.010 · Cited by 81 · see citing works

Adi3 is a Pdk1‐interacting AGC kinase that negatively regulates plant cell death

Devarenne, T. P., Ekengren, S. K., Pedley, K. F., & Martin, G. B. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600910 · Cited by 80 · see citing works

Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores

Gógl, G., Kornev, A. P., Reményi, A., & Taylor, S. S. (2019) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2018.12.002 · Cited by 79 · see citing works

General aspects of muscle glucose uptake

Alvim, R. D. O., CHEUHEN, M. R., MACHADO, S. R., de Sousa, A. G. P., & SANTOS, P. C. J. L. (2015) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201520140225 · Cited by 80 · see citing works

Interactions of LY333531 and Other Bisindolyl Maleimide Inhibitors with PDK1

Komander, D., Kular, G. S., Schüttelkopf, A. W., Deák, M., Prakash, K. R. C., Bain, J., Elliott, M., Garrido-Franco, M., Kozikowski, A. P., Alessi, D. R., et al. (2004) · Structure · doi:10.1016/j.str.2004.01.005 · Cited by 79 · see citing works

Akt1 Intramitochondrial Cycling Is a Crucial Step in the Redox Modulation of Cell Cycle Progression

Arciuch, V. G. A., Galli, S., Franco, M. C., Lam, P. Y., Cadenas, E., Carreras, M. C., & Poderoso, J. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007523 · Cited by 76 · see citing works

Structure- and Similarity-Based Survey of Allosteric Kinase Inhibitors, Activators, and Closely Related Compounds

Laufkötter, O., Hu, H., Miljković, F. N., & Bajorath, J. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c02076 · Cited by 72 · see citing works

3,5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure−Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds†PDB code of 2Z with PDK1: 3HRF.

Stroba, A., Schaeffer, F., Hindie, V., Lopez-Garcia, L. A., Adrian, I., Fröhner, W., Hartmann, R. W., Biondi, R. M., & Engel, M. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm9001499 · Cited by 75 · see citing works

Identification of dual mTORC1 and mTORC2 inhibitors in melanoma cells: Prodigiosin vs. obatoclax

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Regulation of 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) by Src Involves Tyrosine Phosphorylation of PDK1 and Src Homology 2 Domain Binding

Yang, K., Shin, S., Piao, L., Shin, E., Li, Y., Park, K. A., Byun, H. S., Won, M., Hong, J. H., Kweon, G. R., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706361200 · Cited by 72 · see citing works

Regulation of protein kinases in insulin, growth factor and Wnt signalling

Pearl, L. H. (2002) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(02)00386-x · Cited by 70 · see citing works

Tuberous Sclerosis Complex Proteins 1 and 2 Control Serum-Dependent Translation in a TOP-Dependent and -Independent Manner

Bilanges, B., Argonza-Barrett, R., Kolesnichenko, M., Skinner, C., Nair, M., Chen, M., & Stokoe, D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02136-06 · Cited by 69 · see citing works

Yersinia Virulence Factor YopM Induces Sustained RSK Activation by Interfering with Dephosphorylation

Hentschke, M., Berneking, L., Campos, C. E. B., Buck, F., Ruckdeschel, K., & Aepfelbacher, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013165 · Cited by 65 · see citing works

S6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions

Jiang, Q., Zhang, X., Dai, X., Han, S., Wu, X., Wang, L., Wei, W., Zhang, N., Xie, W., & Guo, J. (2022) · Nature Communications · doi:10.1038/s41467-022-28910-8 · Cited by 67 · see citing works

Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells

Nagashima, K., Shumway, S. D., Sathyanarayanan, S., Chen, A. H., Dolinski, B. M., Xu, Y., Keilhack, H., Nguyen, T. P. T., Wiznerowicz, M., Li, L., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.156463 · Cited by 66 · see citing works

CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4

Slagsvold, T., Marchese, A., Brech, A., & Stenmark, H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601267 · Cited by 66 · see citing works

Allosteric Regulation of Protein Kinase PKCζ by the N-Terminal C1 Domain and Small Compounds to the PIF-Pocket

Lopez-Garcia, L. A., Schulze, J. O., Fröhner, W., Zhang, H., Süß, E., Weber, N., Navratil, J., Amon, S., Hindie, V., Zeuzem, S., et al. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.08.010 · Cited by 65 · see citing works

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation

Ruff, E. F., Muretta, J. M., Thompson, A. R., Lake, E. W., Cyphers, S., Albanese, S. K., Hanson, S. M., Behr, J. M., Thomas, D. D., Chodera, J. D., et al. (2018) · eLife · doi:10.7554/elife.32766 · Cited by 64 · see citing works

Mouse 3-Phosphoinositide-dependent Protein Kinase-1 Undergoes Dimerization and trans-Phosphorylation in the Activation Loop

Wick, M. J., Ramos, F. J., Chen, H., Quon, M. J., Dong, L., & Liu, F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304172200 · Cited by 64 · see citing works

Association of SGK1 Gene Polymorphisms with Type 2 Diabetes

Schwab, M. G., Lupescu, A., Moța, M., Moța, E., Frey, A., Simon, P. D., Mertens, P. R., Floege, J., Luft, F. C., Asante-Poku, S., et al. (2008) · Cellular Physiology and Biochemistry · doi:10.1159/000113757 · Cited by 61 · see citing works

The multifaceted allosteric regulation of Aurora kinase A

Levinson, N. M. (2018) · Biochemical Journal · doi:10.1042/bcj20170771 · Cited by 63 · see citing works

In vivo role of the phosphate groove of PDK1 defined by knockin mutation

Collins, B., Deák, M., Murray-Tait, V., Storey, K. G., & Alessi, D. R. (2005) · Journal of Cell Science · doi:10.1242/jcs.02617 · Cited by 58 · see citing works

Phosphoinositide-dependent kinase-1 orthologues from five eukaryotes are activated by the hydrophobic motif in AGC kinases

Silber, J., Antal, T. L., Gammeltoft, S., & Rasmussen, T. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.031 · Cited by 12 · see citing works

A 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Docking Site Is Required for the Phosphorylation of Protein Kinase Cζ (PKCζ) and PKC-related Kinase 2 by PDK1

Balendran, A., Biondi, R. M., Cheung, P., Casamayor, A., Deák, M., & Alessi, D. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000421200 · Cited by 183 · see citing works

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB

Biondi, R. M., Kieloch, A., Currie, R. A., Deak, M., & Alessi, D. R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.16.4380 · Cited by 377 · see citing works

Mechanism for activation of the growth factor‐activated AGC kinases by turn motif phosphorylation

Hauge, C., Antal, T. L., Hirschberg, D., Doehn, U., Thorup, K., Idrissova, L., Hansen, K. H., Jensen, O. N., Jørgensen, T. J. D., Biondi, R. M., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601682 · Cited by 115 · see citing works