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Cited by 371

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Systems biology of stem cell fate and cellular reprogramming

Open access
MacArthur, Ben D., Ma'ayan, Avi, Lemischka, Ihor R.·2009·Nature Reviews Molecular Cell Biology

Abstract

Stem cell differentiation and the maintenance of self-renewal are intrinsically complex processes requiring the coordinated dynamic expression of hundreds of genes and proteins in precise response to external signalling cues. Numerous recent reports have used both experimental and computational techniques to dissect this complexity. These reports suggest that the control of cell fate has both deterministic and stochastic elements: complex underlying regulatory networks define stable molecular 'attractor' states towards which individual cells are drawn over time, whereas stochastic fluctuations in gene and protein expression levels drive transitions between coexisting attractors, ensuring robustness at the population level.

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Crossref · 10.1038/nrm2766

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Metadata

Authors
MacArthur, B. D., Ma'ayan, A., & Lemischka, I. R.
Venue
Nature Reviews Molecular Cell Biology
Published
2009-09-09
Volume
10
Issue
10
Pages
672-681
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W1971445167
Cited by
371
References
18
FWCI
1.98
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.