The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Active DNA demethylation: many roads lead to Rome
Open accessAbstract
DNA methylation is one of the best-characterized epigenetic modifications and has been implicated in numerous biological processes, including transposable element silencing, genomic imprinting and X chromosome inactivation. Compared with other epigenetic modifications, DNA methylation is thought to be relatively stable. Despite its role in long-term silencing, DNA methylation is more dynamic than originally thought as active DNA demethylation has been observed during specific stages of development. In the past decade, many enzymes have been proposed to carry out active DNA demethylation and growing evidence suggests that, depending on the context, this process may be achieved by multiple mechanisms. Insight into how DNA methylation is dynamically regulated will broaden our understanding of epigenetic regulation and have great implications in somatic cell reprogramming and regenerative medicine.
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Cited by
Functions of DNA methylation: islands, start sites, gene bodies and beyond
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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
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Self-citationCpG islands and the regulation of transcription
Deaton, A. M., & Bird, A. (2011) · Genes & Development · doi:10.1101/gad.2037511 · Cited by 3,187
Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
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Metadata
- Authors
- Wu, S. C., & Zhang, Y.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2010-08-04
- Volume
- 11
- Issue
- 9
- Pages
- 607-620
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1996676239
- Cited by
- 1,060
- References
- 14
- FWCI
- 6.88
- Type
- journal article
- Language
- en
- Open access
- green
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