The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Making new contacts: the mTOR network in metabolism and signalling crosstalk
Abstract
More than 20 years after its discovery, our understanding of target of rapamycin (TOR) signalling continues to grow. Recent global 'omics' studies have revealed physiological roles of mammalian TOR (mTOR) in protein, nucleotide and lipid synthesis. Furthermore, emerging evidence provides new insight into the control of mTOR by other pathways such as Hippo, WNT and Notch signalling. Together, this progress has expanded the list of downstream effectors and upstream regulators of mTOR signalling.
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“A family of molecules that are the mechanistic target of the rapamycin (mTOR) complex has been attributed a major role in the biology of cell metabolism, growth, longevity, and even preterm birth(230–236).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [232]
In the citing paper
“Rapamycin can also prolong the life cycle of many species as diverse as worms and mice, and its signaling system has been implicated as the master regulator of cellular growth and metabolism.”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [232]
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Metadata
- Authors
- Shimobayashi, M., & Hall, M. N.
- Affiliations
- University of Basel (CH)
- Corresponding author
- Hall, Michael N.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2014-02-21
- Volume
- 15
- Issue
- 3
- Pages
- 155-162
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1977534471
- Cited by
- 1,053
- References
- 85
- Citations by year
- 2026: 22 · 2025: 48 · 2024: 57 · 2023: 61 · 2022: 70 · 2021: 88 · 2020: 87 · 2019: 103 · 2018: 111 · 2017: 129 · 2016: 120 · 2015: 118 · 2014: 38
- FWCI
- 12.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- mTOR signaling, TOR signaling, Hippo signaling pathway, Wnt signaling, Notch signaling, signaling crosstalk, protein synthesis, nucleotide synthesis, lipogenesis, upstream regulators, downstream effectors
- MeSH terms
- Animals, Antibiotics, Antineoplastic, Humans, Models, Biological, Signal Transduction, Sirolimus, TOR Serine-Threonine Kinases
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