Making new contacts: the mTOR network in metabolism and signalling crosstalk

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1. The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168
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2. New and Emerging Targeted Therapies for Vascular Malformations
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3. FK506-Binding Proteins and Their Diverse Functions
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4. Lysosomes in cancer — living on the edge (of the cell)
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5. Quantitative phosphoproteomics of protein kinase SnRK1 regulated protein phosphorylation in Arabidopsis under submergence
   Hsing‐Yi Cho, Tuan‐Nan Wen, Ying-Tsui Wang, Ming‐Che Shih · 2016 · Journal of Experimental Botany
6. mTOR-Mediated Regulation of Dendritic Cell Differentiation and Function
   Nyamdelger Sukhbaatar, Markus Hengstschläger, Thomas Weichhart · 2016 · Trends in Immunology
7. Evolutionary Conservation of the Components in the TOR Signaling Pathways
   Hisashi Tatebe, Kazuhiro Shiozaki · 2017 · Biomolecules
8. Chronic mTOR inhibition in mice with rapamycin alters T , B , myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient mice
   Vincent J. Hurez, Vinh A Dao, Aijie Liu, Srilakshmi Pandeswara, Jonathan Gelfond, Lishi Sun, Molly Ann Bergman, Carlos Javier Orihuela, Verónica Galván, Alvaro Souto Padron et al. · 2015 · Aging Cell
9. Translational Control Mechanisms in Persistent Pain
   Arkady Khoutorsky, Theodore John Price · 2017 · Trends in Neurosciences
10. mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy
    Bordi, Matteo, Darji, Sandipkumar, Sato, Yutaka, Mellén, Marian, Berg, Martin J., Kumar, Asok, Jiang, Ying, Nixon, Ralph A. · 2019 · Cell Death & Disease
11. The role of Hypoxia-Inducible Factor-1alpha and its signaling in melanoma
    Mohammad Malekan, Mohammad Ali Ebrahimzadeh, Fateme Sheida · 2021 · Biomedicine & Pharmacotherapy
12. Recent Advances in Dual PI3K/mTOR Inhibitors for Tumour Treatment
    Xianbo Wu, Yihua Xu, Qi Liang, Xinwei Yang, Jianli Huang, Jie Wang, Hong Zhang, Jianyou Shi · 2022 · Frontiers in Pharmacology
13. Amino acid activation of mTORC1 by a PB1-domain-driven kinase complex cascade
    J. Linares, A. Duran, M. Reina-Campos, P. Aza-Blanc, A. Campos, J. Moscat, M. Diaz-Meco · 2015 · Cell Reports
14. Lysosomal proteins in cell death and autophagy
    Michaela Mrschtik, Kevin M. Ryan · 2015 · FEBS Journal
15. Vesicular Trafficking and Signaling for Cytokine and Chemokine Secretion in Mast Cells
    Ulrich Blank, Iris Karina Madera-Salcedo, Luca Danelli, Julien Claver, Neeraj Tiwari, Elizabeth Sánchez-Miranda, Genaro Vázquez‐Victorio, Karla A. Ramírez‐Valadez, Marina Macías‐Silva, Claudia González‐Espinosa · 2014 · Frontiers in Immunology
16. Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
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17. Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR
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18. Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages
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19. Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response
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20. Recent Discoveries on the Role of TOR (Target of Rapamycin) Signaling in Translation in Plants
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21. Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington’s disease
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22. Biochemical Genetic Pathways that Modulate Aging in Multiple Species: Figure 1.
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23. miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes
    Keita Tsujimura, Koichiro Irie, Hideyuki Nakashima, Yoshihiro Egashira, Yoichiro Fukao, Masayuki Fujiwara, Masayuki Itoh, Masahiro Uesaka, Takuya Imamura, Yasukazu Nakahata et al. · 2015 · Cell Reports
24. Dopamine D2 receptors gate generalization of conditioned threat responses through mTORC1 signaling in the extended amygdala
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25. Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
    Sharon K. Kuss-Duerkop, Juan Wang, Ignacio Mena, Kris M. White, Giorgi Metreveli, Ramanavelan Sakthivel, Miguel A. Mata, Raquel Muñoz-Moreno, Xiang Chen, Florian Krammer et al. · 2017 · PLoS Pathogens
26. PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells
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27. Safety of mTOR inhibitors in adult solid organ transplantation
    Pedro Ventura‐Aguiar, Josep Maria Campistol, Fritz Diekmann · 2015 · Expert Opinion on Drug Safety
28. mTOR, cardiomyocytes and inflammation in cardiac hypertrophy
    Lifen Xu, Marijke Brink · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
29. mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
    Xiaolei Ding, Wilhelm Bloch, Sandra Iden, Markus A. Rüegg, Michael N. Hall, Maria Leptin, Linda Partridge, Sabine A. Eming · 2016 · Nature Communications
30. Metabolism and TAM functions—it takes two to tango
    Massimiliano Mazzone, Alessio Menga, Alessandra Castegna · 2017 · FEBS Journal
31. Golgi maturation‐dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3
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32. mTORC1 promotes cell growth via m6A-dependent mRNA degradation
    Sungyun Cho, Gina Lee, Brian F. Pickering, Cholsoon Jang, Jin H. Park, Long He, Lavina Mathur, Seung-Soo Kim, Sunhee Jung, Hong-Wen Tang et al. · 2021 · Molecular Cell
33. Targeting Lipid Metabolism in Liver Cancer
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34. Regulation of RNA Polymerase I Transcription in Development, Disease, and Aging
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35. The role of Wnt signaling pathway in tumor metabolic reprogramming
    Yongzhen Mo, Yumin Wang, Lishen Zhang, Liting Yang, Ming Zhou, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong et al. · 2019 · Journal of Cancer
36. Resistance to mTORC1 Inhibitors in Cancer Therapy: From Kinase Mutations to Intratumoral Heterogeneity of Kinase Activity
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37. Role of receptor tyrosine kinases mediated signal transduction pathways in tumor growth and angiogenesis—New insight and futuristic vision
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38. Resveratrol improves osteogenic differentiation of senescent bone mesenchymal stem cells through inhibiting endogenous reactive oxygen species productionviaAMPK activation
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39. Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells
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40. Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell Population
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41. mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway
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42. Optimal dietary alpha-linolenic acid/linoleic acid ratio improved digestive and absorptive capacities and target of rapamycin gene expression of juvenile grass carp (Ctenopharyngodon idellus)
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43. FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention
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44. Applications of fluorine to the construction of bioisosteric elements for the purposes of novel drug discovery
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45. Lipotoxicity and β Cell Maintenance in Obesity and Type 2 Diabetes
    Risheng Ye, Toshiharu Onodera, Philipp E. Scherer · 2019 · Journal of the Endocrine Society
46. Molecular mechanisms of mTOR regulation by stress
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47. Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2
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48. Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention
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49. Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin
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50. Genetic defects in PI3Kδ affect B-cell differentiation and maturation leading to hypogammaglobulineamia and recurrent infections
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51. Occurrence of Morpholine in Central Nervous System Drug Discovery
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52. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion
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53. Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness
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54. Regulation of rDNA transcription in response to growth factors, nutrients and energy
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55. The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury
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56. Autophagy, its mechanisms and regulation: Implications in neurodegenerative diseases
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57. SOX9/miR-203a axis drives PI3K/AKT signaling to promote esophageal cancer progression
    Lianghai Wang, Zhiyu Zhang, Xiaodan Yu, Qihang Li, Qian Wang, Aimin Chang, Xiaoxi Huang, Xueping Han, Yangguang Song, Jianming Hu et al. · 2019 · Cancer Letters
58. Mammalian target of rapamycin complex 1 (mTORC1) Is required for mouse spermatogonial differentiation in vivo
    Jonathan T. Busada, Bryan A. Niedenberger, Ellen K. Velte, Brett D. Keiper, Christopher B. Geyer · 2015 · Developmental Biology
59. Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders
    Denise Rageot, Thomas Bohnacker, Anna Melone, Jean-Baptiste Langlois, Chiara Borsari, Petra Hillmann, Alexander Sele, Florent Beaufils, Marketa Zvelebil, Paul Hebeisen et al. · 2018 · Journal of Medicinal Chemistry
60. Insulin Signaling and Insulin Resistance Facilitate Trained Immunity in Macrophages Through Metabolic and Epigenetic Changes
    Eleftheria Ieronymaki, Maria Daskalaki, Konstantina Lyroni, Christos Tsatsanis · 2019 · Frontiers in Immunology
61. Targeting PI 3‐kinase ( PI 3 K ), AKT and m TOR axis in lymphoma
    James Stewart Blachly, Robert A. Baiocchi · 2014 · British Journal of Haematology
62. mTORC1 promotes aging-related venous thrombosis in mice via elevation of platelet volume and activation
    Jun Yang, Xuan Zhou, Xiaorong Fan, Min Xiao, Dinghua Yang, Bo Liang, Meng Dai, Lanlan Shan, Jingbo Lu, Zhiqi Lin et al. · 2016 · Blood
63. Tuberous sclerosis complex–mediated mTORC1 overactivation promotes age-related hearing loss
    Xiaolong Fu, Xiaoyang Sun, Linqing Zhang, Yecheng Jin, Renjie Chai, Lili Yang, Aizhen Zhang, Xiangguo Liu, Xiaochun Bai, Jianfeng Li et al. · 2018 · Journal of Clinical Investigation
64. Integrated Akt/PKB Signaling in Immunomodulation and Its Potential Role in Cancer Immunotherapy
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65. Transcriptome Analysis of Wnt3a-Treated Triple-Negative Breast Cancer Cells
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66. Serine-threonine kinases in TCR signaling
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67. Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism and Growth of Breast Cancer Cells by Activating the LXRs/SREBP-1c/FAS Signaling Cascade
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68. TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease
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69. Hormonal control of the crustacean molting gland: Insights from transcriptomics and proteomics
    Donald L. Mykles, Ernest S. Chang · 2020 · General and Comparative Endocrinology
70. mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership
    Ángel Cayo, Raúl Segovia, Whitney Venturini, Rodrigo Moore‐Carrasco, Claudio A. Valenzuela, Nelson E. Brown · 2021 · International Journal of Molecular Sciences
71. The Role of Regulated Programmed Cell Death in Osteoarthritis: From Pathogenesis to Therapy
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72. Overexpression of the PP2A regulatory subunit Tap46 leads to enhanced plant growth through stimulation of the TOR signalling pathway
    Chang Sook Ahn, Heekyung Ahn, Hyun‐Sook Pai · 2014 · Journal of Experimental Botany
73. Promoting Autophagic Clearance: Viable Therapeutic Targets in Alzheimer's Disease
    Lauren G. Friedman, Yasir H. Qureshi, Wai Haung Yu · 2014 · Neurotherapeutics
74. Regulatory‐associated protein of TOR ( RAPTOR ) alters the hormonal and metabolic composition of Arabidopsis seeds, controlling seed morphology, viability and germination potential
    Mohamed A. Salem, Yan Li, Andrew A. G. Wiszniewski, Patrick Giavalisco · 2017 · The Plant Journal
75. Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes
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76. mTOR-dependent translation amplifies microglia priming in aging mice
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77. The role of RNA alternative splicing in regulating cancer metabolism
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78. Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype
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79. Multiple Roles of PLK1 in Mitosis and Meiosis
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80. Promotion Effects of miR-375 on the Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells
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81. Critical role for PI3-kinase in regulating the use of proteins as an amino acid source
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82. Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study
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83. mRNA 3′-UTR shortening is a molecular signature of mTORC1 activation
    Jae-Woong Chang, Wei Zhang, Hsin-Sung Yeh, Ebbing P. de Jong, Semo Jun, Kwan‐Hyun Kim, Sun Sik Bae, Kenneth B. Beckman, Tae Hyun Hwang, Kye-Seong Kim et al. · 2015 · Nature Communications
84. Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism
    Terri Iwata, Julita A. Ramírez, Mark Tsang, Heon Park, Daciana H. Margineantu, David M. Hockenbery, Brian M. Iritani · 2016 · The Journal of Immunology
85. Quantitative analysis of autophagic flux by confocal pH-imaging of autophagic intermediates
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86. Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling
    Powis, Katie, Zhang, Tianlong, Panchaud, Nicolas, Wang, Rong, Virgilio, Claudio De, Ding, Jianping · 2015 · Cell Research
87. ATP-Induced Increase in Intracellular Calcium Levels and Subsequent Activation of mTOR as Regulators of Skeletal Muscle Hypertrophy
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88. Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling
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89. mTOR Signaling Confers Resistance to Targeted Cancer Drugs
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90. Chronic activation of mTOR complex 1 by branched chain amino acids and organ hypertrophy
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91. TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition
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92. Canonical signaling and nuclear activity of mTOR —a teamwork effort to regulate metabolism and cell growth
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93. Variation in a range of mTOR-related genes associates with intracranial volume and intellectual disability
    Reijnders, M. R. F., Kousi, M., van Woerden, G. M., Klein, M., Bralten, J., Mancini, G. M. S., van Essen, T., Proietti-Onori, M., Smeets, E. E. J., van Gastel, M. et al. · 2017 · Nature Communications
94. Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease
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95. LncRNA PVT1 links Myc to glycolytic metabolism upon CD4+ T cell activation and Sjögren's syndrome-like autoimmune response
    Jiayao Fu, Huan Shi, Baoli Wang, Tianle Zhan, Yanxiong Shao, Lei Ye, Shufeng Wu, Chuangqi Yu, Lingyan Zheng · 2019 · Journal of Autoimmunity
96. CCL5 activation of CCR5 regulates cell metabolism to enhance proliferation of breast cancer cells
    Darrin F. Gao, Ramtin Rahbar, Eleanor N. Fish · 2016 · Open Biology
97. DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway
    Rajeev Kumar Singh, Pavan Kumar Dhanyamraju, Matthias Lauth · 2016 · Oncotarget
98. De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination
    Laura Montani, Jorge A. Pereira, Camilla Norrmén, Hartmut Pohl, Elisa Tinelli, Martin Trötzmüller, Gianluca Figlia, Penelope Dimas, Belinda von Niederhäusern, Rachel Schwager et al. · 2018 · The Journal of Cell Biology
99. Fasting and rapamycin: diabetes versus benevolent glucose intolerance
    Blagosklonny, Mikhail V. · 2019 · Cell Death & Disease
100. Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression
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