Making new contacts: the mTOR network in metabolism and signalling crosstalk

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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Notch signalling: a simple pathway becomes complex

Bray, S. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2009 · Cited by 2,620

Molecular mechanisms of mTOR-mediated translational control

Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464

Elucidation of a universal size-control mechanism in Drosophila and mammals

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Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

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Oxidative stress and autophagy: The clash between damage and metabolic needs

Filomeni, G., De Zio, D., & Cecconi, F. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.150 · Cited by 2,195

MTOR: a pharmacologic target for autophagy regulation

Kim, Y. C., & Guan, K.-L. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73939 · Cited by 2,126

The functions and regulation of the PTEN tumour suppressor: new modes and prospects

Lee, Y.-R., Chen, M., & Pandolfi, P. P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0015-0 · Cited by 937

Metabolic control of autophagy

Galluzzi, L., Pietrocola, F., Levine, B., & Kroemer, G. (2014) · Cell · doi:10.1016/j.cell.2014.11.006 · Cited by 855

Regulation of innate immune cell function by mTOR

Weichhart, T., Hengstschläger, M., & Linke, M. (2015) · Nature reviews. Immunology · doi:10.1038/nri3901 · Cited by 864

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

González, A., Hall, M. N., Lin, S.-C., & Hardie, D. G. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.015 · Cited by 797

Metabolic Control of Longevity

López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753

ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway

Zhao, Y., Hu, X., Liu, Y., Dong, S., Wen, Z., He, W., Zhang, S., Huang, Q., & Shi, M. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0648-1 · Cited by 735

Nutrient sensing and TOR signaling in yeast and mammals

González, A., & Hall, M. N. (2017) · The EMBO Journal · doi:10.15252/embj.201696010 · Cited by 752

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Tuo, Q., Zhang, S., & Lei, P. (2021) · Medicinal Research Reviews · doi:10.1002/med.21817 · Cited by 758

The interplay between cell signalling and the mevalonate pathway in cancer

Mullen, P., Yu, R., Longo, J., Archer, M. C., & Penn, L. Z. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.76 · Cited by 714

Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response

Wang, P., Zhao, Y., Li, Z., Hsu, C., Liu, X., Fu, L., Hou, Y., Du, Y., Xie, S., Zhang, C., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.12.002 · Cited by 607

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy

Tian, T., Li, X., & Zhang, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030755 · Cited by 602

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

Gruenbaum, Y., & Foisner, R. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034115 · Cited by 565

Hexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy

Roberts, D. J., & Miyamoto, S. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.173 · Cited by 523

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

Zhao, J., Zhai, B., Gygi, S. P., & Goldberg, A. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521919112 · Cited by 497

Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer

Fumarola, C., Bonelli, M. A., Petronini, P. G., & Alfieri, R. R. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.05.011 · Cited by 463

The utilization of extracellular proteins as nutrients is suppressed by mTORC1

Palm, W., Park, Y., Wright, K., Pavlova, N. N., Tuveson, D. A., & Thompson, C. B. (2015) · Cell · doi:10.1016/j.cell.2015.06.017 · Cited by 457

A systems study reveals concurrent activation of AMPK and mTOR by amino acids

Dalle Pezze, P., Ruf, S., Sonntag, A. G., Langelaar-Makkinje, M., Hall, P., Heberle, A. M., Razquin Navas, P., van Eunen, K., Tölle, R. C., Schwarz, J. J., et al. (2016) · Nature Communications · doi:10.1038/ncomms13254 · Cited by 148

Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer

Liu, G., Pei, F., Yang, F., Li, L., Amin, A. D., Liu, S., Buchan, J. R., & Cho, W. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020367 · Cited by 430

mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression

Khan, N. A., Nikkanen, J., Yatsuga, S., Jackson, C. B., Wang, L., Pradhan, S., Kivelä, R., Pessia, A., Velagapudi, V., & Suomalainen, A. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.007 · Cited by 394

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1

Morita, M., Prudent, J., Basu, K., Goyon, V., Katsumura, S., Hulea, L., Pearl, D., Siddiqui, N., Strack, S., McGuirk, S., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.08.013 · Cited by 381

PP2A as a master regulator of the cell cycle

Wlodarchak, N., & Xing, Y. (2016) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2016.1143913 · Cited by 380

Architecture of human mTOR complex 1

Aylett, C. H. S., Sauer, E., Imseng, S., Boehringer, D., Hall, M. N., Ban, N., & Maier, T. (2016) · Science · doi:10.1126/science.aaa3870 · Cited by 344

Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability

Stepanenko, A. A., & Dmitrenko, V. V. (2015) · Gene · doi:10.1016/j.gene.2015.08.009 · Cited by 321

Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time

Crosby, P., Hamnett, R., Putker, M., Hoyle, N. P., Reed, M., Karam, C. J., Maywood, E. S., Stangherlin, A., Chesham, J. E., Hayter, E. A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.017 · Cited by 309

Growing knowledge of the mTOR signaling network

Huang, K., & Fingar, D. C. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.09.011 · Cited by 310

mTOR signaling in cellular and organismal energetics

Albert, V., & Hall, M. N. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.12.001 · Cited by 304

Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes

Takahara, T., Amemiya, Y., Sugiyama, R., Maki, M., & Shibata, H. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00679-2 · Cited by 300

The role of mammalian target of rapamycin (mTOR) in insulin signaling

Yoon, M.-S. (2017) · Nutrients · doi:10.3390/nu9111176 · Cited by 300

mTOR Pathways in Cancer and Autophagy

Paquette, M., El–Houjeiri, L., & Pause, A. (2018) · Cancers · doi:10.3390/cancers10010018 · Cited by 301

The lysosome as a command-and-control center for cellular metabolism

Lim, C.-Y., & Zoncu, R. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201607005 · Cited by 298

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2Preprint

Ye, J., Palm, W., Peng, M., King, B., Lindsten, T., Li, M. O., Koumenis, C., & Thompson, C. B. (2015) · Genes & Development · doi:10.1101/gad.269324.115 · Cited by 285

The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases

Wang, H., Liu, Y., Wang, D., Xu, Y., Dong, R., Yang, Y., Lv, Q., Chen, X., & Zhang, Z. (2019) · Cells · doi:10.3390/cells8121597 · Cited by 286

Current treatment strategies for inhibiting mTOR in cancer

Chiarini, F., Evangelisti, C., McCubrey, J. A., & Martelli, A. M. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.11.004 · Cited by 279

mTORC 1 and mTORC 2 as regulators of cell metabolism in immunity

Linke, M., Fritsch, S. D., Sukhbaatar, N., Hengstschläger, M., & Weichhart, T. (2017) · FEBS Letters · doi:10.1002/1873-3468.12711 · Cited by 283

Application of Metabolomics in Alzheimer’s Disease

Wilkins, J. M., & Trushina, E. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2017.00719 · Cited by 268

MTOR inhibitors in cancer therapy

Xie, J., Wang, X., & Proud, C. G. (2016) · F1000Research · doi:10.12688/f1000research.9207.1 · Cited by 266

Emerging roles of aerobic glycolysis in breast cancer

Wu, Z., Wu, J., Zhao, Q., Fu, S., & Jin, J. (2019) · Clinical & Translational Oncology · doi:10.1007/s12094-019-02187-8 · Cited by 264

AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3

Paquette, M., El–Houjeiri, L., Zirden, L. C., Puustinen, P., Blanchette, P., Jeong, H., Dejgaard, K., Siegel, P. M., & Pause, A. (2021) · Autophagy · doi:10.1080/15548627.2021.1898748 · Cited by 264

Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity

Romero, R., Erez, O., Hüttemann, M., Maymon, E., Panaitescu, B., Conde-Agudelo, A., Pacora, P., Yoon, B. H., & Grossman, L. I. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.06.003 · Cited by 253

Spatial colocalization and functional link of purinosomes with mitochondria

French, J. B., Jones, S. A., Deng, H., Pedley, A. M., Kim, D., Chan, C. Y., Hu, H., Pugh, R. J., Zhao, H., Zhang, Y., et al. (2016) · Science · doi:10.1126/science.aac6054 · Cited by 241

Tunable and reversible drug control of protein production via a self-excising degron

Chung, H. K., Jacobs, C. L., Huo, Y., Yang, J., Krumm, S. A., Plemper, R. K., Tsien, R. Y., & Lin, M. Z. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1869 · Cited by 233

Mitochondria in the signaling pathways that control longevity and health span

Akbari, M., Kirkwood, T. B. L., & Bohr, V. A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100940 · Cited by 234

Targeting immune cells for cancer therapy

Gun, S. Y., Lee, S. W. L., Sieow, J. L., & Wong, S. C. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101174 · Cited by 237

Immunosuppressive Medications

Wiseman, A. C. (2015) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.08570814 · Cited by 234

Targeting mTOR and Metabolism in Cancer: Lessons and Innovations

Magaway, C., Kim, E., & Jacinto, E. (2019) · Cells · doi:10.3390/cells8121584 · Cited by 231

Multiple amino acid sensing inputs to mTORC1

Shimobayashi, M., & Hall, M. N. (2015) · Cell Research · doi:10.1038/cr.2015.146 · Cited by 228

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling

Lee, G., Zheng, Y., Cho, S., Jang, C., England, C., Dempsey, J. M., Yu, Y., Liu, X., He, L., Cavaliere, P. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.037 · Cited by 229

Klippel–Trenaunay syndrome belongs to the PIK3CA‐related overgrowth spectrum (PROS)

Vahidnezhad, H., Youssefian, L., & Uitto, J. (2015) · Experimental Dermatology · doi:10.1111/exd.12826 · Cited by 217

Key proteins and pathways that regulate lifespan

Pan, H., & Finkel, T. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.771915 · Cited by 228

NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer

Karki, R., Man, S. M., Malireddi, R. K. S., Kesavardhana, S., Zhu, Q., Burton, A. R., Sharma, B. R., Qi, X., Pelletier, S. W., Vogel, P., et al. (2016) · Nature · doi:10.1038/nature20597 · Cited by 218

Regulation of mTORC2 Signaling

Fu, W., & Hall, M. N. (2020) · Genes · doi:10.3390/genes11091045 · Cited by 225

The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

Hansen, C. G., Ng, Y. L. D., Lam, W.-L. M., Plouffe, S. W., & Guan, K.-L. (2015) · Cell Research · doi:10.1038/cr.2015.140 · Cited by 212

Roles of mTOR complexes in the kidney: implications for renal disease and transplantation

Fantus, D., Rogers, N. M., Grahammer, F., Huber, T. B., & Thomson, A. W. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.108 · Cited by 208

mTOR signaling regulates central and peripheral circadian clock function

Ramanathan, C., Kathale, N. D., Liu, D., Lee, C., Freeman, D. A., Hogenesch, J. B., Cao, R., & Liu, A. C. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007369 · Cited by 209

nanoCAGE reveals 5′ UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAsPreprint

Gandin, V., Masvidal, L., Hulea, L., Gravel, S., Cargnello, M., McLaughlan, S., Cai, Y., Balanathan, P., Morita, M., Rajakumar, A., et al. (2016) · Genome Research · doi:10.1101/gr.197566.115 · Cited by 204

Organelle-Specific Initiation of Autophagy

Sica, V., Galluzzi, L., Bravo-San Pedro, J. M., Izzo, V., Maiuri, M. C., & Kroemer, G. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.021 · Cited by 205

Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications

Fischer, G. M., Gopal, Y. N. V., McQuade, J. L., Peng, W., DeBerardinis, R. J., & Davies, M. A. (2017) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12661 · Cited by 200

Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation

Tan, H. W. S., Sim, A. Y. L., & Long, Y. C. (2017) · Nature Communications · doi:10.1038/s41467-017-00369-y · Cited by 205

SZT2 dictates GATOR control of mTORC1 signalling

Peng, M., Yin, N., & Li, M. O. (2017) · Nature · doi:10.1038/nature21378 · Cited by 192

GTPase ROP2 binds and promotes activation of target of rapamycin, TOR, in response to auxin

Schepetilnikov, M. V., Makarian, J., Srour, O., Geldreich, A., Yang, Z., Chicher, J., Hammann, P., & Ryabova, L. A. (2017) · The EMBO Journal · doi:10.15252/embj.201694816 · Cited by 194

A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma

Fan, Q., Aksoy, O., Wong, R. A., Ilkhanizadeh, S., Novotny, C. J., Gustafson, W. C., Truong, A. Y.-Q., Cayanan, G., Simonds, E. F., Haas-Kogan, D., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.01.014 · Cited by 180

Metabolic and hypoxic adaptation to anti‐angiogenic therapy: a target for induced essentiality

McIntyre, A., & Harris, A. L. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404271 · Cited by 186

Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?

Singh, S. S. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i43.12261 · Cited by 183

Pathological Roles of Iron in Cardiovascular Disease

Kobayashi, M., Suhara, T., Baba, Y., Kawasaki, N. K., Higa, J. K., & Matsui, T. (2018) · Current Drug Targets · doi:10.2174/1389450119666180605112235 · Cited by 182

Accumulation of autophagosomes confers cytotoxicity

Button, R. W., Roberts, S. L., Willis, T. L., Hanemann, C. O., & Luo, S. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.782276 · Cited by 186

mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis

Wan, W., You, Z., Xu, Y., Zhou, L., Guan, Z., Peng, C., Wong, C. C. L., Su, H., Zhou, T., Xia, H., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.09.020 · Cited by 178

Autophagy Maintains the Function of Bone Marrow Mesenchymal Stem Cells to Prevent Estrogen Deficiency-Induced Osteoporosis

Qi, M., Zhang, L., Ma, Y., Shuai, Y., Li, L., Luo, K., Liu, W., & Jin, Y. J. (2017) · Theranostics · doi:10.7150/thno.17949 · Cited by 177

Getting ready for building: signaling and autophagosome biogenesis

Abada, A., & Elazar, Z. (2014) · EMBO Reports · doi:10.15252/embr.201439076 · Cited by 178

Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance

Hewitt, G., & Korolchuk, V. I. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.11.011 · Cited by 175

Autophagy in the presynaptic compartment in health and disease

Vijayan, V., & Verstreken, P. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201611113 · Cited by 170

mTORC1 signaling in hepatic lipid metabolism

Han, J., & Wang, Y. (2017) · Protein & Cell · doi:10.1007/s13238-017-0409-3 · Cited by 172

Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva

Hino, K., Horigome, K., Nishio, M., Komura, S., Nagata, S., Zhao, C., Jin, Y., Kawakami, K., Yamada, Y., Ohta, A., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93521 · Cited by 168

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

Blandino-Rosano, M., Barbaresso, R., Jiménez-Palomares, M., Bozadjieva-Kramer, N., Werneck‐de‐Castro, J. P., Hatanaka, M., Mirmira, R. G., Sonenberg, N., Liu, M. R., Rüegg, M. A., et al. (2017) · Nature Communications · doi:10.1038/ncomms16014 · Cited by 161

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

Marat, A. L., Wallroth, A., Lo, W., Müller, R., Norata, G. D., Falasca, M., Schultz, C., & Haucke, V. (2017) · Science · doi:10.1126/science.aaf8310 · Cited by 166

Targeting the PI3K/AKT/mTOR Pathway in Bladder Cancer

Sathe, A., & Nawroth, R. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7234-0_23 · Cited by 159

The Mevalonate Pathway, a Metabolic Target in Cancer Therapy

Guerra, B., Recio, C., Aranda-Tavío, H., Guerra-Rodríguez, M., García-Castellano, J. M., & Fernández‐Pérez, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.626971 · Cited by 177

Regulation of Glucose Metabolism – A Perspective From Cell Bioprocessing

Mulukutla, B. C., Yongky, A., Le, T. S., Mashek, D. G., & Hu, W. (2016) · Trends in biotechnology · doi:10.1016/j.tibtech.2016.04.012 · Cited by 165

Microglia promote glioblastoma via mTOR‐mediated immunosuppression of the tumour microenvironment

Dumas, A. A., Pomella, N., Rosser, G., Guglielmi, L., Vinel, C., Millner, T. O., Rees, J. H., Aley, N., Sheer, D., Wei, J., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019103790 · Cited by 159

The Arabidopsis TOR Kinase Specifically Regulates the Expression of Nuclear Genes Coding for Plastidic Ribosomal Proteins and the Phosphorylation of the Cytosolic Ribosomal Protein S6

Dobrenel, T., Mancera-Martínez, E., Forzani, C., Azzopardi, M., Davanture, M., Moreau, M., Schepetilnikov, M. V., Chicher, J., Langella, O., Zivy, M., et al. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01611 · Cited by 160

mTORC1 pathway in DNA damage response

Ma, Y., Vassetzky, Y. S., & Dokudovskaya, S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.06.011 · Cited by 157

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

Cornu, M., Oppliger, W., Albert, V., Robitaille, A. M., Trapani, F., Quagliata, L., Fuhrer, T., Sauer, U., Terracciano, L., & Hall, M. N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412047111 · Cited by 152

High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells

Poulain, L., Sujobert, P., Zylbersztejn, F., Barreau, S., Stuani, L., Lambert, M., Palama, T. L., Chesnais, V, Birsen, R., Vergez, F., et al. (2017) · Leukemia · doi:10.1038/leu.2017.81 · Cited by 145

Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation

Olsen, J. M., Sato, M., Dallner, O. S., Sandström, A. L., Pisani, D. F., Chambard, J., Amri, E., Hutchinson, D. S., & Bengtsson, T. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201403080 · Cited by 158

Eosinophilic Solid and Cystic Renal Cell Carcinoma (ESC RCC)

Trpkov, K., Abou–Ouf, H., Hes, O., Lopez, J. I., Nesi, G., Compérat, É., Sibony, M., Osunkoya, A. O., Zhou, M., Gökden, N., et al. (2017) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000838 · Cited by 154

Glutaminolysis and autophagy in cancer

Villar, V. H., Merhi, F., Djavaheri-Mergny, M., & Durán, R. V. (2015) · Autophagy · doi:10.1080/15548627.2015.1053680 · Cited by 143

Novel links in the plant TOR kinase signaling network

Xiong, Y., & Sheen, J. (2015) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2015.09.006 · Cited by 146

Transforming Growth Factor-β and Interleukin-10 Synergistically Regulate Humoral Immunity via Modulating Metabolic Signals

Komai, T., Inoue, M., Okamura, T., Morita, K., Iwasaki, Y., Sumitomo, S., Shoda, H., Yamamoto, K., & Fujio, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01364 · Cited by 158

Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease

Ren, Q., Sun, Q., & Fu, J. (2023) · Autophagy · doi:10.1080/15548627.2023.2254191 · Cited by 149

The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth ControlPreprint

Hindupur, S. K., González, A., & Hall, M. N. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019141 · Cited by 147

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