Making new contacts: the mTOR network in metabolism and signalling crosstalk

mTOR Signaling in Growth Control and Disease

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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Notch signalling: a simple pathway becomes complex

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Molecular mechanisms of mTOR-mediated translational control

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Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464

Elucidation of a universal size-control mechanism in Drosophila and mammals

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Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S.-I., Natsume, T., Takehana, K., Yamada, N., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1248 · Cited by 2,076

Fatty acid synthase is required for profibrotic TGF‐β signaling

Jung, M., Kang, J. H., Hernandez, D. M., Yin, X., Andrianifahanana, M., Wang, Y., González-Guerrico, A. M., LIMPER, A. H., & Leof, E. B. (2018) · The FASEB Journal · doi:10.1096/fj.201701187r · Cited by 75

Phosphorylated Rho–GDP directly activates mTORC2 kinase towards AKT through dimerization with Ras–GTP to regulate cell migration

Senoo, H., Kamimura, Y., Kimura, R., Nakajima, A., Sawai, S., Sesaki, H., & Iijima, M. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0348-8 · Cited by 76

Caloric restriction and exercise “mimetics”: ready for prime time

Handschin, C. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2015.11.009 · Cited by 72

Control of B lymphocyte development and functions by the mTOR signaling pathways

Iwata, T., Ramírez, J. A., Park, H., & Iritani, B. M. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.04.005 · Cited by 73

mTORC2 controls cancer cell survival by modulating gluconeogenesis

Khan, M. W., Biswas, D., Ghosh, M., Mandloi, S., Chakrabarti, S., & Chakrabarti, P. (2015) · Cell Death Discovery · doi:10.1038/cddiscovery.2015.16 · Cited by 71

CCAAT/enhancer-binding protein beta (C/EBPβ) knockdown reduces inflammation, ER stress, and apoptosis, and promotes autophagy in oxLDL-treated RAW264.7 macrophage cells

Zahid, M. K., Rogowski, M. P., Ponce, C., Choudhury, M., Moustaïd‐Moussa, N., & Rahman, S. M. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03642-4 · Cited by 69

Identification of breast cancer cell subtypes sensitive to ATG4B inhibition

Bortnik, S. B., Choutka, C., Horlings, H. M., Leung, S. C. Y., Baker, J. H. E., Lebovitz, C. B., Dragowska, W. H., Go, N. E., Bally, M. B., Minchinton, A. I., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11408 · Cited by 70

The mTOR Signaling Pathway in Myocardial Dysfunction in Type 2 Diabetes Mellitus

Suhara, T., Baba, Y., Shimada, B. K., Higa, J. K., & Matsui, T. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0865-4 · Cited by 70

MUC16-mediated activation of mTOR and c-MYC reprograms pancreatic cancer metabolism

Shukla, S. K., Gunda, V., Abrego, J., Haridas, D., Mishra, A., Souchek, J. J., Chaika, N. V., Yu, F., Sasson, A. R., Lazenby, A. J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4078 · Cited by 70

Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling

Berard, A. R., Brubaker, D. K., Birse, K., Lamont, A., Mackelprang, R. D., Noël‐Romas, L., Perner, M., Hou, X., Irungu, E., Mugo, N., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112474 · Cited by 71

Obesity and Cancer Metabolism: A Perspective on Interacting Tumor–Intrinsic and Extrinsic Factors

Doerstling, S. S., O’Flanagan, C. H., & Hursting, S. D. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00216 · Cited by 68

mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress

Chau, G. C., Im, D. U., Kang, T. M., Bae, J. M., Kim, W., Pyo, S., Moon, E.-Y., & Um, S. H. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201701085 · Cited by 67

Intervention and potential mechanism of non-starch polysaccharides from natural resources on ulcerative colitis: A review

Wang, Y., Li, Q.-M., Zha, X., & Luo, J. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.04.208 · Cited by 70

Modulation of mTOR Signaling in Cardiovascular Disease to Target Acute and Chronic Inflammation

Kaldirim, M., Lang, A., Pfeiler, S., Fiegenbaum, P., Kelm, M., Bönner, F., & Gerdes, N. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.907348 · Cited by 69

Programmed death of cardiomyocytes in cardiovascular disease and new therapeutic approaches

Cai, K., Jiang, H., Zou, Y., Song, C., Cao, K., Chen, S., Wu, Y., Zhang, Z., Geng, D., Zhang, N., et al. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107281 · Cited by 71

PQLC2 recruits the C9orf72 complex to lysosomes in response to cationic amino acid starvation

Amick, J., Tharkeshwar, A. K., Talaia, G., & Ferguson, S. M. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201906076 · Cited by 68

MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells

Ahumada-Castro, U., Silva-Pavez, E., Lovy, A., Pardo, E., Molgó, J., & Cárdenas, C. (2018) · Autophagy · doi:10.1080/15548627.2018.1537769 · Cited by 67

Aging Research—Where Do We Stand and Where Are We Going?

Guarente, L. (2014) · Cell · doi:10.1016/j.cell.2014.08.041 · Cited by 66

Balance between Cytosolic and Chloroplast Translation Affects Leaf Variegation

Wang, R., Zhao, J. Y., Jia, M., Xu, N., Liang, S., Shao, J., Qi, Y., Liu, X., An, L., & Yu, F. (2017) · PLANT PHYSIOLOGY · doi:10.1104/pp.17.00673 · Cited by 65

Cellular Signaling Pathways in Medium and Large Vessel Vasculitis

Watanabe, R., Berry, G. J., Liang, D. H., Goronzy, J. J., & Weyand, C. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.587089 · Cited by 65

Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy

Shende, P., Xu, L., Morandi, C., Pentassuglia, L., Heim, P., Lebboukh, S., Berthonneche, C., Pedrazzini, T., Kaufmann, B. A., Hall, M. N., et al. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv252 · Cited by 67

PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy

Ruf, S., Heberle, A. M., Langelaar‐Makkinje, M., Gelino, S., Wilkinson, D., Gerbeth, C., Schwarz, J., Holzwarth, B., Warscheid, B., Meisinger, C., et al. (2017) · Autophagy · doi:10.1080/15548627.2016.1263781 · Cited by 65

Fatty acid 2-hydroxylation inhibits tumor growth and increases sensitivity to cisplatin in gastric cancer

Yao, Y., Yang, X., Sun, L., Sun, S., Huang, X., Zhou, D., Li, T., Zhang, W., Abumrad, N. A., Zhu, X., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.01.066 · Cited by 65

Human MAF1 targets and represses active RNA polymerase III genes by preventing recruitment rather than inducing long-term transcriptional arrestPreprint

Orioli, A., Praz, V., Lhôte, P., & Hernandez, N. (2016) · Genome Research · doi:10.1101/gr.201400.115 · Cited by 67

Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress

Samluk, Ł., Urbańska, M., Kisielewska, K., Mohanraj, K., Kim, M., Machnicka, K., Liszewska, E., Jaworski, J., & Chacińska, A. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-10-0628 · Cited by 60

The Sucrose Non-Fermenting 1-Related Protein Kinase 2 (SnRK2) Genes Are Multifaceted Players in Plant Growth, Development and Response to Environmental Stimuli

Mao, X., Li, Y., Rehman, S. U., Miao, L., Zhang, Y., Chen, X., Yu, C., Wang, J., Li, C., & Jing, R. (2019) · Plant and Cell Physiology · doi:10.1093/pcp/pcz230 · Cited by 64

Blood-testis barrier: a review on regulators in maintaining cell junction integrity between Sertoli cells

Wanjari, U. R., & Gopalakrishnan, A. V. (2024) · Cell and Tissue Research · doi:10.1007/s00441-024-03894-7 · Cited by 65

Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo

Nakayama, H., Bruneau, S., Kochupurakkal, N. M., Coma, S., Briscoe, D. M., & Klagsbrun, M. (2015) · Scientific Reports · doi:10.1038/srep11789 · Cited by 64

The spectrum of macrophage activation by immunometabolism

Kang, S., & Kumanogoh, A. (2020) · International Immunology · doi:10.1093/intimm/dxaa017 · Cited by 64

mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy

Schlingmann, K. P., Jouret, F., Shen, K., Nigam, A., Arjona, F. J., Dafinger, C., Houillier, P., Jones, D. P., Kleinerüschkamp, F., Oh, J. S., et al. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.2021030333 · Cited by 63

Loss of Rictor with aging in osteoblasts promotes age-related bone loss

Lai, P., Song, Q., Yang, C., Li, Z., Liu, S., Liu, B., Li, M., Deng, H., Cai, D., Jin, D., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.249 · Cited by 63

The plant hormone abscisic acid regulates the growth and metabolism of endophytic fungus Aspergillus nidulans

Xu, G., Yang, S., Meng, L., & Wang, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-24770-9 · Cited by 65

Mitochondrial stress-dependent regulation of cellular protein synthesis

Topf, U., Uszczynska-Ratajczak, B., & Chacinska, A. (2019) · Journal of Cell Science · doi:10.1242/jcs.226258 · Cited by 52

Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling

WICKI, A. N., Mandalà, M., Massi, D., Taverna, D., Tang, H., Hemmings, B. A., & Xue, G. (2016) · Physiological Reviews · doi:10.1152/physrev.00024.2015 · Cited by 64

Clinical development of mTor inhibitors for renal cancer

Ghidini, M., Petrelli, F., Ghidini, A., Tomasello, G., Hahne, J. C., Passalacqua, R., & Barni, S. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1384813 · Cited by 63

Oncogenic Rag GTPase signalling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR

Ortega-Molina, A., Deleyto-Seldas, N., Carreras, J., Sanz, A., Lebrero‐Fernández, C., Menéndez, C., Vandenberg, A., Fernández-Ruiz, B., Marín-Arraiza, L., Arregui, C. D. L. C., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0098-8 · Cited by 67

Endosomes, lysosomes, and the role of endosomal and lysosomal biogenesis in cancer development

Jeger, J. L. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05993-4 · Cited by 60

Major roles of the circadian clock in cancer

Huang, C. L., Zhang, C., Cao, Y., Li, J., & Bi, F. (2023) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2022.0474 · Cited by 64

Glycometabolic Reprogramming of Microglia in Neurodegenerative Diseases: Insights from Neuroinflammation

Huang, Q., Wang, Y., Chen, S., & Liang, F. (2023) · Aging and disease · doi:10.14336/ad.2023.0807 · Cited by 62

Post-transplantation malignancies: here today, gone tomorrow?

Geissler, E. K. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.186 · Cited by 63

Role of mTORC1–S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia

Ghosh, J., & Kapur, R. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.02.004 · Cited by 69

Design, synthesis and bioevaluation of novel substituted triazines as potential dual PI3K/mTOR inhibitors

Wu, T.-T., Guo, Q., Chen, Z., Wang, L., Du, Y., Chen, R., Mao, Y., Yang, S., Huang, J., Wang, J., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112637 · Cited by 62

HLA Class II–Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection

Jin, Y., Valenzuela, N. M., Zhang, X., Rozengurt, E., & Reed, E. F. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701259 · Cited by 61

Effects of proton pump inhibitors on reversing multidrug resistance via downregulating V-ATPases/PI3K/Akt/mTOR/HIF-1α signaling pathway through TSC1/2 complex and Rheb in human gastric adenocarcinoma cells in vitro and in vivo

Chen, M., Lu, J., Wei, W., Lv, Y., Zhang, X., Yao, Y., Wang, L., Ling, T., & Zou, X. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s161198 · Cited by 61

mTOR in health and in sickness

Liko, D., & Hall, M. N. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1326-7 · Cited by 60

TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation

Fitzian, K., Brückner, A., Brohée, L., Zech, R., Antoni, C., Kiontke, S., Gasper, R., Matos, A. L. L., Beel, S., Wilhelm, S., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.04.019 · Cited by 57

Cell cycle dependence on the mevalonate pathway: Role of cholesterol and non-sterol isoprenoids

Lasunción, M. A., Martínez-Botas, J., Martín-Sánchez, C., Busto, R., & Gómez‐Coronado, D. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114623 · Cited by 62

Transmembrane signaling in Saccharomyces cerevisiae as a model for signaling in metazoans: State of the art after 25years

Engelberg, D., Perlman, R., & Levitzki, A. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.09.003 · Cited by 61

Inhibition of the PI3K–Akt and mTORC1 signaling pathways promotes the elongation of vascular endothelial cells

Tsuji‐Tamura, K., & Ogawa, M. (2016) · Journal of Cell Science · doi:10.1242/jcs.178434 · Cited by 60

Correlation between telomerase and mTOR pathway in cancer stem cells

Doğan, F., & Avcı, Ç. B. (2017) · Gene · doi:10.1016/j.gene.2017.09.072 · Cited by 60

Role of mTORC1 Controlling Proteostasis after Brain Ischemia

Pérez-Álvarez, M. J., Villa-González, M., Benito‐Cuesta, I., & Wandosell, F. G. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00060 · Cited by 63

A review of fasting effects on the response of cancer to chemotherapy

Sadeghian, M., Rahmani, S., Khalesi, S., & Hejazi, E. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.10.037 · Cited by 60

Mincle-Mediated Neutrophil Extracellular Trap Formation by Regulation of Autophagy

Sharma, A., Simonson, T. J., Jondle, C. N., Mishra, B. B., & Sharma, J. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix072 · Cited by 61

mTOR and metabolic regulation of conventional and regulatory T cells

Liu, C., Chapman, N. M., Karmaus, P. W. F., Zeng, H., & Chi, H. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.2ri0814-408r · Cited by 59

Signaling pathways regulating blood–tissue barriers — Lesson from the testis

Wen, Q., Tang, E. I., Gao, Y., Jesus, T. T., Chu, D. S., Lee, W. M., Wong, C. K. C., Liu, Y., Xiao, X., Silvestrini, B., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.04.020 · Cited by 59

Nutritional strategies to support concurrent training

Pérez‐Schindler, J., Hamilton, D. L., Moore, D. R., Baar, K., & Philp, A. (2014) · European Journal of Sport Science · doi:10.1080/17461391.2014.950345 · Cited by 63

Pharmacological regulators of autophagy and their link with modulators of lupus disease

Gros, F., & Muller, S. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12792 · Cited by 60

CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation

Mishra, S. K., Gao, Y., Deng, Y., Chalfant, C. E., Hinchcliffe, E. H., & Brown, R. E. (2017) · Autophagy · doi:10.1080/15548627.2017.1393129 · Cited by 57

Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration

Nguyen, J. T., Ray, C., Fox, A. L., Mendonça, D. B. S., Kim, J. K., & Krebsbach, P. H. (2018) · Science Advances · doi:10.1126/sciadv.aao5838 · Cited by 57

Metabolic Control of m6A RNA Modification

Kim, J., & Lee, G. (2021) · Metabolites · doi:10.3390/metabo11020080 · Cited by 57

Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export

Rodríguez-Vargas, J. M., Rodríguez, M. I., Majuelos‐Melguizo, J., García-Díaz, Á., González-Flores, A., López‐Rivas, A., Virág, L., Illuzzi, G., Schreiber, V., Dantzer, F., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.80 · Cited by 57

The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation

Kim, J. H., Seo, D., Kim, S., Choi, D. W., Park, J. S., Ha, J., Choi, J., Lee, J.-H., Jung, S. M., Seo, K., et al. (2018) · EMBO Reports · doi:10.15252/embr.201744378 · Cited by 58

Immunometabolism and PI(3)K Signaling As a Link between IL-2, Foxp3 Expression, and Suppressor Function in Regulatory T Cells

Fan, M. Y., & Turka, L. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00069 · Cited by 57

Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle

Dutchak, P. A., Estill-Terpack, S. J., Plec, A. A., Zhao, X., Yang, C., Chen, J., Ko, B., Deberardinis, R. J., Yu, Y., & Tu, B. P. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.058 · Cited by 53

Mucins reprogram stemness, metabolism and promote chemoresistance during cancer progression

Marimuthu, S., Rauth, S., Ganguly, K., Zhang, C., Lakshmanan, I., Batra, S. K., & Ponnusamy, M. P. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-09959-1 · Cited by 55

Branched-chain amino acid and lysine deficiencies exert different effects on mammary translational regulation

Doelman, J., Kim, J. J. M., Carson, M., Metcalf, J. A., & Cant, J. P. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-9819 · Cited by 55

4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells

Yun, S., Vincelette, N. D., Knorr, K. L. B., Almada, L. L., Schneider, P. A., Peterson, K. L., Flatten, K. S., Dai, H., Pratz, K. W., Hess, A. D., et al. (2016) · Blood · doi:10.1182/blood-2015-02-629485 · Cited by 55

PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells

Matsumoto, C. S., Almeida, L. O., Guimarães, D. M., Martins, M. D., Papagerakis, P., Papagerakis, S. M., Leopoldino, A. M., CASTILHO, R. M., & SQUARIZE, C. H. (2016) · Oncotarget · doi:10.18632/oncotarget.9877 · Cited by 58

Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology

Guo, J., Cheng, J., North, B. J., & Wei, W. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.07.001 · Cited by 55

Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy

Sathe, A., Chalaud, G., Oppolzer, I. A., Wong, K. Y., von Busch, M., Schmid, S. C., Tong, Z., Retz, M. M., Gschwend, J. E., Schulz, W. A., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190854 · Cited by 55

Insight Into the Role of Autophagy in Osteosarcoma and Its Therapeutic Implication

Niu, J., Yan, T., Guo, W., Wang, W., & Zhao, Z. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01232 · Cited by 57

Eukaryotic elongation factor-2 kinase (eEF2K) signaling in tumor and microenvironment as a novel molecular target

Karakas, D., & Ozpolat, B. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01917-8 · Cited by 54

Modulating pyrimidine ribonucleotide levels for the treatment of cancer

Mollick, T., & Laín, S. (2020) · Cancer & Metabolism · doi:10.1186/s40170-020-00218-5 · Cited by 57

PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1

DeMille, D., Badal, B. D., Evans, J. B., Mathis, A. D., Anderson, J. F., & Grose, J. H. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-06-1088 · Cited by 55

Transcriptome analysis of the molting gland (Y-organ) from the blackback land crab, Gecarcinus lateralis

Das, S., Pitts, N. L., Mudron, M. R., Durica, D. S., & Mykles, D. L. (2015) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2015.11.003 · Cited by 54

Molecular signaling cascades involved in nonmelanoma skin carcinogenesis

Feehan, R. P., & Shantz, L. M. (2016) · Biochemical Journal · doi:10.1042/bcj20160471 · Cited by 54

Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders

Evangelisti, C., Cenni, V., & Lattanzi, G. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12928 · Cited by 53

Overcome tumor heterogeneity-imposed therapeutic barriers through convergent genomic biomarker discovery: A braided cancer river model of kidney cancer

Hsieh, J. J.-D., Manley, B. J., Khan, N. A., Gao, J., Carlo, M. I., & Cheng, E. H. Y. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.09.002 · Cited by 54

Antagonism between Hedgehog and Wnt signaling pathways regulates tumorigenicity (Review)

Ding, M., & Wang, X. (2017) · Oncology Letters · doi:10.3892/ol.2017.7030 · Cited by 55

Collagen type I induces EGFR ‐ TKI resistance in EGFR ‐mutated cancer cells by mTOR activation through Akt‐independent pathway

Yamazaki, S., Higuchi, Y., Ishibashi, M., Hashimoto, H., Yasunaga, M., Matsumura, Y., Tsuchihara, K., Tsuboi, M., Goto, K., Ochiai, A., et al. (2018) · Cancer Science · doi:10.1111/cas.13624 · Cited by 52

Protein kinase N controls a lysosomal lipid switch to facilitate nutrient signalling via mTORC1

Wallroth, A., Koch, P. A., Marat, A. L., Krause, E., & Haucke, V. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0377-3 · Cited by 55

Blockage of Autophagy for Cancer Therapy: A Comprehensive Review

Hassan, A., Zhao, Y., Chen, X., & He, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137459 · Cited by 55

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Fructose supplementation impairs rat liver autophagy through mTORC activation without inducing endoplasmic reticulum stress

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Bisphenol S perturbs Sertoli cell junctions in male rats via alterations in cytoskeletal organization mediated by an imbalance between mTORC1 and mTORC2

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Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

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Multimode drug inducible CRISPR/Cas9 devices for transcriptional activation and genome editing

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Sarcopenia: Tilting the Balance of Protein Homeostasis

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mTOR Signaling: The Interface Linking Cellular Metabolism and Hepatitis B Virus Replication

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Novel Regulatory Mechanisms of mTOR Signaling

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