Three-dimensional organotypic culture: experimental models of mammalian biology and disease

Matrix elasticity directs stem cell lineage specification

Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204

Cerebral organoids model human brain development and microcephaly

Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372

Molecular Biology of the Cell

Alberts, B., Johnson, A. D., Lewis, J. H., RAFF, M. C., Roberts, K. J., & Walter, P. (2007) · W.W. Norton eBooks · doi:10.1201/9780203833445 · Cited by 4,591

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101

Tensional homeostasis and the malignant phenotype

Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941

Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium

Sato, T., Stange, D. E., Ferrante, M., Vries, R. G. J., van Es, J. H., van den Brink, S., van Houdt, W. J., Pronk, A., van Gorp, J., Siersema, P. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.050 · Cited by 3,753

Organoids as a tool for understanding immune-mediated intestinal regeneration and development

Jowett, G. M., Coales, I., & Neves, J. F. (2022) · Development · doi:10.1242/dev.199904 · Cited by 14

Magnetic Nanoheterostructures

Sharma, S. K., & Javed, Y. (2020) · Nanomedicine and nanotoxicology · doi:10.1007/978-3-030-39923-8 · Cited by 15

Development of a Vascularized Human Skin Equivalent with Hypodermis for Photoaging Studies

Sanchez, M. M., Tonmoy, T. I., Park, B. H., & Morgan, J. T. (2022) · Biomolecules · doi:10.3390/biom12121828 · Cited by 15

Hydrogels in three-dimensional dendritic cell (MUTZ-3) culture as a scaffold to mimic human immuno competent subcutaneous tissue

Groell, F., Kalia, Y. N., Jordan, O., & Borchard, G. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.04.050 · Cited by 14

Bioactive factors secreted from mesenchymal stromal cells protect the intestines from experimental colitis in a three-dimensional culture

Gonçalves, F. D. C., Serafini, M. A., Mello, H. F., Pfaffenseller, B., Araújo, A. B., Visioli, F., & Paz, A. H. D. R. (2018) · Cytotherapy · doi:10.1016/j.jcyt.2018.06.007 · Cited by 14

Modeling chemical effects on breast cancer: the importance of the microenvironment in vitro

Morgan, M. M., Schuler, L. A., Ciciliano, J. C., Johnson, B. P., Alarid, E. T., & Beebe, D. J. (2020) · Integrative Biology · doi:10.1093/intbio/zyaa002 · Cited by 14

Transmigration of Trypanosoma cruzi trypomastigotes through 3D cultures resembling a physiological environment

Rodríguez, M. E., Rizzi, M., Caeiro, L. D., Masip, Y. E., Perrone, A. E., Sánchez, D. O., Búa, J., & Tekiel, V. (2020) · Cellular Microbiology · doi:10.1111/cmi.13207 · Cited by 14

3D Tumor Models in Urology

Neuhaus, J., Rabien, A., Reinhold, A., Koehler, L., & Berndt‐Paetz, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076232 · Cited by 13

Three dimensional (3D) gingival models in periodontal research: a systematic review

Fatlawi, Z. M. H. A., Huang, M., Chau, D. Y. S., & D’Aiuto, F. (2023) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-023-06761-z · Cited by 13

Roadmap to Nanomedical Applications: Nanotoxicology and In Vitro Guidelines for Lanthanide‐Doped Luminescence Nanothermometers

Premcheska, S., Skirtach, A. G., & Kaczmarek, A. M. (2025) · Advanced NanoBiomed Research · doi:10.1002/anbr.202500003 · Cited by 13

Fibrous polyisocyanide hydrogels for 3D cell culture applications

Yuan, H., Liu, K., van Velthoven, M. J. J., Kumari, J., Bao, Y., Rocha, S., & Kouwer, P. H. J. (2025) · Nature Protocols · doi:10.1038/s41596-025-01159-3 · Cited by 13

Bringing benign ectomesenchymal odontogenic tumours to the lab: An in vitro study using an organotypic culture model

Bastos, V. C., Pereira, N. B., Diniz, M. G., Andrade, L. O., Castro, W. H., Kitten, G. T., Gomez, R. S., & Gomes, C. C. (2018) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12812 · Cited by 13

Generation of Self-assembled Vascularized Human Skin Equivalents

Sanchez, M. M., & Morgan, J. T. (2021) · Journal of Visualized Experiments · doi:10.3791/62125 · Cited by 14

VCAM1-α4β1 integrin interaction mediates interstitial tissue reconstruction in 3-D re-aggregate culture of dissociated prepubertal mouse testicular cells

Abe, K., Kon, S., Kameyama, H., Zhang, J., Morohashi, K.-I., Shimamura, K., & Abé, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-97729-y · Cited by 13

Three-Dimensional Organoids as a Model to Study Nonalcoholic Fatty Liver Disease

Park, Y., Thadasina, D., Bolujo, I., Isidan, A., Cross-Najafi, A. A., Lopez, K., Li, P., Dahlem, A. M., Kennedy, L. L., Sato, K., et al. (2022) · Seminars in Liver Disease · doi:10.1055/a-1934-5588 · Cited by 13

Using 3D Organoid Cultures to Model Intestinal Physiology and Colorectal Cancer

Short, S. P., Costacurta, P. W., & Williams, C. S. (2017) · Current Colorectal Cancer Reports · doi:10.1007/s11888-017-0363-8 · Cited by 14

Antisense Oligonucleotide-mediated Knockdown in Mammary Tumor Organoids

Diermeier, S. D., & Spector, D. L. (2017) · BIO-PROTOCOL · doi:10.21769/bioprotoc.2511 · Cited by 13

Sensor-free and Sensor-based Heart-on-a-chip Platform: A Review of Design and Applications

Wan, H., Gu, C., Gan, Y., Wei, X., Zhu, K., Hu, N., & Wang, P. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190207170004 · Cited by 13

Computational Models Accurately Predict Multi-Cell Biomarker Profiles in Inflammation and Cancer

Fischer, C. L., Bates, A. M., Lanzel, E. A., Guthmiller, J. M., Johnson, G. K., Singh, N. K., Kumar, A., Vidva, R., Abbasi, T., Vali, S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-47381-4 · Cited by 13

Redox-responsive functionalized hydrogel marble for the generation of cellular spheroids

Ramadhan, W., Ohama, Y., Minamihata, K., Moriyama, K., Wakabayashi, R., Goto, M., & Kamiya, N. (2020) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2020.05.010 · Cited by 13

Optimal, Large-Scale Propagation of Mouse Mammary Tumor Organoids

Wrenn, E. D., Moore, B. M., Greenwood, E., McBirney, M., & Cheung, K. J. (2020) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-020-09464-1 · Cited by 14

An In Vitro Model of Avian Skin Reveals Evolutionarily Conserved Transcriptional Regulation of Epidermal Barrier Formation

Lachner, J., Derdak, S. V., Mlitz, V., Wagner, T., Holthaus, K. B., Ehrlich, F., Mildner, M., Tschachler, E., & Eckhart, L. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.04.029 · Cited by 13

Ensuring Employee Job Security When Implementing Changes in the Company: A Case Study of Lithuanian Industry

Valackienė, A., Meidutė‐Kavaliauskienė, I., & Činčikaitė, R. (2021) · Sustainability · doi:10.3390/su13158383 · Cited by 13

Genomic medicine in Africa: a need for molecular genetics and pharmacogenomics experts

Oluwole, O. G., & Henry, M. (2022) · Current Medical Research and Opinion · doi:10.1080/03007995.2022.2124072 · Cited by 12

The Mini‐Organo: A rapid high‐throughput 3D coculture organotypic assay for oncology screening and drug development

Chitty, J. L., Skhinas, J. N., Filipe, E. C., Wang, S., Cupello, C. R., Grant, R. D., Yam, M., Papanicolaou, M., Major, G. S., Zaratzian, A., et al. (2019) · Cancer Reports · doi:10.1002/cnr2.1209 · Cited by 13

A versatile microfluidic device for multiple ex vivo/in vitro tissue assays unrestrained from tissue topography

de Hoyos‐Vega, J. M., Gonzalez‐Suarez, A. M., & Garcia-Cordero, J. L. (2020) · Microsystems & Nanoengineering · doi:10.1038/s41378-020-0156-0 · Cited by 13

The potential of organoids in toxicologic pathology: role of toxicologic pathologists in in vitro chemical hepatotoxicity assessment

Yoshida, T., Kobayashi, M., Uomoto, S., Ohshima, K., Hara, E., Katoh, Y., Takahashi, N., Harada, T., Usui, T., Elbadawy, M., et al. (2022) · Journal of Toxicologic Pathology · doi:10.1293/tox.2022-0017 · Cited by 12

3D-spheroids: What can they tell us about pancreatic ductal adenocarcinoma cell phenotype?

Gagliano, N., Sforza, C., Sommariva, M., Menon, A., Conte, V., Sartori, P., & Procacci, P. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.05.027 · Cited by 13

Toxicity Assessment of Nanomaterials

Tasso, M., Huvelle, M. A. L., Bessone, I. D., & Picco, A. S. (2020) · Nanomedicine and nanotoxicology · doi:10.1007/978-3-030-39923-8_13 · Cited by 12

Modeling endodermal organ development and diseases using human pluripotent stem cell-derived organoids

Pan, F. C., Evans, T., & Chen, S. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa031 · Cited by 12

Adaptation of the AID system for stem cell and transgenic mouse research

Pryzhkova, M. V., Xu, M. J., & Jordan, P. W. (2020) · Stem Cell Research · doi:10.1016/j.scr.2020.102078 · Cited by 12

Radon Exposure and the Definition of Low Doses—The Problem of Spatial Dose Distribution

Madas, B. G. (2016) · Health Physics · doi:10.1097/hp.0000000000000516 · Cited by 12

Smart Bioinks as de novo Building Blocks to Bioengineer Living Tissues

Blaeser, A., Heilshorn, S. C., & Campos, D. F. D. (2019) · Gels · doi:10.3390/gels5020029 · Cited by 12

Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3D in vitro tissue models of disease

Cadavid, J. L., Li, N. T., & McGuigan, A. P. (2024) · Biophysics Reviews · doi:10.1063/5.0179125 · Cited by 11

OrgDyn: feature- and model-based characterization of spatial and temporal organoid dynamics

Hasnain, Z., Fraser, A. K., Georgess, D., Choi, A., Macklin, P., Bader, J. S., Peyton, S. R., Ewald, A. J., & Newton, P. K. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btaa096 · Cited by 11

Mechanical Cues, E-Cadherin Expression and Cell “Sociality” Are Crucial Crossroads in Determining Pancreatic Ductal Adenocarcinoma Cells Behavior

Bianchi, F., Sommariva, M., Cornaghi, L., Denti, L., Nava, A., Arnaboldi, F., Moscheni, C., & Gagliano, N. (2022) · Cells · doi:10.3390/cells11081318 · Cited by 11

Focal sources of FGF-10 promote the buckling morphogenesis of the embryonic airway epithelium

Peak, K. E., Mohr-Allen, S. R., Gleghorn, J. P., & Varner, V. D. (2022) · Biology Open · doi:10.1242/bio.059436 · Cited by 11

Shell engineering in soft alginate‐based capsules for culturing liver spheroids

Peng, X., Janićijević, Ž., Lemm, S., Laube, M., Pietzsch, J., Bachmann, M., & Baraban, L. (2023) · Biotechnology Journal · doi:10.1002/biot.202200365 · Cited by 11

HPV type 16 E6 and NFX1–123 augment JNK signaling to mediate keratinocyte differentiation and L1 expression

Levan, J., Vliet-Gregg, P. A., Robinson, K. L., Matsumoto, L. R., & Katzenellenbogen, R. A. (2019) · Virology · doi:10.1016/j.virol.2019.03.008 · Cited by 11

The Applications of Lattice Light-Sheet Microscopy for Functional Volumetric Imaging of Hippocampal Neurons in a Three-Dimensional Culture System

Chen, C., Liu, Y., Lu, C.-H., Lee, P., Tsai, Y.-C., Wu, J.-S., Chen, P., & Chen, B. (2019) · Micromachines · doi:10.3390/mi10090599 · Cited by 11

Dual-Functionalizable Streptavidin–SpyCatcher-Fused Protein–Polymer Hydrogels as Scaffolds for Cell Culture

Minamihata, K., Hamada, Y., Kagawa, G., Ramadhan, W., Higuchi, A., Moriyama, K., Wakabayashi, R., Goto, M., & Kamiya, N. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00940 · Cited by 11

Academic collaborative models fostering the translation of physiological in vitro systems from basic research into drug discovery

Silvestri, A., Vicente, F., Vicent, M. J., Stechmann, B., & Fecke, W. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.02.024 · Cited by 12

3D-Embedded Cell Cultures to Study Tendon Biology

Gehwolf, R., Spitzer, G., Wagner, A., Lehner, C., Weißenbacher, N., Tempfer, H., & Traweger, A. (2019) · Methods in molecular biology · doi:10.1007/7651_2019_208 · Cited by 11

Advances in 3D tissue models for neural engineering: self-assembled versus engineered tissue models

Wan, S., Robles, U. A. A., Poole-Warren, L. A., & Esrafilzadeh, D. (2024) · Biomaterials Science · doi:10.1039/d4bm00317a · Cited by 10

Histogel-based techniques for embedding organoids in paraffin blocks enable high throughput downstream histopathological analyses

Havnar, C. A., Holokai, L. L., Ichikawa, R., Chen, W., Scherl, A., & Shamir, E. R. (2024) · Journal of Histotechnology · doi:10.1080/01478885.2024.2398381 · Cited by 10

In Vitro Experimental Model for the Long-Term Analysis of Cellular Dynamics During Bronchial Tree Development from Lung Epithelial Cells

HAGIWARA, M., Maruta, N., & Marumoto, M. (2017) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2017.0126 · Cited by 10

Cellular context-dependent interaction between cancer and stellate cells in hetero-type multicellular spheroids of pancreatic tumor

Nam, S., Khawar, I. A., Park, J. K., Chang, S., & Kuh, H. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.101 · Cited by 10

Modeling pancreatic pathophysiology using genome editing of adult stem cell-derived and induced pluripotent stem cell (iPSC)-derived organoids

Hirshorn, S. T., Steele, N. G., & Zavros, Y. L. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00329.2020 · Cited by 11

Forebrain Organoids to Model the Cell Biology of Basal Radial Glia in Neurodevelopmental Disorders and Brain Evolution

Don, F. K., & Kalebic, N. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.917166 · Cited by 10

Tissue-specific cancer stem/progenitor cells: Therapeutic implications

Yehya, A., Youssef, J., Hachem, S., Ismael, J., & Abou-Kheir, W. G. (2023) · World Journal of Stem Cells · doi:10.4252/wjsc.v15.i5.323 · Cited by 10

Polyethylenimine Inclusion to Develop Aqueous Alginate-Based Core–Shell Capsules for Biomedical Applications

Vaziri, A. S., Alizadeh, M., Vasheghani‐Farahani, E., Karakaya, E., Detsch, R., & Boccaccini, A. R. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c01186 · Cited by 10

Exploring the principles of embryonic mammary gland branching morphogenesis

Lindström, R., Lindström, R., Myllymäki, S.-M., Lan, Q., Trela, E., Prunskaite‐Hyyryläinen, R., Kaczyńska, B., Voutilainen, M., Kuure, S., Vainio, S. J., et al. (2024) · Development · doi:10.1242/dev.202179 · Cited by 10

Dissecting brain tumor growth and metastasis in vitro and ex vivo

Grotzer, M. A., Neve, A., & Baumgartner, M. (2016) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2016.02 · Cited by 10

In vitro interaction of polymeric biomaterials with cells

Sousa, A., Neves, S. C., Gonçalves, I. C., & Barrias, C. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100737-2.00012-1 · Cited by 10

Delivery efficiencies of constituents of combustion-derived aerosols across the air-liquid interface during in vitro exposures

Steiner, S., Diana, P., Dossin, E., Guy, P. A., Vuillaume, G., Kondylis, A., Majeed, S., Frentzel, S., & Hoeng, J. (2018) · Toxicology in Vitro · doi:10.1016/j.tiv.2018.06.024 · Cited by 10

Anticancer Activity of Lesbicoumestan in Jurkat Cells via Inhibition of Oxidative Stress-Mediated Apoptosis and MALT1 Protease

Lee, J., Fang, B., Thủy, N. T. T., Hong, J., Lee, J. S., Cho, N., & Yoo, H. M. (2021) · Molecules · doi:10.3390/molecules26010185 · Cited by 10

A Novel In Vitro Disease Model for Systemic Sclerosis Using Polyisocyanide Hydrogels

Kumari, J., Wubs, T., van Caam, A., Dorst, D. N., Wagener, F. A. D. T. G., & Kouwer, P. H. J. (2022) · Advanced Therapeutics · doi:10.1002/adtp.202200180 · Cited by 10

Cation deficiency effect on negative thermal expansion of ferroelectric PbTiO 3

Peng, X., Rong, Y., Fan, L., Lin, K., Zhu, H. S., Deng, J. N., Chen, J., & Xing, X. (2015) · Inorganic Chemistry Frontiers · doi:10.1039/c5qi00154d · Cited by 10

Decellularized Matrix Produced by Mesenchymal Stem Cells Modulates Growth and Metabolic Activity of Hepatic Cell Cluster

Park, J., Kim, J., Sullivan, K. M., Baik, S., Ko, E. C., Kim, M., Kim, Y. J., & Kong, H. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00494 · Cited by 10

High repeatability from 3D experimental platform for quantitative analysis of cellular branch pattern formations

Hagiwara, M., Nobata, R., & Kawahara, T. (2018) · Integrative Biology · doi:10.1039/c8ib00032h · Cited by 10

3D in vitro modelling of human patient microglia: A focus on clinical translation and drug development in neurodegenerative diseases

Cuní‐López, C., Stewart, R., White, A. R., & Quek, H. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578017 · Cited by 9

Three-dimensional culture model to study the biology of vacuolated notochordal cells from mouse nucleus pulposus explants

Nantes Université, O., Paillat, L., Coutant, K., Dutilleul, M., Lay, S. L., & Camus, A. (2023) · European Cells and Materials · doi:10.22203/ecm.v045a06 · Cited by 9

Establishment of an Ex Vivo Tissue Culture Model for Evaluation of Antitumor Efficacy in Clear Cell Renal Cell Carcinoma

Hong, S., Yuan, Q., Xia, H., Dou, Y., Sun, T., Xie, T., Zhang, Z., He, W., Dong, C., Lu, J. G., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.851191 · Cited by 9

Functional bioengineered tissue models of neurodegenerative diseases

Mullis, A. S., & Kaplan, D. L. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122143 · Cited by 10

The Crosstalk between Tissue Engineering and Pharmaceutical Biotechnology: Recent Advances and Future Directions

Pacheco, D. P., Reis, R. L., Correlo, V. M., & Marques, A. P. (2015) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201016666150826120257 · Cited by 9

Research Update: Electrical monitoring of cysts using organic electrochemical transistors

Huerta, M., Rivnay, J., Ramuz, M. P., Hama, A., & Owens, R. M. (2015) · APL Materials · doi:10.1063/1.4915493 · Cited by 9

Pulling cells out of tumours

Ewald, A. J. (2017) · Nature Cell Biology · doi:10.1038/ncb3484 · Cited by 9

Preparation of EpH4 and 3T3L1 cells aggregates incorporating gelatin hydrogel microspheres for a cell condition improvement

Tajima, S., & Tabata, Y. (2017) · Regenerative Therapy · doi:10.1016/j.reth.2017.03.001 · Cited by 9

Preparation of epithelial cell aggregates incorporating matrigel microspheres to enhance proliferation and differentiation of epithelial cells

Tajima, S., & Tabata, Y. (2017) · Regenerative Therapy · doi:10.1016/j.reth.2017.07.001 · Cited by 9

A Tissue-Engineered Tracheobronchial In Vitro Co-Culture Model for Determining Epithelial Toxicological and Inflammatory Responses

Soriano, L., Khalid, T., O’Brien, F. J., O’Leary, C., & Cryan, S. (2021) · Biomedicines · doi:10.3390/biomedicines9060631 · Cited by 9

Modeling Tumor: Lymphatic Interactions in Lymphatic Metastasis of Triple Negative Breast Cancer

Ji, K., Zhao, Z., Sameni, M., Moin, K., Xu, Y., Gillies, R. J., Sloane, B. F., & Mattingly, R. R. (2021) · Cancers · doi:10.3390/cancers13236044 · Cited by 10

Technological Advances in Cardiovascular Safety Assessment Decrease Preclinical Animal Use and Improve Clinical Relevance

Berridge, B. R., Schultze, A. E., Heyen, J., Searfoss, G. H., & Sarazan, R. D. (2016) · ILAR Journal · doi:10.1093/ilar/ilw028 · Cited by 9

The response of gingiva monolayer, spheroid, and ex vivo tissue cultures to collagen membranes and bone substitute

Janjić, K., Schädl, B., Andrukhov, O., & Agis, H. (2020) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3102 · Cited by 9

A Qualitative Change in the Transcriptome Occurs after the First Cell Cycle and Coincides with Lumen Establishment during MDCKII Cystogenesis

Wang, T., Kwon, S., Peng, X. L., Urdy, S., Lu, Z., Schmitz, R. J., Dalton, S., Mostov, K. E., & Zhao, S. (2020) · iScience · doi:10.1016/j.isci.2020.101629 · Cited by 9

Engineering epithelial-stromal interactions in vitro for toxicology assessment

Belair, D. G., & Abbott, B. D. (2017) · Toxicology · doi:10.1016/j.tox.2017.03.007 · Cited by 9

Establishment of goat mammary organoid cultures modeling the mammary gland development and lactation

Jia, L., Zhang, W., Luo, T., Li, Y., Shu, J., Strand, J., Yuan, Y., Purup, S., Liu, J., & Shi, H. (2024) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-024-01084-7 · Cited by 8

Customizable Fabrication of 2D and Conformal Multielectrode Arrays for 3D Printed Organotypic Bioelectronic Interfaces

Cheah, E., Gao, X., Jaw, W. Q., Goh, G. L., Lee, J. M., Huang, C., Chew, S. Y., & Yeong, W. Y. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202502757 · Cited by 8

Fabrication and Mechanical Properties Measurements of 3D Microtissues for the Study of Cell–Matrix Interactions

Bose, P., Huang, C., Eyckmans, J., Chen, C. S., & Reich, D. H. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7553-2_18 · Cited by 8

Imaging host–pathogen interactions using epithelial and bacterial cell infection models

Park, A. J., Wright, M. A., Roach, E. J., & Khursigara, C. M. (2021) · Journal of Cell Science · doi:10.1242/jcs.250647 · Cited by 8

Triple‐Decker Sandwich Cultures of Intestinal Organoids for Long‐Term Live Imaging, Uniform Perturbation, and Statistical Sampling

Cambra, H. M., Tallapragada, N. P., Mannam, P., Breault, D. T., & Klein, A. M. (2022) · Current Protocols · doi:10.1002/cpz1.330 · Cited by 8

Whole transcriptomic analysis of mesenchymal stem cells cultured in Nichoid micro-scaffolds

Testa, C., Oliveto, S., Jacchetti, E., Donnaloja, F., Martinelli, C., Pinoli, P., Osellame, R., Cerullo, G., Ceri, S., Biffo, S., et al. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.945474 · Cited by 8

Deep silicification–assisted long-term preservation of structural and genomic information across biospecies: From micro to macro

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How Current Direct-Acting Antiviral and Novel Cell Culture Systems for HCV are Shaping Therapy and Molecular Diagnosis of Chronic HCV Infection?

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Specification of embryonic stem cell-derived tissues into eye fields by Wnt signaling using rostral diencephalic tissue-inducing culture

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Rapid Organoid Reconstitution by Chemical Micromolding

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Mechanisms of collective cell movement lacking a leading or free front edge in vivo

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Clinical Toxicity of Nanomedicines

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Microfragmented adipose tissue is associated with improved ex vivo performance linked to HOXB7 and b-FGF expression

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Organotypic Models of Lung Cancer

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High-Throughput In Vitro Assay using Patient-Derived Tumor Organoids

Higa, A., Takahashi, N., Hiyama, G., Tamura, H., Hoshi, H., Shimomura, K., Watanabe, S., & Takagi, M. (2021) · Journal of Visualized Experiments · doi:10.3791/62668 · Cited by 7

Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability

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Real‐Time, Non‐Invasive Monitoring of Neuronal Differentiation Using Intein‐Enabled Fluorescence Signal Translocation in Genetically Encoded Stem Cell‐Based Biosensors

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Comparative Study of Basement-membrane Matrices for Human Stem Cell Maintenance and Intestinal Organoid Generation

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Insights into metabolic changes during epidermal differentiation as revealed by multiphoton microscopy with fluorescence lifetime imaging

Malak, M., Qian, C., James, J., Nair, S., Grantham, J., & Ericson, M. B. (2025) · Scientific Reports · doi:10.1038/s41598-025-90101-4 · Cited by 11

Revolutionizing bladder cancer research: Harnessing 3D organoid technology to decode tumor heterogeneity and propel personalized therapeutics

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A 3D multi-compartment assembloid to study combined immune cell infiltration and cytotoxicity

Hanna, E. A., Crawford, A. J., Du, W., Johnston, A. C., Schell, D., Wan, Z., Chen, T.-H., Wu, F., Ren, K., Lim, Y., et al. (2026) · Cell Reports Methods · doi:10.1016/j.crmeth.2026.101307 · Cited by 7

Morphogenesis in space offers challenges and opportunities for soft matter and biophysics

Amar, M. B., Ciarletta, P., & Haas, P. A. (2023) · Communications Physics · doi:10.1038/s42005-023-01242-9 · Cited by 7

Phenylephrine induces necroptosis and apoptosis in corneal epithelial cells dose- and time-dependently

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Transmigration of Trypanosoma cruzi Trypomastigotes through 3D Spheroids Mimicking Host Tissues

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Three-dimensional models for studying development and disease: moving on from organisms to organs-on-a-chip and organoids

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Demystifying the Effects of a Three‐Dimensional Microenvironment in Tissue Morphogenesis

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Modeling human development in 3D culture

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3D culture models for studying branching morphogenesis in the mammary gland and mammalian lung

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3D Culture Assays of Murine Mammary Branching Morphogenesis and Epithelial Invasion

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