Three-dimensional organotypic culture: experimental models of mammalian biology and disease

Matrix elasticity directs stem cell lineage specification

Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915

RNA-Guided Human Genome Engineering via Cas9

Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204

Cerebral organoids model human brain development and microcephaly

Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372

Molecular Biology of the Cell

Alberts, B., Johnson, A. D., Lewis, J. H., RAFF, M. C., Roberts, K. J., & Walter, P. (2007) · W.W. Norton eBooks · doi:10.1201/9780203833445 · Cited by 4,591

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101

Tensional homeostasis and the malignant phenotype

Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.010 · Cited by 3,941

Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium

Sato, T., Stange, D. E., Ferrante, M., Vries, R. G. J., van Es, J. H., van den Brink, S., van Houdt, W. J., Pronk, A., van Gorp, J., Siersema, P. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.050 · Cited by 3,753

Organoid Models and Applications in Biomedical Research

Xinaris, C., Brizi, V., & Remuzzi, G. (2015) · The Nephron journals/Nephron journals · doi:10.1159/000433566 · Cited by 3,519

A simple method for organotypic cultures of nervous tissue

Stoppini, L., Buchs, P., & Muller, D. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90128-m · Cited by 3,096

Taking Cell-Matrix Adhesions to the Third Dimension

Cukierman, E., Pankov, R., Stevens, D. R., & Yamada, K. M. (2001) · Science · doi:10.1126/science.1064829 · Cited by 3,027

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

Condeelis, J. S., & Pollard, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.01.007 · Cited by 2,677

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature · doi:10.1038/nature09637 · Cited by 2,510

Vascularized and functional human liver from an iPSC-derived organ bud transplant

Takebe, T., Sekine, K., Enomura, M., Koike, H., Kimura, M., Ogaeri, T., Zhang, R.-R., Ueno, Y., Zheng, Y.-W., Koike, N., et al. (2013) · Nature · doi:10.1038/nature12271 · Cited by 2,170

Intra-tumour heterogeneity: a looking glass for cancer?

Marusyk, A., Almendro, V., & Polyák, K. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3261 · Cited by 2,058

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

Debnath, J., Muthuswamy, S. K., & Brugge, J. S. (2003) · Methods · doi:10.1016/s1046-2023(03)00032-x · Cited by 2,001

Self-organizing optic-cup morphogenesis in three-dimensional culture

Eiraku, M., Takata, N., Ishibashi, H., Kawada, M., Sakakura, E., Okuda, S., Sekiguchi, K., Adachi, T., & Sasai, Y. (2011) · Nature · doi:10.1038/nature09941 · Cited by 2,001

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

Friedl, P., & Alexander, S. (2011) · Cell · doi:10.1016/j.cell.2011.11.016 · Cited by 1,940

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

Miller, J. S., Stevens, K. R., Yang, M. T., Baker, B. M., Nguyen, D.-H. T., Cohen, D. M., Toro, E., Chen, A. A., Galie, P. A., Yu, X., et al. (2012) · Nature Materials · doi:10.1038/nmat3357 · Cited by 1,917

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

Spence, J. R., Mayhew, C. N., Rankin, S. A., Kuhar, M. F., Vallance, J. E., Tolle, K. A., Hoskins, E. E., Kalinichenko, V. V., Wells, S. I., Zorn, A. M., et al. (2010) · Nature · doi:10.1038/nature09691 · Cited by 1,911

Collagen reorganization at the tumor-stromal interface facilitates local invasion

Provenzano, P. P., Eliceiri, K. W., Campbell, J. M., Inman, D. R., White, J. G., & Keely, P. J. (2006) · BMC Medicine · doi:10.1186/1741-7015-4-38 · Cited by 1,804

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

Baker, B. M., & Chen, C. S. (2012) · Journal of Cell Science · doi:10.1242/jcs.079509 · Cited by 1,760

Matrigel: Basement membrane matrix with biological activity

Kleinman, H. K., & Martin, G. R. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.05.004 · Cited by 1,673

Basal cells as stem cells of the mouse trachea and human airway epithelium

Rock, J. R., Onaitis, M. W., Rawlins, E. L., Lu, Y., Clark, C. P., Xue, Y., Randell, S. H., & Hogan, B. L. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906850106 · Cited by 1,591

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

Gaggioli, C., Hooper, S., Hidalgo-Carcedo, C., Grosse, R., Marshall, J. F., Harrington, K., & Sahai, E. (2007) · Nature Cell Biology · doi:10.1038/ncb1658 · Cited by 1,589

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Huch, M., Dorrell, C., Boj, S. F., van Es, J. H., Li, V. S. W., van de Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., et al. (2013) · Nature · doi:10.1038/nature11826 · Cited by 1,555

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

Barker, N., Huch, M., Kujala, P., van de Wetering, M., Snippert, H. J., van Es, J. H., Sato, T., Stange, D. E., Begthel, H., van den Born, M., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2009.11.013 · Cited by 1,547

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., & Sasai, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.002 · Cited by 1,522

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

Weaver, V. M., Petersen, O. W., Wang, F., Larabell, C. A., Briand, P., Damsky, C., & Bissell, M. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.231 · Cited by 1,483

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478

Self-formation of optic cups and storable stratified neural retina from human ESCs

Nakano, T., Ando, S., Takata, N., Kawada, M., Muguruma, K., Sekiguchi, K., Saito, K., Yonemura, S., Eiraku, M., & Sasai, Y. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.009 · Cited by 1,447

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

Schwank, G., Koo, B.-K., Sasselli, V., Dekkers, J. F., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, C. K., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.11.002 · Cited by 1,424

Biology of the Laboratory Mouse

Heston, W. E. (1967) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a107528 · Cited by 1,396

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

DeNardo, D. G., Barreto, J., Andreu, P., Vásquez, L. J., Tawfik, D., Kolhatkar, N. S., & Coussens, L. M. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.018 · Cited by 1,395

Collagen density promotes mammary tumor initiation and progression

Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Knittel, J. G., Yan, L., Rueden, C., White, J. G., & Keely, P. J. (2008) · BMC Medicine · doi:10.1186/1741-7015-6-11 · Cited by 1,394

Nanotechnological strategies for engineering complex tissues

Dvir, T., Timko, B. P., Kohane, D. S., & Langer, R. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.246 · Cited by 1,367

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

Conklin, M. W., Eickhoff, J. C., Riching, K. M., Pehlke, C. A., Eliceiri, K. W., Provenzano, P. P., Friedl, A., & Keely, P. J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.076 · Cited by 1,321

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

Egeblad, M., Nakasone, E. S., & Werb, Z. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.05.012 · Cited by 1,294

Growth of cultured human epidermal cells into multiple epithelia suitable for grafting.

Green, H., Kehinde, O., & Thomas, J. M. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.11.5665 · Cited by 1,251

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.

Kubota, Y., Kleinman, H. K., Martin, G. R., & Lawley, T. J. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.4.1589 · Cited by 1,210

Of Extracellular Matrix, Scaffolds, and Signaling: Tissue Architecture Regulates Development, Homeostasis, and Cancer

Nelson, C. M., & Bissell, M. J. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104315 · Cited by 1,153

The perivascular niche regulates breast tumour dormancy

Ghajar, C. M., Peinado, H., Mori, H., Matei, I. R., Evason, K. J., Brazier, H., Almeida, D., Koller, A., Hajjar, K. A., Stainier, D. Y. R., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2767 · Cited by 1,148

Modelling glandular epithelial cancers in three-dimensional cultures

Debnath, J., & Brugge, J. S. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1695 · Cited by 1,036

A functional CFTR assay using primary cystic fibrosis intestinal organoids

Dekkers, J. F., Wiegerinck, C. L., de Jonge, H. R., Bronsveld, I., Janssens, H. M., de Winter-de Groot, K. M., Brandsma, A. M., de Jong, N. W. M., Bijvelds, M. J. C., Scholte, B. J., et al. (2013) · Nature Medicine · doi:10.1038/nm.3201 · Cited by 999

Dynamic interplay between the collagen scaffold and tumor evolution

Egeblad, M., Rasch, M. G., & Weaver, V. M. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.08.015 · Cited by 931

Control of somatic tissue differentiation by the long non-coding RNA TINCR

Kretz, M., Siprashvili, Z., Chu, C., Webster, D., Zehnder, A., Qu, K., Lee, C. S., Flockhart, R., Groff, A., Chow, J. M., et al. (2012) · Nature · doi:10.1038/nature11661 · Cited by 920

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

Ootani, A., Li, X., Sangiorgi, E., Ho, Q. T., Ueno, H., Toda, S., Sugihara, H., Fujimoto, K., Weissman, I. L., Capecchi, M. R., et al. (2009) · Nature Medicine · doi:10.1038/nm.1951 · Cited by 906

In vitro microvessels for the study of angiogenesis and thrombosis

Zheng, Y., Chen, J., Craven, M., Choi, N. W., Totorica, S., Diaz-Santana, A., Kermani, P., Hempstead, B., Fischbach-Teschl, C., López, J. A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201240109 · Cited by 894

Organotypic slice cultures: a technique has come of age

Gähwiler, B. H. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01122-3 · Cited by 884

Directed movements and selective adhesion of embryonic amphibian cells

Townes, P. L., & Holtfreter, J. (1955) · Journal of Experimental Zoology · doi:10.1002/jez.1401280105 · Cited by 872

Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells

Taguchi, A., Kaku, Y., Ohmori, T., Sharmin, S., Ogawa, M., Sasaki, H., & Nishinakamura, R. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.11.010 · Cited by 871

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

Cheung, K. J., Gabrielson, E. W., Werb, Z., & Ewald, A. J. (2013) · Cell · doi:10.1016/j.cell.2013.11.029 · Cited by 859

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

Yui, S., Nakamura, T., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., et al. (2012) · Nature Medicine · doi:10.1038/nm.2695 · Cited by 805

Biology of the Laboratory Mouse

(1941) · JAMA · doi:10.1001/jama.1941.02820440081034 · Cited by 805

In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract

Arnaoutova, I., & Kleinman, H. K. (2010) · Nature Protocols · doi:10.1038/nprot.2010.6 · Cited by 760

Unlimited in vitro expansion of adult bi‐potent pancreas progenitors through the Lgr5/R‐spondin axis

Huch, M., Bonfanti, P., Boj, S. F., Sato, T., Loomans, C. J. M., van de Wetering, M., Sojoodi, M., Li, V. S. W., Schuijers, J., Gracanin, A., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.204 · Cited by 726

Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

Takasato, M., Er, P. X., Becroft, M., Vanslambrouck, J. M., Stanley, E. G., Elefanty, A. G., & Little, M. H. (2013) · Nature Cell Biology · doi:10.1038/ncb2894 · Cited by 723

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.

Streuli, C. H., Bailey, N., & Bissell, M. J. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.5.1383 · Cited by 678

Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells.

Greenburg, G., & Hay, E. D. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.95.1.333 · Cited by 674

Epidermal differentiation: the bare essentials.

Fuchs, E. V. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.6.2807 · Cited by 649

Collagen-based cell migration models in vitro and in vivo

Wolf, K., Alexander, S., Schacht, V., Coussens, L. M., von Andrian, U. H., van Rheenen, J., Deryugina, E., & Friedl, P. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2009.08.005 · Cited by 637

Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis

Ewald, A. J., Brenot, A., Duong, M., Chan, B. S., & Werb, Z. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.03.003 · Cited by 620

Fundamentals of microfluidic cell culture in controlled microenvironments

Young, E. W. K., & Beebe, D. J. (2010) · Chemical Society Reviews · doi:10.1039/b909900j · Cited by 615

Observations on the living developing nerve fiber

Harrison, R. G. (1906) · Experimental Biology and Medicine · doi:10.3181/00379727-4-98 · Cited by 609

A molecular network for de novo generation of the apical surface and lumen

Bryant, D. M., Datta, A., Rodriguez-Fraticelli, A., Peränen, J., Martín‐Belmonte, F., & Mostov, K. E. (2010) · Nature Cell Biology · doi:10.1038/ncb2106 · Cited by 597

Building epithelial architecture: insights from three-dimensional culture models

O'Brien, L. E., Zegers, M. M. P., & Mostov, K. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm859 · Cited by 596

Fibronectin requirement in branching morphogenesis

Sakai, T., Larsen, M., & Yamada, K. M. (2003) · Nature · doi:10.1038/nature01712 · Cited by 559

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

Muthuswamy, S. K., Li, D., Lelièvre, S. A., Bissell, M. J., & Brugge, J. S. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-785 · Cited by 554

Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

Stange, D. E., Koo, B., Huch, M., Sibbel, G., Başak, O., Lyubimova, A., Kujala, P., Bartfeld, S., Köster, J., Geahlen, J. H., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.008 · Cited by 523

Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition

Guðjónsson, Þ., Rønnov‐Jessen, L., Villadsen, R., Rank, F. E., Bissell, M. J., & PETERSEN, O. W. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.1.39 · Cited by 518

Observations of the living developing nerve fiber

Harrison, R. G., Greenman, M. J., Mall, F. P., & Jackson, C. M. (1907) · The Anatomical Record · doi:10.1002/ar.1090010503 · Cited by 515

Self-formation of functional adenohypophysis in three-dimensional culture

Suga, H., Kadoshima, T., Minaguchi, M., Ohgushi, M., Soen, M., Nakano, T., Takata, N., Wataya, T., Muguruma, K., Miyoshi, H., et al. (2011) · Nature · doi:10.1038/nature10637 · Cited by 497

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

Nguyen, D.-H. T., Stapleton, S. C., Yang, M. T., Cha, S. S., Choi, C. K., Galie, P. A., & Chen, C. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221526110 · Cited by 495

Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis

Lee, J., Bhang, D. H., Beede, A. M., Huang, T. L., Stripp, B. R., Bloch, K. D., Wagers, A. J., Tseng, Y., Ryeom, S. W., & Kim, C. F. (2014) · Cell · doi:10.1016/j.cell.2013.12.039 · Cited by 494

p63 regulates proliferation and differentiation of developmentally mature keratinocytesPreprint

Truong, A. B., Kretz, M., Ridky, T. W., Kimmel, R. A., & Khavari, P. A. (2006) · Genes & Development · doi:10.1101/gad.1463206 · Cited by 489

Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly

O’Brien, L. E., Jou, T., Pollack, A. L., Zhang, Q., Hansen, S. H., Yurchenco, P. D., & Mostov, K. E. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-831 · Cited by 485

Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study

Elliott, M. J., Coppi, P. D., Speggiorin, S., Roebuck, D. J., Butler, C. R., Samuel, E. R., Crowley, C., McLaren, C. A., Fierens, A., Vondrys, D., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60737-5 · Cited by 477

The growth, development and phosphatase activity of embryonic avian femora and limb-buds cultivated in vitro

Fell, H. B., & Robison, R. (1929) · Biochemical Journal · doi:10.1042/bj0230767 · Cited by 461

Cellular Pathology As Based upon Physiological and Pathological Histology.

(1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-76-1-157_2 · Cited by 456

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

Li, X., Nadauld, L. D., Ootani, A., Corney, D. C., Pai, R. K., Gevaert, O., Cantrell, M. A., Rack, P. G., Neal, J. T., Chan, C. W. M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3585 · Cited by 449

ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium

Nguyen-Ngoc, K.-V., Cheung, K. J., Brenot, A., Shamir, E. R., Gray, R. S., Hines, W. C., Yaswen, P., Werb, Z., & Ewald, A. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212834109 · Cited by 449

Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

Zhan, L., Rosenberg, A., Bergami, K. C., Yu, M., Xuan, Z., Jaffe, A. B., Allred, C., & Muthuswamy, S. K. (2008) · Cell · doi:10.1016/j.cell.2008.09.045 · Cited by 436

Next-Generation Regenerative Medicine: Organogenesis from Stem Cells in 3D Culture

Sasai, Y. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.04.009 · Cited by 411

The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells

Simian, M., Hirai, Y., Navre, M., Werb, Z., Lochter, A., & Bissell, M. J. (2001) · Development · doi:10.1242/dev.128.16.3117 · Cited by 392

Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells

Muranen, T. E., Selfors, L. M., Worster, D. T., Iwanicki, M., Song, L., Morales, F. C., Gao, S., Mills, G. B., & Brugge, J. S. (2012) · Cancer Cell · doi:10.1016/j.ccr.2011.12.024 · Cited by 387

β1-Integrin Orients Epithelial Polarity via Rac1 and Laminin

Yu, W., Datta, A., Leroy, P., O’Brien, L. E., Mak, G. Z., Jou, T., Matlin, K. S., Mostov, K. E., & Zegers, M. M. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-05-0435 · Cited by 375

Generation of functional thyroid from embryonic stem cells

Antonica, F., Kasprzyk, D. F., Opitz, R., Iacovino, M., Liao, X.-H., Dumitrescu, A. M., Refetoff, S., Peremans, K., Manto, M., Kyba, M., et al. (2012) · Nature · doi:10.1038/nature11525 · Cited by 359

Transplantation of Embryonic and Induced Pluripotent Stem Cell-Derived 3D Retinal Sheets into Retinal Degenerative Mice

Assawachananont, J., Mandai, M., Okamoto, S., Yamada, C., Eiraku, M., Yonemura, S., Sasai, Y., & Takahashi, M. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.03.011 · Cited by 353

Organ culture of mucosal biopsies of human small intestine

Browning, T. H., & Trier, J. S. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106108 · Cited by 353

Parasympathetic Innervation Maintains Epithelial Progenitor Cells During Salivary Organogenesis

Knox, S. M., Lombaert, I. M. A., Reed, X., Vitale-Cross, L. A., Gutkind, J. S., & Hoffman, M. P. (2010) · Science · doi:10.1126/science.1192046 · Cited by 342

Controlled gene expression in primary Lgr5 organoid cultures

Koo, B.-K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., van Es, J. H., & Clevers, H. (2012) · Nature Methods · doi:10.1038/nmeth.1802 · Cited by 320

Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis

Jaffe, A. B., Kaji, N., Durgan, J., & Hall, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200807121 · Cited by 320

Programmed assembly of 3-dimensional microtissues with defined cellular connectivity

Gartner, Z. J., & Bertozzi, C. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900717106 · Cited by 316

Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors

Vaira, V., Fedele, G., Pyne, S., Fasoli, E., Zadra, G., Bailey, D., Snyder, E. L., Faversani, A., Coggi, G., Flavin, R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907676107 · Cited by 282

The Role of GDNF/Ret Signaling in Ureteric Bud Cell Fate and Branching Morphogenesis

Shakya, R., Watanabe, T., & Costantini, F. D. (2005) · Developmental Cell · doi:10.1016/j.devcel.2004.11.008 · Cited by 276

Geometric control of vascular networks to enhance engineered tissue integration and function

Baranski, J. D., Chaturvedi, R. R., Stevens, K. R., Eyckmans, J., Carvalho, B., Solorzano, R. D., Yang, M. T., Miller, J. S., Bhatia, S. N., & Chen, C. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217796110 · Cited by 267

FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis

Steinberg, Z. L., Myers, C., Heim, V. M., Lathrop, C. A., Rebustini, I. T., Stewart, J. S., Larsen, M., & Hoffman, M. P. (2005) · Development · doi:10.1242/dev.01690 · Cited by 264

Par6–aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control

Aranda, V., Haire, T., Nolan, M. E., Calarco, J. P., Rosenberg, A. Z., Fawcett, J. P., Pawson, T. J., & Muthuswamy, S. K. (2006) · Nature Cell Biology · doi:10.1038/ncb1485 · Cited by 247

Precision-cut tissue slices: Applications in pharmacology and toxicology

Parrish, A. R., Gandolfi, A. J., & Brendel, K. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02176-j · Cited by 245

Epidermal growth factor or transforming growth factor alpha is required for kidney tubulogenesis in matrigel cultures in serum-free medium.

Taub, M. L., Wang, Y., Szczesny, T., & Kleinman, H. K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.4002 · Cited by 241

Ret-Dependent Cell Rearrangements in the Wolffian Duct Epithelium Initiate Ureteric Bud Morphogenesis

Chi, X., Michos, O., Shakya, R., Riccio, P. N., Enomoto, H., Licht, J. D., Asai, N., Takahashi, M., Ohgami, N., Kato, M., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.07.013 · Cited by 234

An integrin–ILK–microtubule network orients cell polarity and lumen formation in glandular epithelium

Akhtar, N., & Streuli, C. H. (2012) · Nature Cell Biology · doi:10.1038/ncb2646 · Cited by 233

Outgrowth of single oncogene-expressing cells from suppressive epithelial environments

Leung, C. T., & Brugge, J. S. (2012) · Nature · doi:10.1038/nature10826 · Cited by 233

Cell-Polarity Dynamics Controls the Mechanism of Lumen Formation in Epithelial Morphogenesis

Martín‐Belmonte, F., Yu, W., Rodriguez-Fraticelli, A., Ewald, A. J., Werb, Z., Alonso, M. A., & Mostov, K. E. (2008) · Current Biology · doi:10.1016/j.cub.2008.02.076 · Cited by 224

Social interactions among epithelial cells during tracheal branching morphogenesis

Ghabrial, A. S., & Krasnow, M. A. (2006) · Nature · doi:10.1038/nature04829 · Cited by 222

Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia

Ridky, T. W., Chow, J. M., Wong, D. J., & Khavari, P. A. (2010) · Nature Medicine · doi:10.1038/nm.2265 · Cited by 217

Dissociation of embryonic kidneys followed by reaggregation allows the formation of renal tissues

Unbekandt, M., & Davies, J. A. (2009) · Kidney International · doi:10.1038/ki.2009.482 · Cited by 209

Cell and fibronectin dynamics during branching morphogenesis

Larsen, M., Wei, C., & Yamada, K. M. (2006) · Journal of Cell Science · doi:10.1242/jcs.03079 · Cited by 208

American Society of Clinical Oncology Technology Assessment: Chemotherapy Sensitivity and Resistance Assays

Schrag, D., Garewal, H. S., Burstein, H. J., Samson, D. J., Hoff, D. D. V., & Somerfield, M. R. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.05.065 · Cited by 206

Twist1-induced dissemination preserves epithelial identity and requires E-cadherin

Shamir, E. R., Pappalardo, E., Jorgens, D. M., Coutinho, K., Tsai, W.-T., Aziz, K., Auer, M., Tran, P. T., Bader, J. S., & Ewald, A. J. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201306088 · Cited by 205

The cultivation in fluid medium of organised liver, pancreas and other tissues of foetal rats

Chen, J. M. (1954) · Experimental Cell Research · doi:10.1016/s0014-4827(54)80096-6 · Cited by 200

Patterning Mechanisms of Branched Organs

Lu, P., & Werb, Z. (2008) · Science · doi:10.1126/science.1162783 · Cited by 199

The MAPKERK-1,2 pathway integrates distinct and antagonistic signals from TGFα and FGF7 in morphogenesis of mouse mammary epithelium

Fata, J. E., Mori, H., Ewald, A. J., Zhang, H., Yao, E. S., Werb, Z., & Bissell, M. J. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.03.013 · Cited by 197

Branching morphogenesis independent of mesenchymal–epithelial contact in the developing kidney

Qiao, J., Sakurai, H., & Nigám, S. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7330 · Cited by 192

Parasympathetic stimulation improves epithelial organ regeneration

Knox, S. M., Lombaert, I. M. A., Haddox, C. L., Abrams, S. R., Cotrim, A. P., Wilson, A. J., & Hoffman, M. P. (2013) · Nature Communications · doi:10.1038/ncomms2493 · Cited by 192

Novel Role for Netrins in Regulating Epithelial Behavior during Lung Branching Morphogenesis

Liu, Y., Stein, E., Oliver, T. N., Li, Y. H., Brunken, W. J., Koch, M., Tessier‐Lavigne, M., & Hogan, B. L. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.05.020 · Cited by 192

Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion

Grugan, K. D., Miller, C. G., Yao, Y., Michaylira, C. Z., Ohashi, S., Klein–Szanto, A. J., Diehl, J. A., Herlyn, M., Han, M., Nakagawa, H., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914295107 · Cited by 186

Glioblastoma Stem Cells Are Regulated by Interleukin-8 Signaling in a Tumoral Perivascular Niche

Infanger, D. W., Cho, Y., Lopez, B. S., Mohanan, S., Liu, S. C., Gursel, D. B., Boockvar, J. A., & Fischbach, C. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1355 · Cited by 184

Formation of microvascular networks in vitro

Morgan, J. P., DelNero, P. F., Zheng, Y. Y., Verbridge, S. S., Chen, J., Craven, M., Choi, N., Diaz-Santana, A., Kermani, P., Hempstead, B. L., et al. (2013) · Nature Protocols · doi:10.1038/nprot.2013.110 · Cited by 183

Methods in Mammary Gland Biology and Breast Cancer Research

(2000) · Springer eBooks · doi:10.1007/978-1-4615-4295-7 · Cited by 177

Leading malignant cells initiate collective epithelial cell invasion in a three-dimensional heterotypic tumor spheroid model

Carey, S. P., Starchenko, A., McGregor, A. L., & Reinhart-King, C. A. (2013) · Clinical & Experimental Metastasis · doi:10.1007/s10585-013-9565-x · Cited by 174

The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiationPreprint

Okawa, T., Michaylira, C. Z., Kalabis, J., Stairs, D. B., Nakagawa, H., Andl, C. D., Johnstone, C. N., Klein–Szanto, A. J., El‐Deiry, W. S., Cukierman, E., et al. (2007) · Genes & Development · doi:10.1101/gad.1544507 · Cited by 173

Engineering Three-Dimensional Pulmonary Tissue Constructs

Mondrinos, M. J., Koutzaki, S. H., Jiwanmall, E., Li, M., Dechadarevian, J.-P., Lelkes, P. I., & Finck, C. M. (2006) · Tissue Engineering · doi:10.1089/ten.2006.12.717 · Cited by 164

Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture

Kalabis, J., Wong, G. S., Vega, M. E., Natsuizaka, M., Robertson, E. S., Herlyn, M., Nakagawa, H., & Rustgi, A. K. (2012) · Nature Protocols · doi:10.1038/nprot.2011.437 · Cited by 163

Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium

Ewald, A. J., Huebner, R. J., Pálsdóttir, H., Lee, J. K., Perez, M. J., Jorgens, D. M., Tauscher, A. N., Cheung, K. J., Werb, Z., & Auer, M. (2012) · Journal of Cell Science · doi:10.1242/jcs.096875 · Cited by 161

Loss of Par3 promotes breast cancer metastasis by compromising cell–cell cohesion

Xue, B., Krishnamurthy, K., Allred, D. C., & Muthuswamy, S. K. (2012) · Nature Cell Biology · doi:10.1038/ncb2663 · Cited by 159

Patterned Collagen Fibers Orient Branching Mammary Epithelium through Distinct Signaling Modules

Brownfield, D., Venugopalan, G., Lo, A. T., Mori, H., Tanner, K., Fletcher, D. A., & Bissell, M. J. (2013) · Current Biology · doi:10.1016/j.cub.2013.03.032 · Cited by 158

Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells

Gálvez-Santisteban, M., Rodriguez-Fraticelli, A., Bryant, D. M., Vergarajauregui, S., Yasuda, T., Bañón‐Rodríguez, I., Bernascone, I., Datta, A., Spivak, N., Young, K., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2541 · Cited by 153

Townes and Holtfreter (1955): Directed movements and selective adhesion of embryonic amphibian cells

Steinberg, M. S., & Gilbert, S. F. (2004) · Journal of Experimental Zoology Part A Comparative Experimental Biology · doi:10.1002/jez.a.114 · Cited by 152

Btbd7 Regulates Epithelial Cell Dynamics and Branching Morphogenesis

Onodera, T., Sakai, T., Hsu, J. C., Matsumoto, K., Chiorini, J. A., & Yamada, K. M. (2010) · Science · doi:10.1126/science.1191880 · Cited by 151

Self-Organization and Branching Morphogenesis of Primary Salivary Epithelial Cells

Wei, C., Larsen, M., Hoffman, M. P., & Yamada, K. M. (2007) · Tissue Engineering · doi:10.1089/ten.2006.0123 · Cited by 139

American Society of Clinical Oncology Clinical Practice Guideline Update on the Use of Chemotherapy Sensitivity and Resistance Assays

Burstein, H. J., Mangu, P. B., Somerfield, M. R., Schrag, D., Samson, D. J., Holt, L., Zelman, D., & Ajani, J. A. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.36.0354 · Cited by 139

Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme

Sneddon, J. B., Borowiak, M., & Melton, D. (2012) · Nature · doi:10.1038/nature11463 · Cited by 129

Cellular pathology as based upon physiological and pathological histology; twenty lectures delivered in the Pathological Institute of Berlin during the months of February, March, and April, 1858

Virchow, R., Chance, F., & Goodsir, J. (1860) · doi:10.5962/bhl.title.110759 · Cited by 127

Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments

Merz, F., Gaunitz, F., Dehghani, F., Renner, C., Meixensberger, J., Gutenberg, A., Giese, A., Schopow, K., Hellwig, C. T., Schäfer, M., et al. (2013) · Neuro-Oncology · doi:10.1093/neuonc/not003 · Cited by 123

Apical constriction initiates new bud formation during monopodial branching of the embryonic chicken lung

Kim, H. Y., Varner, V. D., & Nelson, C. M. (2013) · Development · doi:10.1242/dev.093682 · Cited by 121

Luminal Mitosis Drives Epithelial Cell Dispersal within the Branching Ureteric Bud

Packard, A. I., Georgas, K. M., Michos, O., Riccio, P. N., Cebrián, C., Combes, A. N., Ju, A. L., Ferrer‐Vaquer, A., Hadjantonakis, A., Zong, H., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.09.001 · Cited by 120

Chapter 7 The Aortic Ring Model of Angiogenesis

Aplin, A. C., Fogel, E., Zorzi, P., & Nicosia, R. F. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)02007-7 · Cited by 116

Explant culture of gastrointestinal tissue: a review of methods and applications

Randall, K. J., Turton, J. A., & Foster, J. R. (2011) · Cell Biology and Toxicology · doi:10.1007/s10565-011-9187-5 · Cited by 110

The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination

Beck, J. N., Singh, A., Rothenberg, A. R., Elisseeff, J. H., & Ewald, A. J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.08.077 · Cited by 108

Specific Heparan Sulfate Structures Modulate FGF10-mediated Submandibular Gland Epithelial Morphogenesis and Differentiation

Patel, V. N., Likar, K. M., Zisman‐Rozen, S., Cowherd, S. N., Lassiter, K. S., Sher, I., Yates, E. A., Turnbull, J. E., Ron, D., & Hoffman, M. P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709995200 · Cited by 107

Experimental prostate epithelial morphogenesis in response to stroma and three-dimensional matrigel culture.

Lang, S., Stark, M., Collins, A. T., Paul, A., Stower, M. J., & Maitland, N. J. (2001) · PubMed · Cited by 107

Diverse roles of E‐cadherin in the morphogenesis of the submandibular gland: Insights into the formation of acinar and ductal structures

Walker, J. L., Menko, A. S., Khalil, S., Rebustini, I. T., Hoffman, M. P., Kreidberg, J. A., & Kukuruzinska, M. A. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21717 · Cited by 100

Implantable Three-Dimensional Salivary Spheroid Assemblies Demonstrate Fluid and Protein Secretory Responses to Neurotransmitters

Pradhan-Bhatt, S., Harrington, D. A., Duncan, R. L., Jia, X., Witt, R. L., & Farach‐Carson, M. C. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0301 · Cited by 99

[37] Techniques for studying development of normal mammary epithelial cells in organ culture

Topper, Y. J., Oka, T., & Vonderhaar, B. K. (1975) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(75)39039-3 · Cited by 99

Identification of a mechanochemical checkpoint and negative feedback loop regulating branching morphogenesis

Daley, W. P., Gulfo, K. M., Sequeira, S. J., & Larsen, M. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.09.037 · Cited by 95

Formation of Cysts by Alveolar Type II Cells in Three-dimensional Culture Reveals a Novel Mechanism for Epithelial Morphogenesis

Yu, W., Fang, X., Ewald, A. J., Wong, K., Hunt, C. A., Werb, Z., Matthay, M. A., & Mostov, K. E. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-11-1052 · Cited by 91

Role of PI 3-kinase and PIP3 in submandibular gland branching morphogenesis

Larsen, M., Hoffman, M. P., Sakai, T., Neibaur, J. C., Mitchell, J. M., & Yamada, K. M. (2003) · Developmental Biology · doi:10.1016/s0012-1606(02)00047-7 · Cited by 91

Dynamics of embryonic pancreas development using real-time imaging

Puri, S., & Hebrok, M. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.03.003 · Cited by 89

Isolation, culture and genetic manipulation of mouse pancreatic ductal cells

Reichert, M., Takano, S., Heeg, S., Bakir, B. S., Botta, G., & Rustgi, A. (2013) · Nature Protocols · doi:10.1038/nprot.2013.079 · Cited by 89

Microfluidic Culture Models of Tumor Angiogenesis

Stroock, A. D., & Fischbach, C. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0689 · Cited by 82

ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity

Daley, W. P., Gervais, E. M., Centanni, S. W., Gulfo, K. M., Nelson, D. A., & Larsen, M. (2011) · Development · doi:10.1242/dev.075366 · Cited by 80

Scribble is required for normal epithelial cell–cell contacts and lumen morphogenesis in the mammalian lung

Yates, L. L., Schnatwinkel, C., Hazelwood, L., Chessum, L., Paudyal, A., Hilton, H., Romero, M. R., Wilde, J., Bogani, D., Sanderson, J., et al. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2012.11.012 · Cited by 78

An improved kidney dissociation and reaggregation culture system results in nephrons arranged organotypically around a single collecting duct system

Ganeva, V. V., Unbekandt, M., & Davies, J. A. (2011) · Organogenesis · doi:10.4161/org.7.2.14881 · Cited by 74

The ultrastructure of MCF‐10A acini

Underwood, J. M., Imbalzano, K. M., Weaver, V. M., Fischer, A. H., Imbalzano, A. N., & Nickerson, J. A. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20639 · Cited by 73

Mammary ductal elongation and myoepithelial migration are regulated by the composition of the extracellular matrix

Nguyen-Ngoc, K.-V., & Ewald, A. J. (2013) · Journal of Microscopy · doi:10.1111/jmi.12017 · Cited by 72

Breast Cancer Subtype-Specific Interactions with the Microenvironment Dictate Mechanisms of Invasion

Dang, T. T., Prechtl, A. M., & Pearson, G. W. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1818 · Cited by 69

Constructing Kidney-like Tissues from Cells Based on Programs for Organ Development: Toward a Method of In Vitro Tissue Engineering of the Kidney

Rosines, E., Johkura, K., Zhang, X., Schmidt, H. J., DeCambre, M. E., Bush, K. T., & Nigám, S. K. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0548 · Cited by 69

Explant Culture of Mouse Embryonic Whole Lung, Isolated Epithelium, or Mesenchyme Under Chemically Defined Conditions as a System to Evaluate the Molecular Mechanism of Branching Morphogenesis and Cellular Differentiation

del Moral, P.-M., & Warburton, D. (2010) · Methods in molecular biology · doi:10.1007/978-1-59745-019-5_5 · Cited by 68

Nonlinear Optical Imaging of Cellular Processes in Breast Cancer

Provenzano, P. P., Eliceiri, K. W., Yan, L., Ada-Nguema, A. S., Conklin, M. W., Inman, D. R., & Keely, P. J. (2008) · Microscopy and Microanalysis · doi:10.1017/s1431927608080884 · Cited by 64

Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells

Chanson, L., Brownfield, D., Garbe, J. C., Kuhn, I., Stampfer, M. R., Bissell, M. J., & LaBarge, M. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019556108 · Cited by 63

K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc

Magudia, K. A., Lahoz, A., & Hall, A. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201202108 · Cited by 63

Lobuloalveolar Differentiation in Mouse Mammary Tissues in vitro

Ichinose, R. R., & Nandi, S. (1964) · Science · doi:10.1126/science.145.3631.496 · Cited by 58

Biomaterials for stem cell differentiation

Singh, A., & Elisseeff, J. H. (2010) · Journal of Materials Chemistry · doi:10.1039/c0jm01613f · Cited by 57

Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells

Huebner, R. J., Lechler, T., & Ewald, A. J. (2014) · Development · doi:10.1242/dev.103333 · Cited by 57

A strategy for in vitro propagation of rat nephrons

Steer, D. L., Bush, K. T., Meyer, T. N., Schwesinger, C., & Nigám, S. K. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00694.x · Cited by 56

Morphological and Biochemical Analysis of Rac1 in Three‐Dimensional Epithelial Cell Cultures

O’Brien, L. E., Yu, W., Tang, K., Jou, T., Zegers, M. M., & Mostov, K. E. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)06053-8 · Cited by 51

Human enteroids: preclinical models of non-inflammatory diarrhea

Kovbasnjuk, O. N., Zachos, N. C., In, J., Foulke-Abel, J. D., Ettayebi, K., Hyser, J. M., Broughman, J. R., Zeng, X., Middendorp, S., de Jonge, H. R., et al. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt364 · Cited by 51

Pancreatic Ductal Morphogenesis and the Pdx1 Homeodomain Transcription Factor

Wescott, M. P., Rovira, M., Reichert, M., von Burstin, J., Means, A. L., Leach, S. D., & Rustgi, A. K. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-03-0203 · Cited by 50

Explant culture of rat colon: A model system for studying metabolism of chemical carcinogens

Autrup, H. N., Stoner, G. D., Jackson, F., Harris, C. C., Shamsuddin, A. K. M., Barrett, L. A., & Trump, B. F. (1978) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02616157 · Cited by 50

Historical Perspectives of Prolactin and Growth Hormone as Mammogens, Lactogens and Galactagogues—Agog for the Future!

Trott, J. F., Vonderhaar, B. K., & Hovey, R. C. (2008) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-008-9064-x · Cited by 49

A Gutsy Task: Generating Intestinal Tissue from Human Pluripotent Stem Cells

Finkbeiner, S. R., & Spence, J. R. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2620-2 · Cited by 48

Multiparametric image analysis of lung‐branching morphogenesis

Schnatwinkel, C., & Niswander, L. A. (2013) · Developmental Dynamics · doi:10.1002/dvdy.23961 · Cited by 47

Programmed Cell-to-Cell Variability in Ras Activity Triggers Emergent Behaviors during Mammary Epithelial Morphogenesis

Liu, J. S., Farlow, J., Paulson, A. K., LaBarge, M. A., & Gartner, Z. J. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.08.037 · Cited by 45

Generation of Glucose-Responsive Functional Islets with a Three-Dimensional Structure from Mouse Fetal Pancreatic Cells and iPS Cells In Vitro

Saito, H., Takeuchi, M., Chida, K., & Miyajima, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028209 · Cited by 44

Kidney Specific Protein-Positive Cells Derived from Embryonic Stem Cells Reproduce Tubular Structures In Vitro and Differentiate into Renal Tubular Cells

Morizane, R., Monkawa, T., Fujii, S., Yamaguchi, S., Homma, K., Matsuzaki, Y., Okano, H., & Itoh, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064843 · Cited by 43

Suppression of Rac1 activity at the apical membrane of MDCK cells is essential for cyst structure maintenance

Yagi, S., Matsuda, M., & Kiyokawa, E. (2012) · EMBO Reports · doi:10.1038/embor.2011.249 · Cited by 43

Control of Vascular Tube Morphogenesis and Maturation in 3D Extracellular Matrices by Endothelial Cells and Pericytes

Davis, G. E., Kim, D. J., Meng, C., Norden, P. R., Speichinger, K. R., Davis, M. T., Smith, A. O., Bowers, S., & Stratman, A. N. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-604-7_2 · Cited by 37

PI3K/mTOR signaling regulates prostatic branching morphogenesis

Ghosh, S., Lau, H., Simons, B. W., Powell, J. D., Meyers, D. J., Marzo, A. M. D., Berman, D. M., & Lotan, T. L. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.09.027 · Cited by 34

Multiscale tissue engineering for liver reconstruction

Sudo, R. (2014) · Organogenesis · doi:10.4161/org.27968 · Cited by 32

Genetic variation in trophectoderm function in parthenogenetic mouse embryos

Latham, K. E., Kutyna, K., & Wang, Q. (1999) · Developmental Genetics · doi:10.1002/(sici)1520-6408(1999)24:3/4 · Cited by 28

Immunolocalization of mitsugumin29 in developing skeletal muscle and effects of the protein expressed in amphibian embryonic cells

Komazaki, S., Nishi, M., Kangawa, K., & Takeshima, H. (1999) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199906)215:2 · Cited by 28

Practical Considerations for Long-Term Time-Lapse Imaging of Epithelial Morphogenesis in Three-Dimensional Organotypic CulturesPreprint

Ewald, A. J. (2013) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top072884 · Cited by 28

Dissection of Embryonic Mouse Kidney, Culture In Vitro, and Imaging of the Developing OrganPreprint

Costantini, F. D., Watanabe, T., Lu, B. C., Chi, X., & Srinivas, S. (2011) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot5613 · Cited by 25

Synthetic tissue biology: Tissue engineering meets synthetic biology

Sia, S. K., Gillette, B. M., & Yang, G. J. (2007) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20105 · Cited by 22

Activated Ras Protein Accelerates Cell Cycle Progression to Perturb Madin-Darby Canine Kidney Cystogenesis

Sakurai, A., Matsuda, M., & Kiyokawa, E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.377804 · Cited by 20

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Sequeira, S. J., Gervais, E. M., Ray, S., & Larsen, M. (2013) · Journal of Visualized Experiments · doi:10.3791/50060 · Cited by 20

An improved organ culture method for adult mammalian lung

Guerrero, R. R., Rounds, D. E., & Booher, J. (1977) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02615145 · Cited by 20

In Vitro Culture of Embryonic Kidney Rudiments and Isolated Ureteric Buds

Zhang, X., Bush, K. T., & Nigám, S. K. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-851-1_2 · Cited by 16

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Varner, V. D., & Nelson, C. M. (2013) · Integrative Biology · doi:10.1039/c3ib40080h · Cited by 15

Viral Gene Transfer to Developing Mouse Salivary Glands

Hsu, J. C., Pasquale, G. D., Harunaga, J. S., Onodera, T., Hoffman, M. P., Chiorini, J. A., & Yamada, K. M. (2011) · Journal of Dental Research · doi:10.1177/0022034511429346 · Cited by 14

Growth and Morphogenesis of Embryonic Mouse Organs on Non‐Coated and Extracellular Matrix‐Coated Biopore Membrane

Hardman, P., Klement, B. J., & Spooner, B. S. (1993) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.1993.00683.x · Cited by 13

Whole Organ Culture of the Mouse Mammary Gland

Ginsburg, E., & Vonderhaar, B. K. (2000) · Springer eBooks · doi:10.1007/978-1-4615-4295-7_14 · Cited by 10

Functional Profiling of Live Melanoma Samples Using a Novel Automated Platform

Schayowitz, A., Bertenshaw, G. P., Jeffries, E., Schatz, T. F., Cotton, J. B., Villanueva, J., Herlyn, M., Krepler, C., Vultur, A., Xu, W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052760 · Cited by 9

Basal but not Luminal Mammary Epithelial Cells Require PI3K/mTOR Signaling for Ras-Driven Overgrowth

Plichta, K. A., Mathers, J. L., Gestl, S. A., Glick, A. B., & Gunther, E. J. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1635 · Cited by 7

ATLAS AND EPITOME OF HUMAN HISTOLOGY AND MICROSCOPIC ANATOMY

SOBATTA, J., & Huber, G. C. (1903) · The American Journal of the Medical Sciences · doi:10.1097/00000441-190311000-00022 · Cited by 5

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Okugawa, Y., & Hirai, Y. (2013) · Methods in molecular biology · doi:10.1007/7651_2013_45 · Cited by 3

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Organoids as an in vitro model of human development and disease

Fatehullah, A., Tan, S. H., & Barker, N. (2016) · Nature Cell Biology · doi:10.1038/ncb3312 · Cited by 1,508

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

Broutier, L., Mastrogiovanni, G., Verstegen, M. M., Francies, H. E., Gavarró, L. M., Bradshaw, C. R., Allen, G. E., Arnes-Benito, R., Sidorova, O., Gaspersz, M. P., et al. (2017) · Nature Medicine · doi:10.1038/nm.4438 · Cited by 1,471

Organs-on-chips at the frontiers of drug discovery

Esch, E. W., Bahinski, A., & Huh, D. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4539 · Cited by 1,185

Three-Dimensional Cell Cultures in Drug Discovery and Development

Fang, Y., & Eglen, R. M. (2017) · SLAS Discovery · doi:10.1177/1087057117696795 · Cited by 849

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Jackson, E., & Lu, H. (2016) · Integrative Biology · doi:10.1039/c6ib00039h · Cited by 132

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Levental, K. R., Leight, J. L., & Weaver, V. M. (2007) · Methods in cell biology · doi:10.1016/s0091-679x(07)83023-8 · Cited by 87

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Ader, M., & Tanaka, E. M. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.06.013 · Cited by 89

3D culture models for studying branching morphogenesis in the mammary gland and mammalian lung

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3D Culture Assays of Murine Mammary Branching Morphogenesis and Epithelial Invasion

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