Non-histone protein methylation as a regulator of cellular signalling and function

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Analysis of the Substrate Specificity of the SMYD2 Protein Lysine Methyltransferase and Discovery of Novel Non‐Histone Substrates

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Post-Translational Modifications of Transcription Factors Harnessing the Etiology and Pathophysiology in Colonic Diseases

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Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate

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Functional Interplay between Methyltransferases and Inflammasomes in Inflammatory Responses and Diseases

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Methyltransferase and demethylase profiling studies during brown adipocyte differentiation

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PRMT7 deficiency causes dysregulation of the HCN channels in the CA1 pyramidal cells and impairment of social behaviors

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Approaches and Guidelines for the Identification of Novel Substrates of Protein Lysine Methyltransferases

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Analysis of differentially expressed novel post-translational modifications of plasma apolipoprotein E in Taiwanese females with breast cancer

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TAK 1 at the crossroads of multiple regulated cell death pathways: from molecular mechanisms to human diseases

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Discovering a rotational barrier within a charge-transfer state of a photoexcited chromophore in solution

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Mechanical pressure-induced dedifferentiation of myofibroblasts inhibits scarring via SMYD3/ITGBL1 signaling

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The Gridlock transcriptional repressor impedes vertebrate heart regeneration by restricting expression of lysine methyltransferase

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Proteomics in Influenza Research: The Emerging Role of Posttranslational Modifications

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Computational Study of Symmetric Methylation on Histone Arginine Catalyzed by Protein Arginine Methyltransferase PRMT5 through QM/MM MD and Free Energy Simulations

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Chemical modification of biocatalyst for function in supercritical CO2: In silico redesign of stable lipase

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SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress

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Approaching the catalytic mechanism of protein lysine methyltransferases by biochemical and simulation techniques

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Peptidomics of potato protein hydrolysates: implications of post-translational modifications in food peptide structure and behaviour

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Isoform-Specific Lysine Methylation of RORα2 by SETD7 Is Required for Association of the TIP60 Coactivator Complex in Prostate Cancer Progression

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PRMT1-mediated arginine methylation controls ATXN2L localization

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Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies

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Methyltransferase‐like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers

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Substrate docking–mediated specific and efficient lysine methylation by the SET domain–containing histone methyltransferase SETD7

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A crucial RNA-binding lysine residue in the Nab3 RRM domain undergoes SET1 and SET3-responsive methylation

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16S rRNA Methyltransferases as Novel Drug Targets Against Tuberculosis

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Adriamycin induces cardiac fibrosis in mice via PRMT5-mediated cardiac fibroblast activation

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Determining the Mitochondrial Methyl Proteome in Saccharomyces cerevisiae using Heavy Methyl SILAC

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Selective Triazenation Reaction (STaR) of Secondary Amines for Tagging Monomethyl Lysine Post‐Translational Modifications

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How Does Protein Nutrition Affect the Epigenetic Changes in Pig? A Review

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Probing multiple enzymatic methylation events in real time with NMR spectroscopy

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The speckle-type POZ protein (SPOP) inhibits breast cancer malignancy by destabilizing TWIST1

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Understanding mucosal and microbial functionality of the female reproductive tract by metaproteomics: Implications for HIV transmission

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Arginine methylation sites on SepIVA help balance elongation and septation in Mycobacterium smegmatis

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Methylation in cornea and corneal diseases: a systematic review

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Epigenetic regulation of early neural fate commitment

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Personalized Epigenetics

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A Fungus-Specific Protein Domain Is Essential for RasA-Mediated Morphogenetic Signaling in Aspergillus fumigatus

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Oxidatively Modified Proteins: Cause and Control of Diseases

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High-affinity chromodomains engineered for improved detection of histone methylation and enhanced CRISPR-based gene repression

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Decoding protein methylation function with thermal stability analysis

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A new strategy for overcoming drug resistance in liver cancer: Epigenetic regulation

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Improved Discrimination of Asymmetric and Symmetric Arginine Dimethylation by Optimization of the Normalized Collision Energy in Liquid Chromatography–Mass Spectrometry Proteomics

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Post‐translational methylations of the archaeal Mre11:Rad50 complex throughout the DNA damage response

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RUNX‐mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins

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Drug Discovery Researches on Modulators of Lysine-Modifying Enzymes Based on Strategic Chemistry Approaches

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Origins and clinical relevance of proteoforms in pediatric malignancies

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Age-related changes in histone modification in rat gastrocnemius muscle

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Proteome-Wide Alterations of Asymmetric Arginine Dimethylation Associated With Pancreatic Ductal Adenocarcinoma Pathogenesis

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A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial–temporal regulation of histone arginine methylation in neurodevelopment

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Protein arginine methyltransferases interact with intraflagellar transport particles and change location during flagellar growth and resorption

Mizuno, K., & Sloboda, R. D. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-11-0774 · Cited by 14

In vivo methylation of OLA1 revealed by activity-based target profiling of NTMT1

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Approaching Sites of Action of Temozolomide for Pharmacological and Clinical Studies in Glioblastoma

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Klf4 methylated by Prmt1 restrains the commitment of primitive endoderm

Zuo, Z., Yang, G., Wang, H., Liu, S., Zhang, Y., Cai, Y., Chen, F., Dai, H., Xiao, Y., Cheng, M.-B., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac054 · Cited by 12

PeSA: A software tool for peptide specificity analysis

Topcu, E., & Biggar, K. K. (2019) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2019.107145 · Cited by 12

Structural basis for antigen recognition by methylated lysine–specific antibodies

Ishii, M., Nakakido, M., Caaveiro, J. M. M., Kuroda, D., Okumura, C. J., Maruyama, T., Entzminger, K. C., & Tsumoto, K. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015996 · Cited by 12

Specificity Analysis of Protein Methyltransferases and Discovery of Novel Substrates Using SPOT Peptide Arrays

Weirich, S., & Jeltsch, A. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2481-4_15 · Cited by 12

Cryo-EM structure-based selection of computed ligand poses enables design of MTA-synergic PRMT5 inhibitors of better potency

Zhou, W., Yadav, G. P., Yang, X. T., Qin, F., Li, C., & Jiang, Q. (2022) · Communications Biology · doi:10.1038/s42003-022-03991-9 · Cited by 13

The protein methylation network in yeast: A landmark in completeness for a eukaryotic post-translational modification

Hamey, J. J., & Wilkins, M. R. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2215431120 · Cited by 13

KDM2A interacts with estrogen receptor α to promote bisphenol A and S-induced breast cancer cell proliferation by repressing TET2 expression

Li, Z., Ren, Y., Li, X., & Wang, W. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115132 · Cited by 12

Abnormal keratinocyte differentiation in the nasal planum of Labrador Retrievers with hereditary nasal parakeratosis (HNPK)

Bannoehr, J., Balmer, P., Stoffel, M. H., Jagannathan, V., Gaschen, V., Kuehni-Boghenbor, K., Sayar, B. S., Drögemüller, M., Howald, D., Wiener, D. J., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0225901 · Cited by 12

Outer Membrane Protein OmpB Methylation May Mediate Bacterial Virulence

Yang, D. C. H., Abeykoon, A. H., Choi, B.-E., Ching, W., & Chock, P. B. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.09.005 · Cited by 12

Chemical Depletion of Histidine-Containing Peptides Allows Identification of More Low-Abundance Methylation Sites from Proteome Samples

Wang, Q., Li, Z., Zhou, J., Wang, Y., Wang, K., Qin, H., & Ye, M. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.0c00976 · Cited by 11

Orchestrating epigenetics: a comprehensive review of the methyltransferase SETD6

Chopra, A., Feldman, M., & Levy, D. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01423-2 · Cited by 11

Post-translational modifications of epigenetic modifier TIP60: their role in cellular functions and cancer

Gupta, H., & Gupta, A. (2025) · Epigenetics & Chromatin · doi:10.1186/s13072-025-00572-y · Cited by 11

Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses

Sohtome, Y., Shimazu, T., Barjau, J., Fujishiro, S., Akakabe, M., Terayama, N., Dodo, K., Ito, A., Yoshida, M., Shinkai, Y., et al. (2018) · Chemical Communications · doi:10.1039/c8cc03907k · Cited by 11

Crosstalk of Epigenetic and Metabolic Signaling Underpinning Glioblastoma Pathogenesis

Markouli, M., Strepkos, D., Papavassiliou, K. A., Papavassiliou, A. G., & Piperi, C. (2022) · Cancers · doi:10.3390/cancers14112655 · Cited by 12

One-pot chemical pyro- and tri-phosphorylation of peptides by using diamidophosphate in water

Lin, H., Leman, L. J., & Krishnamurthy, R. (2022) · Chemical Science · doi:10.1039/d2sc04160j · Cited by 12

Fine tuning of the transcription juggernaut: A sweet and sour saga of acetylation and ubiquitination

Ghosh, A., Chakraborty, P., & Biswas, D. (2023) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2023.194944 · Cited by 11

In vivo protein allylation to capture protein methylation candidates

Zhang, Y., Pan, Y., Liu, W., Zhou, Y. J., Wang, K., Wang, L., Sohail, M., Ye, M., Zou, H., & Zhao, Z. K. (2016) · Chemical Communications · doi:10.1039/c6cc02386j · Cited by 11

Development of Chaetocin and S ‐Adenosylmethionine Analogues as Tools for Studying Protein Methylation

Sohtome, Y., & Sodeoka, M. (2018) · The Chemical Record · doi:10.1002/tcr.201800118 · Cited by 11

Engineering a methyllysine reader with photoactive amino acid in mammalian cells

Arora, S., Sappa, S., Hinkelman, K., & Islam, K. (2020) · Chemical Communications · doi:10.1039/d0cc03814h · Cited by 11

Histone methyltransferase SUV39H2 serves oncogenic roles in osteosarcoma

Piao, L., Yuan, X., Zhuang, M., Qiu, X., Xu, X., Kong, R., & Liu, Z. (2018) · Oncology Reports · doi:10.3892/or.2018.6843 · Cited by 11

Visualization and Analysis of Epiproteome Dynamics

Kaur, S., Baldi, B. F., Vuong, J., & O’Donoghue, S. I. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.01.044 · Cited by 11

Versatile roles of disordered transcription factor effector domains in transcriptional regulation

Datta, R. R., Akdogan, D., Tezcan, E. B., & Önal, P. (2025) · FEBS Journal · doi:10.1111/febs.17424 · Cited by 10

Mechanistic insights into post-translational modifications in hepatic fibrosis: pathogenic roles and therapeutic potentials

Bai, X., Liu, Z., Li, X., Sun, R., & Yu, Z. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07037-6 · Cited by 10

An Animal Model for Genetic Analysis of Multi-Gene Families: Cloning and Transgenesis of Large Tandemly Repeated Histone Gene Clusters

Meers, M. P., Leatham-Jensen, M. P., Penke, T. J. R., McKay, D. J., Duronio, R. J., & Matera, A. G. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8663-7_17 · Cited by 10

Renal insufficiency and chronic kidney disease – Promotor or consequence of pathological post-translational modifications

Laget, J., Duranton, F., Argilés, À., & Gayrard, N. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101082 · Cited by 11

Modulation of IKs channel–PIP2 interaction by PRMT1 plays a critical role in the control of cardiac repolarization

An, X., Lee, J., Kim, G. H., Kim, H., Pyo, H., Kwon, I., & Cho, H. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30775 · Cited by 10

Effects of environmental concentrations of the fragrance amyl salicylate on the mediterranean mussel Mytilus galloprovincialis

Bernardini, I., Fabrello, J., Vecchiato, M., Ferraresso, S., Babbucci, M., Peruzza, L., Rovere, G. D., Masiero, L., Marin, M. G., Bargelloni, L., et al. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119502 · Cited by 10

Selective editing of a peptide skeleton via C–N bond formation at N-terminal aliphatic side chains

Han, Y., Shi, J., Li, S., Dan, T., Yang, W., & Yang, M. (2022) · Chemical Science · doi:10.1039/d2sc04909k · Cited by 10

Methylated of genes behaving as potential biomarkers in evaluating malignant degree of glioblastoma

Wen, W., Hu, S., Ai, Z., Mou, L., Lu, J., & Li, S. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25831 · Cited by 10

Examining Product Specificity in Protein Arginine Methyltransferase 7 (PRMT7) Using Quantum and Molecular Mechanical Simulations

Thakur, A., Hevel, J. M., & Acevedo, O. (2019) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.9b00137 · Cited by 10

Mammalian HEMK1 methylates glutamine residue of the GGQ motif of mitochondrial release factors

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Hippo signaling and histone methylation control cardiomyocyte cell cycle re-entry through distinct transcriptional pathways

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