Cited by 482Cancer-related gene regulationEpigenetics and DNA MethylationGenomics and Chromatin Dynamics

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Non-histone protein methylation as a regulator of cellular signalling and function

Biggar, Kyle K., Li, Shawn S.-C.·2015·Nature Reviews Molecular Cell Biology

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Abstract

Methylation of Lys and Arg residues on non-histone proteins has emerged as a prevalent post-translational modification and as an important regulator of cellular signal transduction mediated by the MAPK, WNT, BMP, Hippo and JAK-STAT signalling pathways. Crosstalk between methylation and other types of post-translational modifications, and between histone and non-histone protein methylation frequently occurs and affects cellular functions such as chromatin remodelling, gene transcription, protein synthesis, signal transduction and DNA repair. With recent advances in proteomic techniques, in particular mass spectrometry, the stage is now set to decode the methylproteome and define its functions in health and disease.

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“Various transmembraneproteins and receptors are functionally regulated by acetylation on Lys (147, 148) ormethylation on Lys orArg (149); however, these modes of posttranslational regulation are less studied than the control of protein function by phosphorylation.”
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The roles of DNA, RNA and histone methylation in ageing and cancer
Michalak, E. M., Burr, M. L., Bannister, A. J., & Dawson, M. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0143-1 · Cited by 549
Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice
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Authors: Biggar, K. K., & Li, S. S.-C.
Affiliations: Western University (CA)
Corresponding author: Li, Shawn S.-C.
ORCID: Biggar, Kyle K.
Li, Shawn S.-C.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2014-12-10
Volume: 16
Issue: 1
Pages: 5-17
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm3915
OpenAlex: W2037215281
Cited by: 479
References: 138
Citations by year: 2026: 25 · 2025: 29 · 2024: 35 · 2023: 39 · 2022: 44 · 2021: 31 · 2020: 51 · 2019: 56 · 2018: 46 · 2017: 46 · 2016: 54 · 2015: 21 · 2014: 1
FWCI: 3.83
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: non-histone protein methylation, lysine methylation, arginine methylation, post-translational modification crosstalk, histone methylation, MAPK signaling, Wnt signaling, BMP signaling, Hippo signaling pathway, JAK/STAT signaling, signal transduction, DNA repair, chromatin remodeling, gene transcription, proteomics
MeSH terms: Hippo Signaling Pathway, Animals, DNA Repair, Humans, Methylation, Transcription, Genetic, Protein Biosynthesis, Protein Serine-Threonine Kinases, MAP Kinase Signaling System, Chromatin Assembly and Disassembly, Extracellular Signal-Regulated MAP Kinases, STAT Transcription Factors, Wnt Proteins, Wnt Signaling Pathway

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Non-histone protein methylation as a regulator of cellular signalling and function

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