The DOI matches its Crossref record; 137 of the 138 references it cites were found in a registry or an index.
Non-histone protein methylation as a regulator of cellular signalling and function
Abstract
Methylation of Lys and Arg residues on non-histone proteins has emerged as a prevalent post-translational modification and as an important regulator of cellular signal transduction mediated by the MAPK, WNT, BMP, Hippo and JAK-STAT signalling pathways. Crosstalk between methylation and other types of post-translational modifications, and between histone and non-histone protein methylation frequently occurs and affects cellular functions such as chromatin remodelling, gene transcription, protein synthesis, signal transduction and DNA repair. With recent advances in proteomic techniques, in particular mass spectrometry, the stage is now set to decode the methylproteome and define its functions in health and disease.
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“The effect may even be trans -acting, as exemplified by m6A in Xist RNA that is required for it to mediate transcriptional repression 40 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [40]
In the citing paper
“Thus far the tumour-intrinsic mechanisms of resistance appear to be quite different to the paradigm of acquired resistance reported for other targeted therapies such as kinase inhibitors 188 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [188]
Citations
Cites
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High-Resolution Profiling of Histone Methylations in the Human Genome
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The Nuclear Factor NF- B Pathway in InflammationPreprint
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Mdm2 promotes the rapid degradation of p53
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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
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Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
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1 of the 138 references couldn’t be matched to a known paper.
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The molecular hallmarks of epigenetic control
Allis, C. D., & Jenuwein, T. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.59 · Cited by 2,809
Arginine Methylation: The Coming of Age
Blanc, R. S., & Richard, S. (2017) · Molecular Cell · doi:10.1016/j.molcel.2016.11.003 · Cited by 1,054
Specificity, versatility, and control of TGF-β family signaling
Derynck, R., & Budi, E. H. (2019) · Science Signaling · doi:10.1126/scisignal.aav5183 · Cited by 785
“Various transmembraneproteins and receptors are functionally regulated by acetylation on Lys (147, 148) ormethylation on Lys orArg (149); however, these modes of posttranslational regulation are less studied than the control of protein function by phosphorylation.”
BackgroundThe roles of DNA, RNA and histone methylation in ageing and cancer
Michalak, E. M., Burr, M. L., Bannister, A. J., & Dawson, M. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0143-1 · Cited by 549
Morris, M., Knudsen, G. M., Maeda, S., Trinidad, J. C., Ioanoviciu, A., Burlingame, A. L., & Mucke, L. (2015) · Nature Neuroscience · doi:10.1038/nn.4067 · Cited by 472
Metadata
- Authors
- Biggar, K. K., & Li, S. S.-C.
- Affiliations
- Western University (CA)
- Corresponding author
- Li, Shawn S.-C.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2014-12-10
- Volume
- 16
- Issue
- 1
- Pages
- 5-17
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2037215281
- Cited by
- 479
- References
- 138
- Citations by year
- 2026: 25 · 2025: 29 · 2024: 35 · 2023: 39 · 2022: 44 · 2021: 31 · 2020: 51 · 2019: 56 · 2018: 46 · 2017: 46 · 2016: 54 · 2015: 21 · 2014: 1
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- non-histone protein methylation, lysine methylation, arginine methylation, post-translational modification crosstalk, histone methylation, MAPK signaling, Wnt signaling, BMP signaling, Hippo signaling pathway, JAK/STAT signaling, signal transduction, DNA repair, chromatin remodeling, gene transcription, proteomics
- MeSH terms
- Hippo Signaling Pathway, Animals, DNA Repair, Humans, Methylation, Transcription, Genetic, Protein Biosynthesis, Protein Serine-Threonine Kinases, MAP Kinase Signaling System, Chromatin Assembly and Disassembly, Extracellular Signal-Regulated MAP Kinases, STAT Transcription Factors, Wnt Proteins, Wnt Signaling Pathway
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