IAP proteins: blocking the road to death's door

Cited by (1,000)

Items 101–200 of 1,000

1. Linking JNK signaling to NF-κB: a key to survival
   Salvatore Papa, Francesca Zazzeroni, Can G. Pham, Concetta Bubici, Guido Franzoso · 2004 · Journal of Cell Science
2. Enzymatic mechanisms regulating protein S-nitrosylation: implications in health and disease
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3. Regulation of apoptosis in Drosophila
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4. Cell Death in Pancreatitis
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5. Activation and Cross-talk between Akt, NF-κB, and Unfolded Protein Response Signaling in 1-LN Prostate Cancer Cells Consequent to Ligation of Cell Surface-associated GRP78
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6. Alterations in the apoptotic machinery and their potential role in anticancer drug resistance
   Scott H. Kaufmann, David Lawrence Vaux · 2003 · Oncogene
7. Synthetic Smac/DIABLO Peptides Enhance the Effects of Chemotherapeutic Agents by Binding XIAP and cIAP1 in Situ
   Christina R. Arnt, Mihnea V. Chiorean, Michael P. Heldebrant, Gregory James Gores, Scott H. Kaufmann · 2002 · Journal of Biological Chemistry
8. Netrin-1 and its receptors in tumorigenesis
   Hirofumi Arakawa · 2004 · Nature reviews. Cancer
9. Epilepsy and Apoptosis Pathways
   David Clifford Henshall, Roger Pancoast Simon · 2005 · Journal of Cerebral Blood Flow & Metabolism
10. IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis
    Mads Gyrd‐Hansen, Maurice Darding, Maria Miasari, Massimo Mattia Santoro, Lars Zender, Wen Xue, Tencho Tenev, Paula C. A. da Fonseca, Marketa Zvelebil, Janusz Marek Bujnicki et al. · 2008 · Nature Cell Biology
11. Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death
    Maryanne Donovan, Thomas G. Cotter · 2003 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
12. New Approaches and Therapeutics Targeting Apoptosis in Disease
    Ute Fischer, Klaus Schulze‐Osthoff · 2005 · Pharmacological Reviews
13. Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)
    Flygare, John A., Beresini, Maureen, Budha, Nageshwar, Chan, Helen, Chan, Iris T., Cheeti, Sravanthi, Cohen, Frederick, Deshayes, Kurt, Doerner, Karl, Eckhardt, S. Gail et al. · 2012 · Journal of Medicinal Chemistry
14. Sensitization for Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by the Chemopreventive Agent Resveratrol
    Simone Fulda, Klaus‐Michael Debatin · 2004 · Cancer Research
15. Life in the balance – a mechanistic view of the crosstalk between autophagy and apoptosis
    Assaf D. Rubinstein, Adi Kimchi · 2012 · Journal of Cell Science
16. The Apoptosome: Physiological, Developmental, and Pathological Modes of Regulation
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17. Targeting the extrinsic apoptosis signaling pathway for cancer therapy
    Thomas Joseph Sayers · 2011 · Cancer Immunology Immunotherapy
18. Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function
    Yanyan Hao, Keiko Sekine, Atsushi Kawabata, Hitoshi Nakamura, Toshiyasu Ishioka, Hirokazu Ohata, Ryohei Katayama, Chizuko Hashimoto, Xiaodong Zhang, Tetsuo Noda et al. · 2004 · Nature Cell Biology
19. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)
    Ohoka, Nobumichi, Okuhira, Keiichiro, Ito, Masahiro, Nagai, Katsunori, Shibata, Norihito, Hattori, Takayuki, Ujikawa, Osamu, Shimokawa, Kenichiro, Sano, Osamu, Koyama, Ryokichi et al. · 2017 · Journal of Biological Chemistry
20. Mathematical Modeling Identifies Inhibitors of Apoptosis as Mediators of Positive Feedback and Bistability
    Stefan Legewie, Nils Blüthgen, Hanspeter Herzel · 2006 · PLoS Computational Biology
21. Caspase activation – stepping on the gas or releasing the brakes? Lessons from humans and flies
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22. Sunitinib Acts Primarily on Tumor Endothelium rather than Tumor Cells to Inhibit the Growth of Renal Cell Carcinoma
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23. The NF-κB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease
    Salvatore Papa, Concetta Bubici, Francesca Zazzeroni, Can G. Pham, Christian Kuntzen, James R. Knabb, Kathryn Dean, Guido Franzoso · 2006 · Cell Death and Differentiation
24. Mechanisms of Obligatory Intracellular Infection with Anaplasma phagocytophilum
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25. Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology
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26. Antagonists Induce a Conformational Change in cIAP1 That Promotes Autoubiquitination
    Erin C. Dueber, Allyn J. Schoeffler, Andreas Lingel, J. Michael Elliott, Anna V. Fedorova, Anthony M. Giannetti, Kerry Zobel, Brigitte Maurer, Eugene E. Varfolomeev, Ping Wu et al. · 2011 · Science
27. Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro‐inflammatory and anti‐inflammatory agents: key role for TNF‐α
    Sylwia Michlewska, Ian Dransfield, Ian L. Megson, Adriano Giorgio Rossi · 2008 · The FASEB Journal
28. Dual role for TGF-?1 in apoptosis
    Amelia Sánchez‐Capelo · 2005 · Cytokine & Growth Factor Reviews
29. Current concepts in apoptosis: The physiological suicide program revisited
    Indrajit Chowdhury, Binu Tharakan, Ganapathy K. Bhat · 2006 · Cellular & Molecular Biology Letters
30. Granzyme B-Induced Apoptosis Requires Both Direct Caspase Activation and Relief of Caspase Inhibition
    Ing Swie Goping, Michele Barry, Peter Liston, Tracy Sawchuk, Gabriela Constantinescu, Karolina M. Michalak, Irene Shostak, Darren L. Roberts, Allison M. Hunter, Robert G. Korneluk et al. · 2003 · Immunity
31. Smac/DIABLO Selectively Reduces the Levels of c-IAP1 and c-IAP2 but Not That of XIAP and Livin in HeLa Cells
    Qi-Heng Yang, Chunying Du · 2004 · Journal of Biological Chemistry
32. Small-molecule SMAC mimetics as new cancer therapeutics
    Longchuan Bai, David Carl Smith, Shaomeng Wang · 2014 · Pharmacology & Therapeutics
33. Design, Synthesis, and Characterization of a Potent, Nonpeptide, Cell-Permeable, Bivalent Smac Mimetic That Concurrently Targets Both the BIR2 and BIR3 Domains in XIAP
    Haiying Sun, Zaneta Nikolovska‐Coleska, Jianfeng Lü, Jennifer L. Meagher, Chao‐Yie Yang, Su Qiu, York A. Tomita, Yumi Ueda, Sheng Jiang, Krzysztof Krajewski et al. · 2007 · Journal of the American Chemical Society
34. The Domains of Apoptosis: A Genomics Perspective
    John C. Reed, Kutbuddin S. Doctor, Adam Godzik · 2004 · Science s STKE
35. Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis.
    Olivier Blanc‐Brude, Mehdi Mesri, Nathan R. Wall, Janet Plescia, Takehiko Dohi, Dario C. Altieri · 2003 · PubMed
36. TheS. cerevisiaeHtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosis
    Birthe Fahrenkrog, Ursula Sauder, Ueli Aebi · 2003 · Journal of Cell Science
37. MECHANISMS OF APOPTOSIS THROUGH STRUCTURAL BIOLOGY
    Nieng Yan, Yigong Shi · 2005 · Annual Review of Cell and Developmental Biology
38. The Inhibitor of Apoptosis Proteins as Therapeutic Targets in Cancer
    Domagoj Vucic, Wayne J. Fairbrother · 2007 · Clinical Cancer Research
39. The interplay between the Bcl-2 family and death receptor-mediated apoptosis
    Martin Ronald Sprick, Henning Walczak · 2003 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
40. Caspase Mechanisms
    Guy S. Salvesen, Stefan J. Riedl · 2007 · Advances in experimental medicine and biology
41. Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol
    Simone Fulda, Klaus‐Michael Debatin · 2004 · Oncogene
42. E3 Ubiquitin Ligases as Cancer Targets and Biomarkers
    Yi Sun · 2006 · Neoplasia
43. Cell Death and Inflammation: The Role of Mitochondria in Health and Disease
    Anna Picca, Riccardo Calvani, Hélio José Coelho‐Júnior, Emanuele Marzetti · 2021 · Cells
44. A Caspase Cascade Regulating Developmental Axon Degeneration
    David J. Simon, Robby M. Weimer, Todd McLaughlin, Dara Y. Kallop, Karen Stanger, Jing Hui Yang, Dennis D.M. O’Leary, Rami N. Hannoush, Marc Tessier‐Lavigne · 2012 · Journal of Neuroscience
45. Caspase-Dependent Cell Death inDrosophila
    Bruce A. Hay, Ming Guo · 2006 · Annual Review of Cell and Developmental Biology
46. Inflammation-associated Cell Cycle–independent Block of Apoptosis by Survivin in Terminally Differentiated Neutrophils
    Frank Altznauer, Sibylla Martinelli, Shída Yousefi, Christine Thürig, Inès Schmid, Edward M. Conway, Martin H. Schöni, PETER R. VOGT, Christoph Mueller, Martin F. Fey et al. · 2004 · The Journal of Experimental Medicine
47. SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP
    Jianfeng Lü, Longchuan Bai, Haiying Sun, Zaneta Nikolovska‐Coleska, Donna McEachern, Su Qiu, Rebecca S. Miller, Yi Han, Sanjeev Kumar Shangary, Yi Sun et al. · 2008 · Cancer Research
48. Use of combined apoptosis biomarkers for prediction of bladder cancer recurrence and mortality after radical cystectomy
    Jose Antonio Karam, Yair Lotan, Pierre I. Karakiewicz, Raheela Ashfaq, Arthur I. Sagalowsky, Claus G. Roehrborn, Shahrokh François Shariat · 2007 · The Lancet Oncology
49. Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease
    Jermaine Goveia, Peter Conrad Stapor, Peter Carmeliet · 2014 · EMBO Molecular Medicine
50. Overcoming Drug Resistance by Enhancing Apoptosis of Tumor Cells
    Pepita Gimenez‐Bonafé, Avelina Tortosa, Ricardo Pérez‐Tomás · 2009 · Current Cancer Drug Targets
51. Regulation of apoptosis by XIAP ubiquitin-ligase activity
    Andrew J. Schile, María García-Fernández, Hermann Steller · 2008 · Genes & Development
52. Apoptosis inDrosophila: neither fish nor fowl (nor man, nor worm)
    Sally A. Kornbluth, Kristin White · 2005 · Journal of Cell Science
53. Posttranscriptional Downregulation of c-IAP2 by the Ubiquitin Protein Ligase c-IAP1 In Vivo
    Dietrich B. Conze, Lori Albert, David A. Ferrick, David V. Goeddel, Wen‐Chen Yeh, Tak W. Mak, Jonathan D. Ashwell · 2005 · Molecular and Cellular Biology
54. Survivin as a Preferential Target for Cancer Therapy
    Mahsa Mobahat, Aru Narendran, Karl T. Riabowol · 2014 · International Journal of Molecular Sciences
55. Inhibitor of Apoptosis Proteins Are Substrates for the Mitochondrial Serine Protease Omi/HtrA2
    Srinivasa Murty Srinivasula, Sanjeev Gupta, Pinaki Datta, ZhiJia Zhang, R.P. Hegde, Naeun Cheong, Teresa Fernandes‐Alnemri, Emad S. Alnemri · 2003 · Journal of Biological Chemistry
56. Transnitrosylation of XIAP Regulates Caspase-Dependent Neuronal Cell Death
    Tomohiro Nakamura, Lei Wang, Catherine C. L. Wong, Fiona L. Scott, Brendan P. Eckelman, Xuemei Han, Christos Tzitzilonis, Fanjun Meng, Zezong Gu, Emily A. Holland et al. · 2010 · Molecular Cell
57. Golgi structure in stress sensing and apoptosis
    Stuart W. Hicks, Carolyn E. Machamer · 2005 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
58. The mitochondrial ARTS protein promotes apoptosis through targeting XIAP
    Yossi Gottfried, Asaf Rotem, Rona Lotan, Hermann Steller, Sarit Larisch · 2004 · The EMBO Journal
59. Mechanisms of fenretinide-induced apoptosis
    Numsen Hail, H. J. Kim, Reuben Lotan · 2006 · APOPTOSIS
60. Multiple Mechanisms of Unfolded Protein Response–Induced Cell Death
    Nobuhiko Hiramatsu, Wei-Chieh Jerry Chiang, Timothy D. Kurt, Christina J. Sigurdson, Jonathan H. Lin · 2015 · American Journal Of Pathology
61. Apoptotic Killing of HIV-1–Infected Macrophages Is Subverted by the Viral Envelope Glycoprotein
    Simon Swingler, Angela M. Mann, Jin Zhou, Catherine Swingler, Mario Stevenson · 2007 · PLoS Pathogens
62. Interrelated Roles for Mcl-1 and BIM in Regulation of TRAIL-mediated Mitochondrial Apoptosis
    Jie Han, Leslie A. Goldstein, Brian Gastman, Hannah Rabinowich · 2006 · Journal of Biological Chemistry
63. Regulation of survivin expression by IGF-1/mTOR signaling
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64. Drug Insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms
    Reed, John C · 2006 · Nature Clinical Practice Oncology
65. New wirings in the survivin networks
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66. Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells
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67. Novel Curcumin loaded nanoparticles engineered for Blood-Brain Barrier crossing and able to disrupt Abeta aggregates
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68. The role of apoptosis in the development and function of T lymphocytes
    Nu Zhang, Heather M. Hartig, Ivan Lilyanov Dzhagalov, David DRAPER, You Wen He · 2005 · Cell Research
69. The E3 Ubiquitin Ligase cIAP1 Binds and Ubiquitinates Caspase-3 and -7 via Unique Mechanisms at Distinct Steps in Their Processing
    Young Eun Choi, Michael Butterworth, Srinivas Malladi, Colin S. Duckett, Gerald M. Cohen, Shawn B. Bratton · 2009 · Journal of Biological Chemistry
70. Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs
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71. The dependence receptor UNC5H2 mediates apoptosis through DAP‐kinase
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72. Small Molecules Destabilize cIAP1 by Activating Auto-ubiquitylation
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73. Design of Small-Molecule Peptidic and Nonpeptidic Smac Mimetics
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74. E3 ligase ligand chemistries: from building blocks to protein degraders
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75. Phenoxodiol – an isoflavone analog – induces apoptosis in chemoresistant ovarian cancer cells
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76. The Universal Character of the Tumor-Associated Antigen Survivin
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77. Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways
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78. Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment
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79. Distinct BIR Domains of cIAP1 Mediate Binding to and Ubiquitination of Tumor Necrosis Factor Receptor-associated Factor 2 and Second Mitochondrial Activator of Caspases
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80. The Drosophila DIAP1 Protein Is Required to Prevent Accumulation of a Continuously Generated, Processed Form of the Apical Caspase DRONC
    Israel Muro, Bruce A. Hay, Rollie J. Clem · 2002 · Journal of Biological Chemistry
81. Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization
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82. Viral Subversion of Apoptotic Enzymes: Escape from Death Row
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83. Selective targeting of cancer cells using synthetic peptides
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84. Lessons from TRAIL-resistance mechanisms in colorectal cancer cells: paving the road to patient-tailored therapy
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85. Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth
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86. Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases
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87. The clinical trail of TRAIL
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88. RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice
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89. Cancer cells survive with survivin
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90. Mammalian initiator apoptotic caspases
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91. Mycosis fungoides shows concurrent deregulation of multiple genes involved in the TNF signaling pathway: an expression profile study
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92. XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer
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93. Resveratrol and breast cancer chemoprevention: Molecular mechanisms
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94. TRAIL Agonists on Clinical Trials for Cancer Therapy: The Promises and the Challenges
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95. The Molecular Mechanisms of Glucocorticoids-Mediated Neutrophil Survival
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96. IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms
    Tencho Tenev, Anna Zachariou, Rebecca Wilson, Mark Ditzel, Pascal Meier · 2004 · Nature Cell Biology
97. Resveratrol modulation of signal transduction in apoptosis and cell survival: A mini-review
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98. Apoptosis effector mechanisms: A requiem performed in different keys
    Numsen Hail, B Z Carter, Marina Y Konopleva, Michael Andreeff · 2006 · APOPTOSIS
99. Expression of the IAP protein family is dysregulated in pancreatic cancer cells and is important for resistance to chemotherapy
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100. Therapeutic Small Molecules Target Inhibitor of Apoptosis Proteins in Cancers with Deregulation of Extrinsic and Intrinsic Cell Death Pathways
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