IAP proteins: blocking the road to death's door

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673

Apoptosis in the Pathogenesis and Treatment of Disease

Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

Li, H., Zhu, H., Xu, C.-J., & Yuan, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81590-1 · Cited by 4,445

Identification and characterization of a spinal muscular atrophy-determining gene

Lefebvre, S., Bürglen, L., Reboullet, S., Clermont, O., Burlet, P., Viollet, L., Bénichou, B., Cruaud, C., Millasseau, P., Zeviani, M., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90460-3 · Cited by 3,995

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

Du, C., Fang, M., Li, Y., Li, L., & Wang, X. (2000) · Cell · doi:10.1016/s0092-8674(00)00008-8 · Cited by 3,513

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

Ambrosini, G., Adida, C., & Altieri, D. C. (1997) · Nature Medicine · doi:10.1038/nm0897-917 · Cited by 3,174

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

Zou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.

Wang, C.-Y., Mayo, M., Korneluk, R., Goeddel, D., & Baldwin, A. (1998) · Science · doi:10.1126/science.281.5383.1680 · Cited by 2,950

Programmed Cell Death in Animal Development

Jacobson, M. D., Weil, M., & RAFF, M. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81873-5 · Cited by 2,685

Subcellular localization determines the delicate balance between the anti- and pro-apoptotic activity of Livin

Nachmias, B., Lazar, I., Elmalech, M., Elrahman, I. A., Ashab, Y., Mandelboim, O., Perlman, R., & Ben‐Yehuda, D. (2007) · APOPTOSIS · doi:10.1007/s10495-006-0049-1 · Cited by 29

Survivin Inhibitor YM-155 Sensitizes Tumor Necrosis Factor– Related Apoptosis-Inducing Ligand-Resistant Glioma Cells to Apoptosis through Mcl-1 Downregulation and by Engaging the Mitochondrial Death Pathway

Premkumar, D. R., Jane, E. P., Foster, K. A., & Pollack, I. F. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.204743 · Cited by 29

The translation of an antiapoptotic protein HIAP2 is regulated by an upstream open reading frame

Warnakulasuriyarachchi, D., Ungureanu, N. H., & Holčı́k, M. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401256 · Cited by 29

Glycogen Synthase Kinase-3 Inhibition Sensitizes Pancreatic Cancer Cells to TRAIL-Induced Apoptosis

Mamaghani, S., Simpson, C. D., Cao, P. M., Cheung, M., Chow, S., Bandarchi, B., Schimmer, A. D., & Hedley, D. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041102 · Cited by 29

Executioners of apoptosis in pancreatic β-cells: not just for cell death

Choi, D., & Woo, M. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00696.2009 · Cited by 29

MicroRNA-146a-5p enhances cisplatin-induced apoptosis in ovarian cancer cells by targeting multiple anti-apoptotic genes

Li, X., Jin, Y., Mu, Z., Chen, W., & Jiang, S. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4023 · Cited by 29

Assessment of doxorubicin delivery devices based on tailored bare polycaprolactone against glioblastoma

Niza, E., Castro‐Osma, J. A., Posadas, I., Alonso‐Moreno, C., Bravo, I., Garzón‐Ruiz, A., Canales‐Vázquez, J., Ceña, V., Lara‐Sánchez, A., Albaladejo, J., et al. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.12.079 · Cited by 29

Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities

Adnan, M., Rasul, A., Hussain, G., Shah, M. A., Sarfraz, I., Nageen, B., Riaz, A., Khalid, R., Asrar, M., Selamoğlu, Z., et al. (2020) · Current Drug Targets · doi:10.2174/1389450121999201013154542 · Cited by 29

Cutting-Edge Apoptosis-Based Therapeutics

Fischer, U., Janssen, K., & Schulze‐Osthoff, K. (2007) · BioDrugs · doi:10.2165/00063030-200721050-00001 · Cited by 29

Spermatogenesis: borrowing the apoptotic machinery

Cagan, R. L. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00525-6 · Cited by 29

Low expression of XIAP‐associated factor 1 in human colorectal cancers

Tian Le, M. A., Pei Hua, N. I., Zhong, J., Ji Hong, T. A. N., Min Min, Q. I. A. O., & Jiang, S. H. (2005) · Chinese Journal of Digestive Diseases · doi:10.1111/j.1443-9573.2005.00180.x · Cited by 29

Role of caspase-independent apoptosis in cardiovascular diseases

Bae, S. (2007) · Frontiers in bioscience · doi:10.2741/2861 · Cited by 28

Calcineurin Potentiates the Activation of Procaspase-3 by Accelerating Its Proteolytic Maturation

Saeki, M., Irie, Y., Ni, L., Itsuki, Y., Terao, Y., Kawabata, S., & Kamisaki, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609347200 · Cited by 28

Efficacy of MDM2 inhibitor MI-219 against lung cancer cells alone or in combination with MDM2 knockdown, a XIAP inhibitor or etoposide.

Zheng, M., Yang, J., Xu, X., Sebolt, J. T., Wang, S., & Sun, Y. (2010) · PubMed · Cited by 28

An Indirubin Derivative, Indirubin-3′-Monoxime Suppresses Oral Cancer Tumorigenesis through the Downregulation of Survivin

Lo, W., & Chang, N.-W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070198 · Cited by 28

Nitrosylcobalamin Potentiates the Anti-Neoplastic Effects of Chemotherapeutic Agents via Suppression of Survival Signaling

Bauer, J. A., Lupica, J. A., Szugye, H., Morrison, B., Haney, R. M., Masci, R. K., Lee, R. M., DiDonato, J. A., & Lindner, D. J. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001313 · Cited by 28

Leishmania donovani induced Unfolded Protein Response delays host cell apoptosis in PERK dependent manner

Abhishek, K., Das, S., Kumar, A., Kumar, A., Kumar, V., Saini, S., Mandal, A., Verma, S., Kumar, M., & Das, P. K. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006646 · Cited by 28

Apoptosis and Proliferation Markers in Diffusely Infiltrating Astrocytomas

Liu, X., Ni, C., Wang, X., He, Y., Chen, X., Huang, Y., Wu, Y., & Zhou, Q. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000235857.79502.c3 · Cited by 28

The baculovirus anti-apoptotic protein Op-IAP does not inhibit Drosophila caspases or apoptosis in Drosophila S2 cells and instead sensitizes S2 cells to virus-induced apoptosis

Wright, C. W., Means, J. C., Penabaz, T., & Clem, R. J. (2005) · Virology · doi:10.1016/j.virol.2005.02.007 · Cited by 28

Orthotopic Implantation of Human Hepatocellular Carcinoma in Mice

Armengol, C., Tarafa, G., Boix, L., Solé, M., Queralt, R., Costa, D., Bachs, O., Bruix, J., & Capellá, G. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-1028 · Cited by 28

Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs

Sato, S., Aoyama, H., Miyachi, H., Naito, M., & Hashimoto, Y. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.04.031 · Cited by 28

PERK-mediated induction of microRNA-483 disrupts cellular ATP homeostasis during the unfolded protein response

Hiramatsu, N., Chiang, K., Aivati, C., Rodvold, J. J., Lee, J.-M., Han, J., Chea, L., Zanetti, M., Koo, E. H., & Lin, J. H. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008336 · Cited by 28

Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation

Peery, R. C., Kyei‐Baffour, K., Dong, Z., Liu, J., Horn, P. D. A., Dai, M., Liu, J., & Zhang, J. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00475 · Cited by 27

Regulation of Cell Death by Transfer RNA

Hou, Y., & Yang, X. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5171 · Cited by 27

Dimethyl sulfoxide potentiates death receptor-mediated apoptosis in the human myeloid leukemia U937 cell line through enhancement of mitochondrial membrane depolarization

Vondráček, J., Souček, K., Sheard, M. A., Chramostová, K., Andrysík, Z., Hofmanová, J., & Kozubı́k, A. (2005) · Leukemia Research · doi:10.1016/j.leukres.2005.05.016 · Cited by 27

Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone‐refractory prostate cancers through mitochondrial damage stress and survivin downregulation

Yu, C., Wu, P., Hsu, J., Ho, Y., Hsu, L., Chang, Y., Chang, H., Chen, I., & Guh, J. (2012) · The Prostate · doi:10.1002/pros.22548 · Cited by 27

Expression of carboxyl terminus of Hsp70-interacting protein (CHIP) indicates poor prognosis in human gallbladder carcinoma

Liang, Z. L., KIM, M., Huang, S. M., Lee, H. J., & Kim, J. (2013) · Oncology Letters · doi:10.3892/ol.2013.1138 · Cited by 27

The Opposing Roles of Cellular Inhibitor of Apoptosis Proteins in Cancer

Lau, R., & Pratt, M. A. C. (2012) · ISRN Oncology · doi:10.5402/2012/928120 · Cited by 27

A role of P301L tau mutant in anti-apoptotic gene expression, cell cycle and apoptosis

Zhao, Z. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00175-1 · Cited by 27

Bcl-2 proteins: master switches at the intersection of death signaling and the survival control by Raf kinases

Rapp, U. R., Rennefahrt, U. E. E., & Troppmair, J. (2003) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2003.10.015 · Cited by 27

Inhibitor of apoptosis proteins (IAPs) as regulatory factors of hepatic apoptosis

Wang, K., & Lin, B. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.06.003 · Cited by 26

Host cell death during infection withChlamydia: a double-edged sword

Sixt, B. S. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa043 · Cited by 29

Sp1 Upregulates Survivin Expression in Adenocarcinoma of Lung Cell Line A549

Chen, Y., Wang, X., Li, W., Zhang, H., Zhao, C., Li, Y., Wang, Z., & Chen, C. (2011) · The Anatomical Record · doi:10.1002/ar.21378 · Cited by 26

The complete genome sequence of the Alphaentomopoxvirus Anomala cuprea entomopoxvirus, including its terminal hairpin loop sequences, suggests a potentially unique mode of apoptosis inhibition and mode of DNA replication

Mitsuhashi, W., Miyamoto, K., & Wada, S. (2014) · Virology · doi:10.1016/j.virol.2013.12.036 · Cited by 26

Targeting Inhibitor of Apoptosis Proteins (IAPs) for Diagnosis and Treatment of Human Diseases

Fulda, S., & Debatin, K. (2006) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/157489206775246539 · Cited by 26

Molecular mechanism of upregulation of survivin transcription by the AT-rich DNA-binding ligand, Hoechst33342: evidence for survivin involvement in drug resistance

Wu, J., Apontes, P., Song, L., Liang, P., Li, Y., & Li, F. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm149 · Cited by 28

Response of human alveolar bone-derived cells to a novel poly(vinylidene fluoride-trifluoroethylene)/barium titanate membrane

Teixeira, L. N., Crippa, G. E., Gimenes, R., Zaghete, M. A., de Oliveira, P. T., Rosa, A. L., & Beloti, M. M. (2010) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-010-4189-z · Cited by 26

Genistein promotes cell death of ethanol-stressed HeLa cells through the continuation of apoptosis or secondary necrosis

Xie, X., Wang, S., Wong, T. C. S., & Fung, M. C. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-63 · Cited by 27

Bay 61-3606 Sensitizes TRAIL-Induced Apoptosis by Downregulating Mcl-1 in Breast Cancer Cells

Kim, S. Y., Park, S.-E., Shim, S., Park, S., Kim, K. K., Jeong, S.-Y., Choi, E. K., Hwang, J. J., Jin, D.-H., Chung, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0146073 · Cited by 26

Caspase-8 activation by TRAIL monotherapy predicts responses to IAPi and TRAIL combination treatment in breast cancer cell lines

Polański, R., Vincent, J., Polanska, U. M., Petreuş, T., & TANG, E. K. Y. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.234 · Cited by 26

Caspase Enzymology and Activation Mechanisms

Mace, P. D., Riedl, S. J., & Salvesen, G. S. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-417158-9.00007-8 · Cited by 28

Osthole induces lung cancer cell apoptosis through inhibition of inhibitor of apoptosis family proteins

Xu, X., Zhang, M., Zhang, Y., & Zhao, L. (2016) · Oncology Letters · doi:10.3892/ol.2016.5170 · Cited by 26

Expression of apoptosome pathway-related transcripts in non-small cell lung cancer

Krepela, E., Procházka, J., Fiala, P., Zatloukal, P., & Selinger, P. (2005) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-005-0048-6 · Cited by 26

Survivin-Dependent and -Independent Pathways and the Induction of Cancer Cell Death by Tetra-O-methyl Nordihydroguaiaretic Acid

Huang, R., CHANG, C., & Mold, D. E. (2006) · Seminars in Oncology · doi:10.1053/j.seminoncol.2006.04.010 · Cited by 26

Long lasting heat shock stimulation of TRAIL-induced apoptosis in transformed T lymphocytes

Moulin, M., & Arrigo, A. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.02.008 · Cited by 26

Inhibition of caspase‐dependent spontaneous apoptosis via a cAMP‐protein kinase A dependent pathway in neutrophils from sickle cell disease patients

Conran, N., Almeida, C. B., Lanaro, C., Proença‐Ferreira, R., Traina, F., Saad, S. T. O., & Costa, F. F. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06748.x · Cited by 26

Adenoviral expression of XIAP antisense RNA induces apoptosis in glioma cells and suppresses the growth of xenografts in nude mice

Naumann, U., Bähr, O., Wolburg, H., Altenberend, S., Wick, W., Liston, P., Ashkenazi, A., & Weller, M. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302845 · Cited by 26

Apoptosis Regulator Genes Encoded by Poxviruses

Barry, M., Wasilenko, S. T., Stewart, T. L., & Taylor, J. M. (2004) · Progress in molecular and subcellular biology · doi:10.1007/978-3-540-74264-7_2 · Cited by 26

Therapeutic targeting of nuclear export and import receptors in cancer and their potential in combination chemotherapy

Newell, S., van der Watt, P. J., & Leaner, V. D. (2023) · IUBMB Life · doi:10.1002/iub.2773 · Cited by 25

The clinical significance of splice variants and subcellular localisation of survivin in non-small cell lung cancers

Nakano, J., Huang, C., Liu, D., Masuya, D., Yokomise, H., Ueno, M., Haba, R., & Sumitomo, S. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604253 · Cited by 25

Survivin, a Promising Gene for Targeted Cancer Treatment

Shamsabadi, F. T., & Eidgahi, M. R. A. (2016) · PubMed · doi:10.14456/apjcp.2016.159 · Cited by 25

Myeloid cell leukemia-1 dependence in acute myeloid leukemia: a novel approach to patient therapy

Kadia, T. M., Kantarjian, H. M., & Konopleva, M. Y. (2019) · Oncotarget · doi:10.18632/oncotarget.26579 · Cited by 25

Adenosine Activates AMPK to Phosphorylate Bcl-XL Responsible for Mitochondrial Damage and DIABLO Release in HuH-7 Cells

Yang, D., Yaguchi, T., Nakano, T., & Nishizaki, T. (2011) · Cellular Physiology and Biochemistry · doi:10.1159/000325207 · Cited by 25

Granulocyte-Colony Stimulating Factor Inhibits Neuronal Apoptosis in a Rat Model of Diabetic Cerebral Ischemia

Lan, X., Qu, H., Yao, W., & Zhang, C. (2008) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.216.117 · Cited by 25

Cytokine-induced tumor suppressors: A GRIM story

Kalvakolanu, D. V., Nallar, S. C., & Kalakonda, S. (2010) · Cytokine · doi:10.1016/j.cyto.2010.03.009 · Cited by 25

The equilibrium of XIAP and Smac/DIABLO expression is gradually deranged during the development and progression of testicular germ cell tumours

Kempkensteffen, C., Jäger, T., Bub, J., Weikert, S., Hinz, S., Christoph, F., Krause, H., Schostak, M., Miller, K., & Schrader, M. G. (2007) · International Journal of Andrology · doi:10.1111/j.1365-2605.2006.00742.x · Cited by 25

Protein–protein recognition as a first step towards the inhibition of XIAP and Survivin anti‐apoptotic proteins

Obiol‐Pardo, C., Granadino‐Roldán, J. M., & Rubio, J. (2008) · Journal of Molecular Recognition · doi:10.1002/jmr.887 · Cited by 25

Conditional deletion of epithelial IKKβ impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis

Londhe, V. A., Maisonet, T. M., Lopez, B. J., Jeng, J., Xiao, J., Li, C., & Minoo, P. (2011) · Respiratory Research · doi:10.1186/1465-9921-12-134 · Cited by 25

Depletion of BIRC6 leads to retarded bovine early embryonic development and blastocyst formation in vitro

Salilew‐Wondim, D., Hölker, M., Rings, F., Phatsara, C., Mohammadi‐Sangcheshmeh, A., Tholen, E., Schellander, K., & Tesfaye, D. (2010) · Reproduction Fertility and Development · doi:10.1071/rd09112 · Cited by 25

Intratumoral Wnt1 expression affects survivin gene expression in non-small cell lung cancer

Huang (2010) · International Journal of Oncology · doi:10.3892/ijo_00000718 · Cited by 25

Ficus umbellata Vahl. (Moraceae) Stem Bark Extracts Exert Antitumor Activities In Vitro and In Vivo

Silihe, K. K., Zingue, S., Winter, E., Awounfack, C. F., Bishayee, A., Desai, N., de Mello, L. J., Michel, T., Nzufo, F. T., Ndinteh, D. T., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061073 · Cited by 25

Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cell xenograft tumor in nude mice in vivo

Ma, Y., Lin, J., Lin, C., Lien, J., Peng, S., Fan, M., Hsu, F., & Chung, J. (2018) · Environmental Toxicology · doi:10.1002/tox.22581 · Cited by 25

Inhibition of cIAP1 as a strategy for targeting c-MYC–driven oncogenic activity

Li, H., Fang, Y., Niu, C., Cao, H., Mi, T., Zhu, H., Yuan, J., & Zhu, J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1807711115 · Cited by 25

How Can Interleukin-1 Receptor Antagonist Modulate Distinct Cell Death Pathways?

Spinello, A., Vecile, E., Abbate, A., Dobrina, A., & Magistrato, A. (2018) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.8b00565 · Cited by 26

Escape of U251 glioma cells from temozolomide-induced senescence was modulated by CDK1/survivin signaling.

Song, Z., Pan, Y., Ling, G., Wang, S., Huang, M., Jiang, X., & Ke, Y. (2017) · Europe PMC (PubMed Central) · Cited by 25

The ubiquitin ligase ability of IAPs regulates apoptosis

Ni, T., Li, W., & Zou, F. (2005) · IUBMB Life · doi:10.1080/15216540500389013 · Cited by 25

Immunohistochemical detection of X-linked inhibitor of apoptosis in head and neck squamous cell carcinoma

Nagi, C. S., Xiao, G.-Q., Li, G., Genden, E. M., & Burstein, D. E. (2007) · Annals of Diagnostic Pathology · doi:10.1016/j.anndiagpath.2006.12.012 · Cited by 25

X-linked Inhibitor of Apoptosis Regulates T Cell Effector Function

Zehntner, S. P., Bourbonnière, L., Moore, C. S., Morris, S. J., Méthot, D., Jean, M. S., LaCasse, E. C., Hebb, A. L. O., Robertson, G. S., Durkin, J. P., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7553 · Cited by 25

Coupled positive feedbacks provoke slow induction plus fast switching in apoptosis

Choi, H.-S., Han, S., Yokota, H., & Cho, K. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.05.016 · Cited by 25

IAP degradation: decisive blow or altruistic sacrifice?

Ditzel, M. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02366-8 · Cited by 25

Antisense approaches in prostate cancer

Chi, K. N., & Gleave, M. E. (2004) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.4.6.927 · Cited by 25

Experience with peritoneal mesothelioma at the Milan National Cancer Institute

D, M. D. M. (2010) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v2.i2.76 · Cited by 24

Upregulation of LAPTM4B‐35 Promotes Malignant Transformation and Tumorigenesis in L02 Human Liver Cell Line

Li, L., Shan, Y., Yang, H., Zhang, S., Lin, M. T., Zhu, P., Chen, X., Yi, J., McNutt, M. A., Shao, G., et al. (2011) · The Anatomical Record · doi:10.1002/ar.21421 · Cited by 24

Survivin deficiency induces apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells

Dai, D. (2011) · Oncology Reports · doi:10.3892/or.2011.1544 · Cited by 24

Knockdown of GRP78 Promotes Apoptosis in Pancreatic Acinar Cells and Attenuates the Severity of Cerulein and LPS Induced Pancreatic Inflammation

Liu, Y., Yang, L., Chen, K., Zhou, B., Yan, H. M., Zhou, Z., & Li, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092389 · Cited by 24

Concurrent upregulation of endogenous proapoptotic and antiapoptotic factors in failing human hearts

Haider, N., Arbustini, E., Gupta, S., Liu, H., Narula, N., Hajjar, R. J., Moorjani, N., Westaby, S., Semigran, M. J., Dec, G. W., et al. (2009) · Nature Reviews Cardiology · doi:10.1038/ncpcardio1452 · Cited by 24

Enhancement of cellular radiation sensitivity through degradation of Chk1 by the XIAP-XAF1 complex

Kim, K. S., Heo, J., Choi, K. J., & Bae, S. (2014) · Cancer Biology & Therapy · doi:10.4161/15384047.2014.962305 · Cited by 24

Adenosine-induced caspase-3 activation by tuning Bcl-XL/DIABLO/IAP expression in HuH-7 human hepatoma cells

Yang, D., Yaguchi, T., Nakano, T., & Nishizaki, T. (2010) · Cell Biology and Toxicology · doi:10.1007/s10565-009-9145-7 · Cited by 24

Cell‐penetrating peptide‐conjugated XIAP‐inhibitory cyclic hexapeptides enter into Jurkat cells and inhibit cell proliferation

Sasaki, Y., Minamizawa, M., Ambo, A., Sugawara, S., Ogawa, Y., & Nitta, K. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06730.x · Cited by 24

INSECT IMMUNITY TO VIRUSES

Sparks, W. O., Bartholomay, L. C., & Bonning, B. C. (2008) · Elsevier eBooks · doi:10.1016/b978-012373976-6.50011-2 · Cited by 24

Aspirin Enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Mediated Apoptosis in Hormone-Refractory Prostate Cancer Cells through Survivin Down-Regulation

Yoo, J., & Lee, Y. J. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.039610 · Cited by 24

Pulsating electromagnetic field stimulation prevents cell death of puromycin treated U937 cell line.

Kaszuba-Zwoińska, J., Wójcik, K., Bereta, M., Ziomber, A., Pierzchalski, P., Rokita, E., Marcinkiewicz, J., Zaraska, W., & Thor, P. (2010) · PubMed · Cited by 24

Molecular mechanisms and clinical implications of miRNAs in drug resistance of colorectal cancer

Duan, L., Yang, W., Feng, W., Cao, L., Wang, X., Niu, L., Li, Y., Zhou, W. J., Zhang, Y., Liu, J., et al. (2020) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835920947342 · Cited by 24

A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells

Peery, R. C., Cui, Q., Kyei‐Baffour, K., Josephraj, S., Huang, C., Dong, Z., Dai, M., Zhang, J., & Liu, J. (2022) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2022.116761 · Cited by 23

Small Molecule Inhibitors Targeting the “Undruggable” Survivin: The Past, Present, and Future from a Medicinal Chemist’s Perspective

Cui, Q., Huang, C., Liu, J., & Zhang, J. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01130 · Cited by 23

Leukocyte Elastase Inhibitor, the precursor of L-DNase II, inhibits apoptosis by interfering with caspase-8 activation

Padrón-Barthe, L., Courta, J., Leprêtre, C., Nagbou, A., & Torriglia, A. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.06.018 · Cited by 19

X-linked inhibitor of apoptosis (XIAP) and XIAP-associated factor-1 expressions and their relationship to apoptosis in human hepatocellular carcinoma and non-cancerous liver tissues

Sakemi, R., Yano, H., Ogasawara, S., Akiba, J., Nakashima, O., Fukahori, S., Sata, M., & Kojiro, M. (2007) · Oncology Reports · doi:10.3892/or.18.1.65 · Cited by 23

Role of Smac in cephalostatin-induced cell death

Rudy, A., López-Antón, N., Barth, N. D., Pettit, G. R., Dirsch, V. M., Schulze‐Osthoff, K., Rehm, M., Prehn, J. H. M., Vogler, M., Fulda, S., et al. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.125 · Cited by 23

Dual effects of Helicobacter pylori vacuolating cytotoxin on human eosinophil apoptosis in early and late periods of stimulation

Kim, J. M., Kim, J. S., Lee, J., Sim, Y., Kim, Y. J., Oh, Y., Yoon, H. J., Kang, J. S., Youn, J., Kim, N., et al. (2010) · European Journal of Immunology · doi:10.1002/eji.200939882 · Cited by 23

Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue

Qi, S., Mogi, S., Tsuda, H., Tanaka, Y., Kozaki, K.-I., Imoto, I., Inazawa, J., Hasegawa, S., & Omura, K. (2008) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.ijom.2008.06.004 · Cited by 23

A Novel cyano derivative of 11‐Keto‐β‐Boswellic acid causes apoptotic death by disrupting PI3K/AKT/Hsp‐90 cascade, mitochondrial integrity, and other cell survival signaling events in HL‐60 cells

Khan, S., Kaur, R., Shah, B. A., Malik, F. A., Kumar, A., Bhushan, S., Jain, S. K., Taneja, S. C., & Singh, J. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20821 · Cited by 23

Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells

Shiokawa, Z., Hashimoto, K., Saito, B., Oguro, Y., Sumi, H., Yabuki, M., Yoshimatsu, M., Kosugi, Y., Debori, Y., Morishita, N., et al. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.09.067 · Cited by 23

Two MicroRNAs Encoded within the Bovine Herpesvirus 1 Latency-Related Gene Promote Cell Survival by Interacting with RIG-I and Stimulating NF-κB-Dependent Transcription and Beta Interferon Signaling Pathways

da Silva, L. F., & Jones, C. (2011) · Journal of Virology · doi:10.1128/jvi.06550-11 · Cited by 24

Pulsed electromagnetic field affects intrinsic and endoplasmatic reticulum apoptosis induction pathways in MonoMac6 cell line culture.

Kaszuba-Zwoińska, J., Chorobik, P., Juszczak, K., Zaraska, W., & Thor, P. (2012) · PubMed · Cited by 23

Nuclear genes with sex bias inRuditapes philippinarum(Bivalvia, veneridae): Mitochondrial inheritance and sex determination in DUI species

Milani, L., Ghiselli, F., Nuzhdin, S. V., & Passamonti, M. (2013) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.22520 · Cited by 23

Smac Modulates Chemosensitivity in Head and Neck Cancer Cells through the Mitochondrial Apoptotic Pathway

Sun, Q., Zheng, X., Zhang, L., & Yu, J. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2262 · Cited by 23

Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms

Jimenez-Lara, A. M., Aranda, A., & Gronemeyer, H. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-15 · Cited by 23

Updates in the pathophysiological mechanisms of Parkinson’s disease: Emerging role of bone marrow mesenchymal stem cells

Ahmed, H. H., Salem, A. M. H., Atta, H. M., Eskandar, E. F., Farrag, A. R. H., Ghazy, M. A., Salem, N. A., & Aglan, H. A. (2016) · World Journal of Stem Cells · doi:10.4252/wjsc.v8.i3.106 · Cited by 23

Influence of survivin (BIRC5) and caspase-9 (CASP9) functional polymorphisms in renal cell carcinoma development: a study in a southern European population

Marques, I., Teixeira, A. L., Ferreira, M., Assis, J., Lobo, F., Maurício, J., & Medeiros, R. (2013) · Molecular Biology Reports · doi:10.1007/s11033-013-2578-3 · Cited by 23

Systems Biology of Apoptosis

Lavrik, I. N. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4009-3 · Cited by 23

Inhibitors of Apoptosis Proteins in Injury and Disease

Lotocki, G., & Keane, R. W. (2002) · IUBMB Life · doi:10.1080/15216540215675 · Cited by 24

The iap genes: unique arbitrators of cell death

Clem, R. J., & Duckett, C. S. (1997) · Trends in Cell Biology · doi:10.1016/s0962-8924(97)01088-x · Cited by 95

Inhibitor of Apoptosis Proteins

Garrison, J. B., Krieg, A. H., Welsh, K., Wen, Y., & Reed, J. C. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511976094.002 · Cited by 3

IAP family proteins---suppressors of apoptosisPreprint

Deveraux, Q. L., & Reed, J. C. (1999) · Genes & Development · doi:10.1101/gad.13.3.239 · Cited by 2,535

Advances in studies on inhibitor of apoptosis proteins

Li, J. (2005) · Anhui Medical and Pharmaceutical Journal