IAP proteins: blocking the road to death's door

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Items 301–400 of 1,000

1. BRAFV600EPromotes Invasiveness of Thyroid Cancer Cells through Nuclear Factor κB Activation
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2. Advances in the biology of malignant pleural mesothelioma
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3. Pathways of apoptosis and importance in developement
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4. Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo
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5. Effects of ammonia stress on the hemocytes of the Pacific white shrimp Litopenaeus vannamei
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6. Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells
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7. X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
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8. Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas
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9. BcR-induced Apoptosis Involves Differential Regulation of C16 and C24-Ceramide Formation and Sphingolipid-dependent Activation of the Proteasome
   Bart‐Jan Kroesen, Susan C. Jacobs, Benjamin J. Pettus, Hannie Sietsma, Jan Kok, Yusuf Awni Hannun, Lou F. M. H. de Leij · 2003 · Journal of Biological Chemistry
10. Solution Structure of Human Survivin and Its Binding Interface with Smac/Diablo
    Chaohong C. Sun, David G. Nettesheim, Zhihong Liu, Edward T. Olejniczak · 2004 · Biochemistry
11. Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia
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12. Human Caspase-7 Activity and Regulation by Its N-terminal Peptide
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13. The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm
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14. PERK-dependent regulation of IAP translation during ER stress
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15. Degradation of Mcl-1 by Granzyme B
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16. Tim50, a Component of the Mitochondrial Translocator, Regulates Mitochondrial Integrity and Cell Death
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17. Survivin Antisense Oligonucleotides Effectively Radiosensitize Colorectal Cancer Cells in Both Tissue Culture and Murine Xenograft Models
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18. Role of Omi/HtrA2 in Apoptotic Cell Death After Myocardial Ischemia and Reperfusion
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19. Harnessing apoptosis for improved anticancer gene therapy.
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20. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation
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21. Targeting apoptosis pathways in lung cancer
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22. Regulation of survivin by PI3K/Akt/p70S6K1 pathway
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23. How T lymphocytes switch between life and death
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24. Apoptosis regulation in the mammary gland
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25. Cyclic AMP Promotes cAMP-responsive Element-binding Protein-dependent Induction of Cellular Inhibitor of Apoptosis Protein-2 and Suppresses Apoptosis of Colon Cancer Cells through ERK1/2 and p38 MAPK
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26. Is caspase‐dependent apoptosis only cell differentiation taken to the extreme?
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27. Targeting Cell Death in Tumors by Activating Caspases
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28. Vascular remodeling in pulmonary arterial hypertension: Multiple cancer-like pathways and possible treatment modalities
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29. The genetics of cell death: approaches, insights and opportunities in Drosophila
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30. How apoptosis got the immune system in shape
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31. Targeted therapy by disablingcrossroadsignaling networks: the survivin paradigm
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32. cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas
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33. Polymorphisms in the survivin gene and the risk of lung cancer
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34. Antagonism of c-IAP and XIAP Proteins Is Required for Efficient Induction of Cell Death by Small-Molecule IAP Antagonists
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35. The N-end rule and regulation of apoptosis
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36. HDAC6 inhibition induces glioma stem cells differentiation and enhances cellular radiation sensitivity through the SHH/Gli1 signaling pathway
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37. Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene
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38. Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: A role for the IAPs
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39. IAPs, regulators of innate immunity and inflammation
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40. XIAP expression is an independent prognostic marker in clear-cell renal carcinomas1 1The results of the study are part of the PhD thesis of E. Caliskan.
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41. Design, Synthesis, and Evaluation of a Potent, Cell-Permeable, Conformationally Constrained Second Mitochondria Derived Activator of Caspase (Smac) Mimetic
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42. Angiopoietin‐1‐induced phosphatidyl‐inositol 3‐kinase activation prevents neuronal apoptosis
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43. Apoptosis Signaling in Tumor Therapy
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44. Correlation Between the Single-Site CpG Methylation and Expression Silencing of the XAF1 Gene in Human Gastric and Colon Cancers
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45. Smac Mimetic Increases Chemotherapy Response and Improves Survival in Mice with Pancreatic Cancer
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46. XIAP Regulates Cytosol-Specific Innate Immunity to Listeria Infection
    Laura D. Bauler, Colin S. Duckett, Mary X O’Riordan · 2008 · PLoS Pathogens
47. Survivin, a Potential Early Predictor of Tumor Progression in the Oral Mucosa
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48. Regulation of Cell Death and Immunity by XIAP
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49. Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases
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50. Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome
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51. Altered Expression of c-IAP1, Survivin, and Smac Contributes to Chemotherapy Resistance in Thyroid Cancer Cells
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52. The Polypeptide Chain-releasing Factor GSPT1/eRF3 Is Proteolytically Processed into an IAP-binding Protein
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53. Effects of Copper on Hemocyte Apoptosis, ROS Production, and Gene Expression in White Shrimp Litopenaeus vannamei
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54. The Membrane-associated Inhibitor of Apoptosis Protein, BRUCE/Apollon, Antagonizes Both the Precursor and Mature Forms of Smac and Caspase-9
    Xiao‐Bo Qiu, Alfred Lewis Goldberg · 2004 · Journal of Biological Chemistry
55. IAP-IAP Complexes Required for Apoptosis Resistance of C. trachomatis–Infected Cells
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56. Nuclear survivin predicts recurrence and poor survival in patients with resected nonsmall cell lung carcinoma
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57. Near death experiences: Poxvirus regulation of apoptotic death
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58. Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis
    Kevin M. Wright, Michael W. Linhoff, Patrick Ryan Potts, Mohanish Deshmukh · 2004 · The Journal of Cell Biology
59. Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
    Matthew C. Franklin, Saloumeh Kadkhodayan, Heidi Ackerly, Daniela Alexandru, Mark Dewey Distefano, Linda O. Elliott, John A. Flygare, Grace Mausisa, David C. Okawa, Danny Ong et al. · 2003 · Biochemistry
60. Antileukemic Activity of Shepherdin and Molecular Diversity of Hsp90 Inhibitors
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61. Apoptosis-Resistance of Hypoxic Cells
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62. Microtubule stabilizing agents: Their molecular signaling consequences and the potential for enhancement by drug combination
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63. Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1
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64. IAP‐antagonists exhibit non‐redundant modes of action through differential DIAP1 binding
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65. From nature to bedside: Pro-survival and cell death mechanisms as therapeutic targets in cancer treatment
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66. Emodin induces apoptosis through caspase 3-dependent pathway in HK-2 cells
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67. Physalis peruviana extract induces apoptosis in human Hep G2 cells through CD95/CD95L system and the mitochondrial signaling transduction pathway
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68. Overcoming resistance to TRAIL-induced apoptosis in solid tumor cells by simultaneously targeting death receptors, c-FLIP and IAPs
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69. Activation of caspase-3 by the Dot/Icm virulence system is essential for arrested biogenesis of theLegionella-containing phagosome
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70. Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self‐activation
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71. Sept4/ARTS is required for stem cell apoptosis and tumor suppression
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72. Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP
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73. The Rb Pathway and Cancer Therapeutics
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74. The USP19 Deubiquitinase Regulates the Stability of c-IAP1 and c-IAP2
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75. Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks
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76. Combining proteasome inhibition with TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) for cancer therapy
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77. Connective Tissue Growth Factor Confers Drug Resistance in Breast Cancer through Concomitant Up-regulation of Bcl-xL and cIAP1
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78. Survivin expression and its relation with proliferation, apoptosis, and angiogenesis in brain gliomas
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79. The Inhibitor of Apoptosis Protein Fusion c-IAP2·MALT1 Stimulates NF-κB Activation Independently of TRAF1 AND TRAF2
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80. Neutrophil stress and apoptosis underlie myeloid dysfunction in glycogen storage disease type Ib
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81. Six Degrees of Separation: The Oxygen Effect in the Development of Radiosensitizers
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82. XIAP Regulates Caspase Activity in Degenerating Axons
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83. Cord Blood Stem Cell-Mediated Induction of Apoptosis in Glioma Downregulates X-Linked Inhibitor of Apoptosis Protein (XIAP)
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84. A matter of life and death: stem cell survival in tissue regeneration and tumour formation
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85. Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling
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86. Inhibition of the JNK/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic–ischemic brain injury
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87. Molecular cloning and characterization of an inhibitor of apoptosis protein (IAP) from the tiger shrimp, Penaeus monodon
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88. Development of target protein-selective degradation inducer for protein knockdown
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89. Micellar Delivery of Bicalutamide and Embelin for Treating Prostate Cancer
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90. Apoptosis-associated caspase activation assays
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91. Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein
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92. Retinal ganglion cell apoptotic pathway in glaucoma
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93. Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia
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94. Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System
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95. IBRDC2, an IBR‐type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation
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96. Human papillomavirus type 16 E6 and E7 oncoproteins upregulate c-IAP2 gene expression and confer resistance to apoptosis
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97. A Kinase-Independent Role for Unoccupied Insulin and IGF-1 Receptors in the Control of Apoptosis
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98. Activation of p53-Dependent Apoptosis by Acute Ablation of Glycogen Synthase Kinase-3β in Colorectal Cancer Cells
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99. Overcoming cancer therapy resistance by targeting inhibitors of apoptosis proteins and nuclear factor-kappa B.
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100. Targeting survivin for therapeutic discovery: past, present, and future promises
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