Cited by 339RNA Research and SplicingVirus-based gene therapy researchHIV Research and Treatment

How retroviruses select their genomes

D'Souza, Victoria, Summers, Michael F.·2005·Nature Reviews Microbiology

Abstract

As retroviruses assemble in infected cells, two copies of their full-length, unspliced RNA genomes are selected for packaging from a cellular milieu that contains a substantial excess of non-viral and spliced viral RNAs. Understanding the molecular details of genome packaging is important for the development of new antiviral strategies and to enhance the efficacy of retroviral vectors used in human gene therapy. Recent studies of viral RNA structure in vitro and in vivo and high-resolution studies of RNA fragments and protein-RNA complexes are helping to unravel the mechanism of genome packaging and providing the first glimpses of the initial stages of retrovirus assembly.

Integrity signals

Registry

Crossref · 10.1038/nrmicro1210

Cites

166 of 166 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Retroviral genome packaging takes place with great specificity despite the RNA being present in low abundance in infected cells compared to host and viral subgenomic RNAs.

    “This takes place with great specificity despite being present in low abundance in the infected cells in comparison to host and viral subgenomic RNAs”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
D'Souza, V., & Summers, M. F.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Summers, Michael F.
Venue
Nature Reviews Microbiology
Published
2005-08
Volume
3
Issue
8
Pages
643-655
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
OpenAlex
W2016719543
Cited by
339
References
166
Citations by year
2026: 4 · 2025: 3 · 2024: 8 · 2023: 11 · 2022: 8 · 2021: 17 · 2020: 15 · 2019: 12 · 2018: 17 · 2017: 13 · 2016: 21 · 2015: 19 · 2014: 18 · 2013: 23 · 2012: 19
FWCI
1.62
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
retroviruses, genome packaging, viral RNA, RNA splicing, viral RNA structure, retroviral assembly, protein-RNA complex, antiviral strategies, retroviral vectors, gene therapy
MeSH terms
Animals, Base Sequence, Humans, Molecular Sequence Data, Moloney murine leukemia virus, Nucleic Acid Conformation, Retroviridae, RNA, Viral, HIV-1, Gene Products, gag, Genome, Viral, Virus Assembly

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review