Telomerase activity in human germline and embryonic tissues and cells
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The constitutional telomere length in humans and mice is probably established early in embryonic development, during a transient increase in telomerase activity.
“The constitutional telomere length in humans and mice is likely to be set early in embryonic development, when telomerase activity is transiently upregulated44.”
From The telomere syndromes (2012) · cites this paper as [44]
Telomerase expression is low or absent in most human somatic tissues, while it is robust in early proliferative progenitor germ and stem cells.
“Telomerase expression is low or absent in most human somatic tissues6, while it is robust in early proliferative progenitor germ and stem cells 7, 8.”
From Telomere dysfunction and tumour suppression: the senescence connection (2008) · cites this paper as [7]
Telomerase protein expression is generally restricted to cells with the capacity to proliferate.
“Because telomerase protein expression is generally restricted to cells with the capacity to proliferate (26), IPF may result, in part, from the loss or senescence of a cell population in the lung able to respond to repetitive injuries over time.”
From Adult-onset pulmonary fibrosis caused by mutations in telomerase (2007) · cites this paper as [26]
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- Authors
- Wright, W. E., Piatyszek, M. A., Rainey, W. E., Byrd, W., & Shay, J. W.
- Venue
- Developmental Genetics
- Published
- 1996
- References
- 13
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