Cited by 211ATP Synthase and ATPases ResearchRNA and protein synthesis mechanismsBacterial Genetics and Biotechnology

Inventing the dynamo machine: the evolution of the F-type and V-type ATPases

Mulkidjanian, Armen Y., Makarova, Kira S., Galperin, Michael Y., Koonin, Eugene V.·2007·Nature Reviews Microbiology

Abstract

The rotary proton- and sodium-translocating ATPases are reversible molecular machines present in all cellular life forms that couple ion movement across membranes with ATP hydrolysis or synthesis. Sequence and structural comparisons of F- and V-type ATPases have revealed homology between their catalytic and membrane subunits, but not between the subunits of the central stalk that connects the catalytic and membrane components. Based on this pattern of homology, we propose that these ATPases originated from membrane protein translocases, which, themselves, evolved from RNA translocases. We suggest that in these ancestral translocases, the position of the central stalk was occupied by the translocated polymer.

Integrity signals

Registry

Crossref · 10.1038/nrmicro1767

Cites

94 of 94 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Prokaryotic ATPases show a clear dichotomy into eubacterial (F-type) and archaebacterial (A-type) ATPases.

    “Consistent with that, prokaryotic ATPases show a clear dichotomy into two types: the eubacterial (or F-type) ATPase and the archaebacterial (or A-type) ATPase [121].”

    From Early bioenergetic evolution (2013) · cites this paper as [121]

  • Archaea and Bacteria contain primarily A/V-type and F-type ATP synthase subunits, respectively, and eukaryotes harbor complexes of both types.

    “Archaea and Bacteria contain primarily A/V-type and F-type subunits, respectively, and eukaryotes harbor complexes of both types”

    From ATP synthase evolution on a cross-braced dated tree of life (2023) · cites this paper as [29]

  • The catalytic and non-catalytic subunits of the ATP synthase R1 component are paralogs that arose prior to LUCA through an ancient duplication of a RecA family protein (P-loop NTPase) followed by loss of catalytic function in one subunit.

    “The catalytic and non-catalytic subunits comprising the soluble hetero-hexameric R1 component, are paralogs to each other. They arose prior to LUCA through an ancient duplication of a RecA family protein (P-loop NTPase) followed by the loss of the catalytic function in one subunit”

    From ATP synthase evolution on a cross-braced dated tree of life (2023) · cites this paper as [29]

Cites

Flagged first, then by citations

1 of the 95 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Mulkidjanian, A. Y., Makarova, K. S., Galperin, M. Y., & Koonin, E. V.
Affiliations
  • Osnabrück University (DE)
  • National Institutes of Health (US)
Corresponding author
  • Mulkidjanian, Armen Y.
  • Koonin, Eugene V.
Venue
Nature Reviews Microbiology
Published
2007-11
Volume
5
Issue
11
Pages
892-899
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
OpenAlex
W2001138638
Cited by
210
References
95
Citations by year
2026: 7 · 2025: 9 · 2024: 10 · 2023: 7 · 2022: 9 · 2021: 15 · 2020: 15 · 2019: 14 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 16 · 2014: 11 · 2013: 16 · 2012: 9
FWCI
0.71
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
F0F1-ATP synthase, V-type ATPase, molecular machines, bioenergetics
MeSH terms
Adenosine Triphosphatases, Proton-Translocating ATPases, Evolution, Molecular, Cation Transport Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review