The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria
Open accessAbstract
Studies of lactic acid bacteria (LAB) as delivery vehicles have focused mainly on the development of mucosal vaccines, with much effort being devoted to the generation of genetic tools for antigen expression in different bacterial locations. Subsequently, interleukins have been co-expressed with antigens in LAB to enhance the immune response that is raised against the antigen. LAB have also been used as a delivery system for a range of molecules that have different applications, including anti-infectives, therapies for allergic diseases and therapies for gastrointestinal diseases. Now that the first human trial with a Lactococcus strain that expresses recombinant interleukin-10 has been completed, we discuss what we have learnt, what we do not yet understand and what the future holds for therapy and prophylaxis with LAB.
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Cites
Demonstration of safety of probiotics—A review
Salminen, S. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00128-7 · Cited by 884
Vandenbroucke, K., Hans, W., Van Huysse, J., Neirynck, S., Demetter, P., Remaut, E., Rottiers, P., & Steidler, L. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.020 · Cited by 277
Probiotics for the treatment of women with bacterial vaginosis
Falagas, M. E., Betsi, G. I., & Athanasiou, S. (2007) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2007.01688.x · Cited by 253
Cited by
Gut microbiota, obesity and diabetes
Patterson, E., Ryan, P. M., Cryan, J. F., Dinan, T. G., Ross, R. P., Fitzgerald, G. F., & Stanton, C. (2016) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2015-133285 · Cited by 552
An update on the use and investigation of probiotics in health and disease
Sanders, M. E., Guarner, F., Guerrant, R., Holt, P. R., Quigley, E. M., Sartor, R. B., Sherman, P. M., & Mayer, E. A. (2013) · Gut · doi:10.1136/gutjnl-2012-302504 · Cited by 503
“112 117 More effective probiotic interventions for microbiota-associated conditions require a more complete understanding of the interactions between genetic, microbial and environmental in fl uences within individuals.”
BackgroundMicrobiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development
Lee, Y.-S., Kim, T.-Y., Kim, Y., Lee, S.-H., Kim, S., Kang, S. W., Yang, J.-Y., Baek, I.-J., Sung, Y. H., Park, Y.-Y., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.11.002 · Cited by 459
Lactobacillus surface layer proteins: Structure, function and applications
Hynönen, U., & Palva, A. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-4962-2 · Cited by 283
Enhancing Oral Vaccine Potency by Targeting Intestinal M Cells
Azizi, A., Kumar, A., Diaz-Mitoma, F., & Mestecky, J. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001147 · Cited by 180
Metadata
- Authors
- Wells, J. M., & Mercenier, A.
- Venue
- Nature Reviews Microbiology
- Published
- 2008-05
- Volume
- 6
- Issue
- 5
- Pages
- 349-362
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2113645094
- Cited by
- 537
- References
- 3
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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