An update on the use and investigation of probiotics in health and disease

Sanders, Mary Ellen; Guarner, Francisco; Guerrant, Richard; Holt, Peter R; Quigley, Eamonn MM; Sartor, R Balfour; Sherman, Philip M; Mayer, Emeran A

doi:10.1136/gutjnl-2012-302504

Cited by 503Probiotics and Fermented FoodsGut microbiota and healthInfant Nutrition and Health

An update on the use and investigation of probiotics in health and disease

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Sanders, Mary Ellen, Guarner, Francisco, Guerrant, Richard, Holt, Peter R, Quigley, Eamonn MM, Sartor, R Balfour, Sherman, Philip M, Mayer, Emeran A·2013·Gut

DOI 10.1136/gutjnl-2012-302504PMC PMC4351195

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Abstract

Probiotics are derived from traditional fermented foods, from beneficial commensals or from the environment. They act through diverse mechanisms affecting the composition or function of the commensal microbiota and by altering host epithelial and immunological responses. Certain probiotic interventions have shown promise in selected clinical conditions where aberrant microbiota have been reported, such as atopic dermatitis, necrotising enterocolitis, pouchitis and possibly irritable bowel syndrome. However, no studies have been conducted that can causally link clinical improvements to probiotic-induced microbiota changes. Whether a disease-prone microbiota pattern can be remodelled to a more robust, resilient and disease-free state by probiotic administration remains a key unanswered question. Progress in this area will be facilitated by: optimising strain, dose and product formulations, including protective commensal species; matching these formulations with selectively responsive subpopulations; and identifying ways to manipulate diet to modify bacterial profiles and metabolism.

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FMT introduces a complete, stable, and durable community of gut microbiota, unlike probiotics, that temporarily alter the metabolic, or immunologic activity, of the native gut microbiota.
“FMT introduces a complete, stable, and durable community of gut microbiota [26] , unlike probiotics, that temporarily alter the metabolic, or immunologic activity, of the native gut microbiota [27] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [27]
The use of probiotics in preventive medicine to keep a healthy intestinal function is well documented.
“the use of probiotics in preventive medicine to keep a healthy intestinal function is well documented”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [27]

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Probiotics for preventing acute upper respiratory tract infections
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Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial
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Redefining the Role of Intestinal Microbes in the Pathogenesis of Necrotizing Enterocolitis
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The CASE adherence index: A novel method for measuring adherence to antiretroviral therapy
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Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial
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Probiotics, Enteric and Diarrheal Diseases, and Global Health
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Effect of Bifidobacterium lactis on the Incidence of Nosocomial Infections in Very-Low-Birth-Weight Infants: A Randomized Controlled Trial
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Probiotic administration and the incidence of nosocomial infection in pediatric intensive care: A randomized placebo-controlled trial*
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The Role of the Gastrointestinal Microbiota in Colorectal Cancer
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Colorectal carcinogenesis in germ-free and conventionally reared rats: Different intestinal environments affect the systemic immunity
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Updating the DALYs for diarrhoeal disease
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Prebiotic and Probiotic Fortified Milk in Prevention of Morbidities among Children: Community-Based, Randomized, Double-Blind, Controlled Trial
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The mechanisms and efficacy of probiotics in the prevention of Clostridium difficile-associated diarrhoea
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The microbiota link to irritable bowel syndrome
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Probiotics for treating persistent diarrhoea in children
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Fermented Milks, Probiotic Cultures, and Colon Cancer
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A Recombinant Probiotic for Treatment and Prevention of Cholera
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Probiotics: From Bench to Market
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Probiotic Therapy in Radiation‐Induced Intestinal Injury and Repair
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Probiotic and prebiotic claims in Europe: seeking a clear roadmap
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Fecal Microbiota Transplantation: Past, Present and Future
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NECROTIZING ENTEROCOLITIS
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Probiotics in the Treatment and Prevention of Atopic Dermatitis
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Prophylactic ciprofloxacin treatment prevented high mortality, and modified systemic and intestinal immune function in tumour-bearing rats receiving dose-intensive CPT-11 chemotherapy
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Probiotics and Gastro-Intestinal Disorders
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T1794 Selective Alteration of Growth and Virulence for Iron-Dependent Enteric Bacterial Species; Possible Novel Mechanisms of Detrimental Effects of Dietary Iron on Intestinal Inflammation
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Ingestion of Dietary Carbohydrates Influences the Aggressiveness of Colitis and Intestinal Microbial Composition in IL-10-/- Mice
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Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms
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Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut
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A randomized double-blind controlled trial: Impact of probiotics on diarrhea in patients treated with pelvic radiation
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Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms
Felice, V. D., Quigley, E. M., Sullivan, A. M., O'Keeffe, G. W., & O'Mahony, S. M. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.03.012 · Cited by 205 · see citing works
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Involvement of gut microbiome in human health and disease: brief overview, knowledge gaps and research opportunities
Liang, D., Leung, R. K., Guan, W., & Au, W. W. (2018) · Gut Pathogens · doi:10.1186/s13099-018-0230-4 · Cited by 198 · see citing works
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Authors: Sanders, M. E., Guarner, F., Guerrant, R., Holt, P. R., Quigley, E. M., Sartor, R. B., Sherman, P. M., & Mayer, E. A.
Affiliations: Dairy & Food Culture Technologies, Centennial, Colorado, USA
Vall d'Hebron Hospital Universitari (ES)
University of Virginia (US)
Rockefeller University (US)
Houston Methodist (US)
University of North Carolina at Chapel Hill (US)
University of Toronto (CA)
University of California, Los Angeles (US)
Corresponding author: Mayer, Emeran A
ORCID: Sanders, Mary Ellen
Guarner, Francisco
Guerrant, Richard
Holt, Peter R
Quigley, Eamonn MM
Sartor, R Balfour
Sherman, Philip M
Mayer, Emeran A
Venue: Gut
Publisher: BMJ
Published: 2013-03-08
Volume: 62
Issue: 5
Pages: 787-796
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gutjnl-2012-302504
PMC: PMC4351195
OpenAlex: W2148017101
Cited by: 503
References: 134
Citations by year: 2026: 18 · 2025: 23 · 2024: 20 · 2023: 29 · 2022: 29 · 2021: 34 · 2020: 37 · 2019: 29 · 2018: 44 · 2017: 46 · 2016: 52 · 2015: 58 · 2014: 61 · 2013: 22
FWCI: 8.55
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Gut (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion, cc-by-nc)
PubMed Central (acceptedVersion, cc-by-nc)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
HighWire Press Open Archive (submittedVersion)
UNC Libraries
Funders: Procter and Gamble
Mead Johnson Nutrition
Danone
Ironwood Pharmaceuticals, Incorporated
Alimentary Health
Instituto Danone
Norgine
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK048351, U01DK082370)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: probiotics, gut microbiota, commensal microbiota, atopic dermatitis, necrotizing enterocolitis, pouchitis, irritable bowel syndrome, host immune response, diet and microbiome, microbiota resilience
MeSH terms: Colitis, Ulcerative, Crohn Disease, Cross Infection, Diarrhea, Female, Health Status, Humans, Hypersensitivity, Vaginitis, Colorectal Neoplasms, Meta-Analysis as Topic, Evidence-Based Medicine, Probiotics, Enterocolitis, Necrotizing, Irritable Bowel Syndrome

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An update on the use and investigation of probiotics in health and disease

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