The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Pyroptosis: host cell death and inflammation
Open accessAbstract
Eukaryotic cells can initiate several distinct programmes of self-destruction, and the nature of the cell death process (non-inflammatory or proinflammatory) instructs responses of neighbouring cells, which in turn dictates important systemic physiological outcomes. Pyroptosis, or caspase 1-dependent cell death, is inherently inflammatory, is triggered by various pathological stimuli, such as stroke, heart attack or cancer, and is crucial for controlling microbial infections. Pathogens have evolved mechanisms to inhibit pyroptosis, enhancing their ability to persist and cause disease. Ultimately, there is a competition between host and pathogen to regulate pyroptosis, and the outcome dictates life or death of the host.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
Eisenbarth, S. C., Colegio, O. R., O’Connor, W., Sutterwala, F. S., & Flavell, R. A. (2008) · Nature · doi:10.1038/nature06939 · Cited by 1,542
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402195 · Cited by 1,445
Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T.-D., Özören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1346 · Cited by 1,131
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127
Fernandes-Alnemri, T., Wu, J., Yu, J.-W., Datta, P., Miller, B., Jankowski, W., Rosenberg, S., Zhang, J., & Alnemri, E. S. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402194 · Cited by 1,026
Qu, Y., Franchi, L., Nunez, G., & Dubyak, G. R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.3.1913 · Cited by 563
Cited by
Items 101–110 of 110
Mechanisms and emerging functions of DNA degradation in the epidermis
Eckhart, L. (2012) · Frontiers in Bioscience · doi:10.2741/4065 · Cited by 39
Solomon, M. A., Shah, A. A., & D'Souza, G. G. M. (2013) · Mitochondrion · doi:10.1016/j.mito.2012.10.013 · Cited by 39
Bufalin suppresses endometriosis progression by inducing pyroptosis and apoptosis
Cho, Y. J., Lee, J. E., Park, M. J., O’Malley, B. W., & Han, S. J. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0700 · Cited by 37
Revisiting Caspase-11 Function in Host Defense
Ng, T. M., & Monack, D. M. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.06.009 · Cited by 32
NLRP3 inflammasome as therapeutic targets in inflammatory diseases
Prakash, A. V., Park, I.-H., Park, J. W., Bae, J. P., Lee, G. S., & Kang, T. J. (2023) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2023.099 · Cited by 31
Efferocytosis in liver disease
Shi, H., Moore, M. P., Wang, X., & Tabas, I. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2023.100960 · Cited by 30
Cell resilience in species life spans: a link to inflammation?
Finch, C. E., Morgan, T. E., Longo, V. D., & De Magalhaes, J. P. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00578.x · Cited by 29
Chen, P., Zhou, Y.-K., Han, C.-S., Chen, L.-J., Wang, Y.-M., Zhuang, Z.-M., Lin, S., Zhou, Y.-H., Jiang, J.-H., & Yang, R.-L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.860225 · Cited by 25
AIM2 Inhibits BRAF-Mutant Colorectal Cancer Growth in a Caspase-1-Dependent Manner
Shah, S., Qin, S., Luo, Y., Huang, Y., Jing, R., Shah, J. N., Chen, J., Chen, H., & Zhong, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.588278 · Cited by 19
Navigating the complexities of cell death: Insights into accidental and programmed cell death
Lotfi, M.-S., & Rassouli, F. B. (2024) · Tissue and Cell · doi:10.1016/j.tice.2024.102586 · Cited by 15
Metadata
- Authors
- Bergsbaken, T., Fink, S. L., & Cookson, B. T.
- Venue
- Nature Reviews Microbiology
- Published
- 2009-02
- Volume
- 7
- Issue
- 2
- Pages
- 99-109
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W1985970823
- Cited by
- 3,183
- References
- 15
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
